{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:52:16Z","timestamp":1791229936906,"version":"4.1.0"},"reference-count":50,"publisher":"Akademiai Kiado Zrt.","issue":"3","license":[{"start":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T00:00:00Z","timestamp":1768694400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Biofizikai Int\u00e9zet"}],"content-domain":{"domain":["www.akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2026,1,18]]},"abstract":"<jats:p>Az Eg\u00e9szs\u00e9g\u00fcgyi Vil\u00e1gszervezet felm\u00e9r\u00e9se szerint a daganatos megbeteged\u00e9sek\n                    vil\u00e1gszerte a m\u00e1sodik helyen \u00e1llnak a hal\u00e1loz\u00e1si okok list\u00e1j\u00e1n. A tumorok\n                    eredm\u00e9nyes kezel\u00e9se \u00e9s t\u00fal\u00e9l\u00e9se szempontj\u00e1b\u00f3l tov\u00e1bbra is a m\u00e9g t\u00fcnetmentes\n                    daganatok korai felismer\u00e9se, a korai markerek megtal\u00e1l\u00e1sa a legfontosabb c\u00e9l. A\n                    hum\u00e1n v\u00e9rmint\u00e1k vizsg\u00e1lata \u00fan. noninvaz\u00edv m\u00f3dszer a daganatkutat\u00e1s \u00e9s a\n                    betegell\u00e1t\u00e1s sor\u00e1n is. Napjainkban rutinszer\u0171en a v\u00e9rb\u0151l bizonyos g\u00e9nek,\n                    g\u00e9nterm\u00e9kek \u00e9s tumormarkerek m\u00e9r\u00e9se alkalmas r\u00e9szben diagnosztiz\u00e1l\u00e1sra, r\u00e9szben\n                    monitoroz\u00e1sra. Az emberi v\u00e9rplazma proteomj\u00e1nak termoanalitikai vizsg\u00e1lata az\n                    egyik \u00edg\u00e9retes, \u00faj ter\u00fclet, amelyn\u00e9l a v\u00e9rv\u00e9telre mint foly\u00e9kony biopszi\u00e1ra\n                    lehet tekinteni. A differenci\u00e1lis p\u00e1szt\u00e1z\u00f3 kalorimetri\u00e1s (DSC) vizsg\u00e1lat\n                    k\u00f6zvetlen\u00fcl m\u00e9ri a feh\u00e9rje, lipid vagy nukleinsav stabilit\u00e1s\u00e1t \u00e9s felboml\u00e1s\u00e1t a\n                    minta h\u0151m\u00e9rs\u00e9klet\u00e9nek n\u00f6vel\u00e9se vagy cs\u00f6kkent\u00e9se idej\u00e9n, lehet\u0151v\u00e9 t\u00e9ve ezzel az\n                    egyes anyagok nat\u00edv \u00e9s denatur\u00e1lt \u00e1llapotban val\u00f3 tanulm\u00e1nyoz\u00e1s\u00e1t. Az eredm\u00e9ny a\n                    DSC-g\u00f6rbe, egy biomolekula vagy biostrukt\u00fara egyedi, ujjlenyomatszer\u0171\n                    termoanalitikai g\u00f6rb\u00e9je, amely t\u00fckr\u00f6zi a norm\u00e1lis vagy patomorfol\u00f3giai\n                    v\u00e1ltoz\u00e1sokat adott k\u00f6r\u00fclm\u00e9nyek k\u00f6z\u00f6tt. A k\u00fcl\u00f6nb\u00f6z\u0151 klinikai k\u00f3rk\u00e9pekn\u00e9l\n                    (melanoma malignum, eml\u0151tumor, pancreastumor) a betegek v\u00e9rplazm\u00e1inak m\u00e9r\u00e9sei\n                    sor\u00e1n kapott egyedi, de a betegs\u00e9gre jellemz\u0151 DSC-g\u00f6rb\u00e9k \u00f6sszef\u00fcgg\u00e9st mutatnak a\n                    betegs\u00e9g s\u00falyoss\u00e1g\u00e1val, el\u0151rehaladotts\u00e1g\u00e1val vagy a kezel\u00e9sre adott v\u00e1lasszal.\n                    Tov\u00e1bbfejleszt\u00e9s\u00e9t k\u00f6vet\u0151en a v\u00e9rplazma-DSC-g\u00f6rb\u00e9k dekonvol\u00faci\u00f3s anal\u00edzise\n                    felveti a lehet\u0151s\u00e9g\u00e9t a daganatos vagy gyullad\u00e1sos k\u00f3rk\u00e9pek korai\n                    diagnosztiz\u00e1l\u00e1s\u00e1nak, a betegs\u00e9g monitoroz\u00e1s\u00e1nak vagy az alkalmazott ter\u00e1pia\n                    hat\u00e9konys\u00e1g\u00e1nak egy csepp v\u00e9rb\u0151l val\u00f3 meghat\u00e1roz\u00e1s\u00e1ra. Orv Hetil. 2026 167(3):\n                    98\u2013108.<\/jats:p>","DOI":"10.1556\/650.2026.33462","type":"journal-article","created":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T09:02:11Z","timestamp":1768726931000},"page":"98-108","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":5,"title":["Malignus betegs\u00e9gek diagnosztik\u00e1ja \u00e9s ut\u00e1nk\u00f6vet\u00e9se egy csepp v\u00e9r termoanalitikai vizsg\u00e1lat\u00e1val"],"prefix":"10.1556","volume":"167","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1623-9783","authenticated-orcid":true,"given":"Andrea","family":"Ferencz","sequence":"first","affiliation":[{"name":"Budapesti P\u00e9terfy S\u00e1ndor Utcai K\u00f3rh\u00e1z-Rendel\u0151int\u00e9zet, Seb\u00e9szeti Oszt\u00e1ly Budapest, P\u00e9terfy S. u. 8\u201320., 1076 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"R1","doi-asserted-by":"crossref","unstructured":"Michnik A, Drzazga Z. 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