{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T02:19:27Z","timestamp":1766888367058},"reference-count":29,"publisher":"Akademiai Kiado Zrt.","issue":"3","content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,9,1]]},"abstract":"<jats:p>The objective of this study was designed to test whether supplementation of the diet with arginine (Arg) or glutamine (Gln) or their combination influences the production, organ weights and humoral immune response of broilers. A total of 432 one-day-old male Ross 308 broiler chickens were divided into 6 treatment groups: control, Arg-0.5%, Arg-1%, Gln-0.5%, Gln-1% and Arg-0.5%+Gln-0.5%. Drinking water and feed were provided<jats:italic>ad libitum<\/jats:italic>. On day 18 of the experiment 50% of chickens in each treatment group were immunised with bovine serum albumin. Ten and 21 days after immunisation blood samples were collected to determine the anti-albumin IgY titre, interleukin 6 (IL6) and interferon gamma (IFNG) and to measure the weight of the liver, spleen, bursa of Fabricius and thymus. Arg or Gln supplementation of the diets influenced neither the production nor the organ weights until 18 days of age. Between 18 and 39 days of age both Arg (0.5% and 1%) and Arg + Gln supplementation improved the feed conversion ratio (FCR) by 3.7%, 6.3% and 4.9%, respectively, while Gln-1% worsened it by 15%. Immunisation slightly (\u22120.79%) depressed the body weight gain of broilers fed the control diet, which was significantly improved by both Arg (0.5 or 1%) and Arg + Gln supplementation. Immunisation increased the weight of the spleen, bursa and thymus and decreased that of the liver. Supplementation with 1% Gln depressed (\u22125.13%) the body weight gain of the immunised chickens but strongly stimulated the immune response. Supplementations with Arg and Gln did not influence the IL6 and IFNG level of the blood; however, on day 10 after immunisation these two parameters showed a negative correlation with each other. Regarding production, organ weights and immunity, Arg supplementation should be recommended in the grower phase, while Gln supplementation can be useful in pullets raised for egg production, where a good immune response to vaccinations is an important factor.<\/jats:p>","DOI":"10.1556\/avet.2014.017","type":"journal-article","created":{"date-parts":[[2014,7,20]],"date-time":"2014-07-20T01:00:58Z","timestamp":1405818058000},"page":"348-361","update-policy":"http:\/\/dx.doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":9,"title":["Effect of arginine or glutamine supplementation on production, organ weights, interferon gamma, interleukin 6 and antibody titre of broilers"],"prefix":"10.1556","volume":"62","author":[{"given":"J\u00f3zsef","family":"Szab\u00f3","sequence":"first","affiliation":[{"name":"1 Szent Istv\u00e1n University Institute for Animal Breeding, Nutrition and Laboratory Animal Science Istv\u00e1n u. 2 H-1078 Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emese","family":"Andr\u00e1sofszky","sequence":"additional","affiliation":[{"name":"1 Szent Istv\u00e1n University Institute for Animal Breeding, Nutrition and Laboratory Animal Science Istv\u00e1n u. 2 H-1078 Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tam\u00e1s","family":"Tuboly","sequence":"additional","affiliation":[{"name":"2 Szent Istv\u00e1n University Department of Microbiology and Infectious Diseases, Faculty of Veterinary Science Istv\u00e1n u. 2 H-1078 Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e1s","family":"Bers\u00e9nyi","sequence":"additional","affiliation":[{"name":"1 Szent Istv\u00e1n University Institute for Animal Breeding, Nutrition and Laboratory Animal Science Istv\u00e1n u. 2 H-1078 Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Weisz","sequence":"additional","affiliation":[{"name":"1 Szent Istv\u00e1n University Institute for Animal Breeding, Nutrition and Laboratory Animal Science Istv\u00e1n u. 2 H-1078 Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikoletta","family":"Het\u00e9nyi","sequence":"additional","affiliation":[{"name":"1 Szent Istv\u00e1n University Institute for Animal Breeding, Nutrition and Laboratory Animal Science Istv\u00e1n u. 2 H-1078 Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Istv\u00e1n","family":"Hull\u00e1r","sequence":"additional","affiliation":[{"name":"1 Szent Istv\u00e1n University Institute for Animal Breeding, Nutrition and Laboratory Animal Science Istv\u00e1n u. 2 H-1078 Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"252","DOI":"10.3923\/pjn.2012.252.257","article-title":"Effect of dietary L-arginine on productive performance of broiler chickens","volume":"11","author":"Al-Daraji H. J.","year":"2012","journal-title":"Pakistan J. Nutr."},{"key":"2","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1079\/BJN2001451","article-title":"Glutamine: Essential for immune nutrition in the critically ill","volume":"87","author":"Andrews F. J.","year":"2002","journal-title":"Br. J. Nutr."},{"key":"3","volume-title":"Official Methods of Analysis","year":"1990"},{"key":"4","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/S0021-9258(18)74642-5","article-title":"Further studies on the growth factor required by chicks. The essential nature of arginine","volume":"116","author":"Arnold A.","year":"1936","journal-title":"J. Biol. Chem."},{"key":"5","volume-title":"ROSS Broiler Management Manual","year":"2009"},{"key":"6","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1093\/ps\/86.9.1940","article-title":"The effect of supplemental glutamine on growth performance, development of gastrointestinal tract, and humoral immune response of broilers","volume":"86","author":"Bartell S. M.","year":"2007","journal-title":"Poult. Sci."},{"key":"7","first-page":"8A","article-title":"Carryover effects of dietary L-arginine on the immune system in chickens","volume":"14","author":"Deng K.","year":"2003","journal-title":"Rec. Adv. Anim. Nutr. Austr."},{"key":"8","first-page":"325","article-title":"Productivity and immune response of broiler chickens vaccinated with different avian influenza vaccines at one or seven days of age","volume":"5","author":"El-Sayed D. A. A.","year":"2011","journal-title":"Aust. J. Basic Appl. Sci."},{"key":"9","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1136\/bmj.281.6235.263","article-title":"Stimulation of protein synthesis and breakdown by vaccination","volume":"26","author":"Garlick P. J.","year":"1980","journal-title":"Br. Med. J."},{"key":"10","doi-asserted-by":"crossref","first-page":"99","DOI":"10.2527\/jas1983.57199x","article-title":"Effect of excess arginine on swine growth and plasma amino acids","volume":"57","author":"Hagemeier D. L.","year":"1983","journal-title":"J. Anim. Sci."},{"key":"11","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1093\/jn\/104.9.1127","article-title":"Arginine, lysine and glycine interaction in the nutrition of chick","volume":"104","author":"Kadirvel R.","year":"1974","journal-title":"J. Nutr."},{"key":"12","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1093\/ps\/80.11.1535","article-title":"Growth and immunity of broiler chicks as affected by dietary arginine","volume":"80","author":"Kidd M. T.","year":"2001","journal-title":"Poult. Sci."},{"key":"13","volume-title":"Nebraska Swine Rep.","author":"Kitt S. J.","year":"2002"},{"key":"14","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0021-9258(18)73171-2","article-title":"The ability of citrulline to replace arginine in the diet of chick","volume":"135","author":"Klose A. A.","year":"1940","journal-title":"J. Biol. Chem."},{"key":"15","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/S0021-9258(18)74114-8","article-title":"The essential nature of arginine in the diet of the chick","volume":"123","author":"Klose A. A.","year":"1938","journal-title":"J. Biol. Chem."},{"key":"16","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1093\/ps\/78.11.1536","article-title":"Influence of dietary arginine concentration on lymphoid organ growth in chickens","volume":"78","author":"Kwak H.","year":"1999","journal-title":"Poult. Sci."},{"key":"17","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1093\/ps\/80.5.599","article-title":"Lysine and arginine requirements of broiler chickens at two- to three-week intervals to eight weeks of age","volume":"80","author":"Labadan M. C.","year":"2001","journal-title":"Poult. Sci."},{"key":"18","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1093\/jn\/131.9.2467S","article-title":"Mechanisms governing the expression of the enzymes of glutamine metabolism \u2014 glutaminase and glutamine synthetase","volume":"131","author":"Labow B. L.","year":"2001","journal-title":"J. Nutr."},{"key":"19","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1017\/S000711450769936X","article-title":"Amino acids and immune function","volume":"98","author":"Li P.","year":"2007","journal-title":"Br. J. Nutr."},{"key":"20","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.3382\/ps.2009-00152","article-title":"Dietary arginine stimulates humoral and cell-mediated immunity in chickens vaccinated and challenged against hydropericardium syndrome virus","volume":"88","author":"Munir K.","year":"2009","journal-title":"Poult. Sci."},{"key":"21","volume-title":"Nutrient Requirements of Poultry","year":"1994"},{"key":"22","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1113\/expphysiol.1985.sp002935","article-title":"Glutamine metabolism in lymphocytes: its biochemical, physiological and clinical importance","volume":"70","author":"Newsholme E. A.","year":"1985","journal-title":"Quart. J. Exp. Physiol."},{"key":"23","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1042\/CS20040290","article-title":"New insight into amino acid metabolism, beta-cell function and diabetes","volume":"108","author":"Newsholme P.","year":"2005","journal-title":"Clin. Sci."},{"key":"24","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1189\/jlb.0603252","article-title":"Interferon-gamma: an overview of signals, mechanisms and functions","volume":"75","author":"Schroder K.","year":"2004","journal-title":"J. Leukoc. Biol."},{"key":"25","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3923\/ijps.2009.60.68","article-title":"Influence of dietary glutamine supplementation on growth performance, small intestinal morphology, immune response and some blood parameters of broiler chickens","volume":"8","author":"Soltan M. A.","year":"2009","journal-title":"Int. J. Poult. 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