{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T08:59:35Z","timestamp":1785488375725,"version":"3.56.0"},"reference-count":25,"publisher":"Akademiai Kiado Zrt.","issue":"38","license":[{"start":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T00:00:00Z","timestamp":1758412800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"MTA Pr\u00e9mium Posztdoktori \u00d6szt\u00f6nd\u00edj","award":["PPD460004"],"award-info":[{"award-number":["PPD460004"]}]},{"name":"FIKP Neurol\u00f3gia T\u00e9mater\u00fclet","award":["OTKA FK_20 (135222)"],"award-info":[{"award-number":["OTKA FK_20 (135222)"]}]},{"name":"FIKP Neurol\u00f3gia T\u00e9mater\u00fclet","award":["OTKA PD_22 (142288)"],"award-info":[{"award-number":["OTKA PD_22 (142288)"]}]},{"name":"Felfedez\u0151, klinikai \u00e9s kognit\u00edv idegtudom\u00e1nyi kutat\u00e1sok a Semmelweis Egyetemen","award":["TKP2021-EGA-25"],"award-info":[{"award-number":["TKP2021-EGA-25"]}]},{"name":"Idegtudom\u00e1nyi Nemzeti Labor","award":["RRF-2.3.1-212022-00011"],"award-info":[{"award-number":["RRF-2.3.1-212022-00011"]}]}],"content-domain":{"domain":["www.akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2025,9,21]]},"abstract":"\n A perinatalis asphyxia k\u00f6vetkezt\u00e9ben kialakul\u00f3 hypoxi\u00e1s-ischaemi\u00e1s\n encephalopathia (HIE) a gyermekgy\u00f3gy\u00e1szat \u00e9s a neonatol\u00f3gia j\u00f3l ismert k\u00f3rk\u00e9pe.\n Jelent\u0151s\u00e9g\u00e9re utal, hogy a fejlett orsz\u00e1gokban az \u00e9rintettek kb. 5\u201310%-a nem \u00e9li\n t\u00fal az \u00fajsz\u00fcl\u00f6ttkort, \u00e9s a t\u00fal\u00e9l\u0151k kb. 40%-\u00e1ban a k\u00e9s\u0151bbiekben maradv\u00e1nyt\u00fcnetek\n (els\u0151sorban cerebralis paresis, kognit\u00edv deficitek, enyh\u00e9bb form\u00e1ban\n iskol\u00e1skorban tanul\u00e1si zavarok) jelei \u00e9szlelhet\u0151k. A k\u00f6z\u00e9ps\u00falyos-s\u00falyos HIE\n kezel\u00e9s\u00e9ben m\u00e9rf\u00f6ldk\u0151nek sz\u00e1m\u00edt a ter\u00e1pi\u00e1s teljestest-hypothermia el\u0151ny\u00f6s\n volt\u00e1nak felismer\u00e9se \u00e9s az \u00fajsz\u00fcl\u00f6ttkori intenz\u00edv ter\u00e1pi\u00e1s protokollba val\u00f3\n be\u00e9p\u00edt\u00e9se. A teljestest-hypothermia els\u0151dleges c\u00e9lja a neuroprotekci\u00f3. A\n progn\u00f3zis az \u00e9vek alatt sokat javult, de a HIE m\u00e9g mindig sok gondot jelent az\n \u00e9rintett csal\u00e1doknak \u00e9s az eg\u00e9szs\u00e9g\u00fcgyi ell\u00e1t\u00f3h\u00e1l\u00f3zatnak, ez\u00e9rt a HIE-vel\n kapcsolatos klinikai kutat\u00e1sok tov\u00e1bbra is a neonatol\u00f3giai \u00e9rdekl\u0151d\u00e9s el\u0151ter\u00e9ben\n \u00e1llnak. A jelenlegi k\u00f6zlem\u00e9nyben az idevonatkoz\u00f3 eddigi kutat\u00e1saink m\u00e1r k\u00f6z\u00f6lt\n eredm\u00e9nyeit foglaljuk \u00f6ssze. A dolgozat \u00f6sszevontan tekinti \u00e1t h\u00e1rom k\u00e9rd\u00e9sk\u00f6rbe\n rendezhet\u0151 kutat\u00e1si eredm\u00e9nyeinket: 1) a ter\u00e1pi\u00e1s hypothermia helysz\u00edni korai\n megkezd\u00e9s\u00e9nek \u00e9s a neonatalis transzport alatti fenntart\u00e1s\u00e1nak jelent\u0151s\u00e9ge; 2) a\n ter\u00e1pi\u00e1s hypothermia \u00e9s a hypocapnia \u00f6sszef\u00fcgg\u00e9se, a l\u00e9gz\u00e9st\u00e1mogat\u00e1si strat\u00e9gia\n neh\u00e9zs\u00e9gei, a hypocapnia elker\u00fcl\u00e9se kis koncentr\u00e1ci\u00f3j\u00fa\n CO\n 2<\/jats:sub>\n -bel\u00e9legeztet\u00e9ssel; 3) a hemodinamikai instabilit\u00e1s, a hypotensio\n \u00e9s a relat\u00edv mell\u00e9kvesek\u00e9reg-el\u00e9gtelens\u00e9g jelent\u0151s\u00e9ge; a hypotensio ter\u00e1pi\u00e1j\u00e1nak\n \u00faj lehet\u0151s\u00e9ge. Orv Hetil. 2025; 166(38): 1483\u20131489.\n <\/jats:p>","DOI":"10.1556\/650.2025.33393","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T05:35:48Z","timestamp":1758605748000},"page":"1483-1489","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":2,"title":["Az intenz\u00edv ter\u00e1pia optimaliz\u00e1l\u00e1sa \u00fajsz\u00fcl\u00f6ttkori hypoxi\u00e1s-ischaemi\u00e1s encephalopathi\u00e1ban"],"prefix":"10.1556","volume":"166","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2211-7272","authenticated-orcid":true,"given":"\u00c1gnes","family":"Jermendy","sequence":"first","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Gyermekgy\u00f3gy\u00e1szati Klinika, Neonatol\u00f3giai Tansz\u00e9k Budapest, B\u00f3kay J. u. 53\u201354., 1083 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enik\u0151","family":"Szakm\u00e1r","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Gyermekgy\u00f3gy\u00e1szati Klinika, Neonatol\u00f3giai Tansz\u00e9k Budapest, B\u00f3kay J. u. 53\u201354., 1083 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kata","family":"Kov\u00e1cs","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Gyermekgy\u00f3gy\u00e1szati Klinika, Neonatol\u00f3giai Tansz\u00e9k Budapest, B\u00f3kay J. u. 53\u201354., 1083 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00dcn\u0151ke","family":"M\u00e9der","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Gyermekgy\u00f3gy\u00e1szati Klinika, Neonatol\u00f3giai Tansz\u00e9k Budapest, B\u00f3kay J. u. 53\u201354., 1083 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikl\u00f3s","family":"Szab\u00f3","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Gyermekgy\u00f3gy\u00e1szati Klinika, Neonatol\u00f3giai Tansz\u00e9k Budapest, B\u00f3kay J. u. 53\u201354., 1083 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"R1","doi-asserted-by":"crossref","unstructured":"Shah PS. Hypothermia: a systematic review and meta-analysis of\n clinical trials. Semin Fetal Neonatal Med. 2010; 15: 238\u2013246.","DOI":"10.1016\/j.siny.2010.02.003"},{"key":"R2","doi-asserted-by":"crossref","unstructured":"Pierrat V, Haouari N, Liska A, et al. Prevalence, causes, and\n outcome at 2 years of age of newborn encephalopathy: population based study.\n Arch Dis Child Fetal Neonatal Ed. 2005; 90: F257\u2013F261.","DOI":"10.1136\/adc.2003.047985"},{"key":"R3","doi-asserted-by":"crossref","unstructured":"Edwards AD, Brocklehurst P, Gunn AJ, et al. Neurological outcomes at\n 18 months of age after moderate hypothermia for perinatal hypoxic ischaemic\n encephalopathy: synthesis and meta-analysis of trial data. BMJ 2010; 340:\n c363.","DOI":"10.1136\/bmj.c363"},{"key":"R4","doi-asserted-by":"crossref","unstructured":"Sabir H, Scull-Brown E, Liu X, et al. Immediate hypothermia is not\n neuroprotective after severe hypoxia-ischemia and is deleterious when delayed by\n 12 hours in neonatal rats. Stroke 2012; 43: 3364\u20133370.","DOI":"10.1161\/STROKEAHA.112.674481"},{"key":"R5","doi-asserted-by":"crossref","unstructured":"Thoresen M, Tooley J, Liu X, et al. Time is brain: starting\n therapeutic hypothermia within three hours after birth improves motor outcome in\n asphyxiated newborns. Neonatology 2013; 104: 228\u2013233.","DOI":"10.1159\/000353948"},{"key":"R6","doi-asserted-by":"crossref","unstructured":"Kov\u00e1cs K, Szakm\u00e1r E, M\u00e9der \u00dc, et al. Hypothermia treatment in\n asphyxiated neonates \u2013 a single center experience in Hungary. [Ter\u00e1pi\u00e1s\n hypothermia alkalmaz\u00e1sa az asphyxi\u00e1s \u00fajsz\u00fcl\u00f6ttek kezel\u00e9s\u00e9ben. 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