{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T02:08:04Z","timestamp":1780970884731,"version":"3.54.1"},"reference-count":38,"publisher":"Akademiai Kiado Zrt.","issue":"21","content-domain":{"domain":["www.akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2026,5,24]]},"abstract":"<jats:p>\n                    <jats:italic>Bevezet\u00e9s:<\/jats:italic>\n                    A perziszt\u00e1l\u00f3 pulmonalis hypertoni\u00e1ban szenved\u0151\n                    \u00fajsz\u00fcl\u00f6ttek ell\u00e1t\u00e1sa kiemelt jelent\u0151s\u00e9g\u0171. Azonnali helysz\u00edni intenz\u00edv ell\u00e1t\u00e1st\n                    ig\u00e9nyelnek, amelyet a transzport alatt is folytatni kell a h\u00e1rmas szint\u0171\n                    region\u00e1lis k\u00f6zpontba t\u00f6rt\u00e9n\u0151 meg\u00e9rkez\u00e9sig. Az inhal\u00e1lt nitrog\u00e9n-monoxid hat\u00e9kony\n                    pulmonalis vasodilatator, amelynek transzport alatti alkalmaz\u00e1sa seg\u00edts\u00e9get\n                    ny\u00fajthat a pulmonalis hypertonia kezel\u00e9s\u00e9ben \u00e9s a megfelel\u0151 g\u00e1zcsere\n                    biztos\u00edt\u00e1s\u00e1ban az intenz\u00edv oszt\u00e1lyon t\u00f6rt\u00e9n\u0151 \u00e1tad\u00e1sig. A Peter Cerny Alap\u00edtv\u00e1nyi\n                    Ment\u0151szolg\u00e1lat 2018. m\u00e1rcius \u00f3ta alkalmaz az orsz\u00e1gban egyed\u00fclik\u00e9nt inhal\u00e1lt\n                    nitrog\u00e9n-monoxid kezel\u00e9st neonatalis transzport sor\u00e1n.\n                    <jats:italic>C\u00e9lkit\u0171z\u00e9s:<\/jats:italic>\n                    Az inhal\u00e1lt nitrog\u00e9n-monoxid alkalmaz\u00e1s\u00e1nak\n                    vizsg\u00e1lata a definit\u00edv helysz\u00edni ell\u00e1t\u00e1s \u00e9s a neonatalis transzport sor\u00e1n.\n                    <jats:italic>M\u00f3dszer:<\/jats:italic>\n                    Retrospekt\u00edv kohorszvizsg\u00e1latunkban a 2018.\n                    m\u00e1rcius \u00e9s 2025. m\u00e1rcius k\u00f6z\u00f6tt sz\u00fcletett \u00e9s a Peter Cerny Alap\u00edtv\u00e1nyi\n                    Ment\u0151szolg\u00e1lat \u00e1ltal sz\u00e1ll\u00edtott, inhal\u00e1lt nitrog\u00e9n-monoxid ter\u00e1pi\u00e1ban r\u00e9szes\u00fclt\n                    \u00fajsz\u00fcl\u00f6ttek adatait elemezt\u00fck. Kiz\u00e1rtunk 5 beteget, akik postnatalis \u00e9letkora az\n                    1 hetet vagy posztmenstru\u00e1ci\u00f3s \u00e9letkora a 46 hetet meghaladta, valamint tov\u00e1bbi\n                    3 beteget, akik eset\u00e9ben a l\u00e9legeztet\u00e9si adatok egy r\u00e9sze hi\u00e1nyzott.\n                    <jats:italic>Eredm\u00e9nyek:<\/jats:italic>\n                    Elemz\u00e9s\u00fcnk \u00f6sszesen 41 esetet foglalt mag\u00e1ban.\n                    A vizsg\u00e1lt \u00fajsz\u00fcl\u00f6ttek \u00e1tlagos gestati\u00f3s kora 38 (tartom\u00e1ny: 28\u201341) h\u00e9t volt. A\n                    leggyakoribb els\u0151dleges diagn\u00f3zis a meconiumaspirati\u00f3s szindr\u00f3ma volt (n = 19),\n                    ezt k\u00f6vette a velesz\u00fcletett rekeszs\u00e9rv (n = 7). A sz\u00e1ll\u00edt\u00e1st megel\u0151z\u0151en 21\n                    csecsem\u0151 (51%) r\u00e9szes\u00fclt surfactantkezel\u00e9sben. 8 sz\u00e1ll\u00edt\u00e1s az ell\u00e1t\u00e1si r\u00e9gi\u00f3n\n                    k\u00edv\u00fclr\u0151l t\u00f6rt\u00e9nt. 9 esetben a helyi ell\u00e1t\u00f3szem\u00e9lyzet ind\u00edtotta el a kezel\u00e9st, a\n                    t\u00f6bbi esetben az \u00fajsz\u00fcl\u00f6ttsz\u00e1ll\u00edt\u00f3 rohamkocsi szem\u00e9lyzete kezdte meg a ter\u00e1pi\u00e1t,\n                    a betegek t\u00f6bb mint egyharmad\u00e1n\u00e1l 6 \u00f3r\u00e1s \u00e9letkor el\u0151tt. 24 esetben (58%) a\n                    beteget nagyfrekvenci\u00e1s oszcill\u00e1ci\u00f3s l\u00e9legeztet\u00e9ssel sz\u00e1ll\u00edtott\u00e1k a fogad\u00f3\n                    oszt\u00e1lyra. Az inhal\u00e1lt nitrog\u00e9n-monoxid kezel\u00e9sre 14 \u00fajsz\u00fcl\u00f6tt (43,7%) reag\u00e1lt\n                    legal\u00e1bb 20%-os oxig\u00e9nig\u00e9ny-cs\u00f6kken\u00e9ssel a transzport v\u00e9g\u00e9n. 3 esetben\n                    extracorporalis membr\u00e1noxigeniz\u00e1ci\u00f3s kezel\u00e9sre ker\u00fclt sor a sz\u00e1ll\u00edt\u00e1st k\u00f6vet\u0151en.\n                    <jats:italic>Megbesz\u00e9l\u00e9s \u00e9s k\u00f6vetkeztet\u00e9s:<\/jats:italic>\n                    A transzport alatt\n                    alkalmazott inhal\u00e1lt nitrog\u00e9n-monoxid kezel\u00e9s biztons\u00e1ggal kivitelezhet\u0151 \u00e9s\n                    hat\u00e9kony seg\u00edts\u00e9get ny\u00fajt a kritikus \u00e1llapot\u00fa \u00fajsz\u00fcl\u00f6ttek definit\u00edv helysz\u00edni\n                    intenz\u00edv oszt\u00e1lyos ell\u00e1t\u00e1s\u00e1nak bevezet\u00e9s\u00e9re \u00e9s fenntart\u00e1s\u00e1ra a region\u00e1lis\n                    k\u00f6zpontban val\u00f3 \u00e1tad\u00e1sig. Orv Hetil. 2026; 167(21): 824\u2013832.\n                  <\/jats:p>","DOI":"10.1556\/650.2026.33539","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T06:47:49Z","timestamp":1779778069000},"page":"824-832","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":1,"title":["Inhal\u00e1lt nitrog\u00e9n-monoxid alkalmaz\u00e1sa neonatalis transzport sor\u00e1n \u2013 h\u00e9t \u00e9v tapasztalatainak \u00e1ttekint\u00e9se"],"prefix":"10.1556","volume":"167","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0903-7044","authenticated-orcid":true,"given":"Lajos","family":"Lantos","sequence":"first","affiliation":[{"name":"Peter Cerny Alap\u00edtv\u00e1ny Budapest Magyarorsz\u00e1g"},{"name":"Maternity Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Mag\u00e1nklinika Budapest Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsolt","family":"Somogyv\u00e1ri","sequence":"additional","affiliation":[{"name":"Peter Cerny Alap\u00edtv\u00e1ny Budapest Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e1s","family":"Sz\u00e9ll","sequence":"additional","affiliation":[{"name":"Peter Cerny Alap\u00edtv\u00e1ny Budapest Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guszt\u00e1v","family":"B\u00e9lteki","sequence":"additional","affiliation":[{"name":"Peter Cerny Alap\u00edtv\u00e1ny Budapest Magyarorsz\u00e1g"},{"name":"Neonatal Intensive Care Unit, Cambridge University Hospitals NHS Trust Cambridge Egyes\u00fclt Kir\u00e1lys\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"R1","doi-asserted-by":"crossref","unstructured":"Gersony WM. Persistence of the fetal circulation: a commentary. J\n                    Pediatr. 1973; 82: 1103-1106.\n                        https:\/\/doi.org\/10.1016\/S0022-3476(73)80472-X","DOI":"10.1016\/S0022-3476(73)80472-X"},{"key":"R2","doi-asserted-by":"crossref","unstructured":"Walsh-Sukys MC, Tyson JE, Wright LL, et al. Persistent pulmonary\n                    hypertension of the newborn in the era before nitric oxide: practice variation\n                    and outcomes. Pediatrics 2000; 105: 14-20.\n                        https:\/\/doi.org\/10.1542\/peds.105.1.14","DOI":"10.1542\/peds.105.1.14"},{"key":"R3","doi-asserted-by":"crossref","unstructured":"Sharma M, Mohan KR, Narayan S, et al. Persistent pulmonary\n                    hypertension of the newborn: a review. 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Persistent pulmonary\n                    hypertension of the newborn: pathophysiological mechanisms and novel therapeutic\n                    approaches. Front Pediatr. 2020; 8: 342.\n                        https:\/\/doi.org\/10.3389\/fped.2020.00342","DOI":"10.3389\/fped.2020.00342"},{"key":"R7","doi-asserted-by":"crossref","unstructured":"Sankaran D, Lakshminrusimha S. Pulmonary hypertension in the\n                    newborn- etiology and pathogenesis. Semin Fetal Neonatal Med. 2022; 27: 101381.\n                        https:\/\/doi.org\/10.1016\/j.siny.2022.101381","DOI":"10.1016\/j.siny.2022.101381"},{"key":"R8","doi-asserted-by":"crossref","unstructured":"Steurer MA, Jelliffe-Pawlowski LL, Baer RJ, et al. Persistent\n                    pulmonary hypertension of the newborn in late preterm and term infants in\n                    California. 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Persistent pulmonary\n                    hypertension of the newborn with transposition of the great arteries. Ann Thorac\n                    Surg. 2007; 83: 1446-1450.\n                        https:\/\/doi.org\/10.1016\/j.athoracsur.2006.11.001","DOI":"10.1016\/j.athoracsur.2006.11.001"},{"key":"R12","doi-asserted-by":"crossref","unstructured":"Lakshminrusimha S, Konduri GG, Steinhorn RH. Considerations in the\n                    management of hypoxemic respiratory failure and persistent pulmonary\n                    hypertension in term and late preterm neonates. J Perinatol. 2016; 36(Suppl 2):\n                    S12-S19. https:\/\/doi.org\/10.1038\/jp.2016.44","DOI":"10.1038\/jp.2016.44"},{"key":"R13","doi-asserted-by":"crossref","unstructured":"Singh Y, Lakshminrusimha S. Pathophysiology and management of\n                    persistent pulmonary hypertension of the newborn. 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Inhaled nitric oxide and\n                    persistent pulmonary hypertension of the newborn. The Inhaled Nitric Oxide Study\n                    Group. N Engl J Med. 1997; 336: 605-610.\n                        https:\/\/doi.org\/10.1056\/NEJM199702273360902","DOI":"10.1056\/NEJM199702273360902"},{"key":"R17","doi-asserted-by":"crossref","unstructured":"Biban P, Trevisanuto D, Pettenazzo A, et al. Inhaled nitric oxide in\n                    hypoxaemic newborns who are candidates for extracorporeal life support. Eur\n                    Respir J. 1998; 11: 371-376.\n                        https:\/\/doi.org\/10.1183\/09031936.98.11020371","DOI":"10.1183\/09031936.98.11020371"},{"key":"R18","doi-asserted-by":"crossref","unstructured":"Lutz T, Berry A, McGillivray A, et al. Neonatal hypoxic respiratory\n                    failure: referral for ECMO. 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[A neonatol\u00f3giai ell\u00e1t\u00e1s mennyis\u00e9gi \u00e9s min\u0151s\u00e9gi\n                    mutat\u00f3i a Maternity Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Mag\u00e1nklinik\u00e1n 2023-ban.] Orv\n                    Hetil. 2025; 166: 658-668. [Hungarian]\n                        https:\/\/doi.org\/10.1556\/650.2025.33284","DOI":"10.1556\/650.2025.33284"},{"key":"R32","doi-asserted-by":"crossref","unstructured":"Konduri GG, Vohr B, Robertson C, et al. Neonatal inhaled nitric\n                    oxide study group. Early inhaled nitric oxide therapy for term and near-term\n                    newborn infants with hypoxic respiratory failure: neurodevelopmental follow-up.\n                    J Pediatr. 2007; 150: 235-240.\n                        https:\/\/doi.org\/10.1016\/j.jpeds.2006.11.065","DOI":"10.1016\/j.jpeds.2006.11.065"},{"key":"R33","doi-asserted-by":"crossref","unstructured":"Nelin LD, Potenziano JL. 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J Perinatol. 2013; 33:\n                    944-949. https:\/\/doi.org\/10.1038\/jp.2013.83","DOI":"10.1038\/jp.2013.83"},{"key":"R38","doi-asserted-by":"crossref","unstructured":"McNamara PJ, Jain A, El-Khuffash A, et al. Guidelines and\n                    recommendations for targeted neonatal echocardiography and cardiac point-of-care\n                    ultrasound in the neonatal intensive care unit: an update from the American\n                    Society of Echocardiography. J Am Soc Echocardiogr. 2024; 37: 171-215. Erratum:\n                    J Am Soc Echocardiogr. 2024; 37: 722.\n                        https:\/\/doi.org\/10.1016\/j.echo.2023.11.016","DOI":"10.1016\/j.echo.2023.11.016"}],"container-title":["Orvosi Hetilap"],"original-title":[],"link":[{"URL":"https:\/\/www.akjournals.com\/view\/journals\/650\/167\/21\/article-p824.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.akjournals.com\/downloadpdf\/journals\/650\/167\/21\/article-p824.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.akjournals.com\/downloadpdf\/journals\/650\/167\/21\/article-p824.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T06:48:04Z","timestamp":1779778084000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.akjournals.com\/view\/journals\/650\/167\/21\/article-p824.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,24]]},"references-count":38,"journal-issue":{"issue":"21"},"URL":"https:\/\/doi.org\/10.1556\/650.2026.33539","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,24]]}}}