{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T18:23:22Z","timestamp":1784831002967,"version":"3.55.0"},"reference-count":10,"publisher":"Akademiai Kiado Zrt.","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,3,1]]},"abstract":"<jats:p>In this study, synchronous spontaneous, independent liver and gallbladder tumours were detected in a Bearded dragon (<jats:italic>Pogona vitticeps<\/jats:italic>). The multiple tumours consisted of intrahepatic cholangiocarcinoma as well as <jats:italic>in situ<\/jats:italic> adenocarcinoma and two adenomas of the gallbladder. The biliary epithelial cells and the cholangiocarcinoma showed membranous cross-immunoreactivity for claudin-7. The gallbladder epithelial cells, its adenoma and adenocarcinoma showed basolateral cross-reactivity for claudin-7. We think that the humanised anti-claudin-7 antibody is a good marker for the detection of different primary cholangiocellular and gallbladder tumours in Bearded dragons. The cholangiocytes, the cholangiocarcinoma, the endothelial cells of the liver and the epithelial cells and gallbladder tumours all showed claudin-5 cross-reactivity. The humanised anti-cytokeratin AE1\u2013AE3 antibody showed cross-reactivity in the biliary epithelial cells, cholangiocarcinoma cells, epithelial cells and tumour cells of the gallbladder. It seems that this humanised antibody is a useful epithelial marker for the different neoplastic lesions of epithelial cells in reptiles. The humanised anti-\u03b1-smooth muscle actin (\u03b1-SMA) antibody showed intense cross-reactivity in the smooth muscle cells of the hepatic vessels and in the muscle layer of the gallbladder. The portal myofibroblasts, the endothelial cells of the sinusoids and the stromal cells of the cholangiocarcinoma and gallbladder tumours were positive for \u03b1-SMA. The antibovine anti-vimentin and humanised anti-Ki-67 antibodies did not show crossreactivity in the different samples from the Bearded dragon.<\/jats:p>","DOI":"10.1556\/avet.59.2011.1.9","type":"journal-article","created":{"date-parts":[[2011,3,2]],"date-time":"2011-03-02T15:54:14Z","timestamp":1299081254000},"page":"99-112","source":"Crossref","is-referenced-by-count":16,"title":["Claudin-7-positive synchronous spontaneous intrahepatic cholangiocarcinoma, adenocarcinoma and adenomas of the gallbladder in a Bearded dragon (Pogona vitticeps)"],"prefix":"10.1556","volume":"59","author":[{"given":"Csaba","family":"Jakab","sequence":"first","affiliation":[{"name":"1 Szent Istv\u00e1n University Department of Pathology and Forensic Veterinary Medicine Istv\u00e1n u. 2 H-1078 Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikl\u00f3s","family":"Rusvai","sequence":"additional","affiliation":[{"name":"1 Szent Istv\u00e1n University Department of Pathology and Forensic Veterinary Medicine Istv\u00e1n u. 2 H-1078 Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zolt\u00e1n","family":"Szab\u00f3","sequence":"additional","affiliation":[{"name":"2 Szent Istv\u00e1n University Department of Pharmacology and Toxicology, Faculty of Veterinary Science Istv\u00e1n u. 2 H-1078 Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"G\u00e1lfi","sequence":"additional","affiliation":[{"name":"3 C. J. Hall Veterinary Surgeons \u2014 Exotic Centre London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikl\u00f3s","family":"Maros\u00e1n","sequence":"additional","affiliation":[{"name":"1 Szent Istv\u00e1n University Department of Pathology and Forensic Veterinary Medicine Istv\u00e1n u. 2 H-1078 Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janina","family":"Kulka","sequence":"additional","affiliation":[{"name":"4 Semmelweis University 2nd Department of Pathology Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e1nos","family":"G\u00e1l","sequence":"additional","affiliation":[{"name":"1 Szent Istv\u00e1n University Department of Pathology and Forensic Veterinary Medicine Istv\u00e1n u. 2 H-1078 Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"1","unstructured":"Fontenot, D. K., Gregory, C. R., Lamberski, N., Campagnoli, R. P. and Latimer, K. S. (1999): Monocytic leukemia with tissue metastases in a Bearded dragon (<i>Pogona vitticeps<\/i>). Proceedings of International Virtual Conferences in Veterinary Medicine (IVCVM): Diseases of Exotic Animals and Wildlife, 1999."},{"key":"2","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1083\/jcb.141.7.1539","article-title":"Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin","volume":"141","author":"Furuse M.","year":"1998","journal-title":"J. Cell Biol."},{"key":"3","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.cvex.2004.04.002","article-title":"Reptile neoplasia: a retrospective study of case submissions to a specialty diagnostic service","volume":"7","author":"Garner M. M.","year":"2004","journal-title":"Vet. Clin. Exot. Anim."},{"key":"4","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S1094-9194(02)00028-2","article-title":"Neoplasia of reptiles with an emphasis on lizards","volume":"6","author":"Hernandez-Divers S. M.","year":"2003","journal-title":"Vet. Clin. Exot. Anim."},{"key":"5","first-page":"857","article-title":"Claudin-7 protein differentiates canine cholangiocarcinoma from hepatocellular carcinoma","volume":"25","author":"Jakab Cs.","year":"2010","journal-title":"Histol. Histopathol."},{"key":"6","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1354\/vp.42-4-507","article-title":"Multicentric benign peripheral nerve sheath tumors in two related Bearded dragons, Pogona vitticeps","volume":"42","author":"Lemberger K. Y.","year":"2005","journal-title":"Vet. Pathol."},{"key":"7","doi-asserted-by":"crossref","first-page":"9","DOI":"10.5818\/1529-9651.11.1.9","article-title":"Malignant peripheral nerve sheath tumor in a Bearded dragon, Pogona vitticeps","volume":"11","author":"Mikaelian I.","year":"2001","journal-title":"J. Herpetol. Med. Surg."},{"key":"8","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1354\/vp.09-VP-0019-K-FL","article-title":"Gastric neuroendocrine carcinomas in Bearded dragons (Pogona vitticeps)","volume":"46","author":"Ritter J. M.","year":"2009","journal-title":"Vet. Pathol."},{"key":"9","first-page":"10","article-title":"Lymphoblastic leukemia in an inland Bearded dragon, Pogona vitticeps","volume":"4","author":"Suedmeyer K.","year":"1996","journal-title":"Bull. Assoc. Rept. Amphibian Vet."},{"key":"10","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1638\/1042-7260(2001)032[0090:MLIABD]2.0.CO;2","article-title":"Myelogenous leukemia in a Bearded dragon (Acanthodraco vitticeps)","volume":"32","author":"Tocidlowski M. E.","year":"2001","journal-title":"J. Zoo Wildl. Med."}],"container-title":["Acta Veterinaria Hungarica"],"original-title":[],"link":[{"URL":"https:\/\/akjournals.com\/view\/journals\/004\/59\/1\/article-p99.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/akademiai.com\/doi\/pdf\/10.1556\/AVet.59.2011.1.9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,22]],"date-time":"2020-05-22T09:44:17Z","timestamp":1590140657000},"score":1,"resource":{"primary":{"URL":"https:\/\/akjournals.com\/doi\/10.1556\/avet.59.2011.1.9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3,1]]},"references-count":10,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1556\/avet.59.2011.1.9","relation":{},"ISSN":["0236-6290","1588-2705"],"issn-type":[{"value":"0236-6290","type":"print"},{"value":"1588-2705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3,1]]}}}