{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T08:46:32Z","timestamp":1791708392458,"version":"4.3.4"},"reference-count":16,"publisher":"Akademiai Kiado Zrt.","issue":"41","license":[{"start":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T00:00:00Z","timestamp":1791676800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2026,10,11]]},"abstract":"<jats:p>A kr\u00f3nikus obstrukt\u00edv t\u00fcd\u0151betegs\u00e9g (COPD) heterog\u00e9n, a l\u00e9gutak \u00e9s a\n                    t\u00fcd\u0151parenchyma gyullad\u00e1s\u00e1val \u00e9s perziszt\u00e1l\u00f3 l\u00e9g\u00fati t\u00fcnetekkel (l\u00e9gszomj,\n                    k\u00f6h\u00f6g\u00e9s) j\u00e1r\u00f3 betegs\u00e9g. Glob\u00e1lis n\u00e9pbetegs\u00e9g, amely a 40 \u00e9v feletti lakoss\u00e1g\n                    mintegy 10,3%-\u00e1t \u00e9rinti, \u00e9s a n\u00f6vekv\u0151 mortalit\u00e1si tendenci\u00e1t mutat\u00f3 vezet\u0151\n                    hal\u00e1lokok k\u00f6z\u00e9 tartozik. Magyarorsz\u00e1gon a felt\u00e9telezett val\u00f3s betegsz\u00e1m a\n                    nyilv\u00e1ntartott adatok mintegy h\u00e1romszorosa. A COPD jelent\u0151s gazdas\u00e1gi terhet\n                    jelent, els\u0151sorban az akut exacerbati\u00f3k k\u00f3rh\u00e1zi ell\u00e1t\u00e1s\u00e1b\u00f3l fakad\u00f3an. A kr\u00f3nikus\n                    gyullad\u00e1s sziszt\u00e9m\u00e1s k\u00f6vetkezm\u00e9nyei hozz\u00e1j\u00e1rulnak a gyakori komorbidit\u00e1sok\n                    (p\u00e9ld\u00e1ul atherosclerosis, sz\u00edvel\u00e9gtelens\u00e9g) kialakul\u00e1s\u00e1hoz. A stabil COPD\n                    kezel\u00e9s\u00e9nek c\u00e9lja a t\u00fcnetek cs\u00f6kkent\u00e9se, az \u00e9letmin\u0151s\u00e9g jav\u00edt\u00e1sa \u00e9s a\n                    progresszi\u00f3 meg\u00e1ll\u00edt\u00e1sa. A kezel\u00e9s alappill\u00e9rei a doh\u00e1nyz\u00e1sr\u00f3l val\u00f3 leszok\u00e1s, a\n                    fenntart\u00f3 inhal\u00e1ci\u00f3s farmakoter\u00e1pia, valamint a nem farmakoter\u00e1pi\u00e1s\n                    beavatkoz\u00e1sok. Ez ut\u00f3bbiak k\u00f6z\u00e9 tartozik az adekv\u00e1t indik\u00e1ci\u00f3 alapj\u00e1n folytatott\n                    l\u00e9gz\u00e9si rehabilit\u00e1ci\u00f3, a hossz\u00fa t\u00e1v\u00fa otthoni oxig\u00e9nter\u00e1pia \u00e9s a nem invaz\u00edv\n                    l\u00e9legeztet\u00e9s, valamint szelekt\u00e1lt esetekben a t\u00fcd\u0151t\u00e9rfogat-cs\u00f6kkent\u0151\n                    intervenci\u00f3k \u00e9s a t\u00fcd\u0151transzplant\u00e1ci\u00f3. Az optim\u00e1lis, egy\u00e9nre szabott ter\u00e1pia\n                    megv\u00e1laszt\u00e1sa, a betegek j\u00f3 ter\u00e1pi\u00e1s adherenci\u00e1ja jav\u00edtja a betegek t\u00fal\u00e9l\u00e9s\u00e9t.\n                    Orv Hetil. 2026; 167(41): 1639\u20131645.<\/jats:p>","DOI":"10.1556\/650.2026.33585","type":"journal-article","created":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T08:00:07Z","timestamp":1791705607000},"page":"1639-1645","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":0,"title":["A kr\u00f3nikus obstrukt\u00edv t\u00fcd\u0151betegs\u00e9g kezel\u00e9s\u00e9nek alapelvei"],"prefix":"10.1556","volume":"167","author":[{"given":"Bendeg\u00faz","family":"Sramk\u00f3","sequence":"first","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Budapest Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2444-9040","authenticated-orcid":true,"given":"Zs\u00f3fia","family":"L\u00e1z\u00e1r","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Pulmonol\u00f3giai Klinika Budapest, T\u00f6m\u0151 utca 25\u201329., 1083 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"R1","unstructured":"Global Initiative for Chronic Obstructive Lung Disease. 2026 GOLD\n                    Report and Pocket Guide. Global strategy for prevention, diagnosis and\n                    management of COPD: 2026 Report. Available from:\n                        https:\/\/goldcopd.org\/2026-gold-report-and-pocket-guide\/\n                    [accessed: Dec 19, 2025]."},{"key":"R2","unstructured":"Antus B. Chronic obstructive pulmonary disease (COPD). Kr\u00f3nikus\n                    obstrukit\u00edv t\u00fcd\u0151betegs\u00e9g (COPD). Kor\u00e1nyi Bull. 2025; 1: 25-31.\n                    [Hungarian]"},{"key":"R3","unstructured":"Hungarian Central Statistical Office. Deaths by common causes of\n                    death and sex. [K\u00f6zponti Statisztikai Hivatal. Hal\u00e1loz\u00e1sok a gyakoribb hal\u00e1lokok\n                    \u00e9s nem szerint.] Available from:\n                        https:\/\/www.ksh.hu\/stadat_files\/nep\/hu\/nep0010.html [accessed:\n                    Dec 19, 2025]. 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Eg\u00e9szs\u00e9g\u00fcgyi\n                    szakmai ir\u00e1nyelv a kr\u00f3nikus obstrukt\u00edv t\u00fcd\u0151betegs\u00e9g (chronic obstructive\n                    pulmonary disease - COPD) diagnosztik\u00e1j\u00e1r\u00f3l, kezel\u00e9s\u00e9r\u0151l \u00e9s gondoz\u00e1s\u00e1r\u00f3l.]\n                    Available from:\n                        https:\/\/www.neak.gov.hu\/preview\/pfile\/file?path=\/letoltheto\/EOSZEF_letoltheto_doku\/002230-2024-a-kronikus-obstruktiv-tudobetegseg-chronic-obstructive-pulmonary-disease--copd-diagnosztikajarol-kezeleserol-es-gondozasarol&inline=true\n                    [accessed: Dec 19, 2025]. [Hungarian]."},{"key":"R6","unstructured":"Kov\u00e1cs T, Nagy E, S\u00e1nta B, et al. The management of COPD on the\n                    basis of international and domestic professional healthcare guideline. [A COPD\n                    menedzsmentje a nemzetk\u00f6zi \u00e9s hazai ir\u00e1nyelvek t\u00fckr\u00e9ben.] Med Thorac. 2025; 78:\n                    99-107. [Hungarian]"},{"key":"R7","doi-asserted-by":"crossref","unstructured":"L\u00e1z\u00e1r Z, Horv\u00e1th A, Tomisa G, et al. Impact of clinical factors on\n                    generic and disease-specific quality of life in COPD and asthma-COPD overlap\n                    with exacerbations. Pulm Med. 2020; 2020: 6164343.\n                        https:\/\/doi.org\/10.1155\/2020\/6164343","DOI":"10.1155\/2020\/6164343"},{"key":"R8","doi-asserted-by":"crossref","unstructured":"Csoma B, Bikov A, Nagy L, et al. Dysregulation of the endothelial\n                    nitric oxide pathway is associated with airway inflammation in COPD. Respir Res.\n                    2019; 20: 156.\n                    https:\/\/doi.org\/10.1186\/s12931-019-1133-8","DOI":"10.1186\/s12931-019-1133-8"},{"key":"R9","doi-asserted-by":"crossref","unstructured":"Csoma B, Bikov A, T\u00f3th F, et al. Blood eosinophils on hospital\n                    admission for COPD exacerbation do not predict the recurrence of moderate and\n                    severe relapses. ERJ Open Res. 2021; 7: 00543-2020.\n                        https:\/\/doi.org\/10.1183\/23120541.00543-2020","DOI":"10.1183\/23120541.00543-2020"},{"key":"R10","doi-asserted-by":"crossref","unstructured":"Csoma B, Vulpi MR, Dragonieri S, et al. Hypercapnia in COPD: causes,\n                    consequences, and therapy. J Clin Med. 2022; 11: 3180.\n                        https:\/\/doi.org\/10.3390\/jcm11113180","DOI":"10.3390\/jcm11113180"},{"key":"R11","doi-asserted-by":"crossref","unstructured":"Vincze K, Bir\u00f3 M, Kamocsai M, et al. Epidemiological and treatment\n                    characteristics of patients with chronic obstructive pulmonary disease on\n                    maintenance inhaled therapy between 2011 and 2019 in Hungary. [A kr\u00f3nikus\n                    obstrukt\u00edv t\u00fcd\u0151betegs\u00e9g miatt fenntart\u00f3 inhal\u00e1ci\u00f3s kezel\u00e9sben r\u00e9szes\u00fclt betegek\n                    epidemiol\u00f3giai \u00e9s ter\u00e1pi\u00e1s jellemz\u0151i 2011 \u00e9s 2019 k\u00f6z\u00f6tt Magyarorsz\u00e1gon.] Orv\n                    Hetil. 2024; 165: 338-345. [Hungarian]\n                        https:\/\/doi.org\/10.1556\/650.2024.32981","DOI":"10.1556\/650.2024.32981"},{"key":"R12","unstructured":"Ministry of Interior - State Secretariat for Health, Professional\n                    College for Healthcare. Hungarian protocol on supporting smoking cessation.\n                    [Bel\u00fcgyminiszt\u00e9rium - Eg\u00e9szs\u00e9g\u00fcgyi \u00c1llamtitk\u00e1rs\u00e1g, Eg\u00e9szs\u00e9g\u00fcgyi Szakmai\n                    Koll\u00e9gium. Eg\u00e9szs\u00e9g\u00fcgyi szakmai ir\u00e1nyelv - A doh\u00e1nyz\u00e1sr\u00f3l val\u00f3 leszok\u00e1s\n                    t\u00e1mogat\u00e1s\u00e1r\u00f3l.] Available from:\n                        https:\/\/www.neak.gov.hu\/pfile\/file?path=\/letoltheto\/EOSZEF_letoltheto_doku\/002218-2024-a-dohanyzasrol-valo-leszokas-tamogatasarol&inline=true\n                    [accessed: Dec 19, 2025]. [Hungarian]"},{"key":"R13","doi-asserted-by":"crossref","unstructured":"Fekete M, P\u00e1k\u00f3 J, Sz\u0151ll\u0151si G, et al. Significance of nutritional\n                    status in chronic obstructive pulmonary disease: a survey. [A t\u00e1pl\u00e1lts\u00e1gi\n                    \u00e1llapot felm\u00e9r\u00e9se \u00e9s jelent\u0151s\u00e9ge kr\u00f3nikus obstrukt\u00edv t\u00fcd\u0151betegs\u00e9gben.] Orv\n                    Hetil. 2020; 161: 1711-1719. [Hungarian]\n                        https:\/\/doi.org\/10.1556\/650.2020.31824","DOI":"10.1556\/650.2020.31824"},{"key":"R14","doi-asserted-by":"crossref","unstructured":"Fekete M, Sz\u00f6ll\u0151si G, N\u00e9meth AN, et al. Clinical value of omega-3\n                    polyunsaturated fatty acid supplementation in chronic obstructive pulmonary\n                    disease. [Az \u00f3mega-3 zs\u00edrsavak p\u00f3tl\u00e1s\u00e1nak klinikai \u00e9rt\u00e9ke kr\u00f3nikus obstrukt\u00edv\n                    t\u00fcd\u0151betegs\u00e9gben.] Orv Hetil. 2021; 162: 23-30. [Hungarian]\n                        https:\/\/doi.org\/10.1556\/650.2021.31973","DOI":"10.1556\/650.2021.31973"},{"key":"R15","doi-asserted-by":"crossref","unstructured":"Lindenauer PK, Stefan MS, Pekow PS, et al. Association between\n                    initiation of pulmonary rehabilitation after hospitalization for COPD and 1-year\n                    survival among medicare beneficiaries. JAMA 2020; 323: 1813-1823.\n                        https:\/\/doi.org\/10.1001\/jama.2020.4437","DOI":"10.1001\/jama.2020.4437"},{"key":"R16","doi-asserted-by":"crossref","unstructured":"Gieszer B, Radeczky P, Ghimessy A, et al. The start of the Hungarian\n                    lung transplantation program and the first results. [A magyar\n                    t\u00fcd\u0151transzplant\u00e1ci\u00f3s program indul\u00e1sa \u00e9s els\u0151 eredm\u00e9nyei.] Orv Hetil. 2018; 159:\n                    1859-1868. 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