{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T15:00:47Z","timestamp":1785510047127,"version":"3.56.0"},"reference-count":53,"publisher":"Akademiai Kiado Zrt.","issue":"26","license":[{"start":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T00:00:00Z","timestamp":1782604800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2026,6,28]]},"abstract":"<jats:p>Az elh\u00edz\u00e1s k\u00f6zponti szerepet j\u00e1tszik az obstrukt\u00edv alv\u00e1si apnoe\n                    patomechanizmus\u00e1ban, \u00e9s szoros \u00f6sszef\u00fcgg\u00e9st mutat az alv\u00e1s alatt jelentkez\u0151\n                    l\u00e9gz\u00e9szavar s\u00falyoss\u00e1g\u00e1val. Az elh\u00edzott p\u00e1ciensek tests\u00falycs\u00f6kken\u00e9se\n                    bizony\u00edtottan m\u00e9rs\u00e9kli az apnoe-hypopnoe indexet (AHI), jav\u00edtja az\n                    alv\u00e1sstrukt\u00far\u00e1t, \u00e9s cs\u00f6kkenti a kardiometabolikus kock\u00e1zatot. A hagyom\u00e1nyos,\n                    szakmaspecifikus betegell\u00e1t\u00e1si gyakorlat azonban nem kezeli integr\u00e1lt m\u00f3don az\n                    alv\u00e1s- \u00e9s az anyagcserezavarokat, \u00e9s a pozit\u00edv l\u00e9g\u00fati nyom\u00e1s\u00fa (PAP-) kezel\u00e9s\n                    mellett a s\u00falymenedzsment gyakran kisebb figyelmet kap az obstrukt\u00edv alv\u00e1si\n                    apnoe ell\u00e1t\u00e1s\u00e1ban. Mivel az inkretinalap\u00fa ter\u00e1pi\u00e1k \u2013 k\u00fcl\u00f6n\u00f6sen a gl\u00fckagonszer\u0171\n                    peptid-1 (GLP1) \u00e9s a kett\u0151s GLP1\/gl\u00fck\u00f3zdependens insulinotrop polipeptid (GIP)\n                    receptor agonist\u00e1k \u2013 \u00edg\u00e9retes eredm\u00e9nyeket mutattak az elh\u00edz\u00e1s kezel\u00e9s\u00e9ben, ezek\n                    a gy\u00f3gyszerek fokozott \u00e9rdekl\u0151d\u00e9st v\u00e1ltottak ki az obstrukt\u00edv alv\u00e1si apnoe\n                    ter\u00e1pi\u00e1j\u00e1val kapcsolatban is. Randomiz\u00e1lt klinikai vizsg\u00e1latokra alapul\u00f3,\n                    szakirodalmi elemz\u00e9s\u00fcnk r\u00e1mutat, hogy a GLP1\/GIP receptor agonista ter\u00e1pia a\n                    tests\u00falycs\u00f6kkent\u00e9s mellett az alv\u00e1s alatti l\u00e9gz\u00e9szavart is m\u00e9rs\u00e9kli obstrukt\u00edv\n                    alv\u00e1si apno\u00e9ban, amit az AHI cs\u00f6kken\u00e9se jelez. Tov\u00e1bbi kedvez\u0151 szempont, hogy a\n                    tests\u00falycs\u00f6kkent\u00e9s az obstrukt\u00edv alv\u00e1si apnoe s\u00falyoss\u00e1g\u00e1nak m\u00e9rs\u00e9kl\u00e9se mellett\n                    az elh\u00edzott p\u00e1ciensek kardiometabolikus kock\u00e1zat\u00e1t is cs\u00f6kkentheti. Mindezek\n                    alapj\u00e1n a GLP1\/GIP agonista gy\u00f3gyszeres kezel\u00e9s \u00e9s a PAP-ter\u00e1pia kombin\u00e1lt\n                    alkalmaz\u00e1sa \u00faj, komplex \u00e9s hat\u00e9kony ter\u00e1pi\u00e1s megk\u00f6zel\u00edt\u00e9st jelenthet az\n                    obstrukt\u00edv alv\u00e1si apnoe kezel\u00e9s\u00e9ben. Mivel az elh\u00edz\u00e1s kezel\u00e9se sz\u00e1mos testi,\n                    lelki \u00e9s \u00e9letm\u00f3dbeli t\u00e9nyez\u0151 egy\u00fcttes figyelembev\u00e9tel\u00e9t is ig\u00e9nyli, a\n                    multidiszciplin\u00e1ris alv\u00e1s-anyagcsere program siker\u00e9ben fontos az \u00e9rintett\n                    szakemberek (t\u00fcd\u0151gy\u00f3gy\u00e1sz, belgy\u00f3gy\u00e1sz, dietetikus, pszichol\u00f3gus \u00e9s\n                    gy\u00f3gytorn\u00e1sz) \u00f6sszehangolt r\u00e9szv\u00e9tele \u00e9s feladataik egy\u00e9rtelm\u0171 meghat\u00e1roz\u00e1sa.\n                    Tov\u00e1bbi vizsg\u00e1latok sz\u00fcks\u00e9gesek a komplex alv\u00e1s-anyagcsere programok\n                    hat\u00e9konys\u00e1g\u00e1nak \u00e9s az el\u00e9rhet\u0151 klinikai el\u0151ny\u00f6knek a pontos meg\u00edt\u00e9l\u00e9s\u00e9re. Orv\n                    Hetil. 2026; 167(26): 1011\u20131017.<\/jats:p>","DOI":"10.1556\/650.2026.33589","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T05:23:07Z","timestamp":1782883387000},"page":"1011-1017","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":0,"title":["Az elh\u00edz\u00e1s \u00e9s a tests\u00falycs\u00f6kkent\u00e9s szerepe obstrukt\u00edv alv\u00e1si apno\u00e9ban"],"prefix":"10.1556","volume":"167","author":[{"given":"Gell\u00e9rt","family":"Horv\u00e1th","sequence":"first","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Budapest Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia Christine","family":"Berner","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Budapest Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Bogl\u00e1rka","family":"Bard\u00f3czi","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Transzl\u00e1ci\u00f3s Medicina K\u00f6zpont Budapest Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bal\u00e1zs","family":"Csoma","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Pulmonol\u00f3giai Klinika Budapest, T\u00f6m\u0151 u. 25\u201329., 1083 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Pulmonol\u00f3giai Klinika Budapest, T\u00f6m\u0151 u. 25\u201329., 1083 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4079-1698","authenticated-orcid":true,"given":"G\u00e1bor","family":"Horv\u00e1th","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Pulmonol\u00f3giai Klinika Budapest, T\u00f6m\u0151 u. 25\u201329., 1083 Magyarorsz\u00e1g"},{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Transzl\u00e1ci\u00f3s Medicina K\u00f6zpont Budapest Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"R1","doi-asserted-by":"crossref","unstructured":"L\u00e9vy P, Kohler M, McNicholas WT, et al. Obstructive sleep apnoea\n                    syndrome. Nat Rev Dis Primers 2015; 1: 15015.\n                        https:\/\/doi.org\/10.1038\/nrdp.2015.15","DOI":"10.1038\/nrdp.2015.15"},{"key":"R2","doi-asserted-by":"crossref","unstructured":"Peppard PE, Young T, Barnet JH, et al. Increased prevalence of\n                    sleep-disordered breathing in adults. Am J Epidemiol. 2013; 177: 1006-1014.\n                        https:\/\/doi.org\/10.1093\/aje\/kws342","DOI":"10.1093\/aje\/kws342"},{"key":"R3","doi-asserted-by":"crossref","unstructured":"de Araujo Dantas AB, Gon\u00e7alves FM, Martins AA, et al. Worldwide\n                    prevalence and associated risk factors of obstructive sleep apnea: a\n                    meta-analysis and meta-regression. Sleep Breath 2023; 27: 2083-2109.\n                        https:\/\/doi.org\/10.1007\/s11325-023-02810-7","DOI":"10.1007\/s11325-023-02810-7"},{"key":"R4","doi-asserted-by":"crossref","unstructured":"Veasey SC, Rosen IM. Obstructive sleep apnea in adults. N Engl J\n                    Med. 2019; 380: 1442-1449.\n                    https:\/\/doi.org\/10.1056\/NEJMcp1816152","DOI":"10.1056\/NEJMcp1816152"},{"key":"R5","doi-asserted-by":"crossref","unstructured":"Lavie L. Oxidative stress inflammation and endothelial dysfunction\n                    in obstructive sleep apnea. Front Biosci (Elite ed.) 2012; 4: 1391-1403.\n                        https:\/\/doi.org\/10.2741\/e469","DOI":"10.2741\/e469"},{"key":"R6","doi-asserted-by":"crossref","unstructured":"L\u00e9vy P, Bonsignore MR, Eckel J. Sleep, sleep-disordered breathing\n                    and metabolic consequences. Eur Respir J. 2009; 34: 243-260.\n                        https:\/\/doi.org\/10.1183\/09031936.00166808","DOI":"10.1183\/09031936.00166808"},{"key":"R7","doi-asserted-by":"crossref","unstructured":"Logan AG, Perlikowski SM, Mente A, et al. High prevalence of\n                    unrecognized sleep apnoea in drug-resistant hypertension. J Hypertens. 2001; 19:\n                    2271-2277.\n                    https:\/\/doi.org\/10.1097\/00004872-200112000-00022","DOI":"10.1097\/00004872-200112000-00022"},{"key":"R8","doi-asserted-by":"crossref","unstructured":"Gon\u00e7alves SC, Martinez D, Gus M, et al. Obstructive sleep apnea and\n                    resistant hypertension: a case-control study. Chest 2007; 132: 1858-1862.\n                        https:\/\/doi.org\/10.1378\/chest.07-1170","DOI":"10.1378\/chest.07-1170"},{"key":"R9","doi-asserted-by":"crossref","unstructured":"Iiyori N, Alonso LC, Li J, et al. Intermittent hypoxia causes\n                    insulin resistance in lean mice independent of autonomic activity. 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Sleep Med Rev. 2014; 18: 35-48.\n                        https:\/\/doi.org\/10.1016\/j.smrv.2012.12.003","DOI":"10.1016\/j.smrv.2012.12.003"},{"key":"R15","doi-asserted-by":"crossref","unstructured":"Kushida CA, Littner MR, Morgenthaler T, et al. Practice parameters\n                    for the indications for polysomnography and related procedures: an update for\n                    2005. Sleep 2005; 28: 499-521.\n                    https:\/\/doi.org\/10.1093\/sleep\/28.4.499","DOI":"10.1093\/sleep\/28.4.499"},{"key":"R16","doi-asserted-by":"crossref","unstructured":"Messineo L, Bakker JP, Cronin J, et al. Obstructive sleep apnea and\n                    obesity: a review of epidemiology, pathophysiology and the effect of weight-loss\n                    treatments. 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The potential impact of GLP-1 agonists on\n                    obstructive sleep apnoea. Respirology 2023; 28: 824-825.\n                        https:\/\/doi.org\/10.1111\/resp.14545","DOI":"10.1111\/resp.14545"},{"key":"R38","doi-asserted-by":"crossref","unstructured":"Astrup A, Rossner S, Van Gaal L, et al. Effects of liraglutide in\n                    the treatment of obesity: a randomised, double-blind, placebo-controlled study.\n                    Lancet 2009; 374: 1606-1616. Erratum: Lancet 2010 Mar 20; 375: 984.\n                        https:\/\/doi.org\/10.1016\/S0140-6736(09)61375-1","DOI":"10.1016\/S0140-6736(09)61375-1"},{"key":"R39","doi-asserted-by":"crossref","unstructured":"O\u2019Neil PM, Birkenfeld AL, McGowan B, et al. 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Erratum: Nat Med. 2025; 31:\n                    1038. https:\/\/doi.org\/10.1038\/s41591-024-03412-w","DOI":"10.1038\/s41591-024-03412-w"},{"key":"R42","doi-asserted-by":"crossref","unstructured":"Pauza AG, Thakkar P, Tasic T, et al. GLP1R attenuates sympathetic\n                    response to high glucose via carotid body inhibition. Circ Res. 2022; 130:\n                    694-707.\n                    https:\/\/doi.org\/10.1161\/CIRCRESAHA.121.319874","DOI":"10.1161\/CIRCRESAHA.121.319874"},{"key":"R43","doi-asserted-by":"crossref","unstructured":"Chen Y, Shen Y, Shen H, et al. GLP-1RAs: antidiabetic drug\n                    crossover-new hope for chronic inflammatory airway diseases. Respir Res. 2026\n                    27: 144. https:\/\/doi.org\/10.1186\/s12931-026-03569-7","DOI":"10.1186\/s12931-026-03569-7"},{"key":"R44","doi-asserted-by":"crossref","unstructured":"Pi-Sunyer X, Astrup A, Fujioka K, et al. 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Sleep\n                    Breath 2023; 27: 1687-1694.\n                        https:\/\/doi.org\/10.1007\/s11325-022-02768-y","DOI":"10.1007\/s11325-022-02768-y"},{"key":"R47","unstructured":"Liu K, Yuan H, Wang D, et al. Effects of liraglutide on\n                    sleep-disordered breathing and diabetic microangiopathy in patients with type 2\n                    diabetes mellitus and obstructive sleep apnea-hypopnea syndrome. Chin J Diabetes\n                    Mellit. 2020; 12: 86-91."},{"key":"R48","doi-asserted-by":"crossref","unstructured":"Garvey WT, Batterham RL, Bhatta M, et al. Two-year effects of\n                    semaglutide in adults with overweight or obesity: the STEP 5 trial. Nat Med.\n                    2022; 28: 2083-2091.\n                    https:\/\/doi.org\/10.1038\/s41591-022-02026-4","DOI":"10.1038\/s41591-022-02026-4"},{"key":"R49","doi-asserted-by":"crossref","unstructured":"Varga B, Tombacz A, Ladar E, et al. Experiences with a novel\n                    bariatric bypass procedure (SASI). [\u00dajszer\u0171 bari\u00e1triai bypassm\u0171t\u00e9ttel (SASI)\n                    szerzett tapasztalataink.] Orv Hetil. 2025; 166: 67-76. [Hungarian]\n                        https:\/\/doi.org\/10.1556\/650.2025.33201","DOI":"10.1556\/650.2025.33201"},{"key":"R50","doi-asserted-by":"crossref","unstructured":"Malhotra A, Grunstein RR, Fietze I, et al. Tirzepatide for the\n                    treatment of obstructive sleep apnea and obesity. N Engl J Med. 2024; 391:\n                    1193-1205. https:\/\/doi.org\/10.1056\/NEJMoa2404881","DOI":"10.1056\/NEJMoa2404881"},{"key":"R51","doi-asserted-by":"crossref","unstructured":"Teng Y, Fan X, Yu R, et al. Evaluation and comparison of efficacy\n                    and safety of tirzepatide, liraglutide and SGLT2i in patients with type 2\n                    diabetes mellitus: a network meta-analysis. BMC Endocr Disord. 2024; 24: 278.\n                        https:\/\/doi.org\/10.1186\/s12902-024-01805-z","DOI":"10.1186\/s12902-024-01805-z"},{"key":"R52","doi-asserted-by":"crossref","unstructured":"Bard\u00f3czi A, Matics ZZ, Turan C, et al. Efficacy of incretin-based\n                    therapies in obesity-related obstructive sleep apnea: a systematic review and\n                    meta-analysis of randomized controlled trials. Sleep Med Rev. 2025; 82: 102119.\n                        https:\/\/doi.org\/10.1016\/j.smrv.2025.102119","DOI":"10.1016\/j.smrv.2025.102119"},{"key":"R53","doi-asserted-by":"crossref","unstructured":"Winkler G, Folyovich A, Kis JT, et al. Cardio- and neuroprotective\n                    role of glucagon-like receptor-1 agonists in reducing the incidence of ischemic\n                    stroke accompanying type 2 diabetes. [A gl\u00fckagonszer\u0171\n                    peptid-1-receptor-agonist\u00e1k cardio- \u00e9s neuroprotectiv szerepe a 2-es t\u00edpus\u00fa\n                    diabetest k\u00eds\u00e9r\u0151 ischaemi\u00e1s stroke el\u0151fordul\u00e1s\u00e1nak m\u00e9rs\u00e9kl\u00e9s\u00e9ben.] Orv Hetil.\n                    2024; 165: 489-498. 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