{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T05:24:42Z","timestamp":1770528282701,"version":"3.49.0"},"reference-count":42,"publisher":"Akademiai Kiado Zrt.","issue":"4","content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2004,10,1]]},"abstract":"<jats:p>Considering that the excessive usage of vitamin E causes hypervitaminosis and thus reduces blood erythrocyte concentrations, therefore it is worth studying how its pharmacological dosage affects the activity of carbonic anhydrase (CA) enzyme found in erythrocytes of rainbow trout (<jats:italic>Oncorhynchus mykiss<\/jats:italic>)<jats:italic>in vitro<\/jats:italic>and<jats:italic>in vivo<\/jats:italic>. Vitamin E inhibited CA enzyme and the IC<jats:sub>50<\/jats:sub>value of the vitamin was 0.039 mM<jats:italic>in vitro<\/jats:italic>. Similarly, it was seen that vitamin E inhibited CA enzyme activity after the first hour following vitamin E injections<jats:italic>in vivo<\/jats:italic>. The activities of CA in groups of trout given vitamin E injection were measured at 1, 3 and 5 h and the corresponding activities were found to be 772.7 \u00b1 290.5 (P &lt; 0.05), 1286.4 \u00b1 378.2 and 1005.7 \u00b1 436.1 enzyme units (EU) g Hb<jats:sup>-1<\/jats:sup>. The difference over the control was significant (P &lt; 0.05) in the first hour and insignificant at 3 and 5 h (P ? 0.05). The activity of CA in the control, which did not contain vitamin E, was determined as 1597.7 \u00b1 429.0 EU g Hb<jats:sup>-1<\/jats:sup>.<\/jats:p>","DOI":"10.1556\/avet.52.2004.4.4","type":"journal-article","created":{"date-parts":[[2005,3,22]],"date-time":"2005-03-22T15:02:17Z","timestamp":1111503737000},"page":"413-422","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":63,"title":["Effect of vitamin E on carbonic anhydrase enzyme activity in rainbow trout (Oncorhynchus mykiss) erythrocytes in vitro and in vivo"],"prefix":"10.1556","volume":"52","author":[{"given":"\u015e.","family":"Aras-Hisar","sequence":"first","affiliation":[{"name":"1 Department of Aquaculture, Agriculture Faculty, Atat\u00fcrk University 25240 Erzurum, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Hisar","sequence":"additional","affiliation":[{"name":"2 Department of Aquaculture, Agriculture Faculty, Atat\u00fcrk University 25240 Erzurum, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u015e.","family":"Beydemir","sequence":"additional","affiliation":[{"name":"3 Department of Chemistry, Arts and Science Faculty, Atat\u00fcrk University Erzurum, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"G\u00fcl\u00e7in","sequence":"additional","affiliation":[{"name":"4 Department of Chemistry, Arts and Science Faculty, Atat\u00fcrk University Erzurum, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Yanik","sequence":"additional","affiliation":[{"name":"5 Department of Aquaculture, Agriculture Faculty, Atat\u00fcrk University 25240 Erzurum, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"30","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1006\/bbrc.2000.4174","article-title":"\u03b1-Tocopherol inhibits human glutathione s-transferase \u03c0","volume":"280","author":"I. 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