{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T09:03:30Z","timestamp":1785488610531,"version":"3.56.0"},"reference-count":64,"publisher":"Akademiai Kiado Zrt.","issue":"4","license":[{"start":{"date-parts":[[2025,1,26]],"date-time":"2025-01-26T00:00:00Z","timestamp":1737849600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2025,1,26]]},"abstract":"<jats:p>A szomatosztatin (SST) egy multifunkcion\u00e1lis, 14\u201328 aminosavb\u00f3l \u00e1ll\u00f3\n                    peptidhormon, amelyet el\u0151sz\u00f6r a hypothalamusban fedeztek fel, majd k\u00e9s\u0151bb egy\u00e9b\n                    sz\u00f6veti strukt\u00far\u00e1kban is kimutattak. Hat\u00e1s\u00e1t k\u00fcl\u00f6nb\u00f6z\u0151 receptorokon (SST1\u20135)\n                    kereszt\u00fcl fejti ki. Els\u0151sorban inhibitorikus tulajdons\u00e1ggal rendelkezik az\n                    endokrin \u00e9s k\u00fcl\u00f6nb\u00f6z\u0151 idegrendszeri folyamatokban. Fiziol\u00f3giai tulajdons\u00e1ga \u00e9s\n                    szerepe t\u00falmutat a hormonok szab\u00e1lyoz\u00e1s\u00e1n, r\u00e9szt vesz a gyullad\u00e1sos jelleg\u0171\n                    idegrendszeri folyamatok (neurog\u00e9n gyullad\u00e1s) modul\u00e1l\u00e1s\u00e1ban, ir\u00e1ny\u00edt\u00e1s\u00e1ban\n                    egyar\u00e1nt. Neurog\u00e9n gyullad\u00e1s sor\u00e1n a szenzoros neuronokb\u00f3l felszabadul\u00f3\n                    neuropeptidek \u2013 p\u00e9ld\u00e1ul a P-anyag \u00e9s a kalcitoning\u00e9nnel rokon peptid (CGRP) \u2013\n                    gyullad\u00e1sos reakci\u00f3kat v\u00e1ltanak ki. A szomatosztatin g\u00e1tolja e medi\u00e1torok\n                    felszabadul\u00e1s\u00e1t \u00e9s az ezekhez kapcsol\u00f3d\u00f3 gyullad\u00e1sos folyamatokat is.\n                    Gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1sa fontos klinikai jelent\u0151s\u00e9ggel b\u00edr a neurol\u00f3giai \u00e9s\n                    gyullad\u00e1sos betegs\u00e9gek (p\u00e9ld\u00e1ul Alzheimer-k\u00f3r, migr\u00e9n, kr\u00f3nikus f\u00e1jdalom\n                    szindr\u00f3ma, neurodegenerat\u00edv k\u00f3rk\u00e9pek stb.) kezel\u00e9s\u00e9ben. Szintetikus sz\u00e1rmaz\u00e9kai\n                    (p\u00e9ld\u00e1ul rheumatoid), szint\u00e9n alkalmazhat\u00f3k k\u00fcl\u00f6nb\u00f6z\u0151 klinikai \u00e1llapotokban,\n                    tov\u00e1bb\u00e1 neuroendokrin tumorok kezel\u00e9s\u00e9ben (g\u00e1tolj\u00e1k a t\u00falzott hormontermel\u00e9st \u00e9s\n                    a tumor n\u00f6veked\u00e9s\u00e9t). Az ut\u00f3bbi \u00e9vek kutat\u00e1si eredm\u00e9nyei r\u00e1vil\u00e1g\u00edtottak a\n                    szomatosztatin jelent\u0151s\u00e9g\u00e9re a f\u00e1jdalom\u00e9rz\u00e9kel\u00e9s tekintet\u00e9ben is. A\n                    szomatosztatin \u00e9s anal\u00f3gjai k\u00e9pesek cs\u00f6kkenteni a nociceptiv inger\u00fclet\u00e1tvitelt,\n                    \u00edgy modul\u00e1lj\u00e1k a f\u00e1jdalom\u00e9rz\u00e9st, k\u00fcl\u00f6n\u00f6sen kr\u00f3nikus \u00e9s neuropathi\u00e1s f\u00e1jdalmak\n                    eset\u00e9ben. A szomatosztatin \u00e9s anal\u00f3gjai potenci\u00e1lis ter\u00e1pi\u00e1s c\u00e9lpontot\n                    jelentenek a neurog\u00e9n \u00e9s gyullad\u00e1sos patofiziol\u00f3giai folyamatok modul\u00e1l\u00e1s\u00e1ban,\n                    c\u00e9lpontk\u00e9nt szolg\u00e1lnak a f\u00e1jdalomcsillap\u00edt\u00e1sban \u00e9s a gyullad\u00e1sos betegs\u00e9gek\n                    kezel\u00e9s\u00e9ben. Orv Hetil. 2025; 166(4): 123\u2013129.<\/jats:p>","DOI":"10.1556\/650.2025.33215","type":"journal-article","created":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T09:16:19Z","timestamp":1739524579000},"page":"123-129","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":0,"title":["A szomatosztatin \u00e9s sziszt\u00e9m\u00e1s felszabadul\u00e1s\u00e1nak jelent\u0151s\u00e9ge gyullad\u00e1sos, f\u00e1jdalommal j\u00e1r\u00f3 \u00e9s egy\u00e9b \u00e1llapotokban"],"prefix":"10.1556","volume":"166","author":[{"given":"Bal\u00e1zs","family":"Tornai","sequence":"first","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Klinikai K\u00f6zpont, Aneszteziol\u00f3giai \u00e9s Intenz\u00edv Ter\u00e1pi\u00e1s Int\u00e9zet P\u00e9cs, Ifj\u00fas\u00e1g u. 13., 7624 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Het\u00e9nyi","sequence":"additional","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Klinikai K\u00f6zpont, Aneszteziol\u00f3giai \u00e9s Intenz\u00edv Ter\u00e1pi\u00e1s Int\u00e9zet P\u00e9cs, Ifj\u00fas\u00e1g u. 13., 7624 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Istv\u00e1n Zo\u00e1rd","family":"B\u00e1tai","sequence":"additional","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Klinikai K\u00f6zpont, Aneszteziol\u00f3giai \u00e9s Intenz\u00edv Ter\u00e1pi\u00e1s Int\u00e9zet P\u00e9cs, Ifj\u00fas\u00e1g u. 13., 7624 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"R1","doi-asserted-by":"crossref","unstructured":"Brazeau P, Vale W, Burgus R, et al. 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