{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T16:03:37Z","timestamp":1761581017979},"reference-count":39,"publisher":"Akademiai Kiado Zrt.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,9,1]]},"abstract":"<jats:p>Avian leukosis virus subgroup J (ALV-J) can cause a variety of neoplasms, including mainly myeloid leukosis (myelocytomatosis) and nephromas. Other tumours, such as histiocytic sarcoma (HS), haemangiosarcoma and mesothelioma, may also develop. In a previous article we described a case in which myeloid leukosis, haemangiomas and leiomyosarcomas appeared simultaneously in a commercial layer flock with infection by ALV-J. The present research was completed to understand the molecular characteristics of the ALV-J strain that induced clinical myeloid leukosis, haemangiomas and leiomyosarcomas. Two strains of ALV-J (SDAU1001 and SDAU1002) were isolated and identified, and their full-length sequences were analysed. The complete genome nucleotide sequences of these two isolates were different in length, 7652 nt and 7636 nt, respectively. They shared 98.9% identity with each other, and 93.4% to 97.8% nucleotide identity to the reference ALV-J isolates. A 19-nucleotide repeat sequence was identified in the primer binding site (PBS) leader region of isolate SDAU1001. A base substitution mutation (base 15 C-T) in this insertion was identified. However, the identical insertion at the same site was not found in SDAU1002. The<jats:italic>gag<\/jats:italic>and<jats:italic>pol<\/jats:italic>genes of the two viruses were more conserved than the<jats:italic>env<\/jats:italic>gene. One key deletion in the E element was a common feature of SDAU1001 and SDAU1002. SDAU1001 and SDAU1002, possibly recombinants of ALV-J and another avian retrovirus, may share the same ancestor. Co-infection by SDAU1001 and SDAU1002 isolates is a possible explanation why myeloid leukosis, haemangiomas, and leiomyosarcomas appeared simultaneously in the same commercial layer flock.<\/jats:p>","DOI":"10.1556\/avet.2012.029","type":"journal-article","created":{"date-parts":[[2012,8,18]],"date-time":"2012-08-18T03:05:02Z","timestamp":1345259102000},"page":"343-354","source":"Crossref","is-referenced-by-count":8,"title":["Sequence analysis for the complete proviral genome of avian leukosis virus subgroup J associated with haemangiomas, leiomyosarcomas and myelomas in layer flocks"],"prefix":"10.1556","volume":"60","author":[{"given":"Yue","family":"Qu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Honglei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meiyu","family":"Sun","sequence":"additional","affiliation":[{"name":"2 Chinese Academy of Agricultural Sciences Division of Avian Infectious Diseases, National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute Harbin, Heilongjiang P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delong","family":"Li","sequence":"additional","affiliation":[{"name":"1 Shandong Agricultural University College of Animal Science and Veterinary Medicine Taian 271018 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liting","family":"Qin","sequence":"additional","affiliation":[{"name":"2 Chinese Academy of Agricultural Sciences Division of Avian Infectious Diseases, National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute Harbin, Heilongjiang P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yulong","family":"Gao","sequence":"additional","affiliation":[{"name":"2 Chinese Academy of Agricultural Sciences Division of Avian Infectious Diseases, National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute Harbin, Heilongjiang P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaomei","family":"Wang","sequence":"additional","affiliation":[{"name":"2 Chinese Academy of Agricultural Sciences Division of Avian Infectious Diseases, National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute Harbin, Heilongjiang P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sidang","family":"Liu","sequence":"additional","affiliation":[{"name":"1 Shandong Agricultural University College of Animal Science and Veterinary Medicine Taian 271018 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"947","DOI":"10.2307\/1592351","article-title":"A low incidence of histiocytic sarcomatosis associated with infection of chickens with HPRS-103 strain of subgroup J avian leucosis virus","volume":"41","author":"Arshad S. 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