{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:26:34Z","timestamp":1760574394973,"version":"build-2065373602"},"reference-count":32,"publisher":"Akademiai Kiado Zrt.","issue":"9","license":[{"start":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T00:00:00Z","timestamp":1740873600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2025,3,2]]},"abstract":"<jats:p><jats:italic>Bevezet\u00e9s:<\/jats:italic> Amyloidosis eset\u00e9n a szervezetben abnorm\u00e1lis\n                    szerkezet\u0171 feh\u00e9rj\u00e9k (amyloidok) k\u00e9pz\u0151dnek, amelyek lerak\u00f3d\u00e1sa szervi\n                    diszfunkci\u00f3hoz vezet. Sziszt\u00e9m\u00e1s esetben b\u00e1rmely szerv \u00e9rintett lehet, \u00edgy az\n                    em\u00e9szt\u0151rendszer is. A leggyakoribb gastrointestinalis t\u00fcnetek a dysphagia, a\n                    j\u00f3llakotts\u00e1g\u00e9rz\u00e9s, a gastroparesis, a gastrointestinalis dysmotilitas, a v\u00e9rz\u00e9s\n                    \u00e9s a sz\u00e9kreked\u00e9s. <jats:italic>C\u00e9lkit\u0171z\u00e9s:<\/jats:italic> C\u00e9lunk volt feldolgozni a\n                    Semmelweis Egyetemen gondozott, gastrointestinalis \u00e9rintetts\u00e9ggel j\u00e1r\u00f3\n                    amyloidosisos betegek adatait. <jats:italic>M\u00f3dszer:<\/jats:italic> A Semmelweis Egyetemen\n                    2009 \u00e9s 2024 k\u00f6z\u00f6tt amyloidosissal diagnosztiz\u00e1lt betegek k\u00f6z\u00fcl a\n                    gastrointestinalis \u00e9rintetts\u00e9ggel j\u00e1r\u00f3 esetek adatait gy\u0171jt\u00f6tt\u00fck \u00f6ssze\n                    retrospekt\u00edv, konszekut\u00edv m\u00f3don a k\u00f3rh\u00e1zi sz\u00e1m\u00edt\u00f3g\u00e9pes nyilv\u00e1ntart\u00f3 rendszer\n                    seg\u00edts\u00e9g\u00e9vel. R\u00f6gz\u00edtett\u00fck a demogr\u00e1fiai adatokat, az endoszk\u00f3pos, a k\u00e9palkot\u00f3 \u00e9s\n                    a sz\u00f6vettani eredm\u00e9nyeket, illetve a diagn\u00f3zis szempontj\u00e1b\u00f3l relev\u00e1ns\n                    laborat\u00f3riumi param\u00e9tereket. <jats:italic>Eredm\u00e9nyek:<\/jats:italic> \u00d6sszesen 15 beteg\n                    adatait dolgoztuk fel, ebb\u0151l 12 esetben k\u00f6nny\u0171l\u00e1nc-amyloidosis igazol\u00f3dott, m\u00edg\n                    1-1 beteg eset\u00e9n \u00f6r\u00f6kletes form\u00e1j\u00fa transztiretin-amyloidosis,\n                    lysozym-amyloidosis \u00e9s amyloid-A-feh\u00e9rje-amyloidosis fordult el\u0151. A\n                    medi\u00e1n\u00e9letkor a diagn\u00f3ziskor \u00e9s a hal\u00e1loz\u00e1skor is 65 \u00e9v volt, ami v\u00e9lhet\u0151leg a\n                    k\u00e9s\u0151i st\u00e1diumban fel\u00e1ll\u00edtott diagn\u00f3zist t\u00fckr\u00f6zi, illetve a magas Mayo-score\n                    (\u00e1tlag\u00e9rt\u00e9ke: 2,67) a k\u00f6nny\u0171l\u00e1nc-amyloidosis kedvez\u0151tlen progn\u00f3zis\u00e1t vet\u00edti\n                    el\u0151re. A gastrointestinum mellett a leggyakrabban \u00e9rintett szervek a sz\u00edv\n                    (73,3%), a vese (33,3%) \u00e9s a perif\u00e9ri\u00e1s idegek (40%) voltak. A f\u0151\n                    em\u00e9szt\u0151rendszeri t\u00fcnetek az akaratlan fogy\u00e1s (20%), feltehet\u0151en malabszorpci\u00f3\n                    miatt, a nyel\u00e9szavar (6,6%), a haematochesia (6,6%), a hasi f\u00e1jdalom (6,6%) \u00e9s a\n                    hasmen\u00e9s (6,6%) voltak. A leggyakoribb laborat\u00f3riumi elt\u00e9r\u00e9s az anaemia \u00e9s a\n                    kr\u00f3nikus veseel\u00e9gtelens\u00e9g, m\u00edg a legt\u00f6bbsz\u00f6r le\u00edrt gasztroszk\u00f3pos elt\u00e9r\u00e9s a\n                    gastroduodenitis volt, gastroparesis, gyomorfek\u00e9ly \u00e9s polypoid k\u00e9pletek mellett.\n                        <jats:italic>Megbesz\u00e9l\u00e9s:<\/jats:italic> Az em\u00e9szt\u0151rendszeri diszfunkci\u00f3 h\u00e1tter\u00e9ben\n                    \u00e1ll\u00f3 mechanizmusok vil\u00e1gos meg\u00e9rt\u00e9se m\u00e9g mindig hi\u00e1nyzik. Az ereket \u00e9s idegeket\n                    k\u00e1ros\u00edt\u00f3 amyloidlerak\u00f3d\u00e1s k\u00f6vetkezt\u00e9ben alakulhat ki gastroparesis, hasmen\u00e9s,\n                    polyneuropathia, valamint malabszorpci\u00f3, illetve az endoszk\u00f3pia sor\u00e1n l\u00e1tott\n                    haematochesia \u00e9s okkult v\u00e9rz\u00e9s lehetnek a v\u00e9rszeg\u00e9nys\u00e9g forr\u00e1sai.\n                        <jats:italic>K\u00f6vetkeztet\u00e9s:<\/jats:italic> A sziszt\u00e9m\u00e1s amyloidosis sz\u00e1mos szervet\n                    \u00e9rint\u0151, rossz progn\u00f3zis\u00fa k\u00f3rk\u00e9p. A t\u00fcnetek, a laborparam\u00e9terek \u00e9s az endoszk\u00f3pos\n                    elt\u00e9r\u00e9sek v\u00e1ltozatosak, de nem specifikusak, \u00edgy a mihamarabbi diagn\u00f3zishoz\n                    elengedhetetlen a t\u00e1rsszakm\u00e1k szoros egy\u00fcttm\u0171k\u00f6d\u00e9se. Orv Hetil. 2025; 166(9):\n                    351\u2013358.<\/jats:p>","DOI":"10.1556\/650.2025.33238","type":"journal-article","created":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T11:16:37Z","timestamp":1741000597000},"page":"351-358","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":1,"title":["Gastrointestinalis amyloidosis \u2013 retrospekt\u00edv elemz\u00e9s egy budapesti centrum adatai alapj\u00e1n"],"prefix":"10.1556","volume":"166","author":[{"given":"Liza Dalma","family":"S\u00fcmegi","sequence":"first","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Belgy\u00f3gy\u00e1szati \u00e9s Onkol\u00f3giai Klinika Budapest, Kor\u00e1nyi S. \u00fat 2\/A, 1083 Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniella","family":"Nagy","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Belgy\u00f3gy\u00e1szati \u00e9s Hematol\u00f3giai Klinika Budapest Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1d\u00e1m","family":"Vida","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Belgy\u00f3gy\u00e1szati \u00e9s Hematol\u00f3giai Klinika Budapest Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gergely","family":"Varga","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Belgy\u00f3gy\u00e1szati \u00e9s Hematol\u00f3giai Klinika Budapest Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emese","family":"Mih\u00e1ly","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Belgy\u00f3gy\u00e1szati \u00e9s Hematol\u00f3giai Klinika Budapest Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e1nos Mih\u00e1ly","family":"Papp","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Belgy\u00f3gy\u00e1szati \u00e9s Onkol\u00f3giai Klinika Budapest, Kor\u00e1nyi S. \u00fat 2\/A, 1083 Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zolt\u00e1n","family":"Pozsonyi","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Belgy\u00f3gy\u00e1szati \u00e9s Hematol\u00f3giai Klinika Budapest Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1kos","family":"Ili\u00e1s","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Belgy\u00f3gy\u00e1szati \u00e9s Onkol\u00f3giai Klinika Budapest, Kor\u00e1nyi S. \u00fat 2\/A, 1083 Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"ref0","doi-asserted-by":"publisher","first-page":"3","DOI":"10.14797\/mdcj-8-3-3","article-title":"The amyloidoses: clinical features, diagnosis and treatment","volume":"8","author":"Baker KR","year":"2012","unstructured":"1 Baker KR, Rice L. 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