{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T11:00:15Z","timestamp":1785495615453,"version":"3.56.0"},"reference-count":22,"publisher":"Akademiai Kiado Zrt.","issue":"5","license":[{"start":{"date-parts":[[2025,2,2]],"date-time":"2025-02-02T00:00:00Z","timestamp":1738454400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2025,2,2]]},"abstract":"<jats:p>A petef\u00e9szek-krioprezerv\u00e1ci\u00f3 \u00e9s -autotranszplant\u00e1ci\u00f3 \u00edg\u00e9retes lehet\u0151s\u00e9get k\u00edn\u00e1l a\n                    term\u00e9kenys\u00e9g meg\u0151rz\u00e9s\u00e9re a gonadotoxikus kezel\u00e9sen \u00e1tesett daganatos betegek\n                    sz\u00e1m\u00e1ra. Az elj\u00e1r\u00e1s c\u00e9lja a petef\u00e9szek funkci\u00f3j\u00e1nak helyre\u00e1ll\u00edt\u00e1sa a kezel\u00e9st\n                    k\u00f6vet\u0151en \u00e9s a korai petef\u00e9szek-kimer\u00fcl\u00e9s megakad\u00e1lyoz\u00e1sa. Az esettanulm\u00e1ny c\u00e9lja\n                    a petef\u00e9szek-krioprezerv\u00e1ci\u00f3 \u00e9s -autotranszplant\u00e1ci\u00f3 m\u00f3dszer\u00e9nek bemutat\u00e1sa \u00e9s\n                    az aktu\u00e1lis tudom\u00e1nyos irodalom \u00e1ttekint\u00e9se a t\u00e9m\u00e1ban. Egy 25 \u00e9ves, akut\n                    lymphoblastos leukaemi\u00e1val diagnosztiz\u00e1lt n\u0151betegn\u00e9l a myeloablativ kezel\u00e9s\n                    el\u0151tt petef\u00e9szeksz\u00f6vet\u00e9nek krioprezerv\u00e1ci\u00f3j\u00e1t v\u00e9gezt\u00fck el. Remisszi\u00f3j\u00e1t k\u00f6vet\u0151en\n                    a petef\u00e9szeksz\u00f6vet ortotop autotranszplant\u00e1ci\u00f3j\u00e1ra ker\u00fclt sor, ezt k\u00f6vet\u0151en a\n                    beteget hetente t\u00f6rt\u00e9n\u0151 hormonszintm\u00e9r\u00e9sekkel (FSH, LH, \u00f6sztradiol,\n                    progeszteron) \u00e9s transvaginalis ultrahangvizsg\u00e1latokkal k\u00f6vett\u00fck. A\n                    gonadotropin- \u00e9s petef\u00e9szek-hormonszintek a posztoperat\u00edv 7. \u00e9s 63. nap k\u00f6z\u00f6tt\n                    nem mutattak jelent\u0151s v\u00e1ltoz\u00e1st. A 145. napon a petef\u00e9szek endokrin funkci\u00f3ja\n                    helyre\u00e1llt, amit a cs\u00f6kkent gonadotropinszintek \u00e9s a normaliz\u00e1l\u00f3dott\n                    \u00f6sztradiolszintek mutattak. Az irodalomban a hossz\u00fa t\u00e1v\u00fa ut\u00e1nk\u00f6vet\u00e9s sor\u00e1n a\n                    petef\u00e9szekgraftok 5 \u00e9ves t\u00fal\u00e9l\u00e9si ar\u00e1nya 55% volt, \u00e9s a reprodukt\u00edv funkci\u00f3\n                    helyre\u00e1llt, egyes esetekben spont\u00e1n terhess\u00e9gek is bek\u00f6vetkeztek. A m\u00f3dszer\n                    hat\u00e9konynak bizonyult az endokrin \u00e9s a reprodukt\u00edv funkci\u00f3k helyre\u00e1ll\u00edt\u00e1s\u00e1ban, a\n                    legnagyobb es\u00e9llyel a terhess\u00e9g a beavatkoz\u00e1st k\u00f6vet\u0151 r\u00f6vid id\u0151szakban\n                    val\u00f3s\u00edthat\u00f3 meg. Kor\u00e1bbi vizsg\u00e1latok szerint a petef\u00e9szek-krioprezerv\u00e1ci\u00f3t \u00e9s\n                    -autotranszplant\u00e1ci\u00f3t k\u00f6vet\u0151en ak\u00e1r 41%-os \u00e9lvesz\u00fclet\u00e9si ar\u00e1nyt is el\u00e9rtek. A\n                    petef\u00e9szek krioprezerv\u00e1ci\u00f3ja \u00e9s autotranszplant\u00e1ci\u00f3ja \u00e9rt\u00e9kes lehet\u0151s\u00e9get k\u00edn\u00e1l\n                    a term\u00e9kenys\u00e9g meg\u0151rz\u00e9s\u00e9re a gonadotoxikus kezel\u00e9seken \u00e1tesett betegek sz\u00e1m\u00e1ra.\n                    B\u00e1r tapasztalataink egyetlen esetre korl\u00e1toz\u00f3dnak, az eredm\u00e9nyek biztat\u00f3ak.\n                    Tov\u00e1bbi kutat\u00e1sok sz\u00fcks\u00e9gesek az elj\u00e1r\u00e1s optimaliz\u00e1l\u00e1s\u00e1hoz \u00e9s klinikai\n                    alkalmaz\u00e1s\u00e1nak sz\u00e9les\u00edt\u00e9s\u00e9hez. Orv Hetil. 2025; 166(5): 195\u2013200.<\/jats:p>","DOI":"10.1556\/650.2025.33218","type":"journal-article","created":{"date-parts":[[2025,2,2]],"date-time":"2025-02-02T01:01:20Z","timestamp":1738458080000},"page":"195-200","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":0,"title":["A petef\u00e9szek-krioprezerv\u00e1ci\u00f3 \u00e9s -autotranszplant\u00e1ci\u00f3 mint a term\u00e9kenys\u00e9g meg\u0151rz\u00e9s\u00e9nek \u00faj lehet\u0151s\u00e9ge"],"prefix":"10.1556","volume":"166","author":[{"given":"P\u00e1l Botond","family":"S\u00edk","sequence":"first","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Klinika, Baross utcai r\u00e9szleg Budapest Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"Fancsovits","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Klinika, Baross utcai r\u00e9szleg Budapest Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e1nos","family":"Urbancsek","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Klinika, Baross utcai r\u00e9szleg Budapest Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e1szl\u00f3","family":"Piros","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Seb\u00e9szeti, Transzplant\u00e1ci\u00f3s \u00e9s Gasztroenterol\u00f3giai Klinika Budapest Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annam\u00e1ria","family":"Nemes","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Klinika, Baross utcai r\u00e9szleg Budapest Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kata","family":"Jo\u00f3","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Klinika, Baross utcai r\u00e9szleg Budapest Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00e1ndor","family":"\u00c1cs","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Klinika, Baross utcai r\u00e9szleg Budapest Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attila","family":"Bokor","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Klinika, Baross utcai r\u00e9szleg Budapest Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"R1","doi-asserted-by":"crossref","unstructured":"Gosden RG, Baird DT, Wade JC, et al. 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