{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T16:06:24Z","timestamp":1785513984823,"version":"3.56.0"},"reference-count":51,"publisher":"Akademiai Kiado Zrt.","issue":"29","license":[{"start":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T00:00:00Z","timestamp":1784419200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Transzl\u00e1ci\u00f3s Idegtudom\u00e1nyi Nemzeti Laborat\u00f3rium","award":["RRF-2.3.1-21-202200011"],"award-info":[{"award-number":["RRF-2.3.1-21-202200011"]}]}],"content-domain":{"domain":["www.akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2026,7,19]]},"abstract":"Az akut ischaemi\u00e1s \u00e9s v\u00e9rz\u00e9ses stroke a vezet\u0151 hal\u00e1lokok \u00e9s rokkants\u00e1gi okok k\u00f6z\u00e9\n tartozik. A randomiz\u00e1lt vizsg\u00e1latok eredm\u00e9nyei mellett a val\u00f3s klinikai\n gyakorlatot t\u00fckr\u00f6z\u0151 regiszteradatok kulcsszerepet j\u00e1tszanak az ell\u00e1t\u00e1s\n min\u0151s\u00e9g\u00e9nek \u00e9rt\u00e9kel\u00e9s\u00e9ben. A Transzl\u00e1ci\u00f3s Idegtudom\u00e1nyi Nemzeti Laborat\u00f3rium\n STROKE adatplatformja \u00e1tfog\u00f3 k\u00e9pet ny\u00fajt egy hazai komprehenz\u00edv\n stroke-centrumr\u00f3l. C\u00e9lkit\u0171z\u00e9s\u00fcnk volt a STROKE adatplatform \u00e1ltal\u00e1nos jellemz\u00e9se\n \u00e9s az adatain alapul\u00f3 vizsg\u00e1latok eredm\u00e9nyeinek \u00f6sszefoglal\u00e1sa, a f\u0151bb klinikai\n \u00e9s m\u00f3dszertani tanuls\u00e1gok szintetiz\u00e1l\u00e1sa, valamint a hazai stroke-ell\u00e1t\u00e1s\n min\u0151s\u00e9gfejleszt\u00e9si vonatkoz\u00e1sainak bemutat\u00e1sa. Az adatplatform a P\u00e9csi\n Tudom\u00e1nyegyetem Neurol\u00f3giai vagy Idegseb\u00e9szeti Klinik\u00e1j\u00e1n akut ischaemi\u00e1s\n stroke, tranziens ischaemi\u00e1s attak \u00e9s v\u00e9rz\u00e9ses stroke miatt 24 \u00f3r\u00e1n bel\u00fcl\n felvett betegek standardiz\u00e1lt adatgy\u0171jt\u00e9s\u00e9n alapul. R\u00f6gz\u00edt\u00e9sre ker\u00fcltek\n demogr\u00e1fiai, klinikai, k\u00e9palkot\u00f3, laborat\u00f3riumi, ter\u00e1pi\u00e1s \u00e9s 90 napos kimeneteli\n adatok. A kimenetelt t\u00f6bbv\u00e1ltoz\u00f3s line\u00e1ris \u00e9s logisztikus regresszi\u00f3s\n modellekkel, \u2019propensity score\u2019 illeszt\u00e9ssel, valamint g\u00e9pi tanul\u00e1si\n m\u00f3dszerekkel elemezt\u00fck. A r\u00f6gz\u00edtett adatok alapj\u00e1n a betegek 77,0%-a ischaemi\u00e1s\n stroke, 16,9%-a tranziens ischaemi\u00e1s roham, 6,1%-a v\u00e9rz\u00e9ses stroke diagn\u00f3zissal\n szerepelt; az \u00e1tlag\u00e9letkor 72,0 \u00b1 12,5 \u00e9v volt. Ischaemi\u00e1s stroke eset\u00e9n a\n betegek 62,4%-a r\u00e9szes\u00fclt rekanaliz\u00e1ci\u00f3s kezel\u00e9sben. A 90 napos funkcion\u00e1lis\n kimenetel leger\u0151sebb f\u00fcggetlen prediktora a felv\u00e9telkori neurol\u00f3giai status, a\n premorbid funkcion\u00e1lis \u00e1llapot, a korai ischaemia kiterjed\u00e9se \u00e9s az \u00e9letkor\n volt. A h\u00e1rom param\u00e9teren (\u00e9letkor, premorbid \u00e9s neurol\u00f3giai status) alapul\u00f3\n Stroke-SCORE sk\u00e1la er\u0151s predikt\u00edv teljes\u00edtm\u00e9nyt mutatott a 90 napos kimenetelre\n (g\u00f6rbe alatti ter\u00fclet = 0,86). A reperf\u00fazi\u00f3s kezel\u00e9sek sor\u00e1n a <60 perces\n \u2019door-to-needle\u2019 \u00e9s <120 perces \u2019door-to-groin\u2019 id\u0151 szignifik\u00e1nsan kedvez\u0151bb\n 90 napos kimenetellel t\u00e1rsult. Az antikoagul\u00e1ns vagy thrombocytaaggreg\u00e1ci\u00f3-g\u00e1tl\u00f3\n kezel\u00e9s a t\u00f6bbv\u00e1ltoz\u00f3s korrekci\u00f3t k\u00f6vet\u0151en nem bizonyult f\u00fcggetlen kedvez\u0151tlen\n prognosztikai t\u00e9nyez\u0151nek. A STROKE adatplatform meger\u0151s\u00edti azt a megfigyel\u00e9st,\n hogy a funkcion\u00e1lis kimenetelt els\u0151sorban a stroke s\u00falyoss\u00e1ga, a premorbid\n \u00e1llapot, az \u00e9letkor, az ischaemia kiterjed\u00e9se \u00e9s az id\u0151kritikus, szervezett\n reperf\u00fazi\u00f3s ell\u00e1t\u00e1s hat\u00e1rozza meg. A korszer\u0171 statisztikai m\u00f3dszerekkel elemzett\n val\u00f3s \u00e9letbeli adatok \u00e9rdemben hozz\u00e1j\u00e1rulnak a klinikai d\u00f6nt\u00e9shozatalhoz, a\n kontraindik\u00e1ci\u00f3k \u00fajra\u00e9rt\u00e9kel\u00e9s\u00e9hez \u00e9s a hazai stroke-ell\u00e1t\u00e1s\n min\u0151s\u00e9gfejleszt\u00e9s\u00e9hez. Orv Hetil. 2026; 167(29): 1131\u20131141.<\/jats:p>","DOI":"10.1556\/650.2026.33600","type":"journal-article","created":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T04:23:44Z","timestamp":1784435024000},"page":"1131-1141","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":0,"title":["A Transzl\u00e1ci\u00f3s Idegtudom\u00e1nyi Nemzeti Laborat\u00f3rium STROKE adatplatformj\u00e1nak \u00e9s az erre \u00e9p\u00fcl\u0151 klinikai vizsg\u00e1latoknak az \u00f6sszefoglal\u00e1sa \u00e9s k\u00f6vetkeztet\u00e9sei"],"prefix":"10.1556","volume":"167","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5643-0077","authenticated-orcid":true,"given":"D\u00e1niel","family":"Schranz","sequence":"first","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Klinikai K\u00f6zpont, Neurol\u00f3giai Klinika, Stroke Tansz\u00e9k P\u00e9cs, R\u00e9t u. 2., 7623 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gergely","family":"Feh\u00e9r","sequence":"additional","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Foglalkoz\u00e1s-orvostani Int\u00e9zet P\u00e9cs Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eszter","family":"Jozifek","sequence":"additional","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Klinikai K\u00f6zpont, Neurol\u00f3giai Klinika, Stroke Tansz\u00e9k P\u00e9cs, R\u00e9t u. 2., 7623 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zs\u00f3fia","family":"Kar\u00e1di","sequence":"additional","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Klinikai K\u00f6zpont, Neurol\u00f3giai Klinika, Stroke Tansz\u00e9k P\u00e9cs, R\u00e9t u. 2., 7623 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edit","family":"Bosny\u00e1k","sequence":"additional","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Klinikai K\u00f6zpont, Neurol\u00f3giai Klinika, Stroke Tansz\u00e9k P\u00e9cs, R\u00e9t u. 2., 7623 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e1szl\u00f3","family":"Szap\u00e1ry","sequence":"additional","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Klinikai K\u00f6zpont, Neurol\u00f3giai Klinika, Stroke Tansz\u00e9k P\u00e9cs, R\u00e9t u. 2., 7623 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"R1","doi-asserted-by":"crossref","unstructured":"Feigin V, Stark B, Johnson C, et al. Global, regional, and national\n burden of stroke and its risk factors, 1990-2019: a systematic analysis for the\n Global Burden of Disease Study 2019. Lancet Neurol. 2021; 20:\n 795-820.https:\/\/doi.org\/10.1016\/S1474-4422(21)00252-0","DOI":"10.1016\/S1474-4422(21)00252-0"},{"key":"R2","doi-asserted-by":"crossref","unstructured":"Emberson J, Lees KR, Lyden P, et al. Effect of treatment delay, age,\n and stroke severity on the effects of intravenous thrombolysis with alteplase\n for acute ischaemic stroke: a meta-analysis of individual patient data from\n randomised trials. Lancet 2014; 384: 1929-1935.\n https:\/\/doi.org\/10.1016\/S0140-6736(14)60584-5","DOI":"10.1016\/S0140-6736(14)60584-5"},{"key":"R3","doi-asserted-by":"crossref","unstructured":"Goyal M, Menon BK, van Zwam WH, et al. Endovascular thrombectomy\n after large-vessel ischaemic stroke: a meta-analysis of individual patient data\n from five randomised trials. 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