{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T15:09:02Z","timestamp":1785510542141,"version":"3.56.0"},"reference-count":30,"publisher":"Akademiai Kiado Zrt.","issue":"4","license":[{"start":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T00:00:00Z","timestamp":1769299200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009594","name":"P\u00e9csi Tudom\u00e1nyegyetem","doi-asserted-by":"crossref","award":["PTE \u00c1OK-KA 2025\/09"],"award-info":[{"award-number":["PTE \u00c1OK-KA 2025\/09"]}],"id":[{"id":"10.13039\/501100009594","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Nemzeti Kutat\u00e1si, Fejleszt\u00e9si \u00e9s Innov\u00e1ci\u00f3s Hivatal NKFIH ADVANCED","award":["152515"],"award-info":[{"award-number":["152515"]}]}],"content-domain":{"domain":["www.akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2026,1,25]]},"abstract":"A k\u00e9z-l\u00e1b-sz\u00e1j betegs\u00e9g jellemz\u0151en enyhe lefoly\u00e1s\u00fa, \u00f6nkorl\u00e1toz\u00f3\n enterov\u00edrus-fert\u0151z\u00e9s, amelynek klasszikus k\u00f3rokoz\u00f3i a coxsackiev\u00edrus A16 \u00e9s az\n enterov\u00edrus A71. Az ut\u00f3bbi m\u00e1sf\u00e9l \u00e9vtizedben azonban vil\u00e1gszerte, \u00edgy haz\u00e1nkban\n is j\u00e1rv\u00e1nyosan elterjedt az at\u00edpusos klinikai form\u00e1t okoz\u00f3 coxsackiev\u00edrus A6\n (CVA6). Az at\u00edpusos k\u00e9z-l\u00e1b-sz\u00e1j betegs\u00e9g a klasszikus form\u00e1t\u00f3l els\u0151sorban a\n kiterjedt, vesiculobullosus, gyakran f\u00e1jdalmas b\u0151rt\u00fcnetek, a perioralis laesi\u00f3k\n \u00e9s a betegs\u00e9g lezajl\u00e1s\u00e1t k\u00f6vet\u0151en jelentkez\u0151 k\u00f6r\u00f6melt\u00e9r\u00e9sek r\u00e9v\u00e9n k\u00fcl\u00f6nb\u00f6zik.\n Esetbemutat\u00e1sunkban egy 2 \u00e9ves le\u00e1nygyermekn\u00e9l kialakult vesiculobullosus\n ki\u00fct\u00e9sek h\u00e1tter\u00e9ben RT-PCR \u00e9s Sanger-szekven\u00e1l\u00e1s m\u00f3dszereivel a CVA6 (kl\u00e1d D3a)\n k\u00f3roki szerepe igazol\u00f3dott. Az exanthem\u00e1k visszah\u00faz\u00f3d\u00e1s\u00e1t k\u00f6vet\u0151en \u00fajabb\n recid\u00edva, majd 6 h\u00e9t m\u00falva k\u00f6r\u00f6mlev\u00e1l\u00e1s alakult ki, amely maradand\u00f3 sz\u00f6v\u0151dm\u00e9ny\n n\u00e9lk\u00fcl gy\u00f3gyult. A diagn\u00f3zis szempontj\u00e1b\u00f3l kulcsfontoss\u00e1g\u00fa e fert\u0151z\u00e9s at\u00edpusos\n klinikai megjelen\u00e9si form\u00e1j\u00e1nak ismerete, illetve a v\u00edrus molekul\u00e1ris alap\u00fa\n kimutat\u00e1sa, amely h\u00f3lyagbenn\u00e9kb\u0151l, sz\u00e9kletb\u0151l, illetve oropharyngealis mint\u00e1b\u00f3l\n is lehets\u00e9ges. Az at\u00edpusos k\u00e9z-l\u00e1b-sz\u00e1j betegs\u00e9g felismer\u00e9se fontos, mivel\n klinikai megjelen\u00e9se t\u00f6bb m\u00e1s, h\u00f3lyagos-bullosus k\u00f3rk\u00e9pet ut\u00e1nozhat, ami k\u00f6nnyen\n indokolatlan ter\u00e1pi\u00e1s beavatkoz\u00e1sokhoz vezethet. Orv Hetil. 2026; 167(4):\n 156\u2013161.<\/jats:p>","DOI":"10.1556\/650.2026.33469","type":"journal-article","created":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T17:19:47Z","timestamp":1769361587000},"page":"156-161","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":0,"title":["Coxsackiev\u00edrus A6 okozta at\u00edpusos klinikai megjelen\u00e9s\u0171 k\u00e9z-l\u00e1b-sz\u00e1j betegs\u00e9g"],"prefix":"10.1556","volume":"167","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2670-8597","authenticated-orcid":true,"given":"Bence","family":"Horv\u00e1th","sequence":"first","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Klinikai K\u00f6zpont, Gyermekgy\u00f3gy\u00e1szati Klinika P\u00e9cs, J\u00f3zsef A. u. 7., 7624 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T\u00edmea","family":"Kv\u00e1rik","sequence":"additional","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Klinikai K\u00f6zpont, Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Klinika P\u00e9cs Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1kos","family":"Boros","sequence":"additional","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Klinikai K\u00f6zpont, Orvosi Mikrobiol\u00f3giai Int\u00e9zet P\u00e9cs Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1ty\u00e1s","family":"Meggyes","sequence":"additional","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Klinikai K\u00f6zpont, Orvosi Mikrobiol\u00f3giai Int\u00e9zet P\u00e9cs Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e1bor","family":"Reuter","sequence":"additional","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Klinikai K\u00f6zpont, Orvosi Mikrobiol\u00f3giai Int\u00e9zet P\u00e9cs Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zolt\u00e1n","family":"Nyul","sequence":"additional","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Klinikai K\u00f6zpont, Gyermekgy\u00f3gy\u00e1szati Klinika P\u00e9cs, J\u00f3zsef A. u. 7., 7624 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"R1","doi-asserted-by":"crossref","unstructured":"Feh\u00e9r Z, Toldy E, Schneider F. Evaluation of the epidemiological and\n clinical characteristics of central nervous system infections in adults in the\n West Pannonian region. [A feln\u0151ttkori neuroinfekci\u00f3k epidemiol\u00f3giai \u00e9s klinikai\n jellemz\u0151inek vizsg\u00e1lata a nyugat-dun\u00e1nt\u00fali r\u00e9gi\u00f3ban.] Orv Hetil. 2019; 160:\n 1574-1583. [Hungarian]\n https:\/\/doi.org\/10.1556\/650.2019.31489","DOI":"10.1556\/650.2019.31489"},{"key":"R2","doi-asserted-by":"crossref","unstructured":"Modlin JF. Coxsackieviruses, echoviruses, newer enteroviruses, and\n parechoviruses. In: Mandell G, Bennett JE, Dolin R. (eds.) Principles and\n practice of infectious diseases. 7th ed. Churchill Livingstone, Philadelphia,\n PA, 2010.\n https:\/\/doi.org\/10.1016\/B978-0-443-06839-3.00172-7","DOI":"10.1016\/B978-0-443-06839-3.00172-7"},{"key":"R3","unstructured":"Centers for Disease Control and Prevention (CDC). Notes from the\n field: severe hand, foot, and mouth disease associated with Coxsackievirus A6 -\n Alabama, Connecticut, California, and Nevada, November 2011-February 2012. MMWR\n Morb Mortal Wkly Rep. 2012; 61: 213-214."},{"key":"R4","doi-asserted-by":"crossref","unstructured":"Osterback R, Vuorinen T, Linna M, et al. Coxsackievirus A6 and hand,\n foot, and mouth disease. Finland. Emerg Infect Dis. 2009; 15: 1485-1488.\n https:\/\/doi.org\/10.3201\/eid1509.090438","DOI":"10.3201\/eid1509.090438"},{"key":"R5","doi-asserted-by":"crossref","unstructured":"Bracho MA, Gonz\u00e1lez-Candelas F, Valero A, et al. Enterovirus\n co-infections and onychomadesis after hand, foot, and mouth disease, Spain,\n 2008. Emerg Infect Dis. 2011; 17: 2223-2231.\n https:\/\/doi.org\/10.3201\/eid1712.110395","DOI":"10.3201\/eid1712.110395"},{"key":"R6","doi-asserted-by":"crossref","unstructured":"Mirand A, Henquell C, Archimbaud C, et al. Outbreak of hand, foot\n and mouth disease\/herpangina associated with Coxsackievirus A6 and A10\n infections in 2010, France: a large citywide, prospective observational study.\n Clin Microbiol Infect. 2012; 18: E110-E118.\n https:\/\/doi.org\/10.1111\/j.1469-0691.2012.03789.x","DOI":"10.1111\/j.1469-0691.2012.03789.x"},{"key":"R7","doi-asserted-by":"crossref","unstructured":"Sinclair C, Gaunt E, Simmonds P, et al. Atypical hand, foot, and\n mouth disease associated with Coxsackievirus A6 infection, Edinburgh, United\n Kingdom, January to February 2014. Euro Surveill. 2014; 19: 20745.\n https:\/\/doi.org\/10.2807\/1560-7917.ES2014.19.12.20745","DOI":"10.2807\/1560-7917.ES2014.19.12.20745"},{"key":"R8","doi-asserted-by":"crossref","unstructured":"Horsten HH, Kemp M, Fischer TK, et al. 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