{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T14:32:01Z","timestamp":1789914721226,"version":"4.0.1"},"reference-count":38,"publisher":"Akademiai Kiado Zrt.","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,6,1]]},"abstract":"<jats:p>Changes in coagulation parameters were studied in dogs naturally infected with<jats:italic>Babesia canis canis<\/jats:italic>(n = 30), and haemostasis was evaluated and compared to values obtained from healthy dogs (n = 29). To date, there have not been any studies examining the dynamics of thrombin-antithrombin complex formation in cases of canine babesiosis. Coagulation parameters evaluated before (day 0) and on days 1, 2, and 3 after treatment with imidocarb (6 mg\/kg inj. s.c.) included the determination of platelet counts, the formation of thrombin-antithrombin complexes (TAT), prothrombin time (PT), activated partial thromboplastin time (APTT) and antithrombin III (AT III) activity. TAT complexes were significantly elevated in animals with babesiosis on days 0 and 2 (mean 49.7 and 87.7 \u03bcg\/L vs. control, 7.2 \u03bcg\/L). AT III activity was significantly decreased at all time-points examined. There were no differences in PT. On days 2 and 3 the APTT was significantly shortened in the infected dogs when compared to control animals (means of 21.3 and 19.2 s vs. control, 30.0 s). Our analysis demonstrated that infected dogs had significant thrombocytopenia during the course of the study (mean day 0 \u2212 29 \u00d7 10<jats:sup>9<\/jats:sup>\/L, day 1 \u2212 48 \u00d7 10<jats:sup>9<\/jats:sup>\/L, day 2 \u2212 47 \u00d7 10<jats:sup>9<\/jats:sup>\/L and day 3 \u2212 87 \u00d7 10<jats:sup>9<\/jats:sup>\/L, vs. control \u2212259 \u00d7 10<jats:sup>9<\/jats:sup>\/L). These data suggest that babesiosis in dogs compromise primary and secondary haemostasis and that induction of disseminated intravascular coagulation (DIC) occurs in canine babesiosis.<\/jats:p>","DOI":"10.1556\/avet.57.2009.2.10","type":"journal-article","created":{"date-parts":[[2009,7,8]],"date-time":"2009-07-08T01:05:43Z","timestamp":1247015143000},"page":"295-304","source":"Crossref","is-referenced-by-count":26,"title":["Alterations in some blood coagulation parameters in naturally occurring cases of canine babesiosis"],"prefix":"10.1556","volume":"57","author":[{"given":"Renata","family":"Rafaj","sequence":"first","affiliation":[{"name":"1 University of Zagreb Department of Chemistry and Biochemistry Heinzelova 55 10000 Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vesna","family":"Matijatko","sequence":"additional","affiliation":[{"name":"2 University of Zagreb Clinic of Internal Medicine Heinzelova 55 10000 Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Ki\u0161","sequence":"additional","affiliation":[{"name":"2 University of Zagreb Clinic of Internal Medicine Heinzelova 55 10000 Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nada","family":"Ku\u010der","sequence":"additional","affiliation":[{"name":"2 University of Zagreb Clinic of Internal Medicine Heinzelova 55 10000 Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatjana","family":"\u017divi\u010dnjak","sequence":"additional","affiliation":[{"name":"3 University of Zagreb Department of Parasitology, Faculty of Veterinary Medicine Heinzelova 55 10000 Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niksa","family":"Lemo","sequence":"additional","affiliation":[{"name":"2 University of Zagreb Clinic of Internal Medicine Heinzelova 55 10000 Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zdravko","family":"\u017dvorc","sequence":"additional","affiliation":[{"name":"2 University of Zagreb Clinic of Internal Medicine Heinzelova 55 10000 Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirna","family":"Brklja\u010di\u0107","sequence":"additional","affiliation":[{"name":"2 University of Zagreb Clinic of Internal Medicine Heinzelova 55 10000 Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Mrljak","sequence":"additional","affiliation":[{"name":"2 University of Zagreb Clinic of Internal Medicine Heinzelova 55 10000 Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"798","DOI":"10.2460\/javma.1999.215.06.798","article-title":"Diagnosis of disseminated intravascular coagulation in dogs admitted to an intensive care unit","volume":"215","author":"Bateman S. 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