{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:02:35Z","timestamp":1785423755491,"version":"3.56.0"},"reference-count":44,"publisher":"Akademiai Kiado Zrt.","issue":"23","license":[{"start":{"date-parts":[[2025,6,8]],"date-time":"2025-06-08T00:00:00Z","timestamp":1749340800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"HUN-REN\u2013SZTE Idegtudom\u00e1nyi Kutat\u00f3csoport"},{"name":"Szegedi Tudom\u00e1nyegyetem Egyetemi Kutat\u00f3i \u00d6szt\u00f6nd\u00edj Program"}],"content-domain":{"domain":["www.akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2025,6,8]]},"abstract":"<jats:p>A migr\u00e9n a primer fejf\u00e1j\u00e1sok egyik leggyakoribb form\u00e1ja. A betegs\u00e9g az \u00e9rintettek\n                    \u00e9letmin\u0151s\u00e9g\u00e9nek cs\u00f6kken\u00e9se mellett komoly gazdas\u00e1gi probl\u00e9m\u00e1kat okoz vil\u00e1gszerte\n                    a munk\u00e1b\u00f3l val\u00f3 kies\u00e9s miatt. A migr\u00e9n pontos patofiziol\u00f3gi\u00e1ja nem ismert, \u00edgy\n                    az el\u00e9rhet\u0151 ter\u00e1pi\u00e1s lehet\u0151s\u00e9gek sem kiel\u00e9g\u00edt\u0151ek. A n\u00f6vekv\u0151 prevalencia \u00e9s a\n                    ter\u00e1piarezisztens esetek a betegs\u00e9g patomechanizmus\u00e1nak miel\u0151bbi prec\u00edz\n                    felt\u00e9rk\u00e9pez\u00e9s\u00e9t, illetve \u00faj ter\u00e1pi\u00e1s c\u00e9lpontok azonos\u00edt\u00e1s\u00e1t s\u00fcrgetik. B\u00e1r a\n                    betegs\u00e9g patomechanizmus\u00e1val kapcsolatos ismereteink sok\u00e1ig d\u00f6nt\u0151en a szerotonin\n                    k\u00f6r\u00e9 koncentr\u00e1l\u00f3dtak, az elm\u00falt \u00e9vekben egyre nagyobb figyelmet kap a\n                    kinureninanyagcsere-\u00fatvonal. A triptof\u00e1n metabolizmus\u00e1nak kinurenin-\u00fatvonala\n                    hangs\u00falyos szereppel b\u00edr a migr\u00e9n patofiziol\u00f3gi\u00e1j\u00e1ban a glutam\u00e1terg\n                    mechanizmusok szab\u00e1lyoz\u00e1s\u00e1ban bet\u00f6lt\u00f6tt fontos funkci\u00f3ja r\u00e9v\u00e9n. Az el\u0151bbi\n                    metabolikus \u00fatvonal sz\u00e1mos neuroprotekt\u00edv \u00e9s neurotoxikus molekula szint\u00e9zis\u00e9\u00e9rt\n                    felel\u0151s. Az \u00fatvonal egyik v\u00e9gterm\u00e9ke a kinur\u00e9nsav, amely egy endog\u00e9n, ionotrop\n                    glutam\u00e1treceptor-antagonista. K\u00eds\u00e9rletes adatok al\u00e1t\u00e1masztj\u00e1k, hogy a kinur\u00e9nsav\n                    fontos szereppel b\u00edr a migr\u00e9nes rohamok kialakul\u00e1s\u00e1ban. Preklinikai vizsg\u00e1latok\n                    igazolj\u00e1k, hogy a kinur\u00e9nsav \u00e9s szintetikus anal\u00f3gjai k\u00e9pesek a migr\u00e9n alatt\n                    lej\u00e1tsz\u00f3d\u00f3 k\u00f3rtani folyamatok g\u00e1tl\u00e1s\u00e1ra, ez\u00e1ltal potenci\u00e1lis c\u00e9lpontok lehetnek\n                    a j\u00f6v\u0151beli gy\u00f3gyszervizsg\u00e1latokban. Hum\u00e1n klinikai vizsg\u00e1lataink igazolt\u00e1k, hogy\n                    a neuroprotekt\u00edv \u00e9s neurotoxikus kinureninmetabolitok \u00e1ltal fenntartott finom\n                    egyens\u00falyi \u00e1llapot migr\u00e9nes betegekben felborul, ami a neuroprotekt\u00edv molekul\u00e1k\n                    koncentr\u00e1ci\u00f3j\u00e1nak cs\u00f6kken\u00e9s\u00e9ben, illetve a neurotoxikus molekul\u00e1k\n                    koncentr\u00e1ci\u00f3j\u00e1nak emelked\u00e9s\u00e9ben manifeszt\u00e1l\u00f3dik. A primer fejf\u00e1j\u00e1sbetegs\u00e9gek \u00e9s\n                    a triptof\u00e1n metabolizmus\u00e1nak kinurenin-\u00fatvonala k\u00f6z\u00f6tti potenci\u00e1lis kapcsolat\n                    megismer\u00e9se fontos c\u00e9lkit\u0171z\u00e9s lehet a fejf\u00e1j\u00e1s kutat\u00e1s\u00e1ban a patofiziol\u00f3gia\n                    pontos megismer\u00e9se miatt. A migr\u00e9nesekben megfigyelhet\u0151 deprim\u00e1lt\n                    kinureninmetabolizmus a betegs\u00e9g \u00e9s a gastrointestinalis rendszer k\u00f6z\u00f6tti\n                    lehets\u00e9ges kapcsolatra h\u00edvja fel a figyelmet, m\u00edg a kinur\u00e9nsavn\u00e1l kedvez\u0151bb\n                    farmakokinetikai tulajdons\u00e1gokkal rendelkez\u0151 szintetikus anal\u00f3gok \u00faj\n                    perspekt\u00edv\u00e1kat nyithatnak a fejf\u00e1j\u00e1sok j\u00f6v\u0151beli gy\u00f3gyszerel\u00e9s\u00e9ben. Orv Hetil.\n                    2025; 166(23): 879\u2013886.<\/jats:p>","DOI":"10.1556\/650.2025.33327","type":"journal-article","created":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T04:43:55Z","timestamp":1749530635000},"page":"879-886","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":1,"title":["\u00daj perspekt\u00edv\u00e1k a migr\u00e9n kezel\u00e9s\u00e9ben: a kinureninrendszer szerepe a migr\u00e9n patofiziol\u00f3gi\u00e1j\u00e1ban"],"prefix":"10.1556","volume":"166","author":[{"given":"Tam\u00e1s","family":"K\u00f6rt\u00e9si","sequence":"first","affiliation":[{"name":"Szegedi Tudom\u00e1nyegyetem, Eg\u00e9szs\u00e9gtudom\u00e1nyi \u00e9s Szoci\u00e1lis K\u00e9pz\u00e9si Kar, Elm\u00e9leti Eg\u00e9szs\u00e9gtudom\u00e1nyi \u00e9s Eg\u00e9szs\u00e9g\u00fcgyi Menedzsment Tansz\u00e9k Szeged Magyarorsz\u00e1g"},{"name":"HUN-REN\u2013SZTE, Idegtudom\u00e1nyi Kutat\u00f3csoport Szeged Magyarorsz\u00e1g"},{"name":"Szegedi Tudom\u00e1nyegyetem, Interdiszciplin\u00e1ris Kutat\u00e1sfejleszt\u00e9si \u00e9s Innov\u00e1ci\u00f3s Kiv\u00e1l\u00f3s\u00e1gi K\u00f6zpont, Prevent\u00edv Eg\u00e9szs\u00e9gtudom\u00e1nyi Kutat\u00f3csoport Szeged Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelin","family":"V\u00e1gv\u00f6lgyi-S\u00fcmegi","sequence":"additional","affiliation":[{"name":"Szegedi Tudom\u00e1nyegyetem, Eg\u00e9szs\u00e9gtudom\u00e1nyi \u00e9s Szoci\u00e1lis K\u00e9pz\u00e9si Kar, Elm\u00e9leti Eg\u00e9szs\u00e9gtudom\u00e1nyi \u00e9s Eg\u00e9szs\u00e9g\u00fcgyi Menedzsment Tansz\u00e9k Szeged Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilla","family":"Ajkay-Don\u00e1th","sequence":"additional","affiliation":[{"name":"HUN-REN\u2013SZTE, Idegtudom\u00e1nyi Kutat\u00f3csoport Szeged Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e1bor","family":"Nagy-Gr\u00f3cz","sequence":"additional","affiliation":[{"name":"Szegedi Tudom\u00e1nyegyetem, Eg\u00e9szs\u00e9gtudom\u00e1nyi \u00e9s Szoci\u00e1lis K\u00e9pz\u00e9si Kar, Elm\u00e9leti Eg\u00e9szs\u00e9gtudom\u00e1nyi \u00e9s Eg\u00e9szs\u00e9g\u00fcgyi Menedzsment Tansz\u00e9k Szeged Magyarorsz\u00e1g"},{"name":"Szegedi Tudom\u00e1nyegyetem, Interdiszciplin\u00e1ris Kutat\u00e1sfejleszt\u00e9si \u00e9s Innov\u00e1ci\u00f3s Kiv\u00e1l\u00f3s\u00e1gi K\u00f6zpont, Prevent\u00edv Eg\u00e9szs\u00e9gtudom\u00e1nyi Kutat\u00f3csoport Szeged Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e1nos","family":"Tajti","sequence":"additional","affiliation":[{"name":"Szegedi Tudom\u00e1nyegyetem, Szent-Gy\u00f6rgyi Albert Orvostudom\u00e1nyi Kar, Neurol\u00f3giai Klinika Szeged, Semmelweis u. 6., 6725 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e1szl\u00f3","family":"V\u00e9csei","sequence":"additional","affiliation":[{"name":"HUN-REN\u2013SZTE, Idegtudom\u00e1nyi Kutat\u00f3csoport Szeged Magyarorsz\u00e1g"},{"name":"Szegedi Tudom\u00e1nyegyetem, Szent-Gy\u00f6rgyi Albert Orvostudom\u00e1nyi Kar, Neurol\u00f3giai Klinika Szeged, Semmelweis u. 6., 6725 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"R1","doi-asserted-by":"crossref","unstructured":"Bini P, Hohenschurz-Schmidt D, Masullo V, et al. 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