{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T08:57:27Z","timestamp":1785488247968,"version":"3.56.0"},"reference-count":18,"publisher":"Akademiai Kiado Zrt.","issue":"34","license":[{"start":{"date-parts":[[2025,8,24]],"date-time":"2025-08-24T00:00:00Z","timestamp":1755993600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015763","name":"Szegedi Tudom\u00e1nyegyetem","doi-asserted-by":"crossref","award":["IV-134-621\/2024.SZAOK"],"award-info":[{"award-number":["IV-134-621\/2024.SZAOK"]}],"id":[{"id":"10.13039\/501100015763","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2025,8,24]]},"abstract":"<jats:p>Jelenlegi ismereteink alapj\u00e1n a m\u00e1j\u00e1tt\u00e9tek hisztopatol\u00f3giai n\u00f6veked\u00e9si mint\u00e1zatai\n                    prognosztikai jelent\u0151s\u00e9ggel b\u00edrnak, ugyanakkor klinikai alkalmaz\u00e1suk, ter\u00e1pi\u00e1s\n                    d\u00f6nt\u00e9shozatalt befoly\u00e1sol\u00f3 szerep\u00fck egyel\u0151re nem tiszt\u00e1zott. A rendelkez\u00e9sre\n                    \u00e1ll\u00f3 szakirodalom t\u00falnyom\u00f3r\u00e9szt colorectalis carcinom\u00e1k m\u00e1j\u00e1tt\u00e9teire f\u00f3kusz\u00e1l,\n                    \u00e9s mindeddig csup\u00e1n k\u00e9t k\u00f6zlem\u00e9ny foglalkozott a hisztopatol\u00f3giai n\u00f6veked\u00e9si\n                    mint\u00e1zat anal\u00edzis\u00e9vel konszekut\u00edv eseteket tartalmaz\u00f3 betegkohorszban. C\u00e9lunk a\n                    2011 \u00e9s 2016 k\u00f6z\u00f6tti \u00f6sszes m\u00e1j\u00e1tt\u00e9tes beteg hisztopatol\u00f3giai n\u00f6veked\u00e9si\n                    mint\u00e1zat\u00e1nak vizsg\u00e1lata volt konszekut\u00edv jelleggel. A vizsg\u00e1lt id\u0151tartamba\n                    ker\u00fclt esetekn\u00e9l az orvosi dokument\u00e1ci\u00f3b\u00f3l klinikopatol\u00f3giai t\u00e9nyez\u0151ket\n                    gy\u0171jt\u00f6tt\u00fcnk. Az \u00e1tt\u00e9tek sz\u00f6vettani metszeteit gastrointestinalis patol\u00f3gi\u00e1ban\n                    j\u00e1rtas patol\u00f3gus \u00e9rt\u00e9kelte. A statisztikai elemz\u00e9st Kruskal\u2013Wallis \u00e9s\n                    Fisher-f\u00e9le egzakt pr\u00f3b\u00e1val v\u00e9gezt\u00fck. A progresszi\u00f3mentes t\u00fal\u00e9l\u00e9s, a teljes\n                    t\u00fal\u00e9l\u00e9s \u00e9s a progresszi\u00f3ig eltelt id\u0151 becsl\u00e9se Kaplan\u2013Meier-m\u00f3dszerrel t\u00f6rt\u00e9nt,\n                    a t\u00fal\u00e9l\u00e9si g\u00f6rb\u00e9k \u00f6sszehasonl\u00edt\u00e1s\u00e1ra log-rank tesztet alkalmaztunk. Minden pr\u00f3ba\n                    k\u00e9toldalas volt, a 0,05-n\u00e9l kisebb p-\u00e9rt\u00e9ket tekintett\u00fck szignifik\u00e1nsnak.\n                    \u00d6sszesen 41 beteg eredm\u00e9nyeit elemezt\u00fck, t\u00f6bbs\u00e9g\u00fck primer tumora colorectalis\n                    adenocarcinoma volt (n = 32). A leggyakoribbnak a \u2019replacement\u2019 mint\u00e1zat\n                    bizonyult (n = 22), amelyet a desmoplasticus (n = 15) \u00e9s a \u2019pushing\u2019 (n = 4)\n                    k\u00f6vetett. Nem volt statisztikai \u00f6sszef\u00fcgg\u00e9s a hisztopatol\u00f3giai n\u00f6veked\u00e9si\n                    mint\u00e1zat \u00e9s a st\u00e1dium (p = 0,105), az \u00e1tt\u00e9ti fokalit\u00e1s (p = 0,898), a legnagyobb\n                    primer (p = 0,316) \u00e9s szekunder (p = 0,441) tumor\u00e1tm\u00e9r\u0151, a kimetsz\u00e9s\n                    kompletts\u00e9ge (p = 0,492) \u00e9s a v\u00e9n\u00e1s terjed\u00e9s jelenl\u00e9te (p = 1) k\u00f6z\u00f6tt. Nem volt\n                    szignifik\u00e1ns korrel\u00e1ci\u00f3 a n\u00f6veked\u00e9si mint\u00e1zat \u00e9s a progresszi\u00f3mentes t\u00fal\u00e9l\u00e9s (p\n                    = 0,417), a teljes t\u00fal\u00e9l\u00e9s (p = 0,297), illetve a progresszi\u00f3ig eltelt id\u0151 (p =\n                    0,267) k\u00f6z\u00f6tt. Eredm\u00e9nyeink arra utalnak, hogy a hisztopatol\u00f3giai n\u00f6veked\u00e9si\n                    mint\u00e1zatok prognosztikai \u00e9rt\u00e9ke korl\u00e1tozott lehet konszekut\u00edv betegkohorszban. A\n                    j\u00f6v\u0151ben a hisztopatol\u00f3giai n\u00f6veked\u00e9si mint\u00e1zatok prognosztikai \u00e9rt\u00e9k\u00e9nek\n                    r\u00e9szletesebb vizsg\u00e1lat\u00e1ra van sz\u00fcks\u00e9g. Orv Hetil. 2025; 166(34): 1323\u20131332.<\/jats:p>","DOI":"10.1556\/650.2025.33358","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T07:43:05Z","timestamp":1756107785000},"page":"1323-1332","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":0,"title":["M\u00e1j\u00e1tt\u00e9tek hisztopatol\u00f3giai n\u00f6veked\u00e9si mint\u00e1zatai"],"prefix":"10.1556","volume":"166","author":[{"given":"Anita","family":"Sejben","sequence":"first","affiliation":[{"name":"Szegedi Tudom\u00e1nyegyetem, Szent-Gy\u00f6rgyi Albert Orvostudom\u00e1nyi Kar, Pathologiai Int\u00e9zet Szeged, \u00c1llom\u00e1s u. 1., 6725 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1d\u00e1m","family":"Ferenczi","sequence":"additional","affiliation":[{"name":"Szegedi Tudom\u00e1nyegyetem, Szent-Gy\u00f6rgyi Albert Orvostudom\u00e1nyi Kar, Pathologiai Int\u00e9zet Szeged, \u00c1llom\u00e1s u. 1., 6725 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbasi","family":"Parsa","sequence":"additional","affiliation":[{"name":"Szegedi Tudom\u00e1nyegyetem, Szent-Gy\u00f6rgyi Albert Orvostudom\u00e1nyi Kar, Pathologiai Int\u00e9zet Szeged, \u00c1llom\u00e1s u. 1., 6725 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogl\u00e1rka","family":"P\u00f3sfai","sequence":"additional","affiliation":[{"name":"Szegedi Tudom\u00e1nyegyetem, Szent-Gy\u00f6rgyi Albert Orvostudom\u00e1nyi Kar, Pathologiai Int\u00e9zet Szeged, \u00c1llom\u00e1s u. 1., 6725 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tam\u00e1s","family":"Zombori","sequence":"additional","affiliation":[{"name":"Szegedi Tudom\u00e1nyegyetem, Szent-Gy\u00f6rgyi Albert Orvostudom\u00e1nyi Kar, Pathologiai Int\u00e9zet Szeged, \u00c1llom\u00e1s u. 1., 6725 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tam\u00e1s","family":"Lantos","sequence":"additional","affiliation":[{"name":"Szegedi Tudom\u00e1nyegyetem, Szent-Gy\u00f6rgyi Albert Orvostudom\u00e1nyi Kar, Orvosi Fizikai \u00e9s Orvosi Informatikai Int\u00e9zet Szeged Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"R1","doi-asserted-by":"crossref","unstructured":"B\u00e1rdos D, Szakad\u00e1ti H, V\u00e1ncza L, et al. 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