{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T12:09:58Z","timestamp":1648901398200},"reference-count":16,"publisher":"Akademiai Kiado Zrt.","issue":"1","content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,3,1]]},"abstract":"<jats:p>During clinical trials, samples from Hungarian patients of different age groups were tested for antibodies against all 3 serotypes of poliovirus, a member of <jats:italic>Picornaviridae<\/jats:italic> family. During the virus neutralization serological test, blood samples were titrated using permanent virus concentration. Based on the cythopathic effect observed under a light microscope, the antibody level of the patient was assessed. The 100 people examined were classified into 5 groups based on age and type of original vaccine: I. Newborns, no vaccination given; II. Immunosuppressed patients; III. Born before 1986, received only OPV vaccine; IV. Born between 1992\u20132005, received a combination of OPV and IPV vaccines; V. Born after 2006, received only IPV vaccine. Results show that vaccination coverage meets all the criteria. None of the immunized persons was seronegative to all three polioviruses. Both IPV and OPV vaccines are effective against poliovirus. Blood samples from newborn babies with no immunization were also examined. Results show that most newborns have maternal antibodies in their blood. Results of group II show that immunosuppression does not have a negative influence on blood antibody levels against polioviruses. In spite of the low number of samples, our results show that seroconversion after immunization in the Hungarian population is adequate. For more accurate results about vaccination coverage in the population, further trials would be necessary.<\/jats:p>","DOI":"10.1556\/amicr.62.2015.1.6","type":"journal-article","created":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T12:55:11Z","timestamp":1427892911000},"page":"75-85","update-policy":"http:\/\/dx.doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":0,"title":["Comparative study of antibody levels developed by vaccination against polio virus in population after vaccine type alteration"],"prefix":"10.1556","volume":"62","author":[{"given":"\u00c1gnes","family":"Farkas","sequence":"first","affiliation":[{"name":"1 National Center for Epidemiology WHO National Poliovirus Reference Laboratory, Division of Virology Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N\u00f3ra","family":"Magyar","sequence":"additional","affiliation":[{"name":"1 National Center for Epidemiology WHO National Poliovirus Reference Laboratory, Division of Virology Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katalin","family":"Szomor","sequence":"additional","affiliation":[{"name":"1 National Center for Epidemiology WHO National Poliovirus Reference Laboratory, Division of Virology Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1ria","family":"Tak\u00e1cs","sequence":"additional","affiliation":[{"name":"1 National Center for Epidemiology WHO National Poliovirus Reference Laboratory, Division of Virology Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"1","volume-title":"Virus Taxonomy. 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Accessed: 28 January 2015."},{"key":"13","first-page":"4","article-title":"M\u00f3dszertani lev\u00e9l a 2006. \u00e9vi v\u00e9d\u0151olt\u00e1sokr\u00f3l","volume":"13","year":"2005","journal-title":"Epinfo"},{"key":"14","volume-title":"Klinikai \u00e9s j\u00e1rv\u00e1ny\u00fcgyi virol\u00f3gia (in Hungarian)","author":"Kapusinszky B.","year":"2010"},{"key":"15","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1086\/520546","article-title":"Randomized trial of inactivated and live polio vaccine schedules in Guatemalan infants","volume":"196","author":"Asturias E.J.","year":"2007","journal-title":"The Journal of Infectious Diseases"},{"key":"16","first-page":"12","article-title":"Immunity to poliovirus among children and the elderly in north-east Italy","volume":"47","author":"Majori S.","year":"2006","journal-title":"Journal of Preventive Medicine and Hygiene"}],"container-title":["Acta Microbiologica et Immunologica Hungarica"],"original-title":[],"link":[{"URL":"https:\/\/akjournals.com\/view\/journals\/030\/62\/1\/article-p75.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/akjournals.com\/downloadpdf\/journals\/030\/62\/1\/article-p75.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T11:51:27Z","timestamp":1614599487000},"score":1,"resource":{"primary":{"URL":"https:\/\/akjournals.com\/view\/journals\/030\/62\/1\/article-p75.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,1]]},"references-count":16,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1556\/amicr.62.2015.1.6","relation":{},"ISSN":["1217-8950","1588-2640"],"issn-type":[{"value":"1217-8950","type":"print"},{"value":"1588-2640","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,1]]}}}