{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T14:48:49Z","timestamp":1783608529713,"version":"3.55.0"},"reference-count":28,"publisher":"Akademiai Kiado Zrt.","issue":"45","license":[{"start":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T00:00:00Z","timestamp":1762646400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2025,11,9]]},"abstract":"<jats:p>A dementia vil\u00e1gszerte n\u00f6vekv\u0151 n\u00e9peg\u00e9szs\u00e9g\u00fcgyi kih\u00edv\u00e1st jelent id\u0151skorban,\n                    amelynek kialakul\u00e1s\u00e1ban multifaktori\u00e1lis mechanizmusok j\u00e1tszanak szerepet. Az\n                    ut\u00f3bbi \u00e9vekben egyre t\u00f6bb bizony\u00edt\u00e9k t\u00e1masztja al\u00e1, hogy bizonyos\n                    v\u00edrusfert\u0151z\u00e9sek \u2013 k\u00fcl\u00f6n\u00f6sen a herpeszv\u00edrusok, a hum\u00e1n immundeficientia-v\u00edrus \u00e9s\n                    a SARS-CoV-2 \u2013 k\u00f6zvetett vagy k\u00f6zvetlen m\u00f3don hozz\u00e1j\u00e1rulhatnak a\n                    neurodegenerat\u00edv folyamatokhoz. Bebizonyosodott, hogy a vir\u00e1lis \u00e1gensek \u00e1ltal\n                    kiv\u00e1ltott kr\u00f3nikus gyullad\u00e1s, immunrendszeri diszregul\u00e1ci\u00f3 \u00e9s a v\u00e9r\u2013agy g\u00e1t\n                    k\u00e1rosod\u00e1sa potenci\u00e1lisan el\u0151seg\u00edti a dementia, k\u00fcl\u00f6n\u00f6sen az Alzheimer-k\u00f3r\n                    kialakul\u00e1s\u00e1t. Ezzel p\u00e1rhuzamosan figyelemre m\u00e9lt\u00f3 \u00faj kutat\u00e1sok jelentek meg,\n                    amelyek a vakcin\u00e1ci\u00f3 lehets\u00e9ges protekt\u00edv hat\u00e1s\u00e1ra h\u00edvj\u00e1k fel a figyelmet. Egy\n                    2025-ben publik\u00e1lt, a Stanford Egyetem \u00e1ltal v\u00e9gzett vizsg\u00e1lat szerint a herpes\n                    zoster elleni vakcin\u00e1val beoltott id\u0151s feln\u0151ttek k\u00f6r\u00e9ben szignifik\u00e1nsan\n                    ritk\u00e1bban fordult el\u0151 a dementia egy 7 \u00e9ves k\u00f6vet\u00e9si id\u0151tartom\u00e1nyban. A kutat\u00f3k\n                    20%-os relat\u00edv kock\u00e1zatcs\u00f6kken\u00e9st mutattak ki, k\u00fcl\u00f6n\u00f6sen n\u0151kn\u00e9l. M\u00e1s tanulm\u00e1nyok\n                    az influenza, tetanusz, dift\u00e9ria elleni olt\u00e1sok hasonl\u00f3 hat\u00e1s\u00e1t t\u00e1masztott\u00e1k\n                    al\u00e1. K\u00f6zlem\u00e9ny\u00fcnk c\u00e9lja, hogy \u00f6sszefoglaljuk a vir\u00e1lis fert\u0151z\u00e9sek dementi\u00e1ban\n                    bet\u00f6lt\u00f6tt oki szerep\u00e9t, \u00e9s bemutassuk a vakcin\u00e1k ezt g\u00e1tl\u00f3, val\u00f3sz\u00edn\u0171leg nem\n                    csak a speci\u00e1lis antivir\u00e1lis fert\u0151z\u00e9sg\u00e1tl\u00e1son alapul\u00f3 befoly\u00e1s\u00e1t, \u00e9s felh\u00edvjuk a\n                    figyelmet mindezek klinikai \u00e9s n\u00e9peg\u00e9szs\u00e9g\u00fcgyi jelent\u0151s\u00e9g\u00e9re, k\u00fcl\u00f6n\u00f6sen a\n                    megromlott immunrendszer\u0171 id\u0151s koroszt\u00e1lyban. Orv Hetil. 2025; 166(45):\n                    1763\u20131768.<\/jats:p>","DOI":"10.1556\/650.2025.33423","type":"journal-article","created":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T15:33:17Z","timestamp":1762702397000},"page":"1763-1768","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":2,"title":["V\u00edrusfert\u0151z\u00e9sek \u00e9s vakcin\u00e1k kapcsolata a dementi\u00e1val"],"prefix":"10.1556","volume":"166","author":[{"given":"G\u00e1bor","family":"Nadubinszky","sequence":"first","affiliation":[{"name":"D\u00e9l-budai Centrumk\u00f3rh\u00e1z \u2013 Szent Imre Egyetemi Oktat\u00f3k\u00f3rh\u00e1z, Pszichi\u00e1triai Oszt\u00e1ly Budapest Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3007-8568","authenticated-orcid":true,"given":"B\u00e9la","family":"Sz\u00e9k\u00e1cs","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Geri\u00e1triai Tansz\u00e9ki Csoport Budapest Magyarorsz\u00e1g"},{"name":"D\u00e9l-budai Centrumk\u00f3rh\u00e1z \u2013 Szent Imre Egyetemi Oktat\u00f3k\u00f3rh\u00e1z, Pszichi\u00e1triai Oszt\u00e1ly Budapest Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"R1","doi-asserted-by":"crossref","unstructured":"Zsuffa J\u00c1, Kalabay L, Katz S, et al. 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