{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T02:47:49Z","timestamp":1785466069197,"version":"3.56.0"},"reference-count":12,"publisher":"Akademiai Kiado Zrt.","issue":"11","license":[{"start":{"date-parts":[[2025,3,16]],"date-time":"2025-03-16T00:00:00Z","timestamp":1742083200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015763","name":"Szegedi Tudom\u00e1nyegyetem","doi-asserted-by":"crossref","award":["IV-134-621-2024.SZAOK"],"award-info":[{"award-number":["IV-134-621-2024.SZAOK"]}],"id":[{"id":"10.13039\/501100015763","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2025,3,16]]},"abstract":"<jats:p>\n                    A sessilis serrated laesio (SSL) nem ritka entit\u00e1s, \u00e1ltal\u00e1ban a proximalis\n                    colonf\u00e9lre lokaliz\u00e1l\u00f3dik, \u00e9s az endoszk\u00f3pos vizsg\u00e1lat sor\u00e1n gyakran lapos\n                    megjelen\u00e9s\u0171. Az SSL-hez t\u00e1rsul\u00f3 dysplasia (SSL-D) \u00e9s m\u00e9g ink\u00e1bb az inv\u00e1zi\u00f3\n                    jelenl\u00e9te azonban ritkas\u00e1gnak sz\u00e1m\u00edt, aminek oka, hogy ezek a laesi\u00f3k\n                    \u2019low-grade\u2019 dysplasia eset\u00e9ben is gyorsan alakulnak invaz\u00edv carcinom\u00e1v\u00e1.\n                    MLH1-reakci\u00f3 seg\u00edthet az SSL-D diagn\u00f3zis\u00e1nak fel\u00e1ll\u00edt\u00e1s\u00e1ban. Munk\u00e1nkban egy 88\n                    \u00e9ves n\u0151beteg eset\u00e9t mutatjuk be, aki a coecum, illetve a colon transversum\n                    ter\u00fclet\u00e9n \u00e9szlelt tumorgyan\u00fas elv\u00e1ltoz\u00e1sok kolonoszk\u00f3pos elt\u00e1vol\u00edt\u00e1s\u00e1ra\n                    \u00e9rkezett. Sz\u00f6vettani vizsg\u00e1lat sor\u00e1n a coecumban medullaris carcinoma ker\u00fclt\n                    meg\u00e1llap\u00edt\u00e1sra, melyben MLH1 \u00e9s PMS2 \u2019mismatch repair protein\u2019 deficientia volt\n                    megfigyelhet\u0151. A colon transversumb\u00f3l elt\u00e1vol\u00edtott polypus sz\u00f6vettani\n                    vizsg\u00e1lattal SSL-nek bizonyult, centr\u00e1lisan \u2019low-grade\u2019 dysplasi\u00e1val (SSL-D),\n                    melyet az MLH1 veszt\u00e9se is meger\u0151s\u00edtett, tov\u00e1bb\u00e1 egy l\u00e1t\u00f3t\u00e9rben\n                    submucosa-inv\u00e1zi\u00f3 is jelen volt. A Lynch-szindr\u00f3ma kiz\u00e1r\u00e1s\u00e1ra\n                    <jats:italic>BRAF<\/jats:italic>\n                    V600E szekven\u00e1l\u00e1sos vizsg\u00e1lat t\u00f6rt\u00e9nt, mely a mut\u00e1ci\u00f3\n                    fenn\u00e1ll\u00e1s\u00e1t bizony\u00edtotta. Az SSL-D rizik\u00f3t\u00e9nyez\u0151i k\u00f6z\u00e9 sorolhat\u00f3 az id\u0151sebb\n                    \u00e9letkor, t\u00f6bb szinkr\u00f3n SSL jelenl\u00e9te, illetve a 10 mm-n\u00e9l nagyobb m\u00e9ret. SSL-D\n                    eset\u00e9ben a nagy malignit\u00e1si transzform\u00e1ci\u00f3s potenci\u00e1l miatt mindig t\u00f6rekedni\n                    kell a komplett resecti\u00f3ra. Az SSL \u2013 SSL-D \u2013 carcinoma szekvencia eset\u00e9ben a f\u0151\n                    \u2019driver\u2019 mut\u00e1ci\u00f3k a\n                    <jats:italic>BRAF<\/jats:italic>\n                    \u00e9s ritk\u00e1bban a\n                    <jats:italic>KRAS<\/jats:italic>\n                    g\u00e9neket \u00e9rintik. Nagysz\u00e1m\u00fa SSL eset\u00e9n fel kell, hogy mer\u00fclj\u00f6n tov\u00e1bb\u00e1 a sessilis\n                    polyposis szindr\u00f3ma, ritk\u00e1bban a MUTYH-hoz t\u00e1rsult polyposis \u00e9s az \u00f6r\u00f6kl\u00f6tt\n                    kevert polyposis szindr\u00f3ma lehet\u0151s\u00e9ge is. Mind SSL-ben, mind colorectalis\n                    carcinom\u00e1ban gyakori a mikroszatellita-instabilit\u00e1s, a CpG-sziget-metil\u00e1ci\u00f3s\n                    fenot\u00edpus, illetve a\n                    <jats:italic>BRAF<\/jats:italic>\n                    V600E mut\u00e1ci\u00f3 fenn\u00e1llta. A \u2019mismatch\n                    repair\u2019 status meghat\u00e1rozhat\u00f3 immunhisztok\u00e9miai m\u00f3dszerrel az MLH1, PMS2, MSH2\n                    \u00e9s MSH6 reakci\u00f3k haszn\u00e1lat\u00e1val, illetve PCR-m\u00f3dszerrel is. A k\u00e9t vizsg\u00e1lat\n                    kieg\u00e9sz\u00edti egym\u00e1st. Az immunellen\u0151rz\u0151pont-g\u00e1tl\u00f3 kezel\u00e9s v\u00e9gett a \u2019mismatch\n                    repair\u2019 status meghat\u00e1roz\u00e1sa kulcsfontoss\u00e1g\u00fa colorectalis carcinoma diagn\u00f3zisa\n                    eset\u00e9n. Orv Hetil. 2025; 166(11): 427\u2013433.\n                  <\/jats:p>","DOI":"10.1556\/650.2025.33260","type":"journal-article","created":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T00:22:15Z","timestamp":1742170935000},"page":"427-433","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":1,"title":["Sessilis serrated laesio dysplasi\u00e1val \u00e9s inv\u00e1zi\u00f3val"],"prefix":"10.1556","volume":"166","author":[{"given":"\u00c1d\u00e1m","family":"Ferenczi","sequence":"first","affiliation":[{"name":"Szegedi Tudom\u00e1nyegyetem, Szent-Gy\u00f6rgyi Albert Orvostudom\u00e1nyi Kar, Pathologiai Int\u00e9zet Szeged, \u00c1llom\u00e1s u. 1., 6725 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00f3ra","family":"\u00d6rd\u00f6g","sequence":"additional","affiliation":[{"name":"Szegedi Tudom\u00e1nyegyetem, Szent-Gy\u00f6rgyi Albert Orvostudom\u00e1nyi Kar, Pathologiai Int\u00e9zet Szeged, \u00c1llom\u00e1s u. 1., 6725 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsuzsanna","family":"\u00dajfaludi","sequence":"additional","affiliation":[{"name":"Szegedi Tudom\u00e1nyegyetem, Szent-Gy\u00f6rgyi Albert Orvostudom\u00e1nyi Kar, Pathologiai Int\u00e9zet Szeged, \u00c1llom\u00e1s u. 1., 6725 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Levente","family":"Kuthi","sequence":"additional","affiliation":[{"name":"Orsz\u00e1gos Onkol\u00f3giai Int\u00e9zet, Seb\u00e9szeti \u00e9s Molekul\u00e1ris Patol\u00f3giai Oszt\u00e1ly Budapest Magyarorsz\u00e1g"},{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Patol\u00f3giai \u00e9s K\u00eds\u00e9rleti R\u00e1kkutat\u00f3 Int\u00e9zet Budapest Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Sejben","sequence":"additional","affiliation":[{"name":"Szegedi Tudom\u00e1nyegyetem, Szent-Gy\u00f6rgyi Albert Orvostudom\u00e1nyi Kar, Pathologiai Int\u00e9zet Szeged, \u00c1llom\u00e1s u. 1., 6725 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"R1","unstructured":"World Health Organization. WHO Classification of Tumours Editorial\n                    Board. Digestive system tumours \u2013 WHO classification of tumours. 5th edition.\n                    International Agency for Research on Cancer, Lyon, 2019."},{"key":"R2","doi-asserted-by":"crossref","unstructured":"Moussata D, Boschetti G, Chauvenet M, et al. Endoscopic and\n                    histologic characteristics of serrated lesions. World J Gastroenterol. 2015; 21:\n                    2896\u20132904.","DOI":"10.3748\/wjg.v21.i10.2896"},{"key":"R3","doi-asserted-by":"crossref","unstructured":"Tan YY, Tay GS, Wong YJ, et al. Clinical features and predictors of\n                    dysplasia in proximal sessile serrated lesions. Clin Endosc. 2021; 54:\n                    578\u2013588.","DOI":"10.5946\/ce.2020.198"},{"key":"R4","doi-asserted-by":"crossref","unstructured":"Utsumi T, Yamada Y, Diaz-Meco MT, et al. Sessile serrated lesions\n                    with dysplasia: is it possible to nip them in the bud? 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Occurrence, intratumoral\n                    heterogeneity, prognostic and predictive potential of microsatellite instability\n                    following surgical resection of primary colorectal carcinomas and corresponding\n                    liver metastases. [Mikroszatellita-instabilit\u00e1s el\u0151fordul\u00e1sa, intratumoralis\n                    heterogenit\u00e1sa, prognosztikus \u00e9s predikt\u00edv potenci\u00e1lja primer colorectalis\n                    carcinom\u00e1k \u00e9s p\u00e1ros\u00edtott m\u00e1j\u00e1tt\u00e9teik seb\u00e9szi kezel\u00e9s\u00e9t k\u00f6vet\u0151en.] Orv Hetil.\n                    2015; 156: 1460\u20131471. [Hungarian]","DOI":"10.1556\/650.2015.30218"},{"key":"R11","doi-asserted-by":"crossref","unstructured":"Li K, Luo H, Huang L, et al. Microsatellite instability: a review of\n                    what the oncologist should know. 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