{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T09:57:59Z","timestamp":1785491879155,"version":"3.56.0"},"reference-count":33,"publisher":"Akademiai Kiado Zrt.","issue":"41","license":[{"start":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T00:00:00Z","timestamp":1760227200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem Klinikai K\u00f6zpont Gyer\u00admekgy\u00f3gy\u00e1szati Klinika"}],"content-domain":{"domain":["www.akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2025,10,12]]},"abstract":"<jats:p>Pancytopenia \u00e9szlel\u00e9sekor a kiv\u00e1lt\u00f3 ok azonos\u00edt\u00e1sa kih\u00edv\u00e1st jelenthet, mivel az\n                    etiol\u00f3gi\u00e1k sz\u00e9les sk\u00e1l\u00e1ja \u2013 bele\u00e9rtve a gy\u00f3gyszereket, az autoimmun \u00e1llapotokat,\n                    a malignus daganatokat, a fert\u0151z\u00e9seket, a haemophagocytosist \u2013 sokf\u00e9le lehet. A\n                    szerz\u0151k egy 3 \u00e9ves le\u00e1nygyermek eset\u00e9t mutatj\u00e1k be, aki elh\u00faz\u00f3d\u00f3 l\u00e1zas \u00e1llapot\n                    miatt ker\u00fclt felv\u00e9telre. A laborat\u00f3riumi vizsg\u00e1latok pancytopeni\u00e1t, emelkedett\n                    gyullad\u00e1sos aktivit\u00e1st mutattak, a t\u00fcnetek h\u00e1tter\u00e9ben a malignit\u00e1s kiz\u00e1rhat\u00f3\n                    volt. A klinikai t\u00fcnetek \u00e9s a jellegzetes laborat\u00f3riumi eredm\u00e9nyek alapj\u00e1n a\n                    haemophagocyt\u00e1s lymphohistiocytosis (HLH) diagn\u00f3zisa volt fel\u00e1ll\u00edthat\u00f3. A beteg\n                    kombin\u00e1lt immunszuppressz\u00edv kezel\u00e9sben r\u00e9szes\u00fclt intrav\u00e9n\u00e1s szteroid,\n                    interleukin-1-antagonista, ciklosporin alkalmaz\u00e1s\u00e1val. \u00c1llapota stabiliz\u00e1l\u00f3dott,\n                    s a mil\u00e1n\u00f3i egyetem gyermekimmunol\u00f3giai k\u00f6zpontj\u00e1ba ker\u00fclt \u00e1thelyez\u00e9sre. A\n                    kieg\u00e9sz\u00edt\u0151 vizsg\u00e1latok Leishmania-fert\u0151z\u00e9st igazoltak. A ter\u00e1pi\u00e1t\n                    amfotericin-B-kezel\u00e9ssel eg\u00e9sz\u00edtett\u00e9k ki. A kezel\u00e9s hat\u00e1s\u00e1ra a gyermek \u00e1llapota,\n                    laborat\u00f3riumi param\u00e9terei gyorsan javultak, \u00e9s a ter\u00e1pia befejez\u00e9s\u00e9t k\u00f6vet\u0151en is\n                    tart\u00f3s remisszi\u00f3 \u00e9szlelhet\u0151. Esettanulm\u00e1nyunk a pancytopenia h\u00e1tter\u00e9ben \u00e1ll\u00f3\n                    ritka k\u00f3rk\u00e9pre k\u00edv\u00e1nja felh\u00edvni a figyelmet. A betegs\u00e9g kezel\u00e9s\u00e9ben a szervi\n                    manifeszt\u00e1ci\u00f3k m\u00e9rt\u00e9k\u00e9nek f\u00fcggv\u00e9ny\u00e9ben k\u00fcl\u00f6nb\u00f6z\u0151 immunszuppressz\u00edv ter\u00e1pi\u00e1k\n                    alkalmaz\u00e1sa \u00e9s a kiv\u00e1lt\u00f3 ok kezel\u00e9se sz\u00fcks\u00e9ges. Orv Hetil. 2025; 166(41):\n                    1628\u20131633.<\/jats:p>","DOI":"10.1556\/650.2025.33357","type":"journal-article","created":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T07:33:48Z","timestamp":1760340828000},"page":"1628-1633","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":0,"title":["Leishmaniasis okozta gyermekkori haemophagocyt\u00e1s lymphohistiocytosis pancytopeni\u00e1val"],"prefix":"10.1556","volume":"166","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9325-1276","authenticated-orcid":true,"given":"\u00c1d\u00e1m","family":"Gy\u0151ri","sequence":"first","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Gyermekgy\u00f3gy\u00e1szati Klinika P\u00e9cs, J\u00f3zsef A. u. 7., 7623 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e1bor","family":"Ott\u00f3ffy","sequence":"additional","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Gyermekgy\u00f3gy\u00e1szati Klinika P\u00e9cs, J\u00f3zsef A. u. 7., 7623 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Csord\u00e1s","sequence":"additional","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Gyermekgy\u00f3gy\u00e1szati Klinika P\u00e9cs, J\u00f3zsef A. u. 7., 7623 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanga","family":"Parrag","sequence":"additional","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Gyermekgy\u00f3gy\u00e1szati Klinika P\u00e9cs, J\u00f3zsef A. u. 7., 7623 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zolt\u00e1n","family":"Nyul","sequence":"additional","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Gyermekgy\u00f3gy\u00e1szati Klinika P\u00e9cs, J\u00f3zsef A. u. 7., 7623 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernadett","family":"Mosd\u00f3si","sequence":"additional","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Gyermekgy\u00f3gy\u00e1szati Klinika P\u00e9cs, J\u00f3zsef A. u. 7., 7623 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"R1","doi-asserted-by":"crossref","unstructured":"Crayne CB, Albeituni S, Nichols KE, et al. 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