{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:07:09Z","timestamp":1785424029217,"version":"3.56.0"},"reference-count":21,"publisher":"Akademiai Kiado Zrt.","issue":"29","license":[{"start":{"date-parts":[[2025,7,20]],"date-time":"2025-07-20T00:00:00Z","timestamp":1752969600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2025,7,20]]},"abstract":"<jats:p>\n                    <jats:italic>Bevezet\u00e9s:<\/jats:italic>\n                    A hum\u00e1n metapneumov\u00edrus (hMPV) influenzaszer\u0171\n                    t\u00fcneteket okoz\u00f3 l\u00e9g\u00fati patog\u00e9n, \u00e9s bizonyos t\u00e1rsbetegs\u00e9gek fenn\u00e1ll\u00e1sa eset\u00e9n\n                    s\u00falyos l\u00e9g\u00fati sz\u00f6v\u0151dm\u00e9nyekhez vezethet. A tanulm\u00e1ny aktualit\u00e1s\u00e1t a\n                    COVID\u201319-vil\u00e1gj\u00e1rv\u00e1ny sor\u00e1n szerzett tapasztalatok, valamint a K\u00ednai\n                    N\u00e9pk\u00f6zt\u00e1rsas\u00e1g J\u00e1rv\u00e1ny\u00fcgyi \u00e9s Betegs\u00e9gmegel\u0151z\u00e9si K\u00f6zpontja \u00e1ltal 2024 v\u00e9g\u00e9n\n                    \u00e9szlelt, folyamatosan n\u00f6vekv\u0151 hMPV-esetsz\u00e1mok indokolj\u00e1k.\n                    <jats:italic>C\u00e9lkit\u0171z\u00e9s:<\/jats:italic>\n                    A tanulm\u00e1ny c\u00e9lja a D\u00e9l-pesti Centrumk\u00f3rh\u00e1z \u2013\n                    Orsz\u00e1gos Hematol\u00f3giai \u00e9s Infektol\u00f3giai Int\u00e9zetben 2019 \u00e9s 2024 k\u00f6z\u00f6tt\n                    diagnosztiz\u00e1lt hMPV-esetek epidemiol\u00f3giai jellemz\u0151inek \u00e9s klinikai lefoly\u00e1s\u00e1nak\n                    retrospekt\u00edv elemz\u00e9se.\n                    <jats:italic>M\u00f3dszer:<\/jats:italic>\n                    Egycentrumos, retrospekt\u00edv\n                    kohorszvizsg\u00e1latot v\u00e9gezt\u00fcnk, amelybe bevontunk minden, 2019. december \u00e9s 2024.\n                    december k\u00f6z\u00f6tt val\u00f3s idej\u0171 polimer\u00e1z-l\u00e1ncreakci\u00f3val (RT-PCR) igazolt\n                    hMPV-fert\u0151z\u00f6tt feln\u0151tt beteget. R\u00f6gz\u00edtett\u00fck a klinikai adatokat (demogr\u00e1fia,\n                    komorbidit\u00e1sok, kezdeti klinikai k\u00e9p, vir\u00e1lis koinfekci\u00f3) \u00e9s a komplik\u00e1ci\u00f3kat\n                    (hospitaliz\u00e1ci\u00f3, oxig\u00e9nig\u00e9ny, pneumonitis, intenz\u00edv oszt\u00e1lyos kezel\u00e9s,\n                    mechanikai ventil\u00e1ci\u00f3, k\u00f3rh\u00e1zi hal\u00e1loz\u00e1s). A primer v\u00e9gpont \u00f6sszetett v\u00e9gpont\n                    volt, amely a k\u00f3rh\u00e1zi elhal\u00e1loz\u00e1son, az intenz\u00edv oszt\u00e1lyos kezel\u00e9s vagy a\n                    mechanikai ventil\u00e1ci\u00f3 sz\u00fcks\u00e9gess\u00e9g\u00e9n alapult, ez hat\u00e1rozta meg a komplik\u00e1lt\n                    lefoly\u00e1st is.\n                    <jats:italic>Eredm\u00e9nyek:<\/jats:italic>\n                    \u00d6sszesen 80 beteget vontunk be,\n                    \u00e1tlag\u00e9letkoruk 58 \u00b1 30 \u00e9v, t\u00f6bbs\u00e9g\u00fck f\u00e9rfi (n = 47; 58,8%) volt. A fert\u0151z\u00f6tt\n                    betegek 10%-\u00e1n\u00e1l (n = 8) komplik\u00e1lt lefoly\u00e1st \u00e9szlelt\u00fcnk, amely szignifik\u00e1nsan\n                    gyakrabban fordult el\u0151 id\u0151s betegek k\u00f6r\u00e9ben (66 \u00b1 10\n                    <jats:italic>vs.<\/jats:italic>\n                    55 \u00b1\n                    31 \u00e9v, p = 0,05). Pneumonitis 45%-ban (n = 36), hospitaliz\u00e1ci\u00f3 42,5%-ban (n =\n                    34), oxig\u00e9nig\u00e9ny 30%-ban (n = 24), intenz\u00edv oszt\u00e1lyos kezel\u00e9s 8,75%-ban (n = 7),\n                    mechanikai ventil\u00e1ci\u00f3 6,25%-ban (n = 5), k\u00f3rh\u00e1zi elhal\u00e1loz\u00e1s 6,25%-ban (n = 5)\n                    fordult el\u0151. Az intenz\u00edv oszt\u00e1lyos felv\u00e9tel \u00e9s a k\u00f3rh\u00e1zi elhal\u00e1loz\u00e1s nem minden\n                    esetben volt k\u00f6zvetlen\u00fcl a hMPV k\u00f6vetkezm\u00e9nye.\n                    <jats:italic>Megbesz\u00e9l\u00e9s:<\/jats:italic>\n                    Vizsg\u00e1latunk tanuls\u00e1ga alapj\u00e1n a hMPV klinikai jelent\u0151s\u00e9ge kiemelked\u0151en fontos\n                    immunszupprim\u00e1lt, id\u0151s \u00e9s kr\u00f3nikus l\u00e9gz\u0151szervi betegekn\u00e9l, mivel n\u00e1luk a\n                    fert\u0151z\u00e9s s\u00falyos l\u00e9g\u00fati sz\u00f6v\u0151dm\u00e9nyekhez vezethet.\n                    <jats:italic>K\u00f6vetkeztet\u00e9s:<\/jats:italic>\n                    \u00d6sszefoglalva, hMPV-fert\u0151z\u00e9s gyan\u00faja eset\u00e9n hMPV ir\u00e1ny\u00e1ban is javasolt\n                    diagnosztikai vizsg\u00e1latokat kezdem\u00e9nyezni, k\u00fcl\u00f6n\u00f6sen a nagy kock\u00e1zat\u00fa\n                    csoportokban, mivel a korai diagn\u00f3zis \u00e9s a megfelel\u0151 ter\u00e1pia kulcsfontoss\u00e1g\u00fa a\n                    s\u00falyos kimenetelek megel\u0151z\u00e9s\u00e9ben. Orv Hetil. 2025; 166(29): 1132\u20131138.\n                  <\/jats:p>","DOI":"10.1556\/650.2025.33334","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T04:43:52Z","timestamp":1753073032000},"page":"1132-1138","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":1,"title":["A hum\u00e1n metapneumov\u00edrus epidemiol\u00f3gi\u00e1ja \u00e9s klinikai jellemz\u0151i"],"prefix":"10.1556","volume":"166","author":[{"given":"Zs\u00f3fia","family":"G\u00e1sp\u00e1r","sequence":"first","affiliation":[{"name":"D\u00e9l-pesti Centrumk\u00f3rh\u00e1z \u2013 Orsz\u00e1gos Hematol\u00f3giai \u00e9s Infektol\u00f3giai Int\u00e9zet, Infektol\u00f3giai Oszt\u00e1ly Budapest, Albert Fl\u00f3ri\u00e1n \u00fat 5\u20137., 1097 Magyarorsz\u00e1g"},{"name":"Semmelweis Egyetem, Doktori Iskola, R\u00e1cz K\u00e1roly Konzervat\u00edv Orvostudom\u00e1nyi Tagozat Budapest Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e1lint","family":"Tres\u00f3","sequence":"additional","affiliation":[{"name":"D\u00e9l-pesti Centrumk\u00f3rh\u00e1z \u2013 Orsz\u00e1gos Hematol\u00f3giai \u00e9s Infektol\u00f3giai Int\u00e9zet, K\u00f6zponti Laborat\u00f3rium Budapest Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Kocsis","sequence":"additional","affiliation":[{"name":"D\u00e9l-pesti Centrumk\u00f3rh\u00e1z \u2013 Orsz\u00e1gos Hematol\u00f3giai \u00e9s Infektol\u00f3giai Int\u00e9zet, K\u00f6zponti Laborat\u00f3rium Budapest Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Botond","family":"Lakatos","sequence":"additional","affiliation":[{"name":"D\u00e9l-pesti Centrumk\u00f3rh\u00e1z \u2013 Orsz\u00e1gos Hematol\u00f3giai \u00e9s Infektol\u00f3giai Int\u00e9zet, Infektol\u00f3giai Oszt\u00e1ly Budapest, Albert Fl\u00f3ri\u00e1n \u00fat 5\u20137., 1097 Magyarorsz\u00e1g"},{"name":"Semmelweis Egyetem, Doktori Iskola, R\u00e1cz K\u00e1roly Konzervat\u00edv Orvostudom\u00e1nyi Tagozat Budapest Magyarorsz\u00e1g"},{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Belgy\u00f3gy\u00e1szati \u00e9s Hematol\u00f3giai Klinika, Infektol\u00f3giai Tansz\u00e9ki Csoport Budapest Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"R1","unstructured":"National Centre for Public Health and Pharmacy. 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