{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T12:02:25Z","timestamp":1789041745818,"version":"build-2803163510"},"reference-count":36,"publisher":"Akademiai Kiado Zrt.","issue":"1","content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,3,1]]},"abstract":"<jats:p>\n                    The aim of this study was to determine antimicrobial susceptibility of\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    strains to marbofloxacin and gentamicin, and investigate the possible synergistic, additive, indifferent or antagonistic effects between the two agents.\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    strains can develop resistance quickly against certain antibiotics if used alone, thus the need emerges to find synergistic combinations. A total of 68\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    strains isolated from dogs were examined. In order to describe interactions between marbofloxacin and gentamicin the checkerboard microdilution method was utilized. The MICs (minimum inhibitory concentrations) for marbofloxacin and gentamicin were in the range 0.25\u201364 mg\/L and 0.25\u201332 mg\/L, respectively. The combination of marbofloxacin and gentamicin was more effective with a MIC range of 0.031\u20138 mg\/L and a MIC\n                    <jats:sub>90<\/jats:sub>\n                    of 1 mg\/L, compared to 16 mg\/L for marbofloxacin alone and 8 mg\/L for gentamicin alone. The FIC (fractional inhibitory concentration) indices ranged from 0.0945 (pronounced synergy) to 1.0625 (indifference). Synergy between marbofloxacin and gentamicin was found in 33 isolates. The mean FIC index is 0.546, which represents a partial synergistic\/additive effect close to the full synergy threshold.\n                    <jats:italic>In vitro<\/jats:italic>\n                    results indicate that marbofloxacin and gentamicin as partially synergistic agents may prove clinically useful in combination therapy against\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    infections. Although marbofloxacin is not used in the human practice, the interactions between fluoroquinolones and aminoglycosides may have importance outside the veterinary field.\n                  <\/jats:p>","DOI":"10.1556\/amicr.62.2015.1.4","type":"journal-article","created":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T08:55:11Z","timestamp":1427878511000},"page":"45-55","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":7,"title":["Evaluating synergy between marbofloxacin and gentamicin in Pseudomonas aeruginosa strains isolated from dogs with otitis externa"],"prefix":"10.1556","volume":"62","author":[{"given":"\u00c1kos","family":"Jerzsele","sequence":"first","affiliation":[{"name":"1 Szent Istv\u00e1n University Department of Pharmacology and Toxicology, Faculty of Veterinary Sciences Istv\u00e1n u. 2 H-1078 Budapest 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