{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T12:23:52Z","timestamp":1773663832858,"version":"3.50.1"},"reference-count":48,"publisher":"Akademiai Kiado Zrt.","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,6,1]]},"abstract":"<jats:p><jats:italic>Arcobacter cryaerophilus<\/jats:italic>was isolated from naturally infected rainbow trout (<jats:italic>Oncorhynchus mykiss<\/jats:italic>Walbaum), and its pathogenicity was tested by intramuscular injection using healthy 1-year-old rainbow trout under cold-water conditions (at 5 \u00b0C). The lethal dosage of 50% end point (LD<jats:sub>50<\/jats:sub>) for<jats:italic>A. cryaerophilus<\/jats:italic>was calculated as 7.79 \u00d7 10<jats:sup>5<\/jats:sup>viable cells. Experimental infection caused gross clinical abnormalities such as fallen scales, exophthalmia, oedema in injection region and at the base of fins, pale gills, kidney necrosis, hyperaemic areas in pale liver, haemorrhagic spots in heart, elongated spleen and swollen gallbladder. Activities of aspartate aminotransferase and alkaline phosphatase, and concentrations of glucose, total protein, albumin, cholesterol, triglyceride and calcium in the serum of the experimentally infected rainbow trout were significantly decreased compared with the healthy fish. Positive correlations were observed among blood parameters. Total lipid weights increased in the brain, muscle and liver tissues of infected fish and dropped in the gill and spleen tissues. Lipid peroxide contents in the brain, liver, kidney, spleen, muscle and gill tissues of infected rainbow trout were significantly higher than in healthy animals. The present work shows that<jats:italic>A. cryaerophilus<\/jats:italic>can be moderately virulent for rainbow trout at low water temperature, and changes in lipid and lipid peroxide contents of tissues and blood indices can highlight barely detectable effects of<jats:italic>A. cryaerophilus<\/jats:italic>infection in rainbow trout under laboratory conditions. However, the application of these indices in farm biomonitoring using rainbow trout will need more detailed studies and a careful consideration of the environmental parameters.<\/jats:p>","DOI":"10.1556\/avet.57.2009.2.11","type":"journal-article","created":{"date-parts":[[2009,7,8]],"date-time":"2009-07-08T01:05:43Z","timestamp":1247015143000},"page":"305-317","source":"Crossref","is-referenced-by-count":11,"title":["Gross pathology, blood chemistry, lipid and peroxide contents in rainbow trout ( Oncorhynchus mykiss Walbaum) affected by experimental Arcobacter cryaerophilus infection at low water temperature"],"prefix":"10.1556","volume":"57","author":[{"given":"Seyit","family":"Aydin","sequence":"first","affiliation":[{"name":"1 Kastamonu University Education Faculty 37200 Kastamonu Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayati","family":"Gure","sequence":"additional","affiliation":[{"name":"2 Ministry of Rural Affairs Directory of \u00c7anakkale Canakkale Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hasan","family":"Cakici","sequence":"additional","affiliation":[{"name":"3 Canakkale Onsekiz Mart University Medicine College Canakkale Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serhat","family":"Colakoglu","sequence":"additional","affiliation":[{"name":"2 Ministry of Rural Affairs Directory of \u00c7anakkale Canakkale Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Recep","family":"Bircan","sequence":"additional","affiliation":[{"name":"4 Ondokuz May\u0131s University Fisheries Faculty Sinop Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1006\/fsim.2001.0373","article-title":"Effects of rearing temperature on immune functions in sockeye salmon (Oncorhynchus nerka)","volume":"12","author":"Alcorn S. W.","year":"2002","journal-title":"Fish & Shellfish Immunol."},{"key":"2","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.tiv.2006.08.011","article-title":"Proapoptotic effect of fly ash leachates in hepatocytes of freshwater fish (Channa punctata Bloch)","volume":"21","author":"Ali M.","year":"2007","journal-title":"Toxicology in Vitro"},{"key":"3","first-page":"301","article-title":"Haematological investigations of Yersinia ruckeri infection in rainbow trout (Oncorhynchus mykiss Walbaum)","volume":"23","author":"Altun S.","year":"1999","journal-title":"Turkish J. Vet. Anim. Sci."},{"key":"4","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.ijfoodmicro.2006.01.020","article-title":"Detection and diversity of various Arcobacter species in Danish poultry","volume":"109","author":"Atabay H. I.","year":"2006","journal-title":"Int. J. Food Microbiol."},{"key":"5","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1365-2672.2006.03240.x","article-title":"Prevalence and distribution of Arcobacter species in various sources in Turkey and molecular analysis of isolated strains by ERIC-PCR","volume":"103","author":"Aydin F.","year":"2007","journal-title":"J. Appl. Microbiol."},{"key":"6","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1577\/1548-8667(2002)014<0039:ACIOAC>2.0.CO;2","article-title":"A comparative investigation of Arcobacter cryaerophilus infection among albino crosses and high- and low-body-weight rainbow trout","volume":"32","author":"Aydin S.","year":"2002","journal-title":"J. Aquat. Anim. Health"},{"key":"7","first-page":"643","article-title":"Investigations of Serratia liquefaciens infection in rainbow trout (Oncorhynchus mykiss Walbaum)","volume":"25","author":"Aydin S.","year":"2001","journal-title":"Turkish J. Vet. Anim. Sci."},{"key":"8","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3147\/jsfp.35.117","article-title":"Natural and experimental infections of Campylobacter cryaerophila in rainbow trout: gross pathology, bacteriology, clinical pathology, and chemotherapy","volume":"35","author":"Aydin S.","year":"2000","journal-title":"Fish Pathol."},{"key":"9","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/j.1095-8649.1980.tb02761.x","article-title":"The haematological assessment of bacterial infection in rainbow trout, Salmo gairdneri Richardson","volume":"17","author":"Barham W. T.","year":"1980","journal-title":"J. Fish Biol."},{"key":"10","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.ecoenv.2005.11.002","article-title":"Induction of oxidative stress by arsenic in Clarias batrachus: involvement of peroxisomes","volume":"66","author":"Bhattacharya A.","year":"2007","journal-title":"Ecotox. Environ. Safety"},{"key":"11","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1023\/A:1014366701630","article-title":"Effect of bacterial infection on lipid composition of carp blood lymphocytes","volume":"38","author":"Bogdan V. V.","year":"2002","journal-title":"Appl. Biochem. Microbiol."},{"key":"12","volume-title":"Fish Pathology","author":"Bullock A. M.","year":"1989"},{"key":"13","first-page":"378","article-title":"Arcobacter cryaerophilus infection in albino crosses rainbow trout and rainbow trout (Oncorhynchus mykiss Walbaum): bacteriology, gross pathology and clinical pathology","volume":"3","author":"Bulut M.","year":"2004","journal-title":"J. Anim. Vet. Adv."},{"key":"14","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1023\/A:1022166411089","article-title":"Transport stress in matrinxa, Brycon cephalus (Teleostei: Characidae), at different densities","volume":"10","author":"Carneiro P. C. F.","year":"2002","journal-title":"Aquaculture International"},{"key":"15","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.aquaculture.2004.05.033","article-title":"Comparative blood chemistry and histopathology of tilapia infected with Vibrio vulnificus or Streptococcus iniae or exposed to carbon tetrachloride, gentamicin, or copper sulfate","volume":"239","author":"Chen C.-Y.","year":"2004","journal-title":"Aquaculture"},{"key":"16","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0044-8486(02)00499-4","article-title":"Blood chemistry of healthy, nephrocalcinosis-affected and ozone-treated tilapia in a recirculation system, with application of discriminant analysis","volume":"218","author":"Chen C.-Y.","year":"2002","journal-title":"Aquaculture"},{"key":"17","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1111\/j.1365-2672.2007.03275.x","article-title":"Detection of Arcobacter spp. in piggery effluent and effluent-irrigated soils in southeast Queensland","volume":"103","author":"Chinivasagam H. N.","year":"2007","journal-title":"J. Appl. Microbiol."},{"key":"18","first-page":"350","article-title":"Isolation of campylobacters from the canal of Bangkok metropolitan area","volume":"75","author":"Dhamabutra N.","year":"1992","journal-title":"J. Med. Assoc. Thai."},{"key":"19","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1136\/vr.100.21.451","article-title":"Isolation of Spirillum\/Vibrio like organisms from bovine fetuses","volume":"100","author":"Ellis W. A.","year":"1977","journal-title":"Vet. Rec."},{"key":"20","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1128\/AEM.70.3.1271-1276.2004","article-title":"Detection of Arcobacter spp. in the coastal environment of the Mediterranean Sea","volume":"70","author":"Fera M. T.","year":"2004","journal-title":"Appl. Environ. Microbiol."},{"key":"21","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S0021-9258(18)64849-5","article-title":"A simple method for isolation and purification of total lipids from animal tissues","volume":"226","author":"Folch J.","year":"1957","journal-title":"J. Biol. Chem."},{"key":"22","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/j.1751-1097.1990.tb01744.x","article-title":"Photodynamic lipid peroxidation in biological systems","volume":"51","author":"Girotti A. W.","year":"1990","journal-title":"Photochem. Photobiol."},{"key":"23","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1016\/j.chemosphere.2006.04.005","article-title":"Oxidative stress, liver biotransformation and genotoxic effects induced by copper in Anguilla anguilla L. \u2014 the influence of pre-exposure to \u03b2-naphthoflavone","volume":"65","author":"Gravato C.","year":"2006","journal-title":"Chemosphere"},{"key":"24","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1111\/j.1365-2761.1979.tb00391.x","article-title":"Studies on the pathogenesis of vibriosis in coho salmon Oncorhynchus kisutch (Walbaum)","volume":"2","author":"Harbell S. C.","year":"1979","journal-title":"J. Fish Dis."},{"key":"25","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0044-8486(03)00023-1","article-title":"Hematological and biochemical parameters in common carp, Cyprinus carpio, following herbal treatment for Aeromonas hydrophila infection","volume":"221","author":"Harikrishnan R.","year":"2003","journal-title":"Aquaculture"},{"key":"26","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0891-5849(95)00020-X","article-title":"Quantification of lipid peroxidation in tissue extracts based on Fe (III) xylenol orange complex formation","volume":"19","author":"Hermes-Lima M.","year":"1995","journal-title":"Free Radic. Biol. Med."},{"key":"27","volume-title":"Bergey\u2019s Manual of Determinative Bacteriology","author":"Holt J. G.","year":"1994"},{"key":"28","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.mimet.2006.09.020","article-title":"Isolation and characterization of the emerging foodborne pathogen Arcobacter from human stool","volume":"68","author":"Houf K.","year":"2007","journal-title":"J. Microbiol. Methods"},{"key":"29","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.aquaculture.2004.04.002","article-title":"Effect of dietary vitamin E on growth, tissue lipid peroxidation, and liver glutathione level of juvenile hybrid tilapia, Oreochromis niloticus \u00d7 O. aureus, fed oxidized oil","volume":"237","author":"Huang C.-H.","year":"2004","journal-title":"Aquaculture"},{"key":"30","first-page":"189","article-title":"Isolation Arcobacter butzleri in raw water and drinking water treatment plants in Germany","volume":"201","author":"Jacob J.","year":"1998","journal-title":"Zentralbl. Hyg. Umweltmed."},{"key":"31","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.cbpb.2007.07.007","article-title":"Hypoxia induces oxidative stress in tissues of a goby, the rotan Perccottus gleni","volume":"148","author":"Lushchak V.","year":"2007","journal-title":"Comp. Biochem. Physiol. Part B"},{"key":"32","volume-title":"A review and synthesis of effects of alterations to the water temperature regime on freshwater life stages of salmonids, with special reference to Chinook salmon","author":"McCullough D. A.","year":"1999"},{"key":"33","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1007\/s12038-007-0143-8","article-title":"Edwardsiellosis in fish: a brief review","volume":"32","author":"Mohanty B. R.","year":"2007","journal-title":"J. Biosci."},{"key":"34","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1111\/j.1348-0421.2004.tb03548.x","article-title":"Isolation and phylogenetic analysis of Arcobacter spp. in ground chicken meat and environmental water in Japan and Thailand","volume":"48","author":"Morita Y.","year":"2004","journal-title":"Microbiol. Immunol."},{"key":"35","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1111\/j.1365-2761.1993.tb00897.x","article-title":"Changes in serum protein composition occur in Atlantic salmon, Salmo salar L., during Aeromonas salmonicida infection","volume":"16","author":"M\u00f8yner K.","year":"1993","journal-title":"J. Fish Dis."},{"key":"36","volume-title":"Microbial Fish Disease Laboratory Manual","author":"Plumb J. A.","year":"1983"},{"key":"37","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1093\/oxfordjournals.aje.a118408","article-title":"A simple method of estimating fifty percent endpoints","volume":"27","author":"Reed L. J.","year":"1938","journal-title":"Am. J. Epidemiol."},{"key":"38","doi-asserted-by":"crossref","first-page":"351","DOI":"10.2754\/avb200271030351","article-title":"Aeromonas causes severe skin lesions in rainbow trout (Oncorhynchus mykiss): clinical pathology, haematology and biochemistry","volume":"71","author":"\u0158ehulka J.","year":"2002","journal-title":"Acta Vet. Brno"},{"key":"39","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1111\/j.1365-2109.2007.01786.x","article-title":"Blood parameters in brook trout Salvelinus fontinalis (Mitchill, 1815), affected by columnaris disease","volume":"38","author":"\u0158ehulka J.","year":"2007","journal-title":"Aquacult. Res."},{"key":"40","first-page":"1261","article-title":"Liver antioxidant systems and lipid peroxidation in sea bass (Dicentrarchus labrax) adapted to fresh water","volume":"27","author":"Sahan A.","year":"2003","journal-title":"Turk. J. Vet. Anim. Sci."},{"key":"41","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1080\/13921657.2006.10512745","article-title":"Evaluation of quantitative composition of Flavobacterium columnare at the \u017eeimena","volume":"16","author":"Skrodenyt\u00e9-Arba\u010diauskien\u00e9 V.","year":"2006","journal-title":"Acta Zoologica Lituania"},{"key":"42","unstructured":"Statistical Analysis System (1993): Statistical Graphics System. Statistical Graphics Corporation, User\u2019s Guide-Reference, STCS, Inc."},{"key":"43","volume-title":"Organohalogen concentrations and a gross and histologic assessment of multiple organ systems in East Greenland polar bears (Ursus maritimus)","author":"Sonne C.","year":"2004"},{"key":"44","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1017\/S0950268800051050","article-title":"Arcobacter cryaerophilus and thermophilic campylobacters in a sewage treatment plant in Italy: two secondary treatments compared","volume":"110","author":"Stampi S.","year":"1993","journal-title":"Epidemiol. Infect."},{"key":"45","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1099\/00207713-41-1-88","article-title":"Revision of Campylobacter, Helicobacter and Wolinella taxonomy emendation of generic descriptions and proposal of Arcobacter gen. nov","volume":"41","author":"Vandamme P.","year":"1991","journal-title":"Int. J. Syst. Bacteriol."},{"key":"46","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.vetmic.2004.11.002","article-title":"Prevalence, enumeration and strain variation of Arcobacter species in faeces of healthy cattle in Belgium","volume":"105","author":"Driessche E.","year":"2005","journal-title":"Vet. Microbiol."},{"key":"47","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/j.1365-2761.1988.tb00737.x","article-title":"Haematological and biochemical analyses of Atlantic salmon, Salmo salar L., suffering from coldwater vibriosis (Hitra disease)","volume":"11","author":"Waagb\u00f8 R.","year":"1988","journal-title":"J. Fish Dis."},{"key":"48","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1556\/AVet.54.2006.2.6","article-title":"Pathological effects of Arcobacter cryaerophilus infection in rainbow trout (Oncorhynchus mykiss Walbaum)","volume":"54","author":"Yildiz H.","year":"2006","journal-title":"Acta Vet. Hung."}],"container-title":["Acta Veterinaria Hungarica"],"original-title":[],"link":[{"URL":"https:\/\/akjournals.com\/view\/journals\/004\/57\/2\/article-p305.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.akademiai.com\/doi\/pdf\/10.1556\/avet.57.2009.2.11","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T07:00:35Z","timestamp":1633676435000},"score":1,"resource":{"primary":{"URL":"https:\/\/akjournals.com\/doi\/10.1556\/avet.57.2009.2.11"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6,1]]},"references-count":48,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1556\/avet.57.2009.2.11","relation":{},"ISSN":["0236-6290","1588-2705"],"issn-type":[{"value":"0236-6290","type":"print"},{"value":"1588-2705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,6,1]]}}}