{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T02:47:51Z","timestamp":1785466071403,"version":"3.56.0"},"reference-count":14,"publisher":"Akademiai Kiado Zrt.","issue":"43","license":[{"start":{"date-parts":[[2024,10,27]],"date-time":"2024-10-27T00:00:00Z","timestamp":1729987200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015763","name":"Szegedi Tudom\u00e1nyegyetem","doi-asserted-by":"crossref","award":["IV-134-621-2024.SZAOK"],"award-info":[{"award-number":["IV-134-621-2024.SZAOK"]}],"id":[{"id":"10.13039\/501100015763","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Kultur\u00e1lis \u00e9s Innov\u00e1ci\u00f3s Miniszt\u00e9rium","award":["\u00daNKP-23-4-SZTE-389"],"award-info":[{"award-number":["\u00daNKP-23-4-SZTE-389"]}]}],"content-domain":{"domain":["www.akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2024,10,27]]},"abstract":"<jats:p>\n                    <jats:italic>Bevezet\u00e9s:<\/jats:italic>\n                    A liposarcom\u00e1k morfol\u00f3giailag v\u00e1ltozatos csoportot\n                    alkotnak a mesenchymalis malignit\u00e1sok k\u00f6z\u00f6tt. A l\u00e1gyr\u00e9sz-daganatok\n                    diagnosztik\u00e1ja sor\u00e1n mindig fel kell mer\u00fclnie a j\u00f3l differenci\u00e1lt \u00e9s a\n                    dedifferenci\u00e1lt liposarcoma lehet\u0151s\u00e9g\u00e9nek. E daganatok eddigi legmegb\u00edzhat\u00f3bb\n                    immunhisztok\u00e9miai markere az MDM2 volt, a liposarcom\u00e1k azonban m\u00e1s markerekkel\n                    is sokf\u00e9le pozitivit\u00e1st mutathatnak.\n                    <jats:italic>M\u00f3dszer:<\/jats:italic>\n                    Tanulm\u00e1nyunkban a\n                    Szegedi Tudom\u00e1nyegyetemen ism\u00e9telten \u00e1ttekintett\u00fck a 2017 \u00e9s 2022 k\u00f6z\u00f6tt\n                    el\u0151fordult, j\u00f3l \u00e9s dedifferenci\u00e1lt liposarcom\u00e1s eseteket, \u00e9s sz\u00fcks\u00e9g eset\u00e9n\n                    tov\u00e1bbi immunhisztok\u00e9miai vizsg\u00e1latokat v\u00e9gezt\u00fcnk, bele\u00e9rtve az MDM2-, CDK4-,\n                    p16- \u00e9s STAT6-vizsg\u00e1latot.\n                    <jats:italic>Eredm\u00e9nyek:<\/jats:italic>\n                    Kohorszunkban 7 esetben\n                    fordult el\u0151 j\u00f3l differenci\u00e1lt, 11 esetben pedig dedifferenci\u00e1lt liposarcoma.\n                    Minden morfol\u00f3giai mint\u00e1zatot regisztr\u00e1ltunk \u00e9s lef\u00e9nyk\u00e9pezt\u00fcnk. Az esetek t\u00f6bb\n                    mint fel\u00e9ben a tumor a retroperitoneumban helyezkedett el (n = 11), \u00e9s 8\n                    betegn\u00e9l T4-es st\u00e1diumban jelentkezett. Az MDM2 minden esetben fok\u00e1lisan vagy\n                    diff\u00fazan pozit\u00edv volt (n = 18), m\u00edg a CDK4 \u00e9s a p16 szinte minden esetben\n                    diff\u00fazan pozit\u00edvnak bizonyult (n = 17). A morfol\u00f3giai v\u00e1ltozatoss\u00e1g ellen\u00e9re az\n                    \u00f6sszes dedifferenci\u00e1lt liposarcoma (n = 11) pozit\u00edv volt MDM2-, CDK4- \u00e9s\n                    p16-reakci\u00f3val is. A STAT6 3 dedifferenci\u00e1lt liposarcom\u00e1s esetben mutatott\n                    multifok\u00e1lis nukle\u00e1ris pozitivit\u00e1st.\n                    <jats:italic>K\u00f6vetkeztet\u00e9s:<\/jats:italic>\n                    A\n                    liposarcoma diagn\u00f3zis\u00e1nak fel\u00e1ll\u00edt\u00e1s\u00e1hoz MDM2, CDK4 \u00e9s p16 immunhisztok\u00e9miai\n                    reakci\u00f3kat, valamint MDM2 fluoreszcens\n                    <jats:italic>in situ<\/jats:italic>\n                    hibridiz\u00e1ci\u00f3t\n                    sz\u00fcks\u00e9ges v\u00e9gezni. Dedifferenci\u00e1lt liposarcom\u00e1s eseteink jelent\u0151s kisebbs\u00e9ge\n                    mutatott multifok\u00e1lis pozitivit\u00e1st a STAT6-tal, ez\u00e9rt a solitaer fibrosus\n                    tumorokb\u00f3l sz\u00e1rmaz\u00f3 kis mint\u00e1kn\u00e1l az MDM2-reakci\u00f3 elv\u00e9gz\u00e9se aj\u00e1nlott a\n                    liposarcoma lehet\u0151s\u00e9g\u00e9nek kiz\u00e1r\u00e1s\u00e1ra. Tanulm\u00e1nyunk az els\u0151, amely a liposarcom\u00e1k\n                    valamennyi j\u00f3l ismert morfol\u00f3giai mint\u00e1zat\u00e1t tartalmazza. Orv Hetil. 2024;\n                    165(43): 1700\u20131706.\n                  <\/jats:p>","DOI":"10.1556\/650.2024.33168","type":"journal-article","created":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T11:52:37Z","timestamp":1730289157000},"page":"1700-1706","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":1,"title":["A j\u00f3l \u00e9s a dedifferenci\u00e1lt liposarcom\u00e1k morfol\u00f3giai \u00e9s immunhisztok\u00e9miai jellegzetess\u00e9gei"],"prefix":"10.1556","volume":"165","author":[{"given":"Mersad","family":"Akbarzadeh","sequence":"first","affiliation":[{"name":"Szegedi Tudom\u00e1nyegyetem, Szent-Gy\u00f6rgyi Albert Orvostudom\u00e1nyi Kar, Pathologiai Int\u00e9zet Szeged, \u00c1llom\u00e1s u. 1., 6725 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tam\u00e1s","family":"Pancsa","sequence":"additional","affiliation":[{"name":"Szegedi Tudom\u00e1nyegyetem, Szent-Gy\u00f6rgyi Albert Orvostudom\u00e1nyi Kar, Pathologiai Int\u00e9zet Szeged, \u00c1llom\u00e1s u. 1., 6725 Magyarorsz\u00e1g"},{"name":"Bioptick\u00e1 Laboratro\u0159 Pilsen Cseh K\u00f6zt\u00e1rsas\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Sejben","sequence":"additional","affiliation":[{"name":"Szegedi Tudom\u00e1nyegyetem, Szent-Gy\u00f6rgyi Albert Orvostudom\u00e1nyi Kar, Pathologiai Int\u00e9zet Szeged, \u00c1llom\u00e1s u. 1., 6725 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"R1","unstructured":"WHO classification of tumours editorial board. WHO classification of\n                    tumors of soft tissue and bone. 5th ed. International Agency for Research on\n                    Cancer, Lyon, 2020."},{"key":"R2","doi-asserted-by":"crossref","unstructured":"Sbaraglia M, Bellan E, Tos AP. The 2020 WHO classification of soft\n                    tissue tumours: news and perspectives. Pathologica 2021; 113:\n                    70\u201384.","DOI":"10.32074\/1591-951X-213"},{"key":"R3","doi-asserted-by":"crossref","unstructured":"Clay MR, Martinez AP, Weiss SW, et al. MDM2 and CDK4\n                    immunohistochemistry: should it be used in problematic differentiated lipomatous\n                    tumors? A new perspective. Am J Surg Pathol. 2016; 40:\n                    1647\u20131642.","DOI":"10.1097\/PAS.0000000000000713"},{"key":"R4","doi-asserted-by":"crossref","unstructured":"Weaver J, Rao P, Goldblum JR, et al. Can MDM2 analytical tests\n                    performed on core needle biopsy be relied upon to diagnose well-differentiated\n                    liposarcoma? Mod Pathol. 2010; 23: 1301\u20131306.","DOI":"10.1038\/modpathol.2010.106"},{"key":"R5","doi-asserted-by":"crossref","unstructured":"Kobayashi A, Sakuma T, Fujimoto M, et al. Diagnostic utility and\n                    limitations of immunohistochemistry of p16, CDK4, and MDM2 and automated\n                    dual-color in situ hybridization of MDM2 for the diagnosis of challenging cases\n                    of dedifferentiated liposarcoma. Appl Immunohistochem Mol Morphol. 2019; 27:\n                    758\u2013763.","DOI":"10.1097\/PAI.0000000000000677"},{"key":"R6","doi-asserted-by":"crossref","unstructured":"He M, Aisner S, Benevenia J, et al. p16 immunohistochemistry as an\n                    alternative marker to distinguish atypical lipomatous tumor from deep-seated\n                    lipoma. Appl Immunohistochem Mol Morphol. 2009; 17: 51\u201356.","DOI":"10.1097\/PAI.0b013e3181719223"},{"key":"R7","doi-asserted-by":"crossref","unstructured":"Thway K, Robertson D, Thway Y, et al. Dedifferentiated liposarcoma\n                    with meningothelial-like whorls, metaplastic bone formation, and CDK4, MDM2, and\n                    p16 expression: a morphologic and immunohistochemical study. Am J Surg Pathol.\n                    2011; 35: 356\u2013363.","DOI":"10.1097\/PAS.0b013e31820832c1"},{"key":"R8","doi-asserted-by":"crossref","unstructured":"Kammerer-Jacquet SF, Thierry S, Cabillic F, et al. Differential\n                    diagnosis of atypical lipomatous tumor\/well-differentiated liposarcoma and\n                    dedifferentiated liposarcoma: utility of p16 in combination with MDM2 and CDK4\n                    immunohistochemistry. Hum Pathol. 2017; 59: 34\u201340.","DOI":"10.1016\/j.humpath.2016.08.009"},{"key":"R9","doi-asserted-by":"crossref","unstructured":"Creytens D, Libbrecht Louis, Ferdinande L. Nuclear expression of\n                    STAT6 in dedifferentiated liposarcomas with a solitary fibrous tumor-like\n                    morphology: a diagnostic pitfall. Appl Immunohistochem Mol Morphol. 2015; 23:\n                    462\u2013463.","DOI":"10.1097\/PAI.0000000000000081"},{"key":"R10","doi-asserted-by":"crossref","unstructured":"M\u00e1trai Z, T\u00f3th L, Szentirmay Z, et al. Surgical challenges of chest\n                    wall and intra-thoracic desmoid tumors. [Mellkasfali \u00e9s intrathoracalis desmoid\n                    tumorok seb\u00e9szi kezel\u00e9s\u00e9nek kih\u00edv\u00e1sai.] Orv Hetil. 2011; 152: 3\u201313.\n                    [Hungarian]","DOI":"10.1556\/OH.2011.29009"},{"key":"R11","doi-asserted-by":"crossref","unstructured":"Almakrami M, Pancsa T, Kuthi L, et al. Myxoinflammatory fibroblastic\n                    sarcoma of the lower limb. [Az als\u00f3 v\u00e9gtag myxoinflammatoricus fibroblastos\n                    sarcom\u00e1ja.] Orv Hetil. 2023; 164: 1637\u20131641. [Hungarian]","DOI":"10.1556\/650.2023.32891"},{"key":"R12","doi-asserted-by":"crossref","unstructured":"Wu A, Pullarkat S. Follicular dendritic cell sarcoma. Arch Pathol\n                    Lab Med. 2016; 140: 186\u2013190.","DOI":"10.5858\/arpa.2014-0374-RS"},{"key":"R13","doi-asserted-by":"crossref","unstructured":"Chrisinger JS. Update on lipomatous tumors with emphasis on emerging\n                    entities, unusual anatomic sites, and variant histologic patterns. Surg Pathol\n                    Clin. 2019; 12: 21\u201333.","DOI":"10.1016\/j.path.2018.11.001"},{"key":"R14","doi-asserted-by":"crossref","unstructured":"R\u00f3zsav\u00f6lgyi Z, Andr\u00e1si K, D\u00f3ka A, et al. Rapidly growing giant\n                    solitary fibrous tumor of the pleura. [Gyorsan n\u00f6vekv\u0151 \u00f3ri\u00e1s solitaer fibrosus\n                    pleuratumor.] Orv Hetil. 2024; 165: 754\u2013758. 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