{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T15:10:21Z","timestamp":1785510621256,"version":"3.56.0"},"reference-count":38,"publisher":"Akademiai Kiado Zrt.","issue":"6","license":[{"start":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:00:00Z","timestamp":1770508800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Budai Irgalmasrendi K\u00f3rh\u00e1z"}],"content-domain":{"domain":["www.akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2026,2,8]]},"abstract":"<jats:p>A modern orvostudom\u00e1ny fejl\u0151d\u00e9se ellen\u00e9re a klasszikus laborat\u00f3riumi param\u00e9terek\n                    tov\u00e1bbra is a klinikai d\u00f6nt\u00e9shozatal f\u0151 pill\u00e9rei. A k\u00f6zlem\u00e9ny n\u00e9gy, rutinszer\u0171en\n                    m\u00e9rt analitra f\u00f3kusz\u00e1l: sz\u00e9rum-kreatininszint, m\u00e1jtranszamin\u00e1z-aktivit\u00e1sok,\n                    albuminszint. Ezek 2024-ben a magyarorsz\u00e1gi laborat\u00f3riumi meghat\u00e1roz\u00e1sok t\u00f6bb\n                    mint 15%-\u00e1t tett\u00e9k ki. A sz\u00e9rum-kreatininszint m\u00e9r\u00e9s\u00e9t a laborat\u00f3riumok k\u00e9tf\u00e9le\n                    m\u00f3dszerrel m\u00e9rik: Jaff\u00e9- vagy enzimatikus m\u00f3dszerrel. B\u00e1r mindkett\u0151 alkalmas a\n                    glomerulusfiltr\u00e1ci\u00f3s r\u00e1ta (GFR) becsl\u00e9s\u00e9re, az eredm\u00e9nyek 5\u201314%-kal elt\u00e9rhetnek\n                    egym\u00e1st\u00f3l. A szakmai \u00e1ll\u00e1sfoglal\u00e1s szerint mindk\u00e9t m\u00f3dszer haszn\u00e1lhat\u00f3, de a\n                    leleten jel\u00f6lni kell az alkalmazott technik\u00e1t. A transzamin\u00e1z-aktivit\u00e1sok\n                    (GOT\/AST, GPT\/ALT) meghat\u00e1roz\u00e1sakor kritikus a piridox\u00e1l-foszf\u00e1t (B6-vitamin)\n                    jelenl\u00e9te a reagensben. Ennek hi\u00e1ny\u00e1ban a m\u00e9rt \u00e9rt\u00e9kek 15\u201330%-kal alacsonyabbak\n                    lehetnek. Ez t\u00e9ves diagn\u00f3zishoz vezethet, k\u00fcl\u00f6n\u00f6sen a m\u00e1jfibrosis becsl\u00e9s\u00e9re\n                    szolg\u00e1l\u00f3 FIB4-pontsz\u00e1m sz\u00e1m\u00edt\u00e1sakor. Ez\u00e9rt piridox\u00e1l-foszf\u00e1tot tartalmaz\u00f3\n                    reagensek alkalmaz\u00e1sa javasolt a transzamin\u00e1z-aktivit\u00e1sok m\u00e9r\u00e9s\u00e9re. Az albumin\n                    m\u00e9r\u00e9s\u00e9re a br\u00f3mkrezolz\u00f6ld helyett br\u00f3mkrezolv\u00f6r\u00f6s reagens haszn\u00e1lata javasolt,\n                    mivel az el\u0151bbi m\u00e1jbetegs\u00e9gben \u00e9s veseel\u00e9gtelens\u00e9gben pontatlan eredm\u00e9nyeket ad.\n                    A m\u00f3dszerv\u00e1lt\u00e1sokat a klinikusokkal egyeztetve kell v\u00e9grehajtani, illetve oda\n                    kell figyelni arra is, hogy a vizsg\u00e1latok LOINC-k\u00f3dja (egys\u00e9ges nevez\u00e9ktanon\n                    alapul\u00f3 k\u00f3drendszer) v\u00e1ltozhat. Orv Hetil. 2026; 167(6): 211\u2013216.<\/jats:p>","DOI":"10.1556\/650.2026.33490","type":"journal-article","created":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T07:37:47Z","timestamp":1770536267000},"page":"211-216","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":0,"title":["N\u00e9h\u00e1ny gondolat a sz\u00e9rum-kreatininszint, -transzamin\u00e1zaktivit\u00e1s \u00e9s -albuminszint meghat\u00e1roz\u00e1sok m\u00f3dszertan\u00e1r\u00f3l"],"prefix":"10.1556","volume":"167","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0055-7346","authenticated-orcid":true,"given":"Barna","family":"V\u00e1s\u00e1rhelyi","sequence":"first","affiliation":[{"name":"Eg\u00e9szs\u00e9g\u00fcgyi Szakmai Koll\u00e9gium, Orvosi Laborat\u00f3riumi Tagozat Budapest, Nagyv\u00e1rad t\u00e9r 4., 14. emelet, 1089 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsuzsanna","family":"Bereczky","sequence":"additional","affiliation":[{"name":"Eg\u00e9szs\u00e9g\u00fcgyi Szakmai Koll\u00e9gium, Orvosi Laborat\u00f3riumi Tagozat Budapest, Nagyv\u00e1rad t\u00e9r 4., 14. emelet, 1089 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attila","family":"Miseta","sequence":"additional","affiliation":[{"name":"Eg\u00e9szs\u00e9g\u00fcgyi Szakmai Koll\u00e9gium, Orvosi Laborat\u00f3riumi Tagozat Budapest, Nagyv\u00e1rad t\u00e9r 4., 14. emelet, 1089 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"R1","doi-asserted-by":"crossref","unstructured":"N\u00e9meth Z, Tak\u00e1cs I, Moln\u00e1r B. 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[Hungarian]\n                        https:\/\/doi.org\/10.1556\/OH.2011.29007","DOI":"10.1556\/OH.2011.29007"},{"key":"R8","unstructured":"Levin A, Stevens PE, Bilous RW, et al. Kidney Disease: Improving\n                    Global Outcomes (KDIGO) CKD Work Group. KDIGO 2012 clinical practice guideline\n                    for the evaluation and management of chronic kidney disease. Kidney Int Suppl.\n                    2013; 3: 1-150."},{"key":"R9","doi-asserted-by":"crossref","unstructured":"Haris \u00c1, M\u00e1tyus J. Occurrence and prevention of iodinated contrast\n                    agent-induced kidney injury in light of the newest literature data: Time to\n                    change our clinical practice! [Radioj\u00f3d kontrasztanyagok \u00e1ltal okozott\n                    vesek\u00e1rosod\u00e1s \u00e9s megel\u0151z\u00e9se az \u00fajabb irodalmi adatok t\u00fckr\u00e9ben. V\u00e1ltoztassunk a\n                    gyakorlaton!] Orv Hetil. 2022; 163: 83-91. 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