{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T03:25:30Z","timestamp":1773631530227,"version":"3.50.1"},"reference-count":14,"publisher":"Akademiai Kiado Zrt.","issue":"11","license":[{"start":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T00:00:00Z","timestamp":1773532800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2026,3,15]]},"abstract":"A szerz\u0151k egy 63 \u00e9ves n\u0151beteg eset\u00e9t ismertetik, aki testszerte jelentkez\u0151,\n feszes fal\u00fa bull\u00e1k miatt ker\u00fclt b\u0151rgy\u00f3gy\u00e1szati oszt\u00e1lyos felv\u00e9telre. Kor\u00e1bban\n m\u00e1s int\u00e9zm\u00e9nyben kis-k\u00f6zepes d\u00f3zis\u00fa szteroid be\u00e1ll\u00edt\u00e1sa t\u00f6rt\u00e9nt.\n B\u0151relv\u00e1ltoz\u00e1saib\u00f3l sz\u00f6vettani mint\u00e1t vett\u00fcnk, amely direkt immunfluoreszcens\n vizsg\u00e1lattal meger\u0151s\u00edtette a bullosus pemphigoid diagn\u00f3zis\u00e1t. A felv\u00e9telkor\n \u00e9szlelt extr\u00e9m magas m\u00e1jfunkci\u00f3s \u00e9rt\u00e9keit szteroid-mell\u00e9khat\u00e1snak v\u00e9lem\u00e9nyezt\u00fck,\n \u00edgy a tov\u00e1bbi kivizsg\u00e1l\u00e1sig hepatotoxikus szerek ad\u00e1s\u00e1t\u00f3l eltekintett\u00fcnk.\n Kivizsg\u00e1l\u00e1sa sor\u00e1n m\u00e1jfunkci\u00f3s elt\u00e9r\u00e9sei h\u00e1tter\u00e9ben primer biliaris cholangitist\n diagnosztiz\u00e1ltunk. Tekintettel a beteg s\u00falyos \u00e1llapot\u00e1ra, figyelembe v\u00e9ve az\n els\u0151 vonalbeli kezel\u00e9sk\u00e9nt adhat\u00f3 szerek hepatotoxikus mell\u00e9khat\u00e1s\u00e1t,\n plazmafer\u00e9zist ind\u00edtottunk. Ezt k\u00f6vet\u0151en, a nemzetk\u00f6zi aj\u00e1nl\u00e1sokat \u00e1ttekintve,\n omalizumabter\u00e1pia \u2019off-labef bevezet\u00e9se mellett d\u00f6nt\u00f6tt\u00fcnk, amely mellett a\n beteg b\u0151rgy\u00f3gy\u00e1szati szempontb\u00f3l t\u00fcnetmentess\u00e9 v\u00e1lt. Hepatol\u00f3giai indik\u00e1ci\u00f3ban\n urzodezoxik\u00f3lsav-ter\u00e1pia indult. A bullosus pemphigoid \u00e9s a primer biliaris\n cholangitis egy\u00fcttes el\u0151fordul\u00e1sa az irodalmi adatok alapj\u00e1n nagyon ritka. Az\n esetet ritka el\u0151fordul\u00e1sa \u00e9s ter\u00e1pi\u00e1s neh\u00e9zs\u00e9ge miatt tartottuk bemutat\u00e1sra\n \u00e9rdemesnek, hangs\u00falyozva a t\u00e1rsszakm\u00e1k egy\u00fcttm\u0171k\u00f6d\u00e9s\u00e9nek fontoss\u00e1g\u00e1t. Orv Hetil.\n 2026; 167(11): 439\u2013444.<\/jats:p>","DOI":"10.1556\/650.2026.33513","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T02:25:01Z","timestamp":1773627901000},"page":"439-444","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":0,"title":["Bullosus pemphigoid \u00e9s primer biliaris cholangitis ter\u00e1pi\u00e1s kih\u00edv\u00e1ssal j\u00e1r\u00f3 ritka egy\u00fcttes el\u0151fordul\u00e1sa"],"prefix":"10.1556","volume":"167","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1713-8727","authenticated-orcid":true,"given":"Judit","family":"Cs\u0151sz","sequence":"first","affiliation":[{"name":"B\u00e1cs-Kiskun V\u00e1rmegyei Oktat\u00f3k\u00f3rh\u00e1z, B\u0151rgy\u00f3gy\u00e1szat Kecskem\u00e9t, Csabai G\u00e9za krt. 21., 6000 Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e1ra","family":"G\u00e9z\u00e1rt","sequence":"additional","affiliation":[{"name":"B\u00e1cs-Kiskun V\u00e1rmegyei Oktat\u00f3k\u00f3rh\u00e1z, B\u0151rgy\u00f3gy\u00e1szat Kecskem\u00e9t, Csabai G\u00e9za krt. 21., 6000 Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcell","family":"D\u00f6m\u00f6t\u00f6r","sequence":"additional","affiliation":[{"name":"B\u00e1cs-Kiskun V\u00e1rmegyei Oktat\u00f3k\u00f3rh\u00e1z, B\u0151rgy\u00f3gy\u00e1szat Kecskem\u00e9t, Csabai G\u00e9za krt. 21., 6000 Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lajos","family":"Kocsis","sequence":"additional","affiliation":[{"name":"B\u00e1cs-Kiskun V\u00e1rmegyei Oktat\u00f3k\u00f3rh\u00e1z, Patol\u00f3gia Kecskem\u00e9t Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zsolt","family":"Klucsik","sequence":"additional","affiliation":[{"name":"B\u00e1cs-Kiskun V\u00e1rmegyei Oktat\u00f3k\u00f3rh\u00e1z, Hematol\u00f3gia Kecskem\u00e9t Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melinda","family":"Janota","sequence":"additional","affiliation":[{"name":"B\u00e1cs-Kiskun V\u00e1rmegyei Oktat\u00f3k\u00f3rh\u00e1z, Gasztroenterol\u00f3gia Kecskem\u00e9t Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iv\u00e1n","family":"Oroj\u00e1n","sequence":"additional","affiliation":[{"name":"B\u00e1cs-Kiskun V\u00e1rmegyei Oktat\u00f3k\u00f3rh\u00e1z, B\u0151rgy\u00f3gy\u00e1szat Kecskem\u00e9t, Csabai G\u00e9za krt. 21., 6000 Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"R1","doi-asserted-by":"crossref","unstructured":"Terziroli Beretta-Piccoli B, Guillod C, Marsteller I, et al. Primary\n biliary cholangitis associated with skin disorders: a case report and review of\n the literature. Arch Immunol Ther Exp (Warsz). 2017; 65: 299-309.\n https:\/\/doi.org\/10.1007\/s00005-016-0448-0","DOI":"10.1007\/s00005-016-0448-0"},{"key":"R2","doi-asserted-by":"crossref","unstructured":"Hamilton DV, McKenzie AW. Bullous pemphigoid and primary biliary\n cirrhosis. Br J Dermatol. 1978; 99: 447-450.\n https:\/\/doi.org\/10.1111\/j.1365-2133.1978.tb06186.x","DOI":"10.1111\/j.1365-2133.1978.tb06186.x"},{"key":"R3","doi-asserted-by":"crossref","unstructured":"Guerra-Uribe NB, Gonz\u00e1lez-Huezo MS. Bullous pemphigoid and primary\n biliary cirrhosis, an infrequent association: a case report. [P\u00e9nfigo bulloso y\n cirrosis biliar primaria, una asociaci\u00f3n infrecuente. Reporte de caso.] Rev\n Gastroenterol Mex. 2016; 81: 174-176. [Spanish]\n https:\/\/doi.org\/10.1016\/j.rgmx.2015.08.004","DOI":"10.1016\/j.rgmx.2015.08.004"},{"key":"R4","doi-asserted-by":"crossref","unstructured":"Haque T, Ansari RS, Rahman A, et al. AMA-negative primary biliary\n cholangitis and autoimmune hepatitis overlap syndrome presenting with bullous\n pemphigoid: a case report. Clin Case Rep. 2025; 13: e71534.\n https:\/\/doi.org\/10.1002\/ccr3.71534","DOI":"10.1002\/ccr3.71534"},{"key":"R5","doi-asserted-by":"crossref","unstructured":"Fuertes de Vega I, Iranzo-Fern\u00e1ndez P, Mascar\u00f3-Galy JM. Bullous\n pemphigoid: clinical practice guidelines. [Penfigoide ampolloso: gu\u00eda de manejo\n pr\u00e1ctico.] Actas Dermosifiliogr. 2014; 105: 328-346. [Spanish]\n https:\/\/doi.org\/10.1016\/j.ad.2012.10.022","DOI":"10.1016\/j.ad.2012.10.022"},{"key":"R6","doi-asserted-by":"crossref","unstructured":"Israelsen M, Francque S, Tsochatzis EA, et al. Steatotic liver\n disease. Lancet 2024; 404: 1761-1778.\n https:\/\/doi.org\/10.1016\/S0140-6736(24)01811-7","DOI":"10.1016\/S0140-6736(24)01811-7"},{"key":"R7","doi-asserted-by":"crossref","unstructured":"Borradori L, Van Beek N, Feliciani C, et al. Updated S2K guidelines\n for the management of bullous pemphigoid initiated by the European Academy of\n Dermatology and Venereology. J Eur Acad Dermatol Venereol. 2022; 36: 1689-1704.\n https:\/\/doi.org\/10.1111\/jdv.18220","DOI":"10.1111\/jdv.18220"},{"key":"R8","doi-asserted-by":"crossref","unstructured":"Balogh B, P\u00e1lyu E, Vill\u00e1m B, et al. Diagnosis and treatment of\n primary biliary cholangitis (PBC) - Counsel of current clinical practice\n guidelines (CPG) of the European Association for the Study of the Liver (EASL).\n [A primer biliaris cholangitis (PBC) diagnosztik\u00e1ja \u00e9s kezel\u00e9se az Eur\u00f3pai\n M\u00e1jkutat\u00f3 T\u00e1rsas\u00e1g klinikai gyakorlati \u00fatmutat\u00f3ja alapj\u00e1n.] Cent Eur J\n Gastroenterol Hepatol. 2020; 6: 124-146. [Hungarian]\n https:\/\/doi.org\/10.33570\/CEUJGH.6.3.113","DOI":"10.33570\/CEUJGH.6.3.113"},{"key":"R9","doi-asserted-by":"crossref","unstructured":"Trivella J, John BV, Levy C. Primary biliary cholangitis:\n epidemiology, prognosis, and treatment. Hepatol Commun. 2023; 7: e0179.\n https:\/\/doi.org\/10.1097\/HC9.0000000000000179","DOI":"10.1097\/HC9.0000000000000179"},{"key":"R10","doi-asserted-by":"crossref","unstructured":"Lo Schiavo A, Ruocco E, Brancaccio G, et al. Bullous pemphigoid:\n etiology, pathogenesis, and inducing factors: facts and controversies. Clin\n Dermatol. 2013; 31: 391-399.\n https:\/\/doi.org\/10.1016\/j.clindermatol.2013.01.006","DOI":"10.1016\/j.clindermatol.2013.01.006"},{"key":"R11","doi-asserted-by":"crossref","unstructured":"Altan Ferhatoglu Z, Yucesoy SN, Ak T, et al. Omalizumab in the\n treatment of bullous pemphigoid: a single-center series of 15 cases. Medicine\n (Baltimore) 2024; 103: e38684.\n https:\/\/doi.org\/10.1097\/MD.0000000000038684","DOI":"10.1097\/MD.0000000000038684"},{"key":"R12","doi-asserted-by":"crossref","unstructured":"Granados-Betancort E, S\u00e1nchez-D\u00edaz M, Mu\u00f1oz-Barba D, et al.\n Omalizumab and dupilumab for the treatment of bullous pemphigoid: a systematic\n review. J Clin Med. 2024; 13: 4844.\n https:\/\/doi.org\/10.3390\/jcm13164844","DOI":"10.3390\/jcm13164844"},{"key":"R13","doi-asserted-by":"crossref","unstructured":"Cao P, Xu W, Zhang L. Rituximab, omalizumab, and dupilumab treatment\n outcomes in bullous pemphigoid: a systematic review. Front Immunol. 2022; 13:\n 928621. https:\/\/doi.org\/10.3389\/fimmu.2022.928621","DOI":"10.3389\/fimmu.2022.928621"},{"key":"R14","doi-asserted-by":"crossref","unstructured":"Yu KK, Crew AB, Messingham KA, et al. Omalizumab therapy for bullous\n pemphigoid. 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