{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T02:21:10Z","timestamp":1777429270808,"version":"3.51.4"},"reference-count":32,"publisher":"Akademiai Kiado Zrt.","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,3,1]]},"abstract":"<jats:p>The objective of the study was to determine the immunostimulatory effect of \u03b2-(1,3\/1,6)-D-glucan in puppies. The effect exerted on the efficacy of vaccination, especially against canine parvovirus and rabies infection, was studied. The application of vaccine and glucan leads to significant increases in the nonspecific immunological parameters (phagocytic ability of leukocytes, blastogenic response of lymphocytes, metabolic and chemotactic activity of polymorphonuclear cells). The level of antibodies against canine parvovirus (Ab CPV) and rabies infection reached the most statistically significant values on the 28th day after the application of vaccine and a syrup containing \u03b2-(1,3\/1,6)-D-glucan (Group GV) as compared to the control group (Group V, puppies receiving only vaccine). Dogs without glucan supplementation did not produce such significant levels of antibodies. We can conclude that glucan has relevant immunostimulatory effects in dogs with altered immunity. The glucan product tested in this study (PleraSAN V, PLEURAN, Bratislava, Slovakia) could be used in the small animal clinical practice.<\/jats:p>","DOI":"10.1556\/avet.59.2011.1.7","type":"journal-article","created":{"date-parts":[[2011,3,2]],"date-time":"2011-03-02T15:54:14Z","timestamp":1299081254000},"page":"77-86","source":"Crossref","is-referenced-by-count":17,"title":["Immunomodulatory effect of glucan on specific and nonspecific immunity after vaccination in puppies"],"prefix":"10.1556","volume":"59","author":[{"given":"Eva","family":"Haladov\u00e1","sequence":"first","affiliation":[{"name":"1 University of Veterinary Medicine and Pharmacy in Ko\u0161ice Department of Epizootiology and Preventive Veterinary Medicine Komensk\u00e9ho 73 04181 Ko\u0161ice Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jana","family":"Moj\u017ei\u0161ov\u00e1","sequence":"additional","affiliation":[{"name":"1 University of Veterinary Medicine and Pharmacy in Ko\u0161ice Department of Epizootiology and Preventive Veterinary Medicine Komensk\u00e9ho 73 04181 Ko\u0161ice Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Smr\u010do","sequence":"additional","affiliation":[{"name":"1 University of Veterinary Medicine and Pharmacy in Ko\u0161ice Department of Epizootiology and Preventive Veterinary Medicine Komensk\u00e9ho 73 04181 Ko\u0161ice Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Ondrejkov\u00e1","sequence":"additional","affiliation":[{"name":"1 University of Veterinary Medicine and Pharmacy in Ko\u0161ice Department of Epizootiology and Preventive Veterinary Medicine Komensk\u00e9ho 73 04181 Ko\u0161ice Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boris","family":"Vojtek","sequence":"additional","affiliation":[{"name":"1 University of Veterinary Medicine and Pharmacy in Ko\u0161ice Department of Epizootiology and Preventive Veterinary Medicine Komensk\u00e9ho 73 04181 Ko\u0161ice Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari\u00e1n","family":"Proke\u0161","sequence":"additional","affiliation":[{"name":"1 University of Veterinary Medicine and Pharmacy in Ko\u0161ice Department of Epizootiology and Preventive Veterinary Medicine Komensk\u00e9ho 73 04181 Ko\u0161ice Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Petrovov\u00e1","sequence":"additional","affiliation":[{"name":"1 University of Veterinary Medicine and Pharmacy in Ko\u0161ice Department of Epizootiology and Preventive Veterinary Medicine Komensk\u00e9ho 73 04181 Ko\u0161ice Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1016\/0192-0561(92)90007-8","article-title":"Stimulation of human monocyte beta-glucan receptors by glucan particles induces production of TNF-\u03b1 and IL-1\u03b2","volume":"14","author":"Abel G.","year":"1992","journal-title":"Int. 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