{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T03:25:48Z","timestamp":1773631548764,"version":"3.50.1"},"reference-count":50,"publisher":"Akademiai Kiado Zrt.","issue":"11","license":[{"start":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T00:00:00Z","timestamp":1773532800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2026,3,15]]},"abstract":"\n Bevezet\u00e9s:<\/jats:italic>\n Haz\u00e1nkban a tumoros betegek sz\u00e1m\u00e1ra fel\u00edrt er\u0151s\n opioidok mennyis\u00e9ge elmarad a nyugati orsz\u00e1gok \u00e1tlag\u00e1t\u00f3l, ami hozz\u00e1j\u00e1rulhat a\n betegek el\u00e9gtelen f\u00e1jdalomcsillap\u00edt\u00e1s\u00e1hoz. A WHO ir\u00e1nyelve els\u0151dlegesen\n v\u00e1lasztand\u00f3 gy\u00f3gyszerekk\u00e9nt a\n per os<\/jats:italic>\n k\u00e9sz\u00edtm\u00e9nyeket aj\u00e1nlja,\n ennek ellen\u00e9re d\u00f6nt\u0151 t\u00f6bbs\u00e9g\u00e9ben a betegek fentaniltartalm\u00fa tapaszt kapnak.\n C\u00e9lkit\u0171z\u00e9s:<\/jats:italic>\n A tumoros betegek sz\u00e1m\u00e1ra b\u00e1zis- \u00e9s \u00e1tt\u00f6r\u00e9ses\n f\u00e1jdalom csillap\u00edt\u00e1s\u00e1ra fel\u00edrt er\u0151s opioidok magyarorsz\u00e1gi gy\u00f3gyszerforgalmi\n adatainak (2010\u20132024), valamint a felhaszn\u00e1lt gy\u00f3gyszerek ter\u00fcleti megoszl\u00e1s\u00e1nak\n (2024) vizsg\u00e1lata.\n M\u00f3dszer:<\/jats:italic>\n A tumoros betegek sz\u00e1m\u00e1ra fel\u00edrt\n er\u0151s opioidok orsz\u00e1gos \u00e9s megy\u00e9nk\u00e9nti forgalmi adatainak elemz\u00e9s\u00e9t v\u00e9gezt\u00fck, az\n eredm\u00e9nyeket or\u00e1lis morfinekvivalens d\u00f3zisban megadva hasonl\u00edtottuk \u00f6ssze.\n Eredm\u00e9nyek:<\/jats:italic>\n 2010 \u00e9s 2024 k\u00f6z\u00f6tt az \u00f6sszes er\u0151s opioid\n mennyis\u00e9ge mintegy k\u00e9tharmad\u00e1ra cs\u00f6kkent. A b\u00e1zisszerek k\u00f6z\u00fcl cs\u00f6kkent a\n fentanil-, buprenorfintapasz, retard morfin-, hidromorfon-tabletta, n\u0151tt a\n retard oxikodontabletta felhaszn\u00e1l\u00e1sa. Az \u00e1tt\u00f6r\u00e9ses f\u00e1jdalomra haszn\u00e1lt\n gy\u00f3gyszerek k\u00f6z\u00fcl cs\u00f6kkent a morfininjekci\u00f3 \u00e9s -csepp, n\u00f6vekedett a gyors hat\u00e1s\u00fa\n morfin- \u00e9s oxikodontabletta mennyis\u00e9ge. A 2024-es \u00e9vben a fentaniltapasz\n 79,4%-ot, a retard oxikodon 16,7%-ot, a retard morfin 2,7%-ot, az \u00e1tt\u00f6r\u00e9ses\n f\u00e1jdalomra \u00edrt gy\u00f3gyszerek 1,25%-ot tettek ki. Region\u00e1lisan a fentaniltapasz\n egyenletes megoszl\u00e1sa l\u00e1tszott, ett\u0151l Baranya megye \u00e9s Budapest t\u00e9r el, ahol m\u00e1s\n gy\u00f3gyszerek is nagyobb mennyis\u00e9gben ker\u00fclnek fel\u00edr\u00e1sra. A retard morfin \u00e9s\n oxikodon felhaszn\u00e1l\u00e1sa igen nagy variabilit\u00e1st mutatott, az \u00e1tt\u00f6r\u00e9ses f\u00e1jdalomra\n haszn\u00e1lt gy\u00f3gyszerek fel\u00edr\u00e1sa j\u00f3r\u00e9szt Barany\u00e1ban t\u00f6rt\u00e9nt.\n Megbesz\u00e9l\u00e9s:<\/jats:italic>\n Az er\u0151s opioidok felhaszn\u00e1l\u00e1sa az elm\u00falt 15\n \u00e9vben cs\u00f6kkent. A legnagyobb mennyis\u00e9gben fentaniltapaszt \u00edrnak fel, az\n \u00e1tt\u00f6r\u00e9ses f\u00e1jdalom nagy prevalenci\u00e1ja ellen\u00e9re gyors hat\u00e1s\u00fa gy\u00f3gyszereket kis\n mennyis\u00e9gben haszn\u00e1lnak. A megfelel\u0151 f\u00e1jdalomcsillap\u00edt\u00e1s akad\u00e1lyai r\u00e9szben az\n eg\u00e9szs\u00e9g\u00fcgyi ell\u00e1t\u00f3k ismerethi\u00e1ny\u00e1b\u00f3l sz\u00e1rmazhatnak, az er\u0151s opioidok fel\u00edr\u00e1sa\n sokszor nem a szakmai ir\u00e1nyelveknek megfelel\u0151en, hanem a helyi szok\u00e1sok alapj\u00e1n\n t\u00f6rt\u00e9nik. Azokon a ter\u00fcleteken, ahol j\u00f3l szervezett palliat\u00edv ell\u00e1t\u00e1s m\u0171k\u00f6dik, a\n fel\u00edr\u00e1si gyakorlat jobban k\u00f6zel\u00edt a WHO-ir\u00e1nyelvek \u00e1ltal el\u0151\u00edrtakhoz.\n K\u00f6vetkeztet\u00e9s:<\/jats:italic>\n A tumoros betegek f\u00e1jdalomkontrollj\u00e1t\n jav\u00edtan\u00e1 integr\u00e1lt palliat\u00edv rendszerek kialak\u00edt\u00e1sa, az eg\u00e9szs\u00e9g\u00fcgyi szem\u00e9lyzet\n palliat\u00edv ir\u00e1ny\u00fa k\u00e9pz\u00e9se \u00e9s a gy\u00f3gyszerek folyamatos el\u00e9rhet\u0151s\u00e9g\u00e9nek\n biztos\u00edt\u00e1sa. Orv Hetil. 2026; 167(11): 419\u2013429.\n <\/jats:p>","DOI":"10.1556\/650.2026.33517","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T02:25:02Z","timestamp":1773627902000},"page":"419-429","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":0,"title":["A daganatos betegek b\u00e1zis- \u00e9s \u00e1tt\u00f6r\u00e9ses f\u00e1jdalmaira fel\u00edrt er\u0151s opioid gy\u00f3gyszerek hazai forgalmi adatainak elemz\u00e9se"],"prefix":"10.1556","volume":"167","author":[{"given":"Bal\u00e1zs D\u00e1niel","family":"F\u00fcl\u00f6p","sequence":"first","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Alapell\u00e1t\u00e1si Int\u00e9zet, Hospice-Palliat\u00edv Tansz\u00e9k P\u00e9cs, R\u00e1k\u00f3czi \u00fat 2., 7623 Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e1lint","family":"T\u00f3th","sequence":"additional","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Alapell\u00e1t\u00e1si Int\u00e9zet, Hospice-Palliat\u00edv Tansz\u00e9k P\u00e9cs, R\u00e1k\u00f3czi \u00fat 2., 7623 Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N\u00f3ra","family":"Frank","sequence":"additional","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Alapell\u00e1t\u00e1si Int\u00e9zet, Hospice-Palliat\u00edv Tansz\u00e9k P\u00e9cs, R\u00e1k\u00f3czi \u00fat 2., 7623 Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1gnes","family":"Csik\u00f3s","sequence":"additional","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Alapell\u00e1t\u00e1si Int\u00e9zet, Hospice-Palliat\u00edv Tansz\u00e9k P\u00e9cs, R\u00e1k\u00f3czi \u00fat 2., 7623 Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"R1","unstructured":"Hungarian Central Statistical Office Summary tables (STADAT)\n 4.1.1.27. Newly reported malignant tumors. [K\u00f6zponti Statisztikai Hivatal\n \u00d6sszefoglal\u00f3 t\u00e1bl\u00e1k (STADAT) 4.1.1.27. Bejelentett \u00faj rosszindulat\u00fa daganatos\n megbeteged\u00e9sek.] Available from:\n https:\/\/www.ksh.hu\/stadat_files\/ege\/hu\/ege0025.html [accessed:\n Nov 15, 2025]. [Hungarian]"},{"key":"R2","doi-asserted-by":"crossref","unstructured":"Hungarian Central Statistical Office Summary tables (STADAT)\n 22.1.1.10. Deaths by common causes and sex. [K\u00f6zponti Statisztikai Hivatal\n \u00d6sszefoglal\u00f3 t\u00e1bl\u00e1k (STADAT) 22.1.1.10. Hal\u00e1loz\u00e1sok a gyakoribb hal\u00e1lokok \u00e9s nem\n szerint.] Available from:\n https:\/\/www.ksh.hu\/stadat_files\/nep\/hu\/nep0010.html [accessed:\n Nov 15, 2025]. [Hungarian]\n https:\/\/doi.org\/10.30716\/RSZ\/25\/1\/1","DOI":"10.30716\/RSZ\/25\/1\/1"},{"key":"R3","doi-asserted-by":"crossref","unstructured":"Van den Beuken van Everdingen MH, Hochstenbach LM, Joosten EA, et\n al. Update on prevalence of pain in patients with cancer: systematic review and\n meta-analysis. J Pain Symptom Manage 2016; 51: 1070-1090. e9.\n https:\/\/doi.org\/10.1016\/j.jpainsymman.2015.12.340","DOI":"10.1016\/j.jpainsymman.2015.12.340"},{"key":"R4","doi-asserted-by":"crossref","unstructured":"Deandrea S, Corli O, Consonni D, et al. Prevalence of breakthrough\n cancer pain: a systematic review and a pooled analysis of published literature.\n J Pain Symptom Manage 2014; 47: 57-76.\n https:\/\/doi.org\/10.1016\/j.jpainsymman.2013.02.015","DOI":"10.1016\/j.jpainsymman.2013.02.015"},{"key":"R5","doi-asserted-by":"crossref","unstructured":"Portenoy RK, Payne D, Jacobsen P. Breakthrough pain: characteristics\n and impact in patients with cancer pain. Pain 1999; 81: 129-134.\n https:\/\/doi.org\/10.1016\/S0304-3959(99)00006-8","DOI":"10.1016\/S0304-3959(99)00006-8"},{"key":"R6","doi-asserted-by":"crossref","unstructured":"Portenoy RK, Hagen NA. Breakthrough pain: definition, prevalence and\n characteristics. Pain 1990; 41: 273-281.\n https:\/\/doi.org\/10.1016\/0304-3959(90)90004-W","DOI":"10.1016\/0304-3959(90)90004-W"},{"key":"R7","doi-asserted-by":"crossref","unstructured":"Neufeld NJ, Elnahal SM, Alvarez RH. Cancer pain: a review of\n epidemiology, clinical quality and value impact. Future Oncol. 2017; 13:\n 833-841. https:\/\/doi.org\/10.2217\/fon-2016-0423","DOI":"10.2217\/fon-2016-0423"},{"key":"R8","doi-asserted-by":"crossref","unstructured":"Ant\u00f3n A, Montalar J, Carulla J, et al. Pain in clinical oncology:\n patient satisfaction with management of cancer pain. Eur J Pain 2012; 16:\n 381-389.\n https:\/\/doi.org\/10.1002\/j.1532-2149.2011.00036.x","DOI":"10.1002\/j.1532-2149.2011.00036.x"},{"key":"R9","doi-asserted-by":"crossref","unstructured":"Kwon JH. Overcoming barriers in cancer pain management. J Clin\n Oncol. 2014; 32: 1727-1733.\n https:\/\/doi.org\/10.1200\/JCO.2013.52.4827","DOI":"10.1200\/JCO.2013.52.4827"},{"key":"R10","doi-asserted-by":"crossref","unstructured":"Wolfert MZ, Gilson AM, Dahl JL, et al. Opioid analgesics for pain\n control: Wisconsin physicians\u2019 knowledge, beliefs, attitudes, and prescribing\n practices. Pain Med. 2010; 11: 425-434.\n https:\/\/doi.org\/10.1111\/j.1526-4637.2009.00761.x","DOI":"10.1111\/j.1526-4637.2009.00761.x"},{"key":"R11","unstructured":"WHO guidelines for the pharmacological and radiotherapeutic\n management of cancer pain in adults and adolescents. World Health Organization,\n Geneva, 2018."},{"key":"R12","unstructured":"Decree No. 43\/2005 (October 15) of the Ministry of Health on the\n regulation of prescribing, pharmacy distribution, use, registration and storage\n of drugs classified as highly controlled substances. [43\/2005. (X. 15.) 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A kiemelt\n indik\u00e1ci\u00f3hoz k\u00f6t\u00f6tt t\u00e1mogat\u00e1si kateg\u00f3ri\u00e1ba tartoz\u00f3 gy\u00f3gyszerek, indik\u00e1ci\u00f3s\n ter\u00fcletek \u00e9s a fel\u00edr\u00e1sra jogosultak k\u00f6re.] Available from:\n https:\/\/neak.gov.hu\/eupontok [accessed: Dec 20, 2025].\n [Hungarian]"},{"key":"R14","doi-asserted-by":"crossref","unstructured":"Bosetti C, Santucci C, Radrezza S, et al. Trends in the consumption\n of opioids for the treatment of severe pain in Europe, 1990-2016. Eur J Pain\n 2019; 23: 697-707. https:\/\/doi.org\/10.1002\/ejp.1337","DOI":"10.1002\/ejp.1337"},{"key":"R15","unstructured":"International Narcotics Control Board. Narcotic drugs 2023:\n estimated world requirements for 2024: statistics for 2022. United Nations,\n Vienna, 2024."},{"key":"R16","doi-asserted-by":"crossref","unstructured":"B\u00e4ckryd E, Heilig M, Hoffmann M. 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A n\u00e9pess\u00e9g,\n n\u00e9pmozgalom f\u0151bb mutat\u00f3i.] Available from:\n https:\/\/www.ksh.hu\/stadat_files\/nep\/hu\/nep0001.html [accessed:\n Jun 9, 2025]. [Hungarian]"},{"key":"R22","unstructured":"WHO Collaborating Centre for Drug Statistics Methodology. Available\n from: https:\/\/atcddd.fhi.no\/copyright_disclaimer\/ [accessed: Dec 15,\n 2025]."},{"key":"R23","unstructured":"Caraceni A, Hanks G, Kaasa S, et al.; European Palliative Care\n Research Collaborative (EPCRC); European Association for Palliative Care (EAPC).\n Use of opioid analgesics in the treatment of cancer pain: evidence-based\n recommendations from the EAPC. Lancet Oncol. 2012; 13: e58-e68."},{"key":"R24","doi-asserted-by":"crossref","unstructured":"Hanks GW, Conno F, Cherny N, et al. Expert Working Group of the\n Research Network of the European Association for Palliative Care. Morphine and\n alternative opioids in cancer pain: the EAPC recommendations. 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