{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T05:14:49Z","timestamp":1768626889803,"version":"3.49.0"},"reference-count":39,"publisher":"Akademiai Kiado Zrt.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,7,1]]},"abstract":"<jats:p>The effects of salbutamol and norepinephrine on the electrocardiogram (ECG), serum potassium level and enzyme activities were studied in rabbits with hyperkalaemia; norepinephrine and salbutamol may be therapeutically useful. For induction of hyperkalaemia, 300 mM KCl solution was used and then isotonic saline solution containing 6 \u00b5g salbutamol and 3.9 \u00b5g norepinephrine per ml were administered. Norepinephrine and salbutamol decreased the serum potassium from 7.36 \u00b1 0.26 and 7.21 \u00b1 0.31 mmol\/L to 5.62 \u00b1 0.27 and 4.35 \u00b1 0.33 mmol\/L, respectively, and caused the ECG changes (flatness of P wave, widening of QRS complex and bradycardia) to return to the control conditions (time 0). Norepinephrine, but not salbutamol, decreased the activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and lactate dehydrogenase (LDH) to the control levels. These results suggest that monitoring of the enzyme activities might be useful as it yields indexes suitable for evaluating the therapeutic approach with norepinephrine in hyperkalaemia.<\/jats:p>","DOI":"10.1556\/avet.51.2003.3.8","type":"journal-article","created":{"date-parts":[[2004,7,14]],"date-time":"2004-07-14T13:53:41Z","timestamp":1089813221000},"page":"331-342","source":"Crossref","is-referenced-by-count":4,"title":["Experimental hyperkalaemia in rabbits: Effects of salbutamol and norepinephrine treatments on blood biochemistry and electrocardiography"],"prefix":"10.1556","volume":"51","author":[{"given":"S.","family":"Celik","sequence":"first","affiliation":[{"name":"1 Department of Biochemistry, Faculty of Veterinary Medicine, University of Mustafa Kemal 31040 Antakya-Hatay, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Bal","sequence":"additional","affiliation":[{"name":"2 Department of Physiology, Faculty of Veterinary Medicine, University of Mustafa Kemal 31040 Antakya-Hatay, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Durgut","sequence":"additional","affiliation":[{"name":"3 Department of Internal Medicine, Faculty of Veterinary Medicine, University of Mustafa Kemal 31040 Antakya-Hatay, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"27","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1136\/adc.66.4.527","article-title":"Treatment of hyperkalaemia with intravenous salbutamol.","volume":"66","author":"I. 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