{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:02:58Z","timestamp":1785423778507,"version":"3.56.0"},"reference-count":31,"publisher":"Akademiai Kiado Zrt.","issue":"21","license":[{"start":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T00:00:00Z","timestamp":1748131200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2025,5,25]]},"abstract":"\n Bevezet\u00e9s:<\/jats:italic>\n A SARS-CoV-2-vari\u00e1nsok \u00e1ltal a t\u00fcskefeh\u00e9rj\u00e9ben \u00e9s m\u00e1s\n r\u00e9gi\u00f3kban hordozott mut\u00e1ci\u00f3k befoly\u00e1solj\u00e1k a COVID\u221219 klinikai megjelen\u00e9s\u00e9t.\n Kev\u00e9ss\u00e9 ismert azonban a SARS-CoV-2-vari\u00e1nsok jelent\u0151s\u00e9ge az akut betegs\u00e9get\n k\u00f6vet\u0151 4 h\u00e9ten t\u00fal fennmarad\u00f3, poszt-COVID\u221219-komplik\u00e1ci\u00f3k tekintet\u00e9ben.\n C\u00e9lkit\u0171z\u00e9s:<\/jats:italic>\n Kutat\u00e1sunk c\u00e9lja az elt\u00e9r\u0151 SARS-CoV-2-vari\u00e1nsok\n \u00e1ltal el\u0151id\u00e9zett poszt-COVID\u221219-t\u00fcnetek \u00e9s alv\u00e1s-\u00e9brenl\u00e9t zavarok elemz\u00e9se volt.\n M\u00f3dszer:<\/jats:italic>\n Retrospekt\u00edv vizsg\u00e1latunkban a COVID\u221219\n magyarorsz\u00e1gi harmadik (2021. febru\u00e1r\u2212j\u00falius; B.1.1.7, alfa vari\u00e1ns, n = 88),\n negyedik (2021. augusztus\u2212december; B.1.617.2, delta vari\u00e1ns, n = 60) \u00e9s \u00f6t\u00f6dik\n (2022. janu\u00e1r\u2212j\u00fanius; B.1.1.529, omikron vari\u00e1ns, n = 41) epidemiol\u00f3giai\n hull\u00e1m\u00e1ban SARS-CoV-2-fert\u0151z\u00e9sen \u00e1tesett, a fert\u0151z\u00e9s elm\u00falta ut\u00e1n >4 h\u00e9ttel a\n Semmelweis Egyetem Pulmonol\u00f3giai Klinik\u00e1j\u00e1nak ell\u00e1t\u00e1s\u00e1n megjelen\u0151 \u00e9s\n poszt-COVID\u221219-t\u00fcneteket mutat\u00f3 p\u00e1ciensek klinikai adatait elemezt\u00fck. Az\n alv\u00e1s-\u00e9brenl\u00e9t zavarok \u00e9rt\u00e9kel\u00e9se a Pittsburgh Alv\u00e1smin\u0151s\u00e9gi Index (PSQI)\n k\u00e9rd\u0151\u00edv alapj\u00e1n t\u00f6rt\u00e9nt. Az alv\u00e1smin\u0151s\u00e9get PSQI-pontsz\u00e1m >5 eset\u00e9n\n tekintett\u00fck nem megfelel\u0151nek.\n Eredm\u00e9nyek:<\/jats:italic>\n A f\u00e1radts\u00e1g a\n leggyakoribb poszt-COVID\u221219-t\u00fcnet az alfa, a delta \u00e9s az omikron vari\u00e1nsn\u00e1l\n egyar\u00e1nt (61,7\u221264,8\u221265,9%). Az id\u0151rendben egym\u00e1st k\u00f6vet\u0151 hull\u00e1mok kapcs\u00e1n a\n neh\u00e9zl\u00e9gz\u00e9s gyakoris\u00e1ga cs\u00f6kken, m\u00edg a k\u00f6h\u00f6g\u00e9s \u00e9s a sz\u00edvdobog\u00e1s\u00e9rz\u00e9s\n el\u0151fordul\u00e1sa n\u00f6vekedik. A PSQI-pontsz\u00e1m alapj\u00e1n megfelel\u0151 \u00e9s nem megfelel\u0151\n alv\u00e1smin\u0151s\u00e9g\u0171 alcsoportokat \u00f6sszevetve a f\u00e1radts\u00e1g szignifik\u00e1nsan gyakoribb a\n nem megfelel\u0151 alv\u00e1smin\u0151s\u00e9g\u0171 alcsoportban az alfa \u00e9s a delta vari\u00e1ns eset\u00e9n, az\n alv\u00e1smin\u0151s\u00e9gt\u0151l f\u00fcggetlen\u00fcl gyakori (\u226560%) az omikron vari\u00e1ns eset\u00e9n, m\u00edg a\n k\u00f6h\u00f6g\u00e9s \u00e9s a neh\u00e9zl\u00e9gz\u00e9s a nem megfelel\u0151 alv\u00e1smin\u0151s\u00e9g\u0171 alcsoportban gyakoribb\n mindh\u00e1rom vari\u00e1ns eset\u00e9n. A szapora sz\u00edvver\u00e9s el\u0151fordul\u00e1sa az alfa vari\u00e1ns\n eset\u00e9n alacsony (<25%), a delta vari\u00e1ns eset\u00e9n a nem megfelel\u0151\n alv\u00e1smin\u0151s\u00e9g\u0171ekn\u00e9l gyakori (50%), m\u00edg az omikron vari\u00e1ns eset\u00e9n alv\u00e1smin\u0151s\u00e9gt\u0151l\n f\u00fcggetlen\u00fcl magas (\u226550%). Az alv\u00e1s-\u00e9brenl\u00e9t ritmust vizsg\u00e1l\u00f3 elemz\u00e9s\u00fcnk a nem\n megfelel\u0151 alv\u00e1smin\u0151s\u00e9g\u0171 alcsoportok tekintet\u00e9ben az omikron vari\u00e1ns eset\u00e9ben a\n lefekv\u00e9s k\u00e9s\u0151bbre tol\u00f3d\u00e1s\u00e1t, m\u00edg az alfa vari\u00e1ns eset\u00e9n a felkel\u00e9s kor\u00e1bbi\n id\u0151pontj\u00e1t, valamint mindh\u00e1rom vari\u00e1nsn\u00e1l az elalv\u00e1si id\u0151 megny\u00fal\u00e1s\u00e1t \u00e9s az\n alv\u00e1si id\u0151 r\u00f6vid\u00fcl\u00e9s\u00e9t mutatta.\n K\u00f6vetkeztet\u00e9s:<\/jats:italic>\n Vizsg\u00e1latunk\n igazolja a poszt-COVID\u221219-t\u00fcnetek \u00e9s az alv\u00e1s-\u00e9brenl\u00e9t zavarok\n v\u00edrusvari\u00e1ns-f\u00fcgg\u0151 heterogenit\u00e1s\u00e1t. A poszt-COVID\u221219-sz\u00f6v\u0151dm\u00e9nyekkel val\u00f3\n \u00f6sszef\u00fcgg\u00e9sek megismer\u00e9se seg\u00edthet felt\u00e1rni a SARS-CoV-2 genetikai v\u00e1ltoz\u00e1sainak\n jelent\u0151s\u00e9g\u00e9t. Orv Hetil. 2025; 166(21): 817\u2013825.\n <\/jats:p>","DOI":"10.1556\/650.2025.33282","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:24:26Z","timestamp":1748219066000},"page":"817-825","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":1,"title":["Poszt-COVID\u221219-t\u00fcnetek \u00e9s alv\u00e1s-\u00e9brenl\u00e9t zavarok a COVID\u221219 magyarorsz\u00e1gi j\u00e1rv\u00e1nyhull\u00e1mai sor\u00e1n"],"prefix":"10.1556","volume":"166","author":[{"given":"Anna R\u00e9ka","family":"Percze","sequence":"first","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Pulmonol\u00f3giai Klinika Budapest, T\u00f6m\u0151 u. 25\u201329., 1083 Magyarorsz\u00e1g"},{"name":"Orsz\u00e1gos Onkol\u00f3giai Int\u00e9zet, K\u00f6zponti Aneszteziol\u00f3giai \u00e9s Intenz\u00edv Ter\u00e1pi\u00e1s Oszt\u00e1ly Budapest Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Bogl\u00e1rka","family":"Bard\u00f3czi","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Pulmonol\u00f3giai Klinika Budapest, T\u00f6m\u0151 u. 25\u201329., 1083 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Nagy","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Pulmonol\u00f3giai Klinika Budapest, T\u00f6m\u0151 u. 25\u201329., 1083 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Szilvia","family":"Vasas","sequence":"additional","affiliation":[{"name":"\u00c9szak-budai Szent J\u00e1nos Centrumk\u00f3rh\u00e1z, T\u00fcd\u0151gondoz\u00f3 Int\u00e9zet \u00e9s Sz\u0171r\u0151\u00e1llom\u00e1s Budapest Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e1nos Tam\u00e1s","family":"Varga","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Pulmonol\u00f3giai Klinika Budapest, T\u00f6m\u0151 u. 25\u201329., 1083 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Pulmonol\u00f3giai Klinika Budapest, T\u00f6m\u0151 u. 25\u201329., 1083 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e1bor","family":"Horv\u00e1th","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Pulmonol\u00f3giai Klinika Budapest, T\u00f6m\u0151 u. 25\u201329., 1083 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"R1","unstructured":"World Health Organization (WHO). Coronavirus disease (COVID-19):\n post COVID-19 condition. 28 March 2023. Available from:\n http:\/\/www.who.int\/news-room\/questions-and-answers\/item\/coronavirus-disease-(covid-19)-post-covid-19-condition\n [accessed: February 10, 2025]."},{"key":"R2","doi-asserted-by":"crossref","unstructured":"Szekanecz Z, V\u00e1lyi-Nagy I. Post-acute COVID-19 syndrome. [Posztakut\n COVID\u201319 szindr\u00f3ma.] Orv Hetil. 2021; 162: 1067\u20131078.\n [Hungarian]","DOI":"10.1556\/650.2021.32282"},{"key":"R3","doi-asserted-by":"crossref","unstructured":"Crook H, Raza S, Nowell J, et al. Long covid-mechanisms, risk\n factors, and management. BMJ 2021; 374: n1648.","DOI":"10.1136\/bmj.n1648"},{"key":"R4","doi-asserted-by":"crossref","unstructured":"Davis HE, McCorkell L, Vogel JM, et al. Long COVID: major findings,\n mechanisms and recommendations. Nat Rev Microbiol. 2023; 21: 133\u2013146. 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Comparing healthy controls with COVID-19 cases\n of different severity in the international COVID sleep study (ICOSS-II). J Sleep\n Res. 2023: 32: e13754.","DOI":"10.1111\/jsr.13754"},{"key":"R8","doi-asserted-by":"crossref","unstructured":"Gomes BB, Ferreira NN, Garibaldi PM, et al. Impact of SARS-CoV-2\n variants on COVID-19 symptomatology and severity during five waves. Heliyon\n 2024; 10: e40113.","DOI":"10.1016\/j.heliyon.2024.e40113"},{"key":"R9","doi-asserted-by":"crossref","unstructured":"Andre M, Lau LS, Pokharel MD, et al. From alpha to omicron: how\n different variants of concern of the SARS-coronavirus-2 impacted the world.\n Biology (Basel) 2023; 12: 1267.","DOI":"10.3390\/biology12091267"},{"key":"R10","doi-asserted-by":"crossref","unstructured":"Spinicci M, Graziani L, Tilli M, et al. Infection with SARS-CoV-2\n variants is associated with different long COVID phenotypes. Viruses 2022; 14:\n 2367.","DOI":"10.3390\/v14112367"},{"key":"R11","doi-asserted-by":"crossref","unstructured":"Percze AR, Nagy A, Polivka L, et al. Fatigue, sleepiness and sleep\n quality are SARS-CoV-2 variant independent in patients with long COVID symptoms.\n Inflammopharmacology 2023; 31: 2819\u20132825.","DOI":"10.1007\/s10787-023-01190-4"},{"key":"R12","doi-asserted-by":"crossref","unstructured":"Voko Z, Kiss Z, Surj\u00e1n G, et al. Effectiveness and waning of\n protection with different SARS-CoV-2 primary and booster vaccines during the\n delta pandemic wave in 2021 in Hungary (HUN-VE 3 Study). Front Immunol. 2022;\n 13: 919408.","DOI":"10.3389\/fimmu.2022.919408"},{"key":"R13","doi-asserted-by":"crossref","unstructured":"Kiss Z, Wittmann I, Polivka L, et al. Nationwide effectiveness of\n first and second SARS-CoV2 booster vaccines during the delta and omicron\n pandemic waves in Hungary (HUN-VE 2 Study). 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