{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T01:50:46Z","timestamp":1692669046404},"reference-count":26,"publisher":"Akademiai Kiado Zrt.","issue":"4","content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2010,12,1]]},"abstract":"<jats:p>Subcutaneous dirofilariosis caused by \n <jats:italic>Dirofilaria repens<\/jats:italic>\n is common in dogs and it is an emerging helminthozoonosis in Europe, Asia, Africa and also in Hungary. Macrocyclic lactones are used for preventing the infection; however, their activity against the microfilariae and mature stages of this species is questionable. Selamectin is widely used for the prophylaxis of heartworm (\n <jats:italic>D. immitis<\/jats:italic>\n ) infection. The objective of the present study was to test the microfilaricidal efficacy of the topical formulation of selamectin in dogs naturally infected with \n <jats:italic>D. repens<\/jats:italic>\n . A total of 78 Beagle dogs were examined for the presence of circulating microfilariae by Knott\u2019s test. Twenty-three of the microfilaraemic dogs were divided into four groups and included in the trial. The dogs received monthly or biweekly selamectin treatment and were subjected to monthly blood testing for a period of 252 or 336 days. At the end of the study, 65% of the dogs were not microfilaraemic and the rest had low number of microfilariae in their blood. These results indicate that chronic spot-on selamectin treatment may be a useful tool also in the control of canine subcutaneous dirofilariosis.<\/jats:p>","DOI":"10.1556\/avet.58.2010.4.1","type":"journal-article","created":{"date-parts":[[2010,11,19]],"date-time":"2010-11-19T02:21:07Z","timestamp":1290133267000},"page":"405-412","update-policy":"http:\/\/dx.doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":9,"title":["Preliminary findings on the efficacy of selamectin in the treatment of dogs naturally infected with Dirofilaria repens"],"prefix":"10.1556","volume":"58","author":[{"given":"Olga","family":"Jacs\u00f3","sequence":"first","affiliation":[{"name":"1 Szent Istv\u00e1n University Department of Parasitology and Zoology, Faculty of Veterinary Science Istv\u00e1n u. 2 H-1078 Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c9va","family":"Fok","sequence":"additional","affiliation":[{"name":"1 Szent Istv\u00e1n University Department of Parasitology and Zoology, Faculty of Veterinary Science Istv\u00e1n u. 2 H-1078 Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella","family":"Kiss","sequence":"additional","affiliation":[{"name":"2 Pfizer Animal Health Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00e1bor","family":"K\u00f6k\u00e9ny","sequence":"additional","affiliation":[{"name":"3 Dr. Bub\u00f3-Vet Szigetszentmikl\u00f3s Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zsolt","family":"Lang","sequence":"additional","affiliation":[{"name":"4 Szent Istv\u00e1n University Department of Biomathematics and Informatics, Faculty of Veterinary Science Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0304-4017(02)00006-7","article-title":"Dirofilaria repens infection in a dog: diagnosis and treatment with melarsomine and doramectin","volume":"105","author":"Baneth G.","year":"2002","journal-title":"Vet. Parasitol."},{"key":"2","first-page":"177","article-title":"Ivermectin against larval stages of Dirofilaria repens in dogs","volume":"31","author":"Cancrini G.","year":"1989","journal-title":"Parassitologia"},{"key":"3","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.vetpar.2006.06.006","article-title":"A simple molecular method for discriminating common filarial nematodes of dogs (Canis familiaris)","volume":"141","author":"Casiraghi M.","year":"2006","journal-title":"Vet. Parasitol."},{"key":"4","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0304-4017(00)00296-X","article-title":"Efficacy of selamectin in the prevention of adult heartworm (Dirofilaria immitis) infection in dogs in northern Italy","volume":"91","author":"Clemence R. G.","year":"2000","journal-title":"Vet. Parasitol."},{"key":"5","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/1751-0147-50-46","article-title":"A review of the off-label use of selamectin (Stronghold\/Revolution) in dogs and cats","volume":"50","author":"Fisher M. A.","year":"2008","journal-title":"Acta Vet. Scand."},{"key":"6","doi-asserted-by":"crossref","unstructured":"Fok, \u00c9., Jacs\u00f3, O., Szebeni, Zs., Gy\u0151rffy, A., S\u00fck\u00f6sd, L., Luk\u00e1cs, Z. and Schaper, R. (2010): Elimination of <i>Dirofilaria<\/i> (syn. <i>Nochtiella<\/i> ) <i>repens<\/i> microfilariae in dogs with monthly treatments of moxidectin 2.5%\/imidacloprid 10% (Advocate\u00ae, Bayer) spot-on. Parasitology Research, 18 February DOI:10.1007\/s00436-010-1783-4","DOI":"10.1007\/s00436-010-1783-4"},{"key":"7","volume-title":"Mappe Parassitologiche 8","author":"Fok","year":"2007"},{"key":"8","first-page":"218","article-title":"The first autochthonous case of a dog infected with Dirofilaria repens in Hungary (in Hungarian)","volume":"4","author":"Fok","year":"1998","journal-title":"Kis\u00e1llatorvosl\u00e1s"},{"key":"9","first-page":"69","article-title":"Efficacy of selamectin in the prophylaxis of Dirofilaria repens infestations in dogs (in Italian)","volume":"16","author":"Genchi C.","year":"2002","journal-title":"Veterinaria"},{"key":"10","volume-title":"Mappe Parassitologiche 8","author":"Genchi C.","year":"2007"},{"key":"11","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2478\/s11687-009-0030-y","article-title":"First autochthonous Dirofilaria immitis (Leidy, 1856) infection in a dog in Hungary","volume":"46","author":"Jacs\u00f3 O.","year":"2009","journal-title":"Helminthologia"},{"key":"12","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/0304-4017(91)90113-A","article-title":"Canine filariasis caused by Dirofilaria repens in Southeastern Nigeria","volume":"40","author":"Kamalu B. T.","year":"1991","journal-title":"Vet. Parasitol."},{"key":"13","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0304-4017(99)00175-2","article-title":"Comparative distribution of ivermectin and doramectin to parasite location tissues in cattle","volume":"87","author":"Lifschitz A.","year":"2000","journal-title":"Vet. Parasitol."},{"key":"14","volume-title":"Mappe Parassitologiche 8","author":"Manfredi M. T.","year":"2007"},{"key":"15","first-page":"67","article-title":"The value of ivermectin in the prophylaxis of Dirofilaria repens infestation in naturally infected dogs (in Italian)","volume":"35","author":"Marconcini A.","year":"1993","journal-title":"Parassitologia"},{"key":"16","volume-title":"Mappe Parassitologiche 8","author":"McCall J. W.","year":"2007"},{"key":"17","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0304-4017(00)00297-1","article-title":"Prevention of experimentally induced heartworm (Dirofilaria immitis) infections in dogs and cats with a single topical application of selamectin","volume":"91","author":"McTier T. L.","year":"2000","journal-title":"Vet. Parasitol."},{"key":"18","first-page":"231","article-title":"Human dirofilariosis due to Dirofilaria repens: update of world literature from 1995 to 2000","volume":"42","author":"Pampiglione S.","year":"2000","journal-title":"Parassitologia"},{"key":"19","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1556\/AVet.47.1999.1.7","article-title":"Human Dirofilaria repens infection in Hungary: A case in the spermatic cord and a review of the literature","volume":"47","author":"Pampiglione S.","year":"1999","journal-title":"Acta Vet. Hung."},{"key":"20","unstructured":"Pingen, C. H., Lorentz, S., Magnis, J., Menn, B., Schaper, R. and Naucke, T. J. (2009): Successful treatment of <i>Dirofilaria repens<\/i> infections in dogs with melarsomine (Immiticide\u00ae Merial) against adults and a combination of moxidectin 2.5%\/imidacloprid 10% (Advocate\u00ae, Bayer) against microfilariae. Second European Dirofilaria Days (SEDD), 16\u201318 September, Salamanca, Abstract, 021."},{"key":"21","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1136\/vr.150.12.383-a","article-title":"Use of moxidectin tablets in the control of canine subcutaneous dirofilariosis","volume":"150","author":"Rossi L.","year":"2002","journal-title":"Vet. Rec."},{"key":"22","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1136\/vr.154.1.26","article-title":"Use of an injectable, sustained-release formulation of moxidectin to prevent canine subcutaneous dirofilariosis","volume":"154","author":"Rossi L.","year":"2004","journal-title":"Vet. Rec."},{"key":"23","first-page":"100","article-title":"Autochthonous infection with Dirofilaria repens in dogs in Hungary (in Hungarian, with English abstract)","volume":"121","author":"Sz\u00e9ll Z.","year":"1999","journal-title":"Magyar \u00c1llatorvosok Lapja"},{"key":"24","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1007\/s00508-008-0928-2","article-title":"Human dirofilariosis in Hungary: an emerging zoonosis in Central Europe","volume":"120","author":"Sz\u00e9n\u00e1si Zs.","year":"2008","journal-title":"Wiener Klin. Wschr."},{"key":"25","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1556\/AVet.50.2002.1.9","article-title":"Dermatitis associated with Dirofilaria (Nochtiella) repens microfilariae in dogs from Central Italy","volume":"50","author":"Tarello W.","year":"2002","journal-title":"Acta Vet. Hung."},{"key":"26","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0014-4894(55)90007-2","article-title":"Experimental maintenance of Dirofilaria repens and D. immitis in dogs","volume":"4","author":"Webber W. A. F.","year":"1955","journal-title":"Exp. Parasitol."}],"container-title":["Acta Veterinaria Hungarica"],"original-title":[],"link":[{"URL":"https:\/\/akjournals.com\/view\/journals\/004\/58\/4\/article-p405.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/akjournals.com\/downloadpdf\/journals\/004\/58\/4\/article-p405.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,30]],"date-time":"2021-01-30T18:27:42Z","timestamp":1612031262000},"score":1,"resource":{"primary":{"URL":"https:\/\/akjournals.com\/view\/journals\/004\/58\/4\/article-p405.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12,1]]},"references-count":26,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.1556\/avet.58.2010.4.1","relation":{},"ISSN":["0236-6290","1588-2705"],"issn-type":[{"value":"0236-6290","type":"print"},{"value":"1588-2705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12,1]]}}}