{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T10:36:25Z","timestamp":1789468585354,"version":"build-2803163510"},"reference-count":31,"publisher":"Akademiai Kiado Zrt.","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,12,1]]},"abstract":"<jats:p>Changes in ELISA serology are frequently used to determine antibiotic treatment success for Lyme disease in horses. This concept was based upon a previous report showing a marked decline in ELISA values in experimentally infected and antibiotic-treated ponies. Changes in Lyme serology following antibiotic treatment in naturally infected horses have not been reported. The objective of this study was to compare<jats:italic>Borrelia<\/jats:italic>ELISA antibody concentrations in naturally exposed horses both before and following antibiotic treatment for Lyme disease. A retrospective study was performed comparing oxytetracycline- or doxycyclinetreated (n = 68) and untreated (n = 183) horses from a single equine practice and their change in<jats:italic>Borrelia<\/jats:italic>ELISA values over a similar time period. Antibiotictreated horses had a decline in ELISA values in comparison to control horses (P \u2264 0.05) and untreated horses were twice as likely to have their ELISA values increase (OR = 0.5; 95% C.I. = 0.3\u20130.9) compared to treated horses. The magnitude of the decline in ELISA units following treatments was small compared to that previously reported in experimentally infected and treated ponies. Field-exposed horses with high<jats:italic>Borrelia burgdorferi<\/jats:italic>ELISA values who are treated with either oxytetracycline or doxycycline can be expected to have only a small decline in ELISA values following treatment. Persistently high ELISA titres following appropriate treatments for Lyme disease may not, without appropriate clinical signs, be a reason for more prolonged treatment.<\/jats:p>","DOI":"10.1556\/avet.2012.036","type":"journal-article","created":{"date-parts":[[2012,11,17]],"date-time":"2012-11-17T02:54:03Z","timestamp":1353120843000},"page":"421-429","source":"Crossref","is-referenced-by-count":12,"title":["Changes in Borrelia burgdorferi ELISA antibody over time in both antibiotic treated and untreated horses"],"prefix":"10.1556","volume":"60","author":[{"given":"Thomas","family":"Divers","sequence":"first","affiliation":[{"name":"1 Cornell University Department of Clinical Sciences Ithaca NY 14853 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Grice","sequence":"additional","affiliation":[{"name":"3 Rhinebeck Equine 26 Losee Lane Rhinebeck NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hussni","family":"Mohammed","sequence":"additional","affiliation":[{"name":"2 Cornell University Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine Ithaca NY 14853 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Glaser","sequence":"additional","affiliation":[{"name":"2 Cornell University Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine Ithaca NY 14853 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Wagner","sequence":"additional","affiliation":[{"name":"2 Cornell University Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine Ithaca NY 14853 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.2460\/javma.1995.207.11.1435","article-title":"Serologic responses of dogs naturally exposed to or vaccinated against Borrelia burgdorferi infection","volume":"207","author":"Barthold S. 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