{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T10:31:46Z","timestamp":1791109906146,"version":"4.1.0"},"reference-count":10,"publisher":"Akademiai Kiado Zrt.","issue":"2","content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,6,1]]},"abstract":"<jats:p>Human enterovirus 109 (EV109) is a recently identified recombinant enterovirus in family <jats:italic>Picornaviridae<\/jats:italic> from acute paediatric respiratory illness in Nicaragua. EV109 have not been reported elsewhere. Our aims were the molecular detection and genetic analysis of EV109 from acute childhood respiratory infections in Hungary. Nasopharyngeal aspirates were collected from children under age of 10 years with acute respiratory infections treated in Department of Pulmonology, Kaposi M\u00f3r Teaching Hospital, Mosd\u00f3s, Hungary. Samples were taken from 15 October to 15 May in two respiratory seasons 2005\/2006 and 2006\/2007. Samples were tested using EV109 specific VP1 primers by RT-PCR method. One (1.1%) of the 92 nasopharyngeal aspirates was positive for EV109 collected from a 2.5-year-old child in January, 2007. The main symptoms were dropping nose, fever (38.1\u00b0C), hard cough and wheezing associated with bronchitis and pneumonia. Based upon the VP1 gene region EV109 (L87\/HUN\/2007, JN900470) has 93% nucleotide identity and identical recombinant pattern to the prototype EV109. This is the first detection of the novel recombinant enterovirus, EV109, in Hungary (in Europe). This study supports the possibility that EV109 is able to cause acute respiratory infections, in addition, it might be plays a part in lower respiratory disease with hospitalization in children.<\/jats:p>","DOI":"10.1556\/amicr.59.2012.2.13","type":"journal-article","created":{"date-parts":[[2012,7,2]],"date-time":"2012-07-02T19:31:51Z","timestamp":1341257511000},"page":"285-290","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":19,"title":["Human enterovirus 109 (EV109) in acute paediatric respiratory disease in Hungary"],"prefix":"10.1556","volume":"59","author":[{"given":"P\u00e9ter","family":"Pankovics","sequence":"first","affiliation":[{"name":"1 National Reference Laboratory of Gastroenteric Viruses \u00c1NTSZ Regional Institute of State Public Health Service, Regional Laboratory of Virology P\u00e9cs Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1kos","family":"Boros","sequence":"additional","affiliation":[{"name":"1 National Reference Laboratory of Gastroenteric Viruses \u00c1NTSZ Regional Institute of State Public Health Service, Regional Laboratory of Virology P\u00e9cs Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajnalka","family":"Szab\u00f3","sequence":"additional","affiliation":[{"name":"2 Kaposi M\u00f3r Teaching Hospital Department of Pulmonology Mosd\u00f3s Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gy\u00f6ngyi","family":"Sz\u00e9kely","sequence":"additional","affiliation":[{"name":"2 Kaposi M\u00f3r Teaching Hospital Department of Pulmonology Mosd\u00f3s Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00e1lm\u00e1n","family":"Gyurkovits","sequence":"additional","affiliation":[{"name":"2 Kaposi M\u00f3r Teaching Hospital Department of Pulmonology Mosd\u00f3s Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e1bor","family":"Reuter","sequence":"additional","affiliation":[{"name":"1 National Reference Laboratory of Gastroenteric Viruses \u00c1NTSZ Regional Institute of State Public Health Service, Regional Laboratory of Virology P\u00e9cs Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1128\/JCM.01414-07","article-title":"Epidemiological, molecular, and clinical features of enterovirus respiratory infections in French children between 1999 and 2005","volume":"46","author":"Jacques J.","year":"2008","journal-title":"J. Clin. Microbiol."},{"key":"2","volume-title":"Fields Virology","author":"Pallansch M.","year":"2007"},{"key":"3","volume-title":"Clinical Virology","author":"Romero J. R.","year":"2009"},{"key":"4","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1128\/JVI.73.3.1941-1948.1999","article-title":"Molecular evolution of the human enteroviruses: correlation of serotype with VP1 sequence and application to picornavirus classification","volume":"73","author":"Oberste M. S.","year":"1999","journal-title":"J. Virol."},{"key":"5","doi-asserted-by":"crossref","first-page":"719","DOI":"10.3201\/eid1505.081286","article-title":"New respiratory enterovirus and recombinant rhinoviruses among circulating picornaviruses","volume":"15","author":"Tapparel C.","year":"2009","journal-title":"Emerg. Infect. Dis."},{"key":"6","doi-asserted-by":"crossref","first-page":"9047","DOI":"10.1128\/JVI.00698-10","article-title":"Human enterovirus 109: a novel interspecies recombinant enterovirus isolated from a case of acute pediatric respiratory illness in Nicaragua","volume":"84","author":"Yozwiak N. L.","year":"2010","journal-title":"J. Virol."},{"key":"7","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1556\/OH.2009.28473","article-title":"Detection and molecular epidemiology of respiratory syncytial virus type A and B strains in childhood respiratory infections in Hungary (in Hungarian)","volume":"150","author":"Pankovics P.","year":"2009","journal-title":"Orv. Hetil."},{"key":"8","first-page":"2299","article-title":"First detection of human metapneumovirus in a child with respiratory syndrome in Hungary (in Hungarian)","volume":"147","author":"Reuter G.","year":"2006","journal-title":"Orv. Hetil."},{"key":"9","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1007\/s00705-011-1021-0","article-title":"Detection and follow-up of torque teno midi virus (\u201csmall anelloviruses\u201d) in nasopharyngeal aspirates and three other human body fluids in children","volume":"156","author":"Buri\u00e1n Zs.","year":"2011","journal-title":"Arch. Virol."},{"key":"10","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1093\/molbev\/msr121","article-title":"MEGA5: Molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods","volume":"28","author":"Tamura K.","year":"2011","journal-title":"Mol. Biol. 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