{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T09:02:07Z","timestamp":1785488527099,"version":"3.56.0"},"reference-count":21,"publisher":"Akademiai Kiado Zrt.","issue":"39","license":[{"start":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T00:00:00Z","timestamp":1759017600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"MTA Pr\u00e9mium Posztdoktori \u00d6szt\u00f6nd\u00edj","award":["PPD460004"],"award-info":[{"award-number":["PPD460004"]}]},{"name":"FIKP Neurol\u00f3gia T\u00e9mater\u00fclet","award":["OTKA FK_20 (135222)"],"award-info":[{"award-number":["OTKA FK_20 (135222)"]}]},{"name":"FIKP Neurol\u00f3gia T\u00e9mater\u00fclet","award":["OTKA PD_22 (142288)"],"award-info":[{"award-number":["OTKA PD_22 (142288)"]}]},{"name":"Felfedez\u0151, klinikai \u00e9s kognit\u00edv idegtudom\u00e1nyi kutat\u00e1sok a Semmelweis Egyetemen","award":["TKP2021-EGA-25"],"award-info":[{"award-number":["TKP2021-EGA-25"]}]},{"name":"Transzl\u00e1ci\u00f3s Idegtudom\u00e1nyi Nemzeti Labor","award":["RRF-2.3.1-21-2022-00011"],"award-info":[{"award-number":["RRF-2.3.1-21-2022-00011"]}]},{"name":"Semmelweis Egyetem Gyermekgy\u00f3gy\u00e1szati Klinika Neonat\u00e1lis Intenz\u00edv Centrum"}],"content-domain":{"domain":["www.akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2025,9,28]]},"abstract":"A neonatol\u00f3giai gyakorlatban az \u00fajsz\u00fcl\u00f6ttet s\u00fajt\u00f3 perinatalis asphyxia\n kialakul\u00e1sa akut teend\u0151t ig\u00e9nyl\u0151, s\u00falyos klinikai \u00e1llapot, amely a leggondosabb\n azonnali ell\u00e1t\u00e1s ellen\u00e9re is komoly k\u00f6vetkezm\u00e9nyekkel, hypoxi\u00e1s-ischaemi\u00e1s\n encephalopathia (HIE) kialakul\u00e1s\u00e1val j\u00e1rhat. A ter\u00e1pi\u00e1ban nagy el\u0151rel\u00e9p\u00e9st\n jelentett a teljestest-hypothermia, amely \u00e9vekkel ezel\u0151tt be\u00e9p\u00fclt a ter\u00e1pi\u00e1s\n protokollba. A javul\u00f3 klinikai eredm\u00e9nyek ellen\u00e9re a HIE-nek m\u00e9g ma is van\n mortalit\u00e1sa, a t\u00fal\u00e9l\u0151 \u00fajsz\u00fcl\u00f6ttek k\u00f6r\u00e9ben pedig a neurol\u00f3giai sz\u00f6v\u0151dm\u00e9nyek az\n egy\u00e9nre \u00e9s a csal\u00e1dra is sok terhet r\u00f3nak. Fontos kutat\u00e1si ter\u00fclet a kimenetel\n korai el\u0151rejelz\u00e9s\u00e9nek k\u00e9rd\u00e9sk\u00f6re. M\u00e9g ma is neh\u00e9zs\u00e9get jelent a HIE korai\n szakasz\u00e1ban meg\u00edt\u00e9lni, hogy az \u00fajsz\u00fcl\u00f6ttkori esem\u00e9nyek, adatok, ter\u00e1pi\u00e1s\n v\u00e1laszok ismeret\u00e9ben mi v\u00e1rhat\u00f3 az adott t\u00fal\u00e9l\u0151 \u00fajsz\u00fcl\u00f6tt k\u00e9s\u0151bbi fejl\u0151d\u00e9se\n sor\u00e1n, milyen c\u00e9lzott korai intervenci\u00f3k lehetnek indokoltak. Munkacsoportunk a\n Semmelweis Egyetem Gyermekgy\u00f3gy\u00e1szati Klinik\u00e1j\u00e1nak Neonatol\u00f3giai Tansz\u00e9k\u00e9n az\n elm\u00falt \u00e9vekben a k\u00f6z\u00e9ps\u00falyos-s\u00falyos HIE-ben szenved\u0151 \u00fajsz\u00fcl\u00f6ttek intenz\u00edv\n ter\u00e1pi\u00e1j\u00e1nak optimaliz\u00e1l\u00e1s\u00e1n t\u00fal klinikai kutat\u00e1sokat v\u00e9gzett annak \u00e9rdek\u00e9ben,\n hogy a HIE k\u00f3rlefoly\u00e1s\u00e1nak korai el\u0151rejelz\u00e9s\u00e9t biztosabb\u00e1, megalapozottabb\u00e1\n lehessen tenni. A jelenlegi k\u00f6zlem\u00e9ny az ezzel kapcsolatos, n\u00e9gy k\u00e9rd\u00e9s k\u00f6r\u00e9\n csoportos\u00edthat\u00f3 eredm\u00e9nyeinket tekinti \u00e1t. Vizsg\u00e1ltuk 1) a ter\u00e1pi\u00e1s hypothermia\n alatt v\u00e9gzett, amplit\u00fad\u00f3integr\u00e1lt elektroencefalogr\u00e1fia longitudin\u00e1lis\n elemz\u00e9s\u00e9nek, 2) a ter\u00e1pi\u00e1s hypothermia alatti folyamatos hemodinamikai\n monitoroz\u00e1snak, 3) a k\u00f6zponti idegrendszer proton m\u00e1gneses rezonanci\u00e1s\n spektroszk\u00f3pi\u00e1j\u00e1nak \u00e9s 4) a sz\u00fcl\u0151k szocio\u00f6kon\u00f3miai helyzet\u00e9nek a jelent\u0151s\u00e9g\u00e9t a\n fejl\u0151d\u00e9sneurol\u00f3giai kimenetellel \u00f6sszef\u00fcgg\u00e9sben, k\u00fcl\u00f6n\u00f6s tekintettel a korai\n el\u0151rejelz\u00e9s lehet\u0151s\u00e9g\u00e9re. A kialak\u00edtott HIE-regiszter\u00fcnket haszn\u00e1lva, a\n k\u00f6z\u00e9ps\u00falyos-s\u00falyos \u00e1llapot\u00fa \u00fajsz\u00fcl\u00f6ttek szisztematikus, struktur\u00e1lt\n adatregisztr\u00e1l\u00e1sa nyom\u00e1n pontosabb\u00e1 tudtuk tenni a v\u00e1rhat\u00f3 fejl\u0151d\u00e9sneurol\u00f3giai\n kimenetel korai el\u0151rejelz\u00e9s\u00e9t. Orv Hetil. 2025; 166(39): 1523\u20131530.<\/jats:p>","DOI":"10.1556\/650.2025.33394","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T07:43:18Z","timestamp":1759909398000},"page":"1523-1530","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":2,"title":["Az \u00fajsz\u00fcl\u00f6ttkori hypoxi\u00e1s-ischaemi\u00e1s encephalopathia fejl\u0151d\u00e9sneurol\u00f3giai kimenetel\u00e9nek korai el\u0151rejelz\u00e9se"],"prefix":"10.1556","volume":"166","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2211-7272","authenticated-orcid":true,"given":"\u00c1gnes","family":"Jermendy","sequence":"first","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Gyermekgy\u00f3gy\u00e1szati Klinika, Neonatol\u00f3giai Tansz\u00e9k Budapest, B\u00f3kay J. u. 53\u201354., 1083 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00dcn\u0151ke","family":"M\u00e9der","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Gyermekgy\u00f3gy\u00e1szati Klinika, Neonatol\u00f3giai Tansz\u00e9k Budapest, B\u00f3kay J. u. 53\u201354., 1083 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Balog","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Gyermekgy\u00f3gy\u00e1szati Klinika, Neonatol\u00f3giai Tansz\u00e9k Budapest, B\u00f3kay J. u. 53\u201354., 1083 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajnalka","family":"Barta","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Gyermekgy\u00f3gy\u00e1szati Klinika, Neonatol\u00f3giai Tansz\u00e9k Budapest, B\u00f3kay J. u. 53\u201354., 1083 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsuzsanna","family":"Varga","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Gyermekgy\u00f3gy\u00e1szati Klinika, Neonatol\u00f3giai Tansz\u00e9k Budapest, B\u00f3kay J. u. 53\u201354., 1083 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kata","family":"Kov\u00e1cs","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Gyermekgy\u00f3gy\u00e1szati Klinika, Neonatol\u00f3giai Tansz\u00e9k Budapest, B\u00f3kay J. u. 53\u201354., 1083 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikl\u00f3s","family":"Szab\u00f3","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Gyermekgy\u00f3gy\u00e1szati Klinika, Neonatol\u00f3giai Tansz\u00e9k Budapest, B\u00f3kay J. u. 53\u201354., 1083 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"R1","doi-asserted-by":"crossref","unstructured":"Lawn JE, Kerber K, Enweronu-Laryea C, et al. 3.6 million neonatal\n deaths \u2013 what is progressing and what is not? 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[A korai nyelvi fejl\u0151d\u00e9si k\u00e9s\u00e9s vizsg\u00e1lata\n \u00fajsz\u00fcl\u00f6ttkori hypoxi\u00e1s-ischaemi\u00e1s encephalopathi\u00e1t neurol\u00f3giai k\u00e1rosod\u00e1s n\u00e9lk\u00fcl\n t\u00fal\u00e9lt gyermekekben.] Orv Hetil. 2025; 166: 990\u2013999.\n [Hungarian]","DOI":"10.1556\/650.2025.33323"},{"key":"R5","doi-asserted-by":"crossref","unstructured":"Edwards AD, Brocklehurst P, Gunn AJ, et al. Neurological outcomes at\n 18 months of age after moderate hypothermia for perinatal hypoxic ischaemic\n encephalopathy: Synthesis and meta-analysis of trial data. BMJ 2010; 340:\n c363.","DOI":"10.1136\/bmj.c363"},{"key":"R6","doi-asserted-by":"crossref","unstructured":"Szakm\u00e1r E, Kov\u00e1cs K, M\u00e9der \u00dc, et al. Feasibility and safety of\n controlled active hypothermia treatment during transport in neonates with\n hypoxic-ischemic encephalopathy. 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Optimization of intensive\n treatment in neonates with hypoxic-ischaemic encephalopathy.\n [Hypoxi\u00e1s-ischaemi\u00e1s encephalopathi\u00e1t elszenvedett \u00fajsz\u00fcl\u00f6ttek intenz\u00edv\n ter\u00e1pi\u00e1j\u00e1nak optimaliz\u00e1l\u00e1sa.] Orv Hetil. 2025; 166(38): 1483\u20131489.\n [Hungarian]","DOI":"10.1556\/650.2025.33393"},{"key":"R13","doi-asserted-by":"crossref","unstructured":"M\u00e9der \u00dc, Csek\u0151 AJ, Szak\u00e1cs L, et al. Longitudinal analysis of\n amplitude-integrated electroencephalography for outcome prediction in\n hypoxic-ischemic encephalopathy. J Pediatr. 2022; 246:\n 19\u201325.e5.","DOI":"10.1016\/j.jpeds.2022.04.013"},{"key":"R14","unstructured":"HOPE (HIE Outcome Prediction using aEEG). Available from:\n https:\/\/suneonatalgroup.shinyapps.io\/aeegpredictiontool\/\n [accessed: 30 July 2025]."},{"key":"R15","doi-asserted-by":"crossref","unstructured":"Rondagh M, de Vries LS, van Steenis A, et al. Longitudinal analysis\n of amplitude-integrated electroencephalography for outcome prediction in infants\n with hypoxic-ischemic encephalopathy: a validation study. J Pediatr. 2024; 277:\n 114407.","DOI":"10.1016\/j.jpeds.2024.114407"},{"key":"R16","doi-asserted-by":"crossref","unstructured":"Giesinger RE, Bailey LJ, Deshpande P, et al. Hypoxic-ischemic\n encephalopathy and therapeutic hypothermia: the hemodynamic perspective. J\n Pediatr. 2017; 180: 22\u201330.e2.","DOI":"10.1016\/j.jpeds.2016.09.009"},{"key":"R17","doi-asserted-by":"crossref","unstructured":"Zakari\u00e1s D, Marics G, Kov\u00e1cs K, et al. 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