{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:17:34Z","timestamp":1785403054335,"version":"3.56.0"},"reference-count":64,"publisher":"Akademiai Kiado Zrt.","issue":"12","license":[{"start":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T00:00:00Z","timestamp":1742688000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Debreceni Orvostudom\u00e1nyi Egyetem Laborat\u00f3riumi Medicina Int\u00e9zet"},{"DOI":"10.13039\/501100024601","name":"Debreceni Egyetem \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100024601","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2025,3,23]]},"abstract":"<jats:p>\n                    A Debreceni Egyetem Gyermekgy\u00f3gy\u00e1szati Klinik\u00e1j\u00e1n Karmazsin L\u00e1szl\u00f3 professzor\n                    alapozta meg a korszer\u0171 neonatol\u00f3giai intenz\u00edv betegell\u00e1t\u00e1st. A perinatol\u00f3giai\n                    szakter\u00fclet fejl\u0151d\u00e9s\u00e9hez munkacsoportj\u00e1nak az \u00fajsz\u00fcl\u00f6ttkori immunbiol\u00f3gia ter\u00e9n\n                    el\u00e9rt kutat\u00e1si eredm\u00e9nyei is hozz\u00e1j\u00e1rultak. A neonatalis antioxid\u00e1ns rendszer\n                    vizsg\u00e1lata nyom\u00e1n fontos szerepet v\u00e1llalt a korasz\u00fcl\u00f6tts\u00e9ggel \u00f6sszef\u00fcgg\u0151\n                    k\u00f3rk\u00e9pek patomechanizmus\u00e1nak felt\u00e1r\u00e1s\u00e1ban. A magzati fejl\u0151d\u00e9sre \u00e9s a perinatalis\n                    morbidit\u00e1sra az antenatalis kortikoszteroid-profilaxis mellett egy endog\u00e9n\n                    szteroidhormon, a D-vitamin is jelent\u0151s hat\u00e1ssal b\u00edr. Karmazsin L\u00e1szl\u00f3\n                    professzor munkacsoportja vil\u00e1g\u00edtott r\u00e1 a II-es t\u00edpus\u00fa pneumocyt\u00e1kban \u00e9s\n                    leukaemi\u00e1s sejtekben tal\u00e1lhat\u00f3 kortikoszteroid-receptoroknak az endog\u00e9n\n                    hormonhat\u00e1s kifejez\u0151d\u00e9s\u00e9ben bet\u00f6lt\u00f6tt meghat\u00e1roz\u00f3 szerep\u00e9re. K\u00f6zlem\u00e9ny\u00fcnkben e\n                    k\u00e9t t\u00e9nyez\u0151 egym\u00e1ssal is \u00f6sszef\u00fcgg\u0151 vonatkoz\u00e1sait elemezz\u00fck a korasz\u00fcl\u00f6ttek\n                    kimenetel\u00e9t illet\u0151en, az irodalmi adatok t\u00fckr\u00e9ben. Emellett besz\u00e1molunk a\n                    neonatalis intenz\u00edv centrumunkban v\u00e9gzett kohorszvizsg\u00e1lat eredm\u00e9nyeir\u0151l. A kis\n                    esetsz\u00e1m\u00fa (n: 37), igen kis sz\u00fclet\u00e9si s\u00faly\u00fa korasz\u00fcl\u00f6ttekre f\u00f3kusz\u00e1l\u00f3\n                    vizsg\u00e1latban az el\u00e9gtelen D-vitamin-szint \u00e9s az \u00fajsz\u00fcl\u00f6ttkori megbeteged\u00e9sek\n                    k\u00f6z\u00f6tti lehets\u00e9ges \u00f6sszef\u00fcgg\u00e9seket elemezt\u00fck. Az \u00e1ltalunk vizsg\u00e1lt el\u00e9gtelen\n                    (&lt;50 nmol\/l) D-vitamin-szinttel rendelkez\u0151 korasz\u00fcl\u00f6ttek csoportj\u00e1ban (6\/37)\n                    \u2013 szemben az el\u00e9gs\u00e9ges (50\u201375 nmol\/l), illetve az optim\u00e1lis (&gt;75 nmol\/l)\n                    25(OH)D-ell\u00e1totts\u00e1ggal rendelkez\u0151k csoportj\u00e1val (31\/37) \u2013 nagyobb ar\u00e1nyban\n                    fordult el\u0151 a korai (1\/6\n                    <jats:italic>vs.<\/jats:italic>\n                    0\/31; p: 0,021) \u00e9s a k\u00e9s\u0151i (1\/6\n                    <jats:italic>vs.<\/jats:italic>\n                    1\/31; p: 0,183) \u00fajsz\u00fcl\u00f6ttkori fert\u0151z\u00e9s, a\n                    bronchopulmonalis dysplasia (3\/6\n                    <jats:italic>vs.<\/jats:italic>\n                    8\/31; p: 0,235), az\n                    enterocolitis necrotisans (1\/6\n                    <jats:italic>vs.<\/jats:italic>\n                    1\/31; p: 0,183), valamint a\n                    korasz\u00fcl\u00f6ttek retinopathi\u00e1j\u00e1nak s\u00falyos form\u00e1ja (1\/6\n                    <jats:italic>vs.<\/jats:italic>\n                    0\/31;\n                    p: 0,060). Az elt\u00e9r\u00e9s a korai fert\u0151z\u00e9sek tekintet\u00e9ben bizonyult szignifik\u00e1nsnak.\n                    Eredm\u00e9nyeinket a kis esetsz\u00e1m korl\u00e1toz\u00f3 szerep\u00e9t figyelembe v\u00e9ve kell \u00e9rt\u00e9kelni.\n                    Orv Hetil. 2025; 166(12): 443\u2013449.\n                  <\/jats:p>","DOI":"10.1556\/650.2025.33251","type":"journal-article","created":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T20:30:18Z","timestamp":1743021018000},"page":"443-449","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":1,"title":["A szteroidhormonok csod\u00e1latos vil\u00e1ga a neonatol\u00f3gi\u00e1ban \u2013 az els\u0151 50 \u00e9v"],"prefix":"10.1556","volume":"166","author":[{"given":"Istv\u00e1n","family":"Pataki","sequence":"first","affiliation":[{"name":"Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Gyermekgy\u00f3gy\u00e1szati Int\u00e9zet Debrecen Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e1s","family":"Balajthy","sequence":"additional","affiliation":[{"name":"Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Gyermekgy\u00f3gy\u00e1szati Int\u00e9zet Debrecen Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Csongor","family":"Kiss","sequence":"additional","affiliation":[{"name":"Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Gyermekgy\u00f3gy\u00e1szati Int\u00e9zet Debrecen Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"R1","doi-asserted-by":"crossref","unstructured":"Berger TM, Fontana M, Stocker M. The journey towards lung protective\n                    respiratory support in preterm neonates. Neonatology 2013; 104:\n                    265\u2013274.","DOI":"10.1159\/000354419"},{"key":"R2","doi-asserted-by":"crossref","unstructured":"Perin J, Mulick A, Yeung D, et al. Global, regional, and national\n                    causes of under-5 mortality in 2000\u20132019: an updated systematic analysis with\n                    implications for the Sustainable Development Goals. Lancet Child Adolesc Health\n                    2022; 6: 106\u2013115. Erratum: Lancet Child Adolesc Health 2022; 6:\n                    e4.","DOI":"10.1016\/S2352-4642(21)00311-4"},{"key":"R3","doi-asserted-by":"crossref","unstructured":"Ohuma E, Moller AB, Bradley E, et al. National, regional, and global\n                    estimates of preterm birth in 2020, with trends from 2010: a systematic\n                    analysis. Lancet 2023; 402: 1261\u20131271. 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Antenatal corticosteroids\n                    for accelerating fetal lung maturation for women at risk of preterm birth.\n                    Cochrane Database Syst Rev. 2020; 12: CD004454.","DOI":"10.1002\/14651858.CD004454.pub4"},{"key":"R7","doi-asserted-by":"crossref","unstructured":"Liggins GC, Howie RN. A controlled trial of antepartum\n                    glucocorticoid treatment for prevention of the respiratory distress syndrome in\n                    premature infants. Pediatrics 1972; 50: 515\u2013525.","DOI":"10.1542\/peds.50.4.515"},{"key":"R8","doi-asserted-by":"crossref","unstructured":"Morrison JC, Whybrew WD, Bucovaz ET, et al. Injection of\n                    corticosteroids into mother to prevent neonatal respiratory distress syndrome.\n                    Am J Obstet Gynecol. 1978; 131: 358\u2013366.","DOI":"10.1016\/0002-9378(78)90408-8"},{"key":"R9","unstructured":"Nagy Gy, Kardos Z, Poh\u00e1nka O, et al. Prevention of respiratory\n                    distress syndrome prior to delivery using steroids. [Steroidprophylaxe des\n                    Atemnotsyndroms vor der Geburt.] Zentralbl Gynakol. 1977; 99: 610\u2013617.\n                    [German]"},{"key":"R10","unstructured":"Kerepesi T, Ar\u00e1nyi P. Glucocorticoid receptors in circulating\n                    lymphocytes of premature infants and newborns. Acta Paediatr Hung. 1983; 24:\n                    343\u2013347."},{"key":"R11","doi-asserted-by":"crossref","unstructured":"Kerepesi T, Ar\u00e1nyi P. Low levels of glucocorticoid binding sites in\n                    circulating lymphocytes of premature infants suffering from hyaline membrane\n                    disease. J Steroid Biochem. 1985; 22: 151\u2013154.","DOI":"10.1016\/0022-4731(85)90106-2"},{"key":"R12","doi-asserted-by":"crossref","unstructured":"Ballard PL, Hawgood S, Liley H, et al. Regulation of pulmonary\n                    surfactant apoprotein SP 28-36 gene in fetal human lung. Proc Natl Acad Sci U S\n                    A 1986; 83: 9527\u20139531.","DOI":"10.1073\/pnas.83.24.9527"},{"key":"R13","doi-asserted-by":"crossref","unstructured":"Ballard PL, Ertsey R, Gonzales LW, et al. Transcriptional regulation\n                    of human pulmonary surfactant proteins SP-B and SP-C by glucocorticoids. Am J\n                    Respir Cell Mol Biol. 1996; 14: 599\u2013607.","DOI":"10.1165\/ajrcmb.14.6.8652188"},{"key":"R14","unstructured":"Kiss C, Kov\u00e1cs I, Kerepesi T, et al. Clinical significance of\n                    glucocorticoid receptors in acute leukaemia. Preliminary observations in Hungary\n                    and review of the literature. Acta Paediatr Hung. 1987; 28:\n                    127\u2013135."},{"key":"R15","doi-asserted-by":"crossref","unstructured":"Toscan CE, Jing D, Mayoh C, et al. Reversal of glucocorticoid\n                    resistance in paediatric acute lymphoblastic leukaemia is dependent on restoring\n                    BIM expression. Br J Cancer 2020; 122: 1769\u20131781.","DOI":"10.1038\/s41416-020-0824-8"},{"key":"R16","doi-asserted-by":"crossref","unstructured":"Saugstad OD. Oxidative stress in the newborn \u2013 a 30-year\n                    perspective. Biol Neonate 2005; 88: 228\u2013236.","DOI":"10.1159\/000087586"},{"key":"R17","unstructured":"Oroszl\u00e1n Gy, Lakatos L, Matkovics B, et al. Antioxidant effects of\n                    D-penicillamine in the neonatal period. [A D-Penicillamin antioxid\u00e1ns hat\u00e1sai\n                    \u00fajsz\u00fcl\u00f6ttkorban.] Gyermekgy\u00f3gy\u00e1szat 1981; 32: 564\u2013570.\n                    [Hungarian]"},{"key":"R18","unstructured":"Karmazsin L, Balla Gy, G\u00f6m\u00f6ry A, et al. 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Antenatal steroids and\n                    antioxidant enzyme activity in preterm infants: influence of gender and timing.\n                    Antioxid Redox Signal 2009; 11: 2945\u20132955.","DOI":"10.1089\/ars.2009.2671"},{"key":"R22","doi-asserted-by":"crossref","unstructured":"Frank L, Sosenko RS. Development of lung antioxidant enzyme system\n                    in late gestation: possible implications for the prematurely born infant. J\n                    Pediatr. 1987; 110: 9\u201314.","DOI":"10.1016\/S0022-3476(87)80279-2"},{"key":"R23","doi-asserted-by":"crossref","unstructured":"Saugstad OD. Mechanisms of tissue injury by oxygen radicals:\n                    implications for neonatal disease. Acta P\u00e6diatr. 1996; 85: 1\u20134.","DOI":"10.1111\/j.1651-2227.1996.tb13880.x"},{"key":"R24","doi-asserted-by":"crossref","unstructured":"Comporti M, Signorini C, Leoncini S, et al. Plasma F2-isoprostanes\n                    are elevated in newborns and inversely correlated to gestational age. Free Radic\n                    Biol Med. 2004; 37: 724\u2013732.","DOI":"10.1016\/j.freeradbiomed.2004.06.007"},{"key":"R25","doi-asserted-by":"crossref","unstructured":"Cannav\u00f2 L, Rulli I, Falsaperla R, et al. Ventilation, oxidative\n                    stress and risk of brain injury in preterm newborn. Ital J Pedi\u00e1tr. 2020; 46:\n                    100.","DOI":"10.1186\/s13052-020-00852-1"},{"key":"R26","doi-asserted-by":"crossref","unstructured":"Balajthy A, Kov\u00e1cs PE, M\u00e1rki M, et al. Trends in the management of\n                    respiratory distress syndrome in very preterm infants transferred to the\n                    Clinical Center of the University of Debrecen. [A respir\u00e1ci\u00f3s distressz\n                    szindr\u00f3ma kezel\u00e9s\u00e9nek trendjei a Debreceni Egyetem Klinikai K\u00f6zpontj\u00e1ba\n                    sz\u00e1ll\u00edtott igen \u00e9retlen korasz\u00fcl\u00f6ttekben.] Orv Hetil. 2023; 164: 571\u2013576.\n                    [Hungarian]","DOI":"10.1556\/650.2023.32735"},{"key":"R27","doi-asserted-by":"crossref","unstructured":"Valerio E, Meneghelli M, Stocchero M, et al. The impact of antenatal\n                    corticosteroids on the metabolome of preterm newborns: an untargeted approach.\n                    Int J Mol Sci. 2024; 25: 5860.","DOI":"10.3390\/ijms25115860"},{"key":"R28","doi-asserted-by":"crossref","unstructured":"Phokela SS, Peleg S, Moya FR, et al. Regulation of human pulmonary\n                    surfactant protein gene expression by 1\u03b1,25-dihydroxyvitamin D3. 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[A D-vitamin-hi\u00e1ny mint a cerebrovascularis\n                    betegs\u00e9gek kock\u00e1zati t\u00e9nyez\u0151je.] Orv Hetil. 2024; 165: 1958\u20131968.\n                    [Hungarian]","DOI":"10.1556\/650.2024.32962"},{"key":"R46","doi-asserted-by":"crossref","unstructured":"Lips P, Cashman KD, Lamberg-Allardt C, et al. Current vitamin D\n                    status in European and Middle East countries and strategies to prevent vitamin D\n                    deficiency: a position statement of the European Calcified Tissue Society. Eur J\n                    Endocrinol. 2019; 180: P23\u2013P54.","DOI":"10.1530\/EJE-18-0736"},{"key":"R47","doi-asserted-by":"crossref","unstructured":"Wyskida M, Owczarek A, Szybalska A, et al. Socio-economic\n                    determinants of vitamin D deficiency in the older Polish population: results\n                    from the PolSenior study. 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