{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T01:21:59Z","timestamp":1778376119583,"version":"3.51.4"},"reference-count":15,"publisher":"Akademiai Kiado Zrt.","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,6,1]]},"abstract":"<jats:p>This paper describes the occurrence of a rare skin tumour that has been removed surgically from the upper lip of a 13-year-old Tibetan spaniel. The tumour was 0.5 cm in diameter and macroscopically appeared as a single dermal mass, but histopathological analysis identified it as a biphasic collision mixed tumour. In the anatomically uniform tumour, 70% (4 mm in diameter) of the total parenchyma was formed by a high-grade sarcoma (with the presence of giant cells), and about 30% of it (1 mm in diameter) was a malignant melanoma (again with the presence of giant cells). The histologically distinct, but anatomically uniform tumour parts were separated by a macroscopically invisible, non-neoplastic epithelial process originating from the overlying hyperplastic epidermis. The two malignant components did not infiltrate the peritumoural vessels and each other\u2019s substance. In the sarcoma part, the mitotic and apoptotic indexes were 32 and 8, respectively, whereas in the melanoma part the same parameters were 10 and 6, respectively. During the immunohistochemical investigations anti-\u03b1-SMA, anticytokeratin AE1-AE3, anti-Melan-A, anti-Ki-67 and anti-claudin-5 antibodies were applied. In conclusion, this is the first report of a primary cutaneous malignant biphasic collision mixed tumour formed by an anaplastic sarcoma with giant cells and a malignant melanoma.<\/jats:p>","DOI":"10.1556\/avet.2012.021","type":"journal-article","created":{"date-parts":[[2012,5,20]],"date-time":"2012-05-20T15:51:45Z","timestamp":1337529105000},"page":"245-255","source":"Crossref","is-referenced-by-count":10,"title":["First report of a malignant collision skin tumour with malignant melanoma and anaplastic sarcoma components in a dog"],"prefix":"10.1556","volume":"60","author":[{"given":"Csaba","family":"Jakab","sequence":"first","affiliation":[{"name":"1 Szent Istv\u00e1n University Department of Pathology and Forensic Veterinary Medicine, Faculty of Veterinary Science Istv\u00e1n utca 2 H-1078 Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gyula","family":"Balka","sequence":"additional","affiliation":[{"name":"1 Szent Istv\u00e1n University Department of Pathology and Forensic Veterinary Medicine, Faculty of Veterinary Science Istv\u00e1n utca 2 H-1078 Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"1","first-page":"6","article-title":"A principal case of multiple lymphoid collision tumors involving both B-cell chronic lymphocytic leukemia and metastatic malignant melanoma","volume":"7","author":"Cantor A. 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Oncological case report and literature data [in Hungarian, with English abstract and figures]","volume":"132","author":"L\u00e9gr\u00e1dy A.","year":"2010","journal-title":"Magyar \u00c1llatorvosok Lapja"},{"key":"9","first-page":"461","article-title":"Claudin-5 positive perianal collision mixed skin tumour in dog","volume":"132","author":"L\u00e9gr\u00e1dy A.","year":"2010","journal-title":"Magyar \u00c1llatorvosok Lapja"},{"key":"10","doi-asserted-by":"crossref","first-page":"397","DOI":"10.3109\/07357908609017520","article-title":"Canine oral melanoma: comparison of surgery versus surgery plus Corynebacterium parvum","volume":"4","author":"MacEwen E. G.","year":"1986","journal-title":"Cancer Invest."},{"key":"11","first-page":"291","article-title":"Beitrag zur Verstandigung \u00fcber die Namengeburg in den Geschw\u00fclsten","volume":"30","author":"Meyer R.","year":"1920","journal-title":"Zbl. Allgem. Pathol."},{"key":"12","first-page":"165","article-title":"Dermal melanocytoma-acanthoma in an adult mixed breed dog","volume":"3\u20134","author":"Park S. I.","year":"2010","journal-title":"Jap. J. Vet. Res."},{"key":"13","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1177\/030098589303000310","article-title":"A clinicopathologic, histologic, and immunohistochemical study of mixed germ cell-stromal tumors of the testis in 16 dogs","volume":"30","author":"Patnaik A. K.","year":"1993","journal-title":"Vet. Pathol."},{"key":"14","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1354\/vp.42-4-499","article-title":"Melanocytic matricoma in a dog","volume":"4","author":"Saito S.","year":"2005","journal-title":"Vet. 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