{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:06:17Z","timestamp":1785416777457,"version":"3.56.0"},"reference-count":29,"publisher":"Akademiai Kiado Zrt.","issue":"19","content-domain":{"domain":["www.akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2025,5,11]]},"abstract":"<jats:p>Adenocarcinoma a v\u00e9konyb\u00e9lben ritk\u00e1bban fordul el\u0151, mint a vastagb\u00e9lben.\n                    Esetenk\u00e9nt Crohn-betegs\u00e9g talaj\u00e1n, a hosszan tart\u00f3 kr\u00f3nikus gyullad\u00e1snak\n                    tulajdon\u00edthat\u00f3an alakul ki. Egy \u00e9vek \u00f3ta nem kezelt, fiatal Crohn-beteg f\u00e9rfi\n                    esete ker\u00fclt bemutat\u00e1sra, akinek sz\u00f6vettani vizsg\u00e1lata pecs\u00e9tgy\u0171r\u0171sejtes\n                    carcinom\u00e1t igazolt a terminalis ileumban. A carcinoma egy m\u00e9ly fissuralis\n                    ter\u00fclet k\u00f6rnyezet\u00e9ben j\u00f6tt l\u00e9tre, ahol dysplasticus mirigyek igazol\u00f3dtak,\n                    meger\u0151s\u00edtend\u0151 a lok\u00e1lis kialakul\u00e1st. A tumor a muscularis propri\u00e1t is\n                    infiltr\u00e1lta perineuralis \u00e9s vascularis terjed\u00e9ssel. Az ilyen t\u00edpus\u00fa m\u0171t\u00e9ti\n                    prepar\u00e1tum feldolgoz\u00e1sa sor\u00e1n alapos gondoss\u00e1ggal kell elj\u00e1rni, \u00e9s minden\n                    hasonl\u00f3 esetben gondolni kell esetleges malignus folyamat megl\u00e9t\u00e9re. A jelen\n                    esetben is ez t\u00f6rt\u00e9nt, \u00e9s mivel a tumor makroszk\u00f3posan nem volt egy\u00e9rtelm\u0171en\n                    beazonos\u00edthat\u00f3, az eg\u00e9sz v\u00e9lt ter\u00fclet feldolgoz\u00e1sra ker\u00fclt. Nem l\u00e9teznek a\n                    v\u00e9konyb\u00e9leredetet al\u00e1t\u00e1maszt\u00f3 specifikus immunvizsg\u00e1latok, azonban a CK7, CK20,\n                    CDX2, SATB2, EMA (MUC1), MUC5AC, MUC6 \u00e9s a Villinreakci\u00f3k seg\u00edthetnek. A hosszan\n                    tart\u00f3 kr\u00f3nikus gyullad\u00e1s mellett tov\u00e1bbi etiol\u00f3giai t\u00e9nyez\u0151k lehetnek az ilealis\n                    conduitok, rezervo\u00e1rok, savas expoz\u00edci\u00f3, glut\u00e9nszenzit\u00edv enteropathia, jelent\u0151s\n                    alkoholfogyaszt\u00e1s, cukor vagy feldolgozott sz\u00e9nhidr\u00e1tok fogyaszt\u00e1sa, \u00e9s v\u00e9g\u00fcl,\n                    de nem utols\u00f3sorban a doh\u00e1nyz\u00e1s. A kurat\u00edv m\u0171t\u00e9ti megold\u00e1sok mellett adjuv\u00e1ns\n                    kemo- \u00e9s sug\u00e1rter\u00e1pia j\u00f6n sz\u00f3ba kezel\u00e9sk\u00e9nt. A Crohn-betegs\u00e9ggel sz\u00f6v\u0151d\u00f6tt\n                    pecs\u00e9tgy\u0171r\u0171sejtes carcinoma 5 \u00e9ves t\u00fal\u00e9l\u00e9si ar\u00e1nya alig 20\u201330%. Orv Hetil. 2025;\n                    166(19): 744\u2013749.<\/jats:p>","DOI":"10.1556\/650.2025.33283","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T04:49:13Z","timestamp":1747025353000},"page":"744-749","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":0,"title":["Crohn-betegs\u00e9g talaj\u00e1n kialakult pecs\u00e9tgy\u0171r\u0171sejtes carcinoma a terminalis ileumban"],"prefix":"10.1556","volume":"166","author":[{"given":"Viktor","family":"Nagy","sequence":"first","affiliation":[{"name":"Kom\u00e1rom-Esztergom V\u00e1rmegyei Szent Borb\u00e1la K\u00f3rh\u00e1z, Patol\u00f3gia Tatab\u00e1nya, D\u00f3zsa Gy. \u00fat 77., 2800 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"R1","unstructured":"WHO Classification of Tumours Editorial Board. WHO Classification of\n                    Tumours. 5th ed., volume 1: Digestive system tumours. International Agency for\n                    Research on Cancer, Lyon, 2019; pp. 85\u201395., 116\u2013117., 124\u2013126.,\n                    177\u2013187."},{"key":"R2","doi-asserted-by":"crossref","unstructured":"Benesch MG, Mathieson A. Epidemiology of signet ring cell\n                    adenocarcinomas. Cancers (Basel) 2020; 12: 1544.","DOI":"10.3390\/cancers12061544"},{"key":"R3","doi-asserted-by":"crossref","unstructured":"Benesch MG, Nelson ED, O\u2019Brien SB. Malignant transformation of\n                    long-standing ileal Crohn\u2019s disease likely favors signet ring cell\n                    adenocarcinoma histology. World J Oncol. 2023; 14: 447\u2013456.","DOI":"10.14740\/wjon1605"},{"key":"R4","doi-asserted-by":"crossref","unstructured":"Brierley JD, Mary K. Gospodarowicz MK, Christian Wittekind C. (eds.)\n                    TNM classification of malignant tumours. 8th edition. John Wiley, Chichester,\n                    2017.","DOI":"10.1002\/9780471420194.tnmc26.pub3"},{"key":"R5","doi-asserted-by":"crossref","unstructured":"Aparicio T, Zaanan A, Svrcek M, et al. Small bowel adenocarcinoma:\n                    epidemiology, risk factors, diagnosis and treatment. Dig Liver Dis. 2014; 46:\n                    97\u2013104.","DOI":"10.1016\/j.dld.2013.04.013"},{"key":"R6","doi-asserted-by":"crossref","unstructured":"Schottenfeld D, Beebe-Dimmer JL, Vigneau FD. The epidemiology and\n                    pathogenesis of neoplasia in the small intestine. Ann Epidemiol. 2009; 19:\n                    58\u201369.","DOI":"10.1016\/j.annepidem.2008.10.004"},{"key":"R7","doi-asserted-by":"crossref","unstructured":"Pan SY, Morrison H. Epidemiology of cancer of the small intestine.\n                    World J Gastrointest. Oncol. 2011; 3: 33\u201342.","DOI":"10.4251\/wjgo.v3.i3.33"},{"key":"R8","doi-asserted-by":"crossref","unstructured":"Delaunoit T, Neczyporenko F, Limburg PJ, et al. Pathogenesis and\n                    risk factors of small bowel adenocarcinoma: a colorectal cancer sibling? Am J\n                    Gastroenterol. 2005; 100: 703\u2013710.","DOI":"10.1111\/j.1572-0241.2005.40605.x"},{"key":"R9","doi-asserted-by":"crossref","unstructured":"Clarke LM, Riascos MC, Redston MS, et al. Ileal signet ring\n                    adenocarcinoma in Crohn\u2019s disease: unanticipated diagnosis after surgical\n                    resection of a symptomatic stricture. Dig Dis Sci. 2024; 69:\n                    3620\u20133623.","DOI":"10.1007\/s10620-024-08621-4"},{"key":"R10","doi-asserted-by":"crossref","unstructured":"Egan L, D\u2019Inca R, Jess T, et al. Non-colorectal intestinal tract\n                    carcinomas in inflammatory bowel disease: results of the 3rd ECCO Pathogenesis\n                    Scientific Workshop (II). J Crohns Colitis 2014; 8: 19\u201330.","DOI":"10.1016\/j.crohns.2013.04.009"},{"key":"R11","doi-asserted-by":"crossref","unstructured":"Wu AH, Yu MC, Mack TM. Smoking, alcohol use, dietary factors and\n                    risk of small intestinal adenocarcinoma. Int J Cancer 1997; 70:\n                    512\u2013517.","DOI":"10.1002\/(SICI)1097-0215(19970304)70:5<512::AID-IJC4>3.0.CO;2-0"},{"key":"R12","doi-asserted-by":"crossref","unstructured":"Aparicio T, Zaanan A, Mary F, et al. Small bowel adenocarcinoma.\n                    Gastroenterol Clin North Am. 2016; 45: 447\u2013457.","DOI":"10.1016\/j.gtc.2016.04.004"},{"key":"R13","doi-asserted-by":"crossref","unstructured":"Palascak-Juif V, Bouvier AM, Cosnes J, et al. Small bowel\n                    adenocarcinoma in patients with Crohn\u2019s disease compared with small bowel\n                    adenocarcinoma de novo. Inflamm Bowel Dis. 2005; 11: 828\u2013832.","DOI":"10.1097\/01.mib.0000179211.03650.b6"},{"key":"R14","doi-asserted-by":"crossref","unstructured":"Grolleau C, Pote NM, Guedj NS, et al. Small bowel adenocarcinoma\n                    complicating Crohn\u2019s disease: a single-centre experience emphasizing the\n                    importance of screening for dysplasia. Virchows Arch. 2017; 471:\n                    611\u2013617.","DOI":"10.1007\/s00428-017-2125-z"},{"key":"R15","doi-asserted-by":"crossref","unstructured":"Khosla D, Dey T, Madan R, et al. Small bowel adenocarcinoma: an\n                    overview. World J Gastrointest Oncol. 2022; 14: 413\u2013422.","DOI":"10.4251\/wjgo.v14.i2.413"},{"key":"R16","doi-asserted-by":"crossref","unstructured":"Overman MJ, Pozadzides J, Kopetz S, et al. Immunophenotype and\n                    molecular characterisation of adenocarcinoma of the small intestine. Br J Cancer\n                    2010; 102: 144\u2013150.","DOI":"10.1038\/sj.bjc.6605449"},{"key":"R17","doi-asserted-by":"crossref","unstructured":"Xue Y, Vanoli A, Balci S, et al. Non-ampullary-duodenal carcinomas:\n                    clinicopathologic analysis of 47 cases and comparison with ampullary and\n                    pancreatic adenocarcinomas. Mod Pathol. 2017; 30: 255\u2013266.","DOI":"10.1038\/modpathol.2016.174"},{"key":"R18","doi-asserted-by":"crossref","unstructured":"Shepherd NA, Hall PA. Epithelial-mesenchymal interactions can\n                    influence the phenotype of carcinoma metastases in the mucosa of the intestine.\n                    J Pathol. 1990; 160: 103\u2013109.","DOI":"10.1002\/path.1711600203"},{"key":"R19","doi-asserted-by":"crossref","unstructured":"Mann K, Gilbert T, Cicconi S, et al. Tumour stage and resection\n                    margin status are independent survival factors following partial\n                    pancreatoduodenectomy for duodenal adenocarcinoma. Langenbecks Arch Surg. 2019;\n                    404: 439\u2013449.","DOI":"10.1007\/s00423-019-01779-w"},{"key":"R20","doi-asserted-by":"crossref","unstructured":"Overman MJ, Hu CY, Wolff RA, et al. Prognostic value of lymph node\n                    evaluation in small bowel adenocarcinoma: analysis of the surveillance,\n                    epidemiology, and end results database. Cancer 2010; 116:\n                    5374\u20135382.","DOI":"10.1002\/cncr.25324"},{"key":"R21","doi-asserted-by":"crossref","unstructured":"Arai M, Shimizu S, Imai Y, et al. Mutations of the\n                        Ki-ras, p53 and APC genes\n                    in adenocarcinomas of the human small intestine. Int J Cancer 1997; 70:\n                    390\u2013395.","DOI":"10.1002\/(SICI)1097-0215(19970207)70:4<390::AID-IJC3>3.3.CO;2-S"},{"key":"R22","doi-asserted-by":"crossref","unstructured":"Benson AB, Venook AP, Al-Hawary MM, et al. Small bowel\n                    adenocarcinoma. Version 1. 2020. NCCN Clinical Practice Guidelines in Oncology.\n                    J Natl Compr Canc Netw. 2019; 17: 1109\u20131133.","DOI":"10.6004\/jnccn.2019.0043"},{"key":"R23","doi-asserted-by":"crossref","unstructured":"Chang HK, Yu E, Kim J, et al. Adenocarcinoma of the small intestine:\n                    a multi-institutional study of 197 surgically resected cases. Hum Pathol. 2010;\n                    41: 1087\u20131096.","DOI":"10.1016\/j.humpath.2010.01.006"},{"key":"R24","doi-asserted-by":"crossref","unstructured":"Latham A, Shia J, Patel Z, et al. Characterization and clinical\n                    outcomes of DNA mismatch repair-deficient small bowel adenocarcinoma. Clin\n                    Cancer Res. 2021; 27: 1429\u20131437.","DOI":"10.1158\/1078-0432.CCR-20-2892"},{"key":"R25","doi-asserted-by":"crossref","unstructured":"Carvalho JR, Tavares J, Goulart I, et al. Signet ring cell\n                    carcinoma, ileal Crohn disease or both? \u2013 A case of diagnostic challenge. GE\n                    Port J Gastroenterol. 2018; 25: 47\u201351.","DOI":"10.1159\/000479590"},{"key":"R26","doi-asserted-by":"crossref","unstructured":"von Roon AC, Reese G, Teare J, et al. The risk of cancer in patients\n                    with Crohn\u2019s disease. Dis Colon Rectum 2007; 50: 839\u2013855.","DOI":"10.1007\/s10350-006-0848-z"},{"key":"R27","doi-asserted-by":"crossref","unstructured":"Jess T, Gamborg M, Matzen P, et al. Increased risk of intestinal\n                    cancer in Crohn\u2019s disease: a meta-analysis of population-based cohort studies.\n                    Am J Gastroenterol. 2005; 100: 2724\u20132729.","DOI":"10.1111\/j.1572-0241.2005.00287.x"},{"key":"R28","doi-asserted-by":"crossref","unstructured":"Yu J, Refsum E, Perrin V, et al. Inflammatory bowel disease and risk\n                    of adenocarcinoma and neuroendocrine tumors in the small bowel. Ann Oncol. 2022;\n                    33: 649\u2013656.","DOI":"10.1016\/j.annonc.2022.02.226"},{"key":"R29","doi-asserted-by":"crossref","unstructured":"Maguire A, Sheahan K. Primary small bowel adenomas and\n                    adenocarcinomas \u2013 recent advances. Virchows Arch. 2018; 473:\n                    265\u2013273.","DOI":"10.1007\/s00428-018-2400-7"}],"container-title":["Orvosi Hetilap"],"original-title":[],"link":[{"URL":"https:\/\/www.akjournals.com\/view\/journals\/650\/166\/19\/article-p744.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.akjournals.com\/downloadpdf\/journals\/650\/166\/19\/article-p744.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.akjournals.com\/downloadpdf\/journals\/650\/166\/19\/article-p744.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T12:55:36Z","timestamp":1785416136000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.akjournals.com\/view\/journals\/650\/166\/19\/article-p744.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,11]]},"references-count":29,"journal-issue":{"issue":"19"},"URL":"https:\/\/doi.org\/10.1556\/650.2025.33283","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,11]]}}}