{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T00:10:06Z","timestamp":1743984606932,"version":"3.40.3"},"reference-count":25,"publisher":"Akademiai Kiado Zrt.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,9,1]]},"abstract":"<jats:p>To demonstrate the relationship between tumour development and virus replication, eight specific-pathogen-free pullets of line P2 (Group P; 14 weeks old) and five adult chickens (Group A; 96 weeks old) were inoculated with virulent Marek\u2019s disease virus (vMDV). Five chickens of Group P died or were euthanised due to moribund condition following the development of neoplastic lesions between days 53 and 91. On histopathological examination, these lesions were characterised by the proliferation of lymphoid cells of variable size. On analysis by polymerase chain reaction (PCR), the MDV<jats:italic>meq<\/jats:italic>gene was detected in Group P from day 21, and it was continuously identified in five chickens until they died or were euthanised. Abnormal signs and histopathological changes were not observed in chickens of Group A. The MDV<jats:italic>meq<\/jats:italic>gene was temporarily detected in some chickens of Group A, but it remained almost undetectable throughout the experimental period. In older chickens inoculated with vMDV, the onset of MD lymphoma development tended to be delayed as compared with the young chicks. The relationship between MD lymphoma development and virus replication in older chickens has been suggested. Our data might indicate the underlying existence of an age-related resistance to vMDV challenge.<\/jats:p>","DOI":"10.1556\/avet.2012.028","type":"journal-article","created":{"date-parts":[[2012,8,18]],"date-time":"2012-08-18T03:05:02Z","timestamp":1345259102000},"page":"333-342","source":"Crossref","is-referenced-by-count":2,"title":["Relationship between tumour development and detection of Marek\u2019s disease virus in the feather follicular epithelium of older chickens"],"prefix":"10.1556","volume":"60","author":[{"given":"Mitsutaka","family":"Ikezawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Sasaki","sequence":"additional","affiliation":[{"name":"2 Iwate University Department of Veterinary Pathology, Faculty of Agriculture 3-18-8 Ueda Iwate 020-8550 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanobu","family":"Goryo","sequence":"additional","affiliation":[{"name":"2 Iwate University Department of Veterinary Pathology, Faculty of Agriculture 3-18-8 Ueda Iwate 020-8550 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"935","DOI":"10.2460\/ajvr.1971.32.06.935","article-title":"Age susceptibility of chickens to Marek\u2019s disease","volume":"32","author":"Anderson D. 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