{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T18:50:10Z","timestamp":1791571810944,"version":"4.3.4"},"reference-count":17,"publisher":"Akademiai Kiado Zrt.","issue":"1","content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1999,1,1]]},"abstract":"<jats:p>The purpose of this study was to determine whether intravaginal prostaglandin F2\u03b1(PGF2\u03b1) would be effective for the treatment of metritis or pyometra in the bitch. Seventeen bitches with metritis or pyometra were treated with PGF2\u03b1. Prostaglandin F2\u03b1(150 (g\/kg body weight) was administered once or twice daily by infusing 0.3 ml per 10 kg body wt into the vaginal lumen. Bitches were also treated with amoxicillin (15 mg\/kg body wt\/48 h) and\/or gentamicin (4 mg\/kg body wt\/day) administered as intramuscular (i.m.) injections. Fifteen bitches were treated successfully with intravaginally administered PGF2\u03b1for 3 to 12 days and with intramuscularly administered antibiotics for 4 to 12 days. Success of treatment was judged by cessation of vaginal discharge, the absence of fluid in the uterus as determined by ultrasonography, and the overall health status of the animal. As two bitches with pyometra showed clinical deterioration in spite of medical treatment, ovariohysterectomy was performed after the first and the second treatment, respectively. No side effects (salivation, vomiting, diarrhoea, hyperpnoea, ataxia, urination, anxiety, pupillary dilatation followed by contraction) were observed after PGF2\u03b1treatment. The disease did not recur during the subsequent oestrous cycles within 12 months after the initial treatment. The results demonstrate that intravaginal administration of PGF2\u03b1was effective in 13 dogs (86.6%) with metritis or pyometra, and caused no side effects. Although the study was based on a relatively small number of cases, it is concluded that prostaglandin F2\u03b1can be a useful means of treating bitches with metritis or pyometra. However, in severe cases of pyometra ovariohysterectomy is needed.<\/jats:p>","DOI":"10.1556\/avet.47.1999.1.10","type":"journal-article","created":{"date-parts":[[2005,10,21]],"date-time":"2005-10-21T19:28:11Z","timestamp":1129922891000},"page":"103-108","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":22,"title":["INTRAVAGINAL PROSTAGLANDIN F 2\u03b1 FOR THE TREATMENT OF METRITIS AND PYOMETRA IN THE BITCH"],"prefix":"10.1556","volume":"47","author":[{"given":"G.","family":"G\u00e1bor","sequence":"first","affiliation":[{"name":"1 Research Institute for Animal Breeding and Nutrition, H.2053 Herceghalom, Geszteny\u00e9s u., Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Siver","sequence":"additional","affiliation":[{"name":"2 FeliCaVet Veterinary Clinic Ltd., Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Szenci","sequence":"additional","affiliation":[{"name":"3 Department of Obstetrics and Reproduction, University of Veterinary Science, Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"14","first-page":"363","article-title":"Zur Therapie des Endometritis-Pyometra-Komplexes der H\u00fcndin mit niedrig dosiertem Prostaglandin F2a.","volume":"38","author":"I. 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Arnold","year":"1988","journal-title":"J. Small Anim. Pract."},{"key":"2","first-page":"381","article-title":"Use of prostaglandin F2a in treatment of uterine diseases in the bitch.","author":"J. Brown","year":"1985"},{"key":"3","first-page":"528","volume-title":"Population control in the bitch.","author":"T. Burke","year":"1986"},{"key":"4","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/j.1748-5827.1982.tb01667.x","article-title":"A preliminary study of pregnancy termination in the bitch with slow-release formulations of prostaglandin analogues.","volume":"23","author":"P. Jackson","year":"1982","journal-title":"J. Small Anim. Pract."},{"key":"8","doi-asserted-by":"crossref","first-page":"509","DOI":"10.2460\/javma.1993.203.04.0509","article-title":"Diagnosis and treatment of closed-cervix pyometra in a bitch.","volume":"203","author":"M. Memon","year":"1993","journal-title":"J. Am. Vet. Med. 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Assoc."},{"key":"5","first-page":"654","volume-title":"Disorders of the vagina and uterus.","author":"C. Johnson","year":"1992"},{"key":"6","first-page":"510","article-title":"Commentary to: Memon M. A., Mickelsen, W. D.: Diagnosis and treatment of closed-cervix pyometra in a bitch.","volume":"203","author":"C. Johnson","year":"1993","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"7","volume-title":"Prostaglandin therapy in small animal reproduction.","author":"D. Lein","year":"1986"}],"container-title":["Acta Veterinaria Hungarica"],"original-title":[],"link":[{"URL":"https:\/\/akjournals.com\/view\/journals\/004\/47\/1\/article-p103.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/akjournals.com\/downloadpdf\/journals\/004\/47\/1\/article-p103.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T06:01:22Z","timestamp":1706680882000},"score":1,"resource":{"primary":{"URL":"https:\/\/akjournals.com\/view\/journals\/004\/47\/1\/article-p103.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,1,1]]},"references-count":17,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1556\/avet.47.1999.1.10","relation":{},"ISSN":["0236-6290","1588-2705"],"issn-type":[{"value":"0236-6290","type":"print"},{"value":"1588-2705","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,1,1]]}}}