{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T13:11:39Z","timestamp":1785503499198,"version":"3.56.0"},"reference-count":68,"publisher":"Akademiai Kiado Zrt.","issue":"17","license":[{"start":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T00:00:00Z","timestamp":1777161600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2026,4,26]]},"abstract":"\n A Hashimoto-thyreoiditis az autoimmun pajzsmirigy-k\u00e1rosod\u00e1s leggyakoribb form\u00e1ja,\n amelyben az immunrendszer t\u00f6bb t\u00e1mad\u00e1sponton kereszt\u00fcl kr\u00f3nikus limfocit\u00e1s\n gyullad\u00e1st, a pajzsmirigy-folliculusok destrukci\u00f3j\u00e1t, v\u00e9gs\u0151 soron pedig\n hypothyreosist id\u00e9z el\u0151. A k\u00f3rk\u00e9p kialakul\u00e1s\u00e1ban a genetikai hajlam,\n epigenetikai v\u00e1ltoz\u00e1sok mellett k\u00f6rnyezeti hat\u00e1sok \u00e9s gy\u00f3gyszerek egyar\u00e1nt\n szerepet kapnak. Jelent\u0151s patogenetikai t\u00e9nyez\u0151 a pajzsmirigyben fokoz\u00f3d\u00f3\n H\n 2<\/jats:sub>\n O\n 2<\/jats:sub>\n termel\u00e9s, a gyenge antioxid\u00e1ns enzimatikus\n v\u00e9delem, a j\u00f3d- \u00e9s f\u00e9mion-koncentr\u00e1ci\u00f3k egyens\u00faly\u00e1nak, valamint a\n j\u00f3dtironin-dejodin\u00e1z enzimek finom szab\u00e1lyoz\u00e1s\u00e1nak zavara. Immunol\u00f3giai\n szempontb\u00f3l a sejtes immunv\u00e1lasz dominanci\u00e1ja figyelhet\u0151 meg, a gyullad\u00e1sos\n citokinek t\u00faltermel\u0151d\u00e9s\u00e9vel. Megjelennek a tireoperoxid\u00e1z- \u00e9s\n tireoglobulin-ellenes, valamint ritk\u00e1bban a thyreoideastimul\u00e1l\u00f3 hormon\n receptor\u00e1val szembeni autoantitestek. E komplex elt\u00e9r\u00e9sek egy\u00fcttesen teszik a\n Hashimoto-thyreoiditist \u00e9rz\u00e9keny, t\u00f6bbszint\u0171 immunoendokrin betegs\u00e9gg\u00e9. Az\n autoimmun pajzsmirigybetegs\u00e9gek elt\u00e9r\u0151 klinikai megjelen\u00e9si form\u00e1i ellen\u00e9re\n egyre t\u00f6bb bizony\u00edt\u00e9k utal k\u00f6z\u00f6s immunol\u00f3giai h\u00e1tt\u00e9rre. Orv Hetil. 2026;\n 167(17): 673\u2013681.\n <\/jats:p>","DOI":"10.1556\/650.2026.33547","type":"journal-article","created":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T02:28:42Z","timestamp":1777688922000},"page":"673-681","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":0,"title":["A redox-homeostasist befoly\u00e1sol\u00f3 t\u00e9nyez\u0151k Hashimoto-thyreoiditisben"],"prefix":"10.1556","volume":"167","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9781-8906","authenticated-orcid":true,"given":"Anna","family":"Bl\u00e1zovics","sequence":"first","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, K\u00eds\u00e9rletes Kardiol\u00f3giai \u00e9s Seb\u00e9szeti M\u0171t\u00e9ttani Tansz\u00e9k Budapest, Nagyv\u00e1rad t\u00e9r 4., 1089 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"R1","doi-asserted-by":"crossref","unstructured":"Rigutto S, Hoste C, Grasberger H, et al. 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