{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T20:16:56Z","timestamp":1788121016325,"version":"build-2803163510"},"reference-count":33,"publisher":"Akademiai Kiado Zrt.","issue":"28","license":[{"start":{"date-parts":[[2025,7,13]],"date-time":"2025-07-13T00:00:00Z","timestamp":1752364800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Eur\u00f3pai Uni\u00f3 Helyre\u00e1ll\u00edt\u00e1si \u00e9s Ellen\u00e1ll\u00f3k\u00e9pess\u00e9gi Eszk\u00f6z","award":["RRF-2.3.1-212022-00012"],"award-info":[{"award-number":["RRF-2.3.1-212022-00012"]}]}],"content-domain":{"domain":["www.akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2025,7,13]]},"abstract":"<jats:p>\n                    <jats:italic>Bevezet\u00e9s:<\/jats:italic>\n                    Az oxidat\u00edv stressz szerepe a medd\u0151s\u00e9gben \u00e9s annak\n                    kezel\u00e9s\u00e9ben egyre ink\u00e1bb kutatott ter\u00fclet. A sterilit\u00e1shoz t\u00e1rsul\u00f3 \u00e1llapotok,\n                    betegs\u00e9gek, valamint az assziszt\u00e1lt reprodukci\u00f3s technik\u00e1k \u00f6nmagukban is\n                    oxidat\u00edvstressz-terhel\u00e9ssel j\u00e1rnak. A p\u00e1ciensek klinikai jellemz\u0151i k\u00f6z\u00fcl a\n                    testt\u00f6megindex (BMI) \u00e9s a hormonkezel\u00e9sek kiemelt szerepet j\u00e1tszanak az oxidat\u00edv\n                    stressz alakul\u00e1s\u00e1ban. Az\n                    <jats:italic>in vitro<\/jats:italic>\n                    fertiliz\u00e1ci\u00f3 (IVF) sor\u00e1n a\n                    t\u00fcsz\u0151folyad\u00e9k \u00e9s a granulosasejtek 8-hidroxi-2-deoxiguanozin (8-OHdG)-szintj\u00e9nek\n                    m\u00e9r\u00e9se elfogadott m\u00f3dszer az oxidat\u00edv stressz meghat\u00e1roz\u00e1s\u00e1ra.\n                    <jats:italic>C\u00e9lkit\u0171z\u00e9s:<\/jats:italic>\n                    C\u00e9lunk a 8-OHdG \u00e9s a k\u00f6rnyezeti vagy\n                    betegjellemz\u0151k (BMI, folliculusstimul\u00e1l\u00f3 hormon [FSH], luteiniz\u00e1l\u00f3 hormon [LH],\n                    \u00f6sztradiol stb.) k\u00f6z\u00f6tti \u00f6sszef\u00fcgg\u00e9sek felt\u00e1r\u00e1sa t\u00f6bbv\u00e1ltoz\u00f3s statisztikai\n                    m\u00f3dszerek seg\u00edts\u00e9g\u00e9vel.\n                    <jats:italic>M\u00f3dszer:<\/jats:italic>\n                    A P\u00e9csi Tudom\u00e1nyegyetemen\n                    2022. janu\u00e1r \u00e9s m\u00e1jus k\u00f6z\u00f6tt IVF-kezel\u00e9sben r\u00e9szes\u00fcl\u0151 35 beteg t\u00fcsz\u0151folyad\u00e9k- \u00e9s\n                    granulosasejt-mint\u00e1it elemezt\u00fck, \u00e9s az oxidat\u00edvstressz-markereket \u00f6sszevetett\u00fck\n                    a betegjellemz\u0151kkel \u00e9s a kimeneteli mutat\u00f3kkal.\n                    <jats:italic>Eredm\u00e9nyek:<\/jats:italic>\n                    A\n                    terhes \u00e9s a nem terhes csoport k\u00f6z\u00f6tt az oxidat\u00edvstressz-markerek szintjeiben\n                    nem volt szignifik\u00e1ns k\u00fcl\u00f6nbs\u00e9g. A kanonikus korreszpondenciaanal\u00edzis szerint a\n                    BMI, az FSH, az LH, az \u00f6sztradiol \u00e9s az FSH-d\u00f3zis szignifik\u00e1nsan befoly\u00e1solta az\n                    oxidat\u00edv stresszt. A generaliz\u00e1lt addit\u00edv modellek alapj\u00e1n a BMI n\u00f6veked\u00e9se\n                    emelte az oxidat\u00edvstressz-szintet, m\u00edg az \u00f6sztradiol koncentr\u00e1ci\u00f3f\u00fcgg\u0151\n                    nemline\u00e1ris hat\u00e1st fejtett ki. Az FSH-szint pozit\u00edv line\u00e1ris kapcsolatban \u00e1llt\n                    az oxidat\u00edvstressz-markerekkel.\n                    <jats:italic>Megbesz\u00e9l\u00e9s \u00e9s k\u00f6vetkeztet\u00e9s:<\/jats:italic>\n                    Az elh\u00edz\u00e1s \u00e9s az oxidat\u00edv stressz fokoz\u00f3d\u00e1sa egy\u00e9rtelm\u0171en kimutathat\u00f3. Az\n                    FSH-d\u00f3zis hat\u00e1sa az oxidat\u00edv stresszre tov\u00e1bbra sem egy\u00e9rtelm\u0171 az irodalmi\n                    adatok alapj\u00e1n. Az oxidat\u00edv stressz felm\u00e9r\u00e9se seg\u00edthet a sikeress\u00e9gi mutat\u00f3k\n                    jav\u00edt\u00e1s\u00e1ban, \u00e9s a kontroll\u00e1lt petef\u00e9szek-stimul\u00e1ci\u00f3 protokollj\u00e1t ennek\n                    figyelembev\u00e9tel\u00e9vel kell optimaliz\u00e1lni. Orv Hetil. 2025; 166(28): 1107\u20131116.\n                  <\/jats:p>","DOI":"10.1556\/650.2025.33332","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T03:29:26Z","timestamp":1752463766000},"page":"1107-1116","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":1,"title":["IVF-kezel\u00e9sbe bevont p\u00e1ciensek oxidat\u00edvstressz-szintjeinek anal\u00edzise klinikai jellemz\u0151k f\u00fcggv\u00e9ny\u00e9ben"],"prefix":"10.1556","volume":"166","author":[{"given":"S\u00e1ndor","family":"P\u00e9ntek","sequence":"first","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Klinikai K\u00f6zpont, Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Klinika P\u00e9cs, \u00c9desany\u00e1k \u00fatja 17., 7624 Magyarorsz\u00e1g"},{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Hum\u00e1n Reprodukci\u00f3s Nemzeti Laborat\u00f3rium P\u00e9cs Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"Mauchart","sequence":"additional","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Klinikai K\u00f6zpont, Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Klinika P\u00e9cs, \u00c9desany\u00e1k \u00fatja 17., 7624 Magyarorsz\u00e1g"},{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Hum\u00e1n Reprodukci\u00f3s Nemzeti Laborat\u00f3rium P\u00e9cs Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1kos","family":"V\u00e1rnagy","sequence":"additional","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Klinikai K\u00f6zpont, Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Klinika P\u00e9cs, \u00c9desany\u00e1k \u00fatja 17., 7624 Magyarorsz\u00e1g"},{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Hum\u00e1n Reprodukci\u00f3s Nemzeti Laborat\u00f3rium P\u00e9cs Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00e1lm\u00e1n","family":"Kov\u00e1cs","sequence":"additional","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Klinikai K\u00f6zpont, Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Klinika P\u00e9cs, \u00c9desany\u00e1k \u00fatja 17., 7624 Magyarorsz\u00e1g"},{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Hum\u00e1n Reprodukci\u00f3s Nemzeti Laborat\u00f3rium P\u00e9cs Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f3zsef","family":"B\u00f3dis","sequence":"additional","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Klinikai K\u00f6zpont, Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Klinika P\u00e9cs, \u00c9desany\u00e1k \u00fatja 17., 7624 Magyarorsz\u00e1g"},{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Hum\u00e1n Reprodukci\u00f3s Nemzeti Laborat\u00f3rium P\u00e9cs Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Endre","family":"Sulyok","sequence":"additional","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Hum\u00e1n Reprodukci\u00f3s Nemzeti Laborat\u00f3rium P\u00e9cs Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"R1","doi-asserted-by":"crossref","unstructured":"Petraglia F, Serour GI, Chapron C. The changing prevalence of\n                    infertility. Int J Gynecol Obstet. 2013; 123: S4\u2013S8.","DOI":"10.1016\/j.ijgo.2013.09.005"},{"key":"R2","doi-asserted-by":"crossref","unstructured":"Kov\u00e1cs Z, B\u00e1lint B, Keszthelyi M, et al. The possibilities of\n                    fertility awareness methods in family planning. [A term\u00e9kenys\u00e9gtudatoss\u00e1gon\n                    alapul\u00f3 m\u00f3dszerek lehet\u0151s\u00e9gei a csal\u00e1dtervez\u00e9sben.] Orv Hetil. 2024; 165:\n                    851\u2013858. [Hungarian]","DOI":"10.1556\/650.2024.33044"},{"key":"R3","doi-asserted-by":"crossref","unstructured":"Borght MV, Wyns C. Fertility and infertility: definition and\n                    epidemiology. Clin Biochem. 2018; 62: 2\u201310.","DOI":"10.1016\/j.clinbiochem.2018.03.012"},{"key":"R4","unstructured":"Agarwal A, Allamaneni SS. The effect of sperm DNA damage on assisted\n                    reproduction outcomes. A review. Minerva Ginecol. 2004; 56:\n                    235\u2013245."},{"key":"R5","unstructured":"Agarwal A, Allamaneni SS. Oxidants and antioxidants in human\n                    fertility. Middle East Fertil Soc J. 2004; 9: 187\u2013197."},{"key":"R6","doi-asserted-by":"crossref","unstructured":"Agarwal A, Aponte-Mellado A, Premkumar BJ, et al. The effects of\n                    oxidative stress on female reproduction: a review. Reprod Biol Endocrinol. 2012;\n                    10: 49.","DOI":"10.1186\/1477-7827-10-49"},{"key":"R7","doi-asserted-by":"crossref","unstructured":"V\u00e1rnagy \u00c1, K\u0151szegi T, Gy\u00f6rgyi E, et al. Levels of total antioxidant\n                    capacity and 8-hydroxy-2'-deoxyguanosine of serum and follicular fluid in women\n                    undergoing in vitro fertilization: focusing on endometriosis. Hum Fertil (Camb).\n                    2018; 23: 200\u2013208.","DOI":"10.1080\/14647273.2018.1535719"},{"key":"R8","doi-asserted-by":"crossref","unstructured":"M\u00e1t\u00e9 G, Ball\u00f3 A, Sz\u00e1nt\u00f3 \u00c1, et al. Assessment of lifestyle habits of\n                    women and men participating in infertility treatment. [Medd\u0151s\u00e9gi kezel\u00e9sben\n                    r\u00e9szt vev\u0151 n\u0151k \u00e9s f\u00e9rfiak \u00e9letviteli szok\u00e1sainak felm\u00e9r\u00e9se.] Orv Hetil. 2024;\n                    165: 1423\u20131432. [Hungarian]","DOI":"10.1556\/650.2024.33124"},{"key":"R9","doi-asserted-by":"crossref","unstructured":"Mauchart P, Vass RA, Nagy B, et al. Oxidative stress in assisted re\n                    productive techniques, with a focus on an underestimated risk factor. Curr\n                    Issues Mol Biol. 2023; 45: 1272\u20131286.","DOI":"10.3390\/cimb45020083"},{"key":"R10","doi-asserted-by":"crossref","unstructured":"Agarwal A, Maldonado Rosas I, Anagnostopoulou C, et al. Oxidative\n                    stress and assisted reproduction: a comprehensive review of its\n                    pathophysiological role and strategies for optimizing embryo culture\n                    environment. Antioxidants (Basel) 2022; 11: 477.","DOI":"10.3390\/antiox11030477"},{"key":"R11","doi-asserted-by":"crossref","unstructured":"Liguori I, Russo G, Curcio F, et al. Oxidative stress, aging, and\n                    diseases. Clin Interv Aging 2018; 13: 757\u2013772.","DOI":"10.2147\/CIA.S158513"},{"key":"R12","doi-asserted-by":"crossref","unstructured":"\u00d6zer A, Bakacak M, Kiran H, et al. Increased oxidative stress is\n                    associated with insulin resistance and infertility in polycystic ovary syndrome.\n                    Ginekol Pol. 2016; 87: 733\u2013738.","DOI":"10.5603\/GP.2016.0079"},{"key":"R13","unstructured":"Ashok A, Gupta S, Mahfouz R, et al. Oxidative stress and its role in\n                    female infertility and assisted reproduction: clinical implications. Int J\n                    Fertil Steril. 2009; 2: 147\u2013164."},{"key":"R14","doi-asserted-by":"crossref","unstructured":"Metwally M, Li TC, Ledger WL. The impact of obesity on female\n                    reproductive function. Obes Rev. 2007; 8: 515\u2013523.","DOI":"10.1111\/j.1467-789X.2007.00406.x"},{"key":"R15","doi-asserted-by":"crossref","unstructured":"Chainy GB, Sahoo DK. Hormones and oxidative stress: an overview.\n                    Free Radic Res. 2019; 54: 1\u201326.","DOI":"10.1080\/10715762.2019.1702656"},{"key":"R16","doi-asserted-by":"crossref","unstructured":"Appasamy M, Jauniaux E, Serhal P, et al. Evaluation of the\n                    relationship between follicular fluid oxidative stress, ovarian hormones, and\n                    response to gonadotropin stimulation. Fertil Steril. 2008; 89:\n                    912\u2013921.","DOI":"10.1016\/j.fertnstert.2007.04.034"},{"key":"R17","doi-asserted-by":"crossref","unstructured":"Seino T, Saito H, Kaneko T, et al. Eight-hydroxy-2\u2019-deoxyguanosine\n                    in granulosa cells is correlated with the quality of oocytes and embryos in an\n                    in vitro fertilization-embryo transfer program. Fertil Steril. 2002; 77:\n                    1184\u20131190.","DOI":"10.1016\/S0015-0282(02)03103-5"},{"key":"R18","doi-asserted-by":"crossref","unstructured":"Marseglia L, Manti S, D\u2019Angelo G, et al. Oxidative stress in\n                    obesity: a critical component in human diseases. Int J Mol Sci. 2014; 16:\n                    378\u2013400.","DOI":"10.3390\/ijms16010378"},{"key":"R19","doi-asserted-by":"crossref","unstructured":"Vincent HK, Innes KE, Vincent KR. Oxidative stress and potential\n                    interventions to reduce oxidative stress in overweight and obesity. Diabetes\n                    Obes Metab. 2007; 9: 813\u2013839.","DOI":"10.1111\/j.1463-1326.2007.00692.x"},{"key":"R20","doi-asserted-by":"crossref","unstructured":"Fern\u00e1ndez-S\u00e1nchez A, Madrigal-Santill\u00e1n E, Bautista M, et al.\n                    Inflammation, oxidative stress, and obesity. Int J Mol Sci. 2011; 12:\n                    3117\u20133132.","DOI":"10.3390\/ijms12053117"},{"key":"R21","doi-asserted-by":"crossref","unstructured":"Tuli\u0107 L, Vidakovi\u0107 S, Tuli\u0107 I, et al. Oxidative stress markers in\n                    GnRH agonist and antagonist protocols in IVF. J Med Biochem. 2017; 36:\n                    163\u2013170.","DOI":"10.1515\/jomb-2017-0001"},{"key":"R22","doi-asserted-by":"crossref","unstructured":"Tuli\u0107 L, Tuli\u0107 I, Stojni\u0107 J, et al. Different doses of recombinant\n                    FSH and determining parameters of oxidative stress. J Med Biochem. 2024; 43:\n                    219\u2013225.","DOI":"10.5937\/jomb0-46156"},{"key":"R23","doi-asserted-by":"crossref","unstructured":"Thaker R, Mishra V, Gor M, et al. The role of stimulation protocol,\n                    number of oocytes retrieved with respect to follicular fluid oxidative stress\n                    and IVF outcome. Hum Fertil (Camb). 2020; 23: 23\u201331.","DOI":"10.1080\/14647273.2018.1551630"},{"key":"R24","doi-asserted-by":"crossref","unstructured":"Al-Saleh I, Coskun S, Al-Rouqi R, et al. Oxidative stress and DNA\n                    damage status in couples undergoing in vitro fertilization treatment. Reprod\n                    Fertil. 2021; 2: 117\u2013139.","DOI":"10.1530\/RAF-20-0062"},{"key":"R25","doi-asserted-by":"crossref","unstructured":"Cagnacci A, Gazzo I, Stigliani S, et al. Oxidative stress: the role\n                    of estrogen and progesterone. J Clin Med. 2023; 12: 7304.","DOI":"10.3390\/jcm12237304"},{"key":"R26","doi-asserted-by":"crossref","unstructured":"Abbas AM, Elsamanoudy AZ. Effects of 17\u03b2-estradiol and antioxidant\n                    administration on oxidative stress and insulin resistance in ovariectomized\n                    rats. Can J Physiol Pharmacol. 2011; 89: 497\u2013504.","DOI":"10.1139\/y11-053"},{"key":"R27","doi-asserted-by":"crossref","unstructured":"G\u00f3mez-Zubeldia MA, Corrales S, Arbu\u00e9s J, et al. Influence of\n                    estradiol and gestagens on oxidative stress in the rat uterus. Gynecol Oncol.\n                    2002; 86: 250\u2013258.","DOI":"10.1006\/gyno.2002.6753"},{"key":"R28","doi-asserted-by":"crossref","unstructured":"Yan F, Zhao Q, Li Y, et al. The role of oxidative stress in ovarian\n                    aging: a review. J Ovarian Res. 2022; 15: 100.","DOI":"10.1186\/s13048-022-01032-x"},{"key":"R29","doi-asserted-by":"crossref","unstructured":"Smotrich DB, Widra EA, Gindoff PR, et al. Prognostic value of day 3\n                    estradiol on in vitro fertilization outcome. Fertil Steril. 1995; 64:\n                    1136\u20131140.","DOI":"10.1016\/S0015-0282(16)57974-6"},{"key":"R30","doi-asserted-by":"crossref","unstructured":"Trout SW, Seifer DB. Do women with unexplained recurrent pregnancy\n                    loss have higher day 3 serum FSH and estradiol values? Fertil Steril. 2000; 74:\n                    335\u2013337.","DOI":"10.1016\/S0015-0282(00)00625-7"},{"key":"R31","doi-asserted-by":"crossref","unstructured":"Scott RT, Toner JP, Muasher SJ, et al. Follicle-stimulating hormone\n                    levels on cycle day 3 are predictive of in vitro fertilization outcome. Fertil\n                    Steril. 1989; 51: 651\u2013654.","DOI":"10.1016\/S0015-0282(16)60615-5"},{"key":"R32","doi-asserted-by":"crossref","unstructured":"Luddi A, Capaldo A, Focarelli R, et al. Antioxidants reduce\n                    oxidative stress in follicular fluid of aged women undergoing IVF. Reprod Biol\n                    Endocrinol 2016; 14: 57.","DOI":"10.1186\/s12958-016-0184-7"},{"key":"R33","unstructured":"Jo\u00f3 JG, Csatl\u00f3s \u00c9, B\u00f6rzs\u00f6nyi B, et al. The role of oxidative stress\n                    in female reproduction. [Az oxidat\u00edv stressz szerepe a n\u0151i reprodukci\u00f3ban.]\n                    Magyar N\u0151orv L. 2023; 86: 207\u2013213. [Hungarian]"}],"container-title":["Orvosi Hetilap"],"original-title":[],"link":[{"URL":"https:\/\/www.akjournals.com\/view\/journals\/650\/166\/28\/article-p1107.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.akjournals.com\/downloadpdf\/journals\/650\/166\/28\/article-p1107.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.akjournals.com\/downloadpdf\/journals\/650\/166\/28\/article-p1107.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:42:43Z","timestamp":1785422563000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.akjournals.com\/view\/journals\/650\/166\/28\/article-p1107.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,13]]},"references-count":33,"journal-issue":{"issue":"28"},"URL":"https:\/\/doi.org\/10.1556\/650.2025.33332","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,13]]}}}