{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:09:15Z","timestamp":1780445355028,"version":"3.54.1"},"reference-count":37,"publisher":"Akademiai Kiado Zrt.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Physiologica Hungarica"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1556\/aphysiol.101.2014.3.1","type":"journal-article","created":{"date-parts":[[2014,9,3]],"date-time":"2014-09-03T01:42:23Z","timestamp":1409708543000},"page":"263-272","source":"Crossref","is-referenced-by-count":25,"title":["Effects of hypoxia and hypercapnia on human HRV and respiratory sinus arrhythmia"],"prefix":"10.1556","volume":"101","author":[{"given":"Stephen","family":"Brown","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.J.","family":"Barnes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"M\u00fcndel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1126\/science.6166045","article-title":"Power spectrum analysis of heart rate fluctuation: A quantitative probe of beat-to-beat cardiovascular control","volume":"213","author":"Akselrod S.","year":"1981","journal-title":"Science"},{"key":"2","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1152\/jappl.1964.19.3.479","article-title":"Respiratory sinus arrhythmia: a frequency dependent phenomenon","volume":"19","author":"Angelone A.","year":"1964","journal-title":"J. Appl. Physiol."},{"key":"3","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1042\/CS19980046","article-title":"Cardiovascular autonomic modulation and activity of carotid baroreceptors at altitude","volume":"95","author":"Bernardi L.","year":"1998","journal-title":"Clin. Sci."},{"key":"4","doi-asserted-by":"crossref","first-page":"337","DOI":"10.2170\/physiolsci.RP009407","article-title":"Cardiac vagal control and respiratory sinus arrhythmia during hypercapnia in humans","volume":"57","author":"Brown S.J.","year":"2007","journal-title":"J. Physiol. Sci."},{"key":"5","doi-asserted-by":"crossref","first-page":"975","DOI":"10.3357\/ASEM.2331.2008","article-title":"Critique of the equivalent air altitude model","volume":"79","author":"Conkin J.","year":"2008","journal-title":"Aviat. Space Environ. Med."},{"key":"6","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1152\/japplphysiol.00239.2004","article-title":"Autonomic control of the cardiovascular system during acclimatization to high altitude: effects of sildenafil","volume":"97","author":"Cornolo J.","year":"2004","journal-title":"J. Appl. Physiol."},{"key":"7","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1152\/jappl.1983.54.4.961","article-title":"Human sinus arrhythmia as an index of vagal cardiac outflow","volume":"54","author":"Eckberg D.L.","year":"1983","journal-title":"J. Appl. Physiol."},{"key":"8","doi-asserted-by":"crossref","first-page":"H2152","DOI":"10.1152\/ajpheart.1994.266.5.H2152","article-title":"Dissociation of heart rate variability from parasympathetic tone","volume":"266","author":"Goldberger J.J.","year":"1994","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"9","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1161\/01.CIR.103.15.1977","article-title":"Relationship of heart rate variability to parasympathetic effect","volume":"103","author":"Goldberger J.J.","year":"2001","journal-title":"Circulation"},{"key":"10","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s10286-006-0395-7","article-title":"The autonomic nervous system at high altitude","volume":"17","author":"Hainsworth R.","year":"2007","journal-title":"Clin. Auton. Res."},{"key":"11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0008-6363(02)00851-9","article-title":"Hypothesis: respiratory sinus arrhythmia is an intrinsic resting function of cardiopulmonary system","volume":"58","author":"Hayano J.","year":"2003","journal-title":"Cardiovasc. Res."},{"key":"12","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1161\/01.CIR.94.4.842","article-title":"Respiratory sinus arrhythmia: A phenomenon improving pulmonary gas exchange and circulatory efficiency","volume":"94","author":"Hayano J.","year":"1996","journal-title":"Circulation"},{"key":"13","doi-asserted-by":"crossref","first-page":"H620","DOI":"10.1152\/ajpheart.1981.241.4.H620","article-title":"Respiratory sinus arrhythmia in humans: how breathing pattern modulates heart rate","volume":"241","author":"Hirsch J.A.","year":"1981","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"14","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1152\/jappl.1994.77.6.2537","article-title":"Sympathetic and parasympathetic indicators of heart rate control at altitude studied by spectral analysis","volume":"77","author":"Hughson R.L.","year":"1994","journal-title":"J. Appl. Physiol."},{"key":"15","first-page":"1015","article-title":"Cardiovascular regulation response to hypoxia during stepwise decreases from 21% to 15% inhaled oxygen","volume":"77","author":"Iwasaki K.","year":"2006","journal-title":"Aviat. Space Environ. Med."},{"key":"16","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1113\/jphysiol.1990.sp018070","article-title":"Respiratory sinus arrhythmia is a limited measure of cardiac parasympathetic control in man","volume":"424","author":"Kollai M.","year":"1990","journal-title":"J. Physiol."},{"key":"17","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/0034-5687(78)90134-2","article-title":"Arterial PO2 and PCO2 stimulus threshold for carotid chemoreceptors and breathing","volume":"34","author":"Lahiri S.","year":"1978","journal-title":"Respir. Physiol."},{"key":"18","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1161\/01.CIR.84.2.482","article-title":"Cardiovascular neural regulation explored in the frequency domain","volume":"84","author":"Malliani A.","year":"1991","journal-title":"Circulation"},{"key":"19","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1152\/physrev.1994.74.3.543","article-title":"Peripheral chemoreceptors and cardiovascular regulation","volume":"74","author":"Marshall J.M.","year":"1994","journal-title":"Physiol. Rev."},{"key":"20","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1152\/jappl.1998.84.4.1151","article-title":"Catecholamine response during 12 days of high-altitude exposure (4,300 m) in women","volume":"84","author":"Mazzeo R.S.","year":"1998","journal-title":"J. Appl. Physiol."},{"key":"21","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1161\/01.RES.59.2.178","article-title":"Power spectral analysis of heart rate and arterial pressure variabilities as a marker of sympathovagal interaction in man and conscious dog","volume":"59","author":"Pagani M.","year":"1986","journal-title":"Circ. Res."},{"key":"22","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/BF00357674","article-title":"Effects of high altitude acclimatization on heart rate variability in resting humans","volume":"73","author":"Perini R.","year":"1996","journal-title":"Eur. J. Appl. Physiol. Occup. Physiol."},{"key":"23","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s00421-003-0953-9","article-title":"Heart rate variability and autonomic activity at rest and during exercise in various physiological conditions","volume":"90","author":"Perini R.","year":"2003","journal-title":"Eur. J. Appl. Physiol."},{"key":"24","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1093\/oxfordjournals.eurheartj.a060415","article-title":"Cardiovascular neural regulation during and after prolonged high altitude exposure","volume":"15","author":"Ponchia A.","year":"1994","journal-title":"Eur. Heart J."},{"key":"25","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ajem.2004.09.023","article-title":"Relationship between arterial oxygen saturation and heart rate variability at high altitudes","volume":"23","author":"Saito S.","year":"2005","journal-title":"Am. J. Emerg. Med."},{"key":"26","doi-asserted-by":"crossref","first-page":"H973","DOI":"10.1152\/ajpheart.00554.2001","article-title":"Direct effect of PaCO2 on respiratory sinus arrhythmia in conscious humans","volume":"282","author":"Sasano N.","year":"2002","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"27","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1007\/s00421-002-0789-8","article-title":"Normo- and hypobaric hypoxia: are there any physiological differences?","volume":"89","author":"Savourey G.","year":"2003","journal-title":"Eur. J. Appl. Physiol."},{"key":"28","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s00421-007-0417-8","article-title":"Normo- and hypobaric hypoxic tests: propositions for the determination of the individual susceptibility to altitude illnesses","volume":"100","author":"Savourey G.","year":"2007","journal-title":"Eur. J. Appl. Physiol."},{"key":"29","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1046\/j.1365-201X.2001.00925.x","article-title":"Reduced autonomic activity during stepwise exposure to high altitude","volume":"173","author":"Sevre K.","year":"2001","journal-title":"Acta Physiol. Scand."},{"key":"30","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1172\/JCI115221","article-title":"Interaction of baroreceptor and chemoreceptor reflex control of sympathetic nerve activity in normal humans","volume":"87","author":"Somers V.K.","year":"1991","journal-title":"J. Clin. Invest."},{"key":"31","doi-asserted-by":"crossref","first-page":"H2397","DOI":"10.1152\/ajpheart.00817.2006","article-title":"Effects of hypercapnia and hypoxia on respiratory sinus arrhythmia in conscious humans during spontaneous breathing","volume":"292","author":"Tzeng Y.C.","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"32","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1172\/JCI106322","article-title":"Hypoxic ventilatory drive in normal man","volume":"49","author":"Weil J.V.","year":"1970","journal-title":"J. Clin. Invest."},{"key":"33","volume-title":"Best and Taylor\u2019s Physiological Basis of Medical Practice","author":"West J.B.","year":"1984"},{"key":"34","doi-asserted-by":"crossref","first-page":"H2344","DOI":"10.1152\/ajpheart.2000.279.5.H2344","article-title":"Impact of acute hypoxia on heart rate and blood pressure variability in conscious dogs","volume":"279","author":"Yasuma F.","year":"2000","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"35","doi-asserted-by":"crossref","first-page":"H2336","DOI":"10.1152\/ajpheart.2001.280.5.H2336","article-title":"Augmentation of respiratory sinus arrhythmia in response to progressive hypercapnia in conscious dogs","volume":"280","author":"Yasuma F.","year":"2001","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"36","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1378\/chest.125.2.683","article-title":"Respiratory sinus arrhythmia: why does the heartbeat synchronize with respiratory rhythm?","volume":"125","author":"Yasuma F.","year":"2004","journal-title":"Chest"},{"key":"37","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s00421-009-1123-5","article-title":"Effect of hypobaric hypoxia on heart rate variability during exercise: a pilot field study","volume":"107","author":"Zupet P.","year":"2009","journal-title":"Eur. J. Appl. Physiol."}],"container-title":["Acta Physiologica Hungarica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.akademiai.com\/doi\/pdf\/10.1556\/aphysiol.101.2014.3.1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,22]],"date-time":"2020-05-22T09:35:32Z","timestamp":1590140132000},"score":1,"resource":{"primary":{"URL":"https:\/\/akjournals.com\/doi\/10.1556\/aphysiol.101.2014.3.1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["10.1556\/APhysiol.101.2014.3.1"],"URL":"https:\/\/doi.org\/10.1556\/aphysiol.101.2014.3.1","relation":{},"ISSN":["0231-424X","1588-2683"],"issn-type":[{"value":"0231-424X","type":"print"},{"value":"1588-2683","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9]]}}}