{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T08:46:36Z","timestamp":1791708396753,"version":"4.3.4"},"reference-count":19,"publisher":"Akademiai Kiado Zrt.","issue":"41","license":[{"start":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T00:00:00Z","timestamp":1791676800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2026,10,11]]},"abstract":"\n Az \u00e9letkorral \u00f6sszef\u00fcgg\u0151 izomvesztes\u00e9g (sarcopenia) a glob\u00e1lisan \u00f6reged\u0151 n\u00e9pess\u00e9g\n egyik legjelent\u0151sebb eg\u00e9szs\u00e9g\u00fcgyi terhe. A b\u00e9lmikrobiom \u00e9s a v\u00e1zizomzat k\u00f6z\u00f6tti\n \u00f6sszef\u00fcgg\u00e9srendszert, az \u00fagynevezett b\u00e9l\u2013izom tengelyt (gut\u2013muscle axis) egyre\n kiterjedtebb kutat\u00e1s vizsg\u00e1lja, azonban a konkr\u00e9t mechanizmusok \u00e9s a felel\u0151s\n mikrobi\u00e1lis fajok azonos\u00edt\u00e1sa eddig korl\u00e1tozott volt. A jelen \u00f6sszefoglal\u00f3\n k\u00f6zlem\u00e9ny c\u00e9lja a b\u00e9l\u2013izom tengely jelenlegi bizony\u00edt\u00e9kainak \u00e1ttekint\u00e9se,\n k\u00fcl\u00f6n\u00f6s tekintettel a\n Roseburia inulinivorans<\/jats:italic>\n b\u00e9lbakt\u00e9riumfaj\n \u00e9s az izomteljes\u00edtm\u00e9ny k\u00f6z\u00f6tti, 2026-ban a\n Gut<\/jats:italic>\n foly\u00f3iratban\n k\u00f6z\u00f6lt \u00f6sszef\u00fcgg\u00e9sre, valamint e kapcsolat klinikai \u00e9s ter\u00e1pi\u00e1s relevanci\u00e1j\u00e1nak\n \u00e9rt\u00e9kel\u00e9s\u00e9re. Narrat\u00edv irodalmi \u00f6sszefoglal\u00f3, amelynek alapj\u00e1t a\n Martinez-Tellez \u00e9s mtsai<\/jats:italic>\n \u00e1ltal 2026-ban publik\u00e1lt vizsg\u00e1lat\n k\u00e9pezi, kieg\u00e9sz\u00edtve a b\u00e9l\u2013izom tengely, a sarcopenia \u00e9s az \u00f6reged\u0151 mikrobiom\n t\u00e9mak\u00f6r\u00e9ben megjelent relev\u00e1ns k\u00f6zlem\u00e9nyekkel. A szakirodalmi besz\u00e1mol\u00f3k szerint\n az\n R. inulinivorans<\/jats:italic>\n relat\u00edv abundanci\u00e1ja pozit\u00edvan korrel\u00e1lt a\n k\u00e9zszor\u00edt\u00f3 er\u0151vel, a l\u00e1bpr\u00e9ssel \u00e9s a mellpr\u00e9ssel. A bakt\u00e9riumot hordoz\u00f3 id\u0151s\n feln\u0151ttekben 29%-kal nagyobb volt a k\u00e9zszor\u00edt\u00f3 er\u0151, a cardiorespiratoricus\n kapacit\u00e1s v\u00e1ltoz\u00e1sa n\u00e9lk\u00fcl. Eg\u00e9rmodellben az or\u00e1lis szupplement\u00e1ci\u00f3 k\u00f6r\u00fclbel\u00fcl\n 30%-os izomer\u0151-n\u00f6veked\u00e9st eredm\u00e9nyezett. A hat\u00e1s mechanizmusa nem butir\u00e1ton,\n hanem az izom purin- \u00e9s pent\u00f3z-foszf\u00e1t-anyagcser\u00e9j\u00e9nek aktiv\u00e1l\u00e1s\u00e1n kereszt\u00fcl\n val\u00f3sulhat meg. Az eddigi szakirodalmi adatok szerint a\n R.\n inulinivorans<\/jats:italic>\n fajspecifikus \u00f6sszef\u00fcgg\u00e9st mutat az izomer\u0151vel, \u00e9s\n \u00edg\u00e9retes mikrobi\u00e1lis jel\u00f6lt a sarcopenia, valamint a cachexia kezel\u00e9s\u00e9re\n ir\u00e1nyul\u00f3 nutraceutikai fejleszt\u00e9sek sz\u00e1m\u00e1ra. Az eredm\u00e9nyek meger\u0151s\u00edt\u00e9s\u00e9hez hum\u00e1n\n randomiz\u00e1lt klinikai vizsg\u00e1latok, valamint a nemi k\u00fcl\u00f6nbs\u00e9geket figyelembe vev\u0151\n longitudin\u00e1lis elemz\u00e9sek sz\u00fcks\u00e9gesek. Orv Hetil. 2026; 167(41): 1646\u20131654.\n <\/jats:p>","DOI":"10.1556\/650.2026.33641","type":"journal-article","created":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T08:00:09Z","timestamp":1791705609000},"page":"1646-1654","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":0,"title":["A b\u00e9l\u2013izom tengely \u00e9s a Roseburia inulinivorans szerepe az \u00e9letkorral \u00f6sszef\u00fcgg\u0151 izomvesztes\u00e9gben"],"prefix":"10.1556","volume":"167","author":[{"given":"Viktor","family":"Guly\u00e1s-Oldal","sequence":"first","affiliation":[{"name":"MicroBiome Bank Kft. Budapest Magyarorsz\u00e1g"},{"name":"Sz\u00e9chenyi Istv\u00e1n Egyetem, Eg\u00e9szs\u00e9g- \u00e9s Sporttudom\u00e1nyi Kar Gy\u0151r Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e1bor","family":"Patay","sequence":"additional","affiliation":[{"name":"MicroBiome Bank Kft. 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