{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:09:33Z","timestamp":1785402573494,"version":"3.56.0"},"reference-count":77,"publisher":"Akademiai Kiado Zrt.","issue":"10","license":[{"start":{"date-parts":[[2025,3,9]],"date-time":"2025-03-09T00:00:00Z","timestamp":1741478400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"D\u00e9l-pesti Centrumk\u00f3rh\u00e1z K\u00f6zponti Laborat\u00f3rium"},{"name":"Patol\u00f3giai \u00e9s R\u00e1kkutat\u00f3 Int\u00e9zet"},{"DOI":"10.13039\/501100016222","name":"Sapientia Erd\u00e9lyi Magyar Tudom\u00e1nyegyetem","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100016222","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Szegedi Tudom\u00e1nyegyetem, Mikrobiol\u00f3giai Tansz\u00e9k"},{"name":"Westmead Institute for Medical Research, The University of Sydney"},{"name":"Instituto de Salud Carlos III, Madrid"},{"name":"Magyar R\u00e1kkutat\u00e1s \u00e9s Molekul\u00e1ris Patol\u00f3gia Alap\u00edtv\u00e1ny"},{"name":"Fungal Infection Trust"}],"content-domain":{"domain":["www.akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2025,3,9]]},"abstract":"\n Az onkohematol\u00f3giai k\u00f3rk\u00e9pekben szenved\u0151 betegeket nagym\u00e9rt\u00e9kben vesz\u00e9lyeztetik\n az invaz\u00edv gombafert\u0151z\u00e9sek. A leggyakrabban candidiasis, aspergillosis,\n mucormycosis, cryptococcosis, valamint\n Pneumocystis<\/jats:italic>\n -pneumonia\n fordul el\u0151. Az invaz\u00edv mycosisok diagnosztik\u00e1j\u00e1t t\u00e1mogat\u00f3 t\u00f6bbf\u00e9le m\u00f3dszer\n (teny\u00e9szt\u00e9s, sz\u00f6vettan, szerol\u00f3gia, k\u00e9palkot\u00f3 elj\u00e1r\u00e1sok) ellen\u00e9re kimutat\u00e1suk\n gyakran kih\u00edv\u00e1st jelent. A gyors technol\u00f3giai fejl\u0151d\u00e9s k\u00f6vetkezt\u00e9ben a\n molekul\u00e1ris biol\u00f3giai m\u00f3dszereket ma m\u00e1r rutinszer\u0171en alkalmazz\u00e1k a bakt\u00e9rium-\n \u00e9s v\u00edrusdiagnosztik\u00e1ban is. Ugyanakkor a molekul\u00e1ris vizsg\u00e1latok hat\u00e9konyan\n seg\u00edthetik a mycosisok felismer\u00e9s\u00e9t is, \u00edgy sz\u00e1mos nemzetk\u00f6zi orvosi ir\u00e1nyelv\n tartalmaz ilyen ir\u00e1ny\u00fa aj\u00e1nl\u00e1sokat. B\u00e1r a molekul\u00e1ris gombavizsg\u00e1latok n\u00e9melyike\n m\u00e1r megjelent a hazai eg\u00e9szs\u00e9g\u00fcgyi ell\u00e1t\u00e1sban, sz\u00e9les k\u00f6r\u0171 elterjed\u00e9s\u00fck nem\n t\u00f6rt\u00e9nt meg. \u00d6sszefoglal\u00f3 k\u00f6zlem\u00e9ny\u00fcnkben bemutatjuk a gomb\u00e1k \u00e1ltal okozott\n invaz\u00edv infekci\u00f3k molekul\u00e1ris diagnosztikai eszk\u00f6zt\u00e1r\u00e1t. Kit\u00e9r\u00fcnk a k\u00fcl\u00f6nb\u00f6z\u0151\n taxonspecifikus polimer\u00e1z-l\u00e1ncreakci\u00f3kra (PCR), valamint a szekven\u00e1l\u00e1si\n elj\u00e1r\u00e1sokra (Sanger-szekven\u00e1l\u00e1s, \u00fajgener\u00e1ci\u00f3s szekven\u00e1l\u00e1s), tov\u00e1bb\u00e1 a gomb\u00e1k\n azonos\u00edt\u00e1sa, illetve az antifung\u00e1lis rezisztencia kimutat\u00e1sa ter\u00e9n bet\u00f6lt\u00f6tt\n szerep\u00fckre. R\u00f6viden ismertetj\u00fck a D\u00e9l-pesti Centrumk\u00f3rh\u00e1z \u2013 Orsz\u00e1gos\n Hematol\u00f3giai \u00e9s Infektol\u00f3giai Int\u00e9zetben \u00e9s a Semmelweis Egyetem Patol\u00f3giai \u00e9s\n K\u00eds\u00e9rleti R\u00e1kkutat\u00f3 Int\u00e9zet\u00e9ben el\u00e9rhet\u0151 vizsg\u00e1latokat, v\u00e9g\u00fcl k\u00e9t\n esetismertet\u00e9sen kereszt\u00fcl mutatjuk be a m\u00f3dszerek gyakorlati alkalmazhat\u00f3s\u00e1g\u00e1t.\n A jelen \u00e1ttekint\u00e9s hozz\u00e1j\u00e1rul\u00e1st k\u00edv\u00e1n ny\u00fajtani a molekul\u00e1ris gombadiagnosztikai\n m\u00f3dszerek magyarorsz\u00e1gi orvosi ell\u00e1t\u00e1sban t\u00f6rt\u00e9n\u0151 nagyobb m\u00e9rt\u00e9k\u0171\n implement\u00e1ci\u00f3j\u00e1hoz. Orv Hetil. 2025; 166(10): 363\u2013376.\n <\/jats:p>","DOI":"10.1556\/650.2025.33241","type":"journal-article","created":{"date-parts":[[2025,3,9]],"date-time":"2025-03-09T11:21:31Z","timestamp":1741519291000},"page":"363-376","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":0,"title":["A molekul\u00e1ris diagnosztika lehet\u0151s\u00e9gei onkohematol\u00f3giai betegek invaz\u00edv gombainfekci\u00f3inak ell\u00e1t\u00e1s\u00e1ban"],"prefix":"10.1556","volume":"166","author":[{"given":"Erik","family":"Zajta","sequence":"first","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Patol\u00f3giai \u00e9s K\u00eds\u00e9rleti R\u00e1kkutat\u00f3 Int\u00e9zet, Molekul\u00e1ris Diagnosztikai Labor Budapest, \u00dcll\u0151i \u00fat 26., 1085 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gergely","family":"Pesk\u00f3","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Belgy\u00f3gy\u00e1szati \u00e9s Hematol\u00f3giai Klinika Budapest Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. D\u00e1niel","family":"Knapp","sequence":"additional","affiliation":[{"name":"ELTE E\u00f6tv\u00f6s Lor\u00e1nd Tudom\u00e1nyegyetem, Term\u00e9szettudom\u00e1nyi Kar, Biol\u00f3giai Int\u00e9zet, N\u00f6v\u00e9nyszervezettani Tansz\u00e9k Budapest Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eszter","family":"Vad","sequence":"additional","affiliation":[{"name":"D\u00e9l-pesti Centrumk\u00f3rh\u00e1z \u2013 Orsz\u00e1gos Hematol\u00f3giai \u00e9s Infektol\u00f3giai Int\u00e9zet, Mikrobiol\u00f3giai Profil, K\u00f6zponti Laborat\u00f3rium Budapest Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Csaba","family":"B\u00f6d\u00f6r","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Patol\u00f3giai \u00e9s K\u00eds\u00e9rleti R\u00e1kkutat\u00f3 Int\u00e9zet, Molekul\u00e1ris Diagnosztikai Labor Budapest, \u00dcll\u0151i \u00fat 26., 1085 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e1nos","family":"Sink\u00f3","sequence":"additional","affiliation":[{"name":"D\u00e9l-pesti Centrumk\u00f3rh\u00e1z \u2013 Orsz\u00e1gos Hematol\u00f3giai \u00e9s Infektol\u00f3giai Int\u00e9zet, Hematol\u00f3giai \u00e9s \u0150ssejt-transzplant\u00e1ci\u00f3s Oszt\u00e1ly Budapest Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"R1","doi-asserted-by":"crossref","unstructured":"Denning DW. 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