{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T12:41:11Z","timestamp":1689079271981},"reference-count":39,"publisher":"Akademiai Kiado Zrt.","issue":"3","content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,9,1]]},"abstract":"<jats:p>This study aimed to investigate the adjuvant effect of recombinant attenuated<jats:italic>Salmonella<\/jats:italic>expressing cholera toxin B subunit (CTB) and<jats:italic>Escherichia coli<\/jats:italic>heat-labile enterotoxin B subunit (LTB) for the P-fimbriae subunit-based vaccine of avian pathogenic<jats:italic>E. coli<\/jats:italic>(APEC) in a murine model. The PapA-specific sIgA and IgG responses were significantly enhanced after immunisation with the<jats:italic>Salmonella<\/jats:italic>-PapA vaccine in the presence of CTB or LTB. The group immunised with the<jats:italic>Salmonella<\/jats:italic>-LTB strain promoted Th1-type immunity, whereas that immunised with the<jats:italic>Salmonella<\/jats:italic>-CTB strain produced Th2-type immunity. We concluded that both<jats:italic>Salmonella<\/jats:italic>-CTB and -LTB strains can enhance the immune response to PapA, and that the LTB strain may be a more effective adjuvant for APEC vaccination, which requires higher Th1-type immunity for protection. Thus, our findings provide evidence that immunisation with an adjuvant, LTB, is one of the strategies of developing effective vaccines against P-fimbriated APEC.<\/jats:p>","DOI":"10.1556\/avet.2014.006","type":"journal-article","created":{"date-parts":[[2014,3,23]],"date-time":"2014-03-23T01:09:59Z","timestamp":1395536999000},"page":"293-303","update-policy":"http:\/\/dx.doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":0,"title":["The B subunits of cholera and Escherichia coli heat-labile toxins enhance the immune responses in mice orally immunised with a recombinant live P-fimbrial vaccine for avian pathogenic E. coli"],"prefix":"10.1556","volume":"62","author":[{"given":"In-Gyeong","family":"Oh","sequence":"first","affiliation":[{"name":"1 Chonbuk National University College of Veterinary Medicine and Bio-Safety Research Institute 561-756 Jeonju South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chetan","family":"Jawale","sequence":"additional","affiliation":[{"name":"1 Chonbuk National University College of Veterinary Medicine and Bio-Safety Research Institute 561-756 Jeonju South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Lee","sequence":"additional","affiliation":[{"name":"1 Chonbuk National University College of Veterinary Medicine and Bio-Safety Research Institute 561-756 Jeonju South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.femsle.2005.09.024","article-title":"An avian pathogenic Escherichia coli isolate induces caspase 3\/7 activation in J774 macrophages","volume":"253","author":"Bastiani M.","year":"2005","journal-title":"FEMS. 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