{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:02:35Z","timestamp":1785423755746,"version":"3.56.0"},"reference-count":137,"publisher":"Akademiai Kiado Zrt.","issue":"23","license":[{"start":{"date-parts":[[2025,6,8]],"date-time":"2025-06-08T00:00:00Z","timestamp":1749340800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Semmelweis Egyetem, Idegseb\u00e9szeti \u00e9s Neurointervenci\u00f3s Klinika"}],"content-domain":{"domain":["www.akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2025,6,8]]},"abstract":"\n Bevezet\u00e9s:<\/jats:italic>\n A k\u00f6zponti idegrendszeri erek fal\u00e1nak gyullad\u00e1sa\n (vasculitis) az agyi ischaemia egy ritka form\u00e1ja. Felismer\u00e9se, diagnosztik\u00e1ja,\n kezel\u00e9se multidiszciplin\u00e1ris megk\u00f6zel\u00edt\u00e9st ig\u00e9nyel.\n C\u00e9lkit\u0171z\u00e9s:<\/jats:italic>\n C\u00e9lunk volt egy magyar nyelv\u0171 \u00f6sszefoglal\u00f3 k\u00f6zlem\u00e9ny, kivizsg\u00e1l\u00e1si protokoll\n meg\u00edr\u00e1sa, amely a klinikusokat seg\u00edti a k\u00f6zponti idegrendszeri vasculitisek\n felismer\u00e9s\u00e9ben, diagnosztiz\u00e1l\u00e1s\u00e1ban, valamint a megfelel\u0151 ter\u00e1pia\n kiv\u00e1laszt\u00e1s\u00e1ban.\n Megbesz\u00e9l\u00e9s:<\/jats:italic>\n A k\u00f6zponti idegrendszeri\n vasculitisen bel\u00fcl megk\u00fcl\u00f6nb\u00f6ztetj\u00fck a primer k\u00f6zponti idegrendszeri\n vasculitist, valamint a szekunder form\u00e1kat, amelyekben az idegrendszeri\n \u00e9rintetts\u00e9g m\u00e1s, ak\u00e1r sziszt\u00e9m\u00e1s betegs\u00e9g r\u00e9szjelens\u00e9ge lehet. A k\u00f6zponti\n idegrendszeri vasculitiseket az \u00e9rintett erek \u00e1tm\u00e9r\u0151je alapj\u00e1n is\n csoportos\u00edthatjuk, elk\u00fcl\u00f6n\u00edtve ezzel a kis-, a k\u00f6zepes \u00e9s a nagyereket \u00e9rint\u0151\n k\u00f3rform\u00e1kat, amelyek klinikai megjelen\u00e9se v\u00e1ltozatos, \u00e9s kezel\u00e9s\u00fck is elt\u00e9r\u0151. A\n diagn\u00f3zis fel\u00e1ll\u00edt\u00e1s\u00e1t seg\u00edt\u0151 specifikus laborat\u00f3riumi vagy k\u00e9palkot\u00f3 biomarker\n egyel\u0151re nem \u00e1ll rendelkez\u00e9sre. A fizik\u00e1lis vizsg\u00e1lat \u00e9s az anamn\u00e9zisfelv\u00e9tel\n mellett kiemelked\u0151en fontos szerepet j\u00e1tszanak t\u00f6bbek k\u00f6z\u00f6tt \u2013 a rutin k\u00e9palkot\u00f3\n elj\u00e1r\u00e1sokon t\u00fal \u2013 az \u00e9rfali \u00e9rintetts\u00e9get igazol\u00f3 elj\u00e1r\u00e1sok (p\u00e9ld\u00e1ul a \u2019black\n blood\u2019 technika), a rutin \u00e9s speci\u00e1lis laborat\u00f3riumi \u00e9s liquorvizsg\u00e1latok,\n valamint a biopszi\u00e1s mintav\u00e9teli lehet\u0151s\u00e9gek. A differenci\u00e1ldiagnosztik\u00e1ban\n els\u0151dleges a sziszt\u00e9m\u00e1s vasculitisek \u00e9s autoimmun k\u00f3rk\u00e9pek, a fert\u0151z\u0151 vagy\n egy\u00e9b, a k\u00f6zponti idegrendszert is \u00e9rint\u0151 megbeteged\u00e9sek kiz\u00e1r\u00e1sa vagy\n meger\u0151s\u00edt\u00e9se. A diagn\u00f3zis fel\u00e1ll\u00edt\u00e1s\u00e1t k\u00f6vet\u0151en a megfelel\u0151 kezel\u00e9si strat\u00e9gia\n meghat\u00e1roz\u00e1s\u00e1ban a neurol\u00f3gus mellett kiemelked\u0151 az immunol\u00f3gus\/reumatol\u00f3gus\n szerepe, valamint a betegs\u00e9g progressz\u00edv term\u00e9szete miatt szoros ut\u00e1nk\u00f6vet\u00e9s\n javasolt.\n K\u00f6vetkeztet\u00e9s:<\/jats:italic>\n A k\u00f6zponti idegrendszeri vasculitis\n progressz\u00edv, de sok esetben kezelhet\u0151 betegs\u00e9g, ha id\u0151ben felfedezik.\n Felismer\u00e9s\u00e9ben, ell\u00e1t\u00e1s\u00e1ban kiemelked\u0151 szerepe van az orvosi szakter\u00fcletek\n k\u00f6z\u00f6tti rugalmas egy\u00fcttm\u0171k\u00f6d\u00e9snek, s a kivizsg\u00e1l\u00e1s \u00e9s a hossz\u00fa t\u00e1v\u00fa gondoz\u00e1s\n \u00f6sszetetts\u00e9ge miatt hasznos lehet a betegs\u00e9g kezel\u00e9s\u00e9ben j\u00e1rtas centrumok \u00e9s\n munkacsoportok kialak\u00edt\u00e1sa. Orv Hetil. 2025; 166(23): 887\u2013906.\n <\/jats:p>","DOI":"10.1556\/650.2025.33307","type":"journal-article","created":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T04:43:09Z","timestamp":1749530589000},"page":"887-906","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":1,"title":["Az agyi ischaemia ritk\u00e1n felismert oka: a k\u00f6zponti idegrendszeri vasculitis"],"prefix":"10.1556","volume":"166","author":[{"given":"Anik\u00f3","family":"Papp","sequence":"first","affiliation":[{"name":"Semmelweis Egyetem, Klinikai K\u00f6zpont, Idegseb\u00e9szeti \u00e9s Neurointervenci\u00f3s Klinika Budapest, Amerikai \u00fat 57., 1145 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikt\u00f3ria","family":"Varga","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Reumatol\u00f3giai \u00e9s Immunol\u00f3giai Klinika Budapest Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gr\u00e9ta","family":"Zaja","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, Klinikai K\u00f6zpont, Idegseb\u00e9szeti \u00e9s Neurointervenci\u00f3s Klinika Budapest, Amerikai \u00fat 57., 1145 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danuta","family":"Szirmai","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, Klinikai K\u00f6zpont, Idegseb\u00e9szeti \u00e9s Neurointervenci\u00f3s Klinika Budapest, Amerikai \u00fat 57., 1145 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Fut\u00f3","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, Klinikai K\u00f6zpont, Idegseb\u00e9szeti \u00e9s Neurointervenci\u00f3s Klinika Budapest, Amerikai \u00fat 57., 1145 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Frendl","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, Klinikai K\u00f6zpont, Idegseb\u00e9szeti \u00e9s Neurointervenci\u00f3s Klinika Budapest, Amerikai \u00fat 57., 1145 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Kov\u00e1cs","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, Klinikai K\u00f6zpont, Idegseb\u00e9szeti \u00e9s Neurointervenci\u00f3s Klinika Budapest, Amerikai \u00fat 57., 1145 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1gnes","family":"Szappanos","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, V\u00e1rosmajori Sz\u00edv- \u00e9s \u00c9rgy\u00f3gy\u00e1szati Klinika Budapest Magyarorsz\u00e1g"},{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Reumatol\u00f3giai \u00e9s Klinikai Immunol\u00f3giai Tansz\u00e9k Budapest Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"V\u00e1rallyay","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, Klinikai K\u00f6zpont, Idegseb\u00e9szeti \u00e9s Neurointervenci\u00f3s Klinika Budapest, Amerikai \u00fat 57., 1145 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kinga","family":"Pozs\u00e1r","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, Klinikai K\u00f6zpont, Idegseb\u00e9szeti \u00e9s Neurointervenci\u00f3s Klinika Budapest, Amerikai \u00fat 57., 1145 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Kamondi","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, Klinikai K\u00f6zpont, Idegseb\u00e9szeti \u00e9s Neurointervenci\u00f3s Klinika Budapest, Amerikai \u00fat 57., 1145 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"R1","doi-asserted-by":"crossref","unstructured":"Shavit E, Alavi A, Sibbald RG. Vasculitism \u2013 What do we have to\n know? A review of literature. Int J Low Extrem Wounds 2018; 17:\n 218\u2013226.","DOI":"10.1177\/1534734618804982"},{"key":"R2","doi-asserted-by":"crossref","unstructured":"Kallenberg CG, Heeringa P. Pathogenesis of vasculitis. Lupus 1998;\n 7: 280\u2013284.","DOI":"10.1191\/096120398678920109"},{"key":"R3","doi-asserted-by":"crossref","unstructured":"Salvarani C, Brown RD Jr., Christianson TJ, et al. Adult primary\n central nervous system vasculitis treatment and course: analysis of one hundred\n sixty-three patients. Arthritis Rheumatol. 2015; 67: 1637\u20131645.","DOI":"10.1002\/art.39068"},{"key":"R4","doi-asserted-by":"crossref","unstructured":"Jennette JC, Falk RJ, Bacon PA, et al. 2012 revised International\n Chapel Hill consensus conference nomenclature of vasculitides. Arthritis Rheum.\n 2013; 65: 1\u201311.","DOI":"10.1007\/s10157-013-0869-6"},{"key":"R5","doi-asserted-by":"crossref","unstructured":"H\u00e4hnel S. (ed.) 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