{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T11:01:39Z","timestamp":1785495699337,"version":"3.56.0"},"reference-count":52,"publisher":"Akademiai Kiado Zrt.","issue":"52","license":[{"start":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T00:00:00Z","timestamp":1766880000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011019","name":"NKFIH","doi-asserted-by":"crossref","award":["K132695"],"award-info":[{"award-number":["K132695"]}],"id":[{"id":"10.13039\/501100011019","id-type":"DOI","asserted-by":"crossref"}]},{"name":"\u00c9szak-pesti Centrum K\u00f3rh\u00e1z \u2013 Honv\u00e9dk\u00f3rh\u00e1z"}],"content-domain":{"domain":["www.akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2025,12,28]]},"abstract":"<jats:p>Sejtjeink genetikai \u00e1llom\u00e1nya szinte azonos minden testi sejt\u00fcnk eset\u00e9ben, de az\n                    epigenetikai hat\u00e1soknak k\u00f6sz\u00f6nhet\u0151en fenot\u00edpusuk jelent\u0151s elt\u00e9r\u00e9seket mutathat.\n                    Az epigenetika a molekul\u00e1ris biol\u00f3gia relat\u00edve \u00faj ter\u00fclete, amely az adott\n                    genot\u00edpus mellett a megv\u00e1ltozott \u00f6r\u00f6k\u00f6lhet\u0151 fenot\u00edpussal, a g\u00e9nexpresszi\u00f3val \u00e9s\n                    a g\u00e9naktivit\u00e1st befoly\u00e1sol\u00f3 v\u00e1ltoz\u00e1sokkal foglalkozik. Az immun- \u00e9s a\n                    daganatsejtek g\u00e9nexpresszi\u00f3j\u00e1t epigenetikai folyamatok szab\u00e1lyozz\u00e1k. E\n                    folyamatok feler\u0151s\u00edthetik a k\u00fcl\u00f6nb\u00f6z\u0151 daganatsejteknek az immunrendszert\n                    elker\u00fcl\u0151 mechanizmusait, m\u00edg m\u00e1s folyamatok eredm\u00e9nye \u00e9ppen az immunrendszer\n                    m\u0171k\u00f6d\u00e9s\u00e9t seg\u00edtheti. A munka a hazai \u00e9s a nemzetk\u00f6zi irodalom alapos \u00e1ttekint\u00e9se\n                    r\u00e9v\u00e9n a n\u0151i nemi szervi daganatok epigenetikai aspektusait j\u00e1rja k\u00f6r\u00fcl, k\u00fcl\u00f6n\u00f6s\n                    tekintettel a m\u00e9hnyak, a m\u00e9htest, a petef\u00e9szek \u00e9s az eml\u0151 daganatos\n                    folyamataira. \u00c9rinti a gestati\u00f3s daganatokat is. Kit\u00e9r tov\u00e1bb\u00e1 az endometriosis\n                    epigenetikai vonatkoz\u00e1saira, amely nem tartozik a klasszikus daganatos\n                    betegs\u00e9gek csoportj\u00e1ba, patomechanizmus\u00e1t tekintve viszont sok hasonl\u00f3s\u00e1got\n                    mutat sok m\u00e1s neoplasi\u00e1val. V\u00e9gezet\u00fcl az epigenetikai medicina \u00e9s ter\u00e1pia \u00faj\n                    eredm\u00e9nyeit t\u00e1rgyalja. Orv Hetil. 2025; 166(52): 2043\u20132054.<\/jats:p>","DOI":"10.1556\/650.2025.33442","type":"journal-article","created":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T06:10:12Z","timestamp":1766902212000},"page":"2043-2054","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":0,"title":["A gestati\u00f3s eredet\u0171 \u00e9s a n\u0151i nemi szervekben el\u0151fordul\u00f3 daganatok epigenetikai vonatkoz\u00e1sai"],"prefix":"10.1556","volume":"166","author":[{"given":"Vilmos","family":"F\u00fcl\u00f6p","sequence":"first","affiliation":[{"name":"Miskolci Egyetem, Eg\u00e9szs\u00e9gtudom\u00e1nyi Kar Miskolc Magyarorsz\u00e1g"},{"name":"\u00c9szak-pesti Centrumk\u00f3rh\u00e1z \u2013 Honv\u00e9dk\u00f3rh\u00e1z, Sz\u00fcl\u00e9szet-n\u0151gy\u00f3gy\u00e1szati Oszt\u00e1ly Budapest Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e1szl\u00f3","family":"Kalm\u00e1r","sequence":"additional","affiliation":[{"name":"\u00c9szak-pesti Centrumk\u00f3rh\u00e1z \u2013 Honv\u00e9dk\u00f3rh\u00e1z, Sz\u00fcl\u00e9szet-n\u0151gy\u00f3gy\u00e1szati Oszt\u00e1ly Budapest Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2789-1673","authenticated-orcid":true,"given":"Korn\u00e9l","family":"Lakatos","sequence":"additional","affiliation":[{"name":"Sz\u00e9chenyi Istv\u00e1n Egyetem, Eg\u00e9szs\u00e9g- \u00e9s Sporttudom\u00e1nyi Kar Gy\u0151r Magyarorsz\u00e1g"},{"name":"Gy\u0151r-Moson-Sopron V\u00e1rmegyei Petz Alad\u00e1r Egyetemi Oktat\u00f3 K\u00f3rh\u00e1z, Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Oszt\u00e1ly Gy\u0151r, Vasv\u00e1ri P\u00e1l u. 2\u20134., 9024 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gy\u00f6rgy","family":"V\u00e9gh","sequence":"additional","affiliation":[{"name":"\u00c9szak-budai Szent J\u00e1nos Centrumk\u00f3rh\u00e1z, Sz\u00fcl\u00e9szeti-N\u0151gy\u00f3gy\u00e1szati Oszt\u00e1ly Budapest Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tam\u00e1s","family":"Ar\u00e1nyi","sequence":"additional","affiliation":[{"name":"HUN-REN Term\u00e9szettudom\u00e1nyi Kutat\u00f3k\u00f6zpont, Molekul\u00e1ris \u00c9lettudom\u00e1nyi Int\u00e9zet Budapest Magyarorsz\u00e1g"},{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Molekul\u00e1ris Biol\u00f3giai Tansz\u00e9k Budapest Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"R1","doi-asserted-by":"crossref","unstructured":"F\u00fcl\u00f6p V, Kalm\u00e1r L, Kiss A, et al. 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