{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T00:11:17Z","timestamp":1689293477770},"reference-count":24,"publisher":"Akademiai Kiado Zrt.","issue":"2","content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["IMAS"],"published-print":{"date-parts":[[2014,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>It is well known that mitral stenosis (MS) is complicated by pulmonary hypertension (PH) of varying degrees. The hemodynamic derangement is associated with structural changes in the pulmonary vessels and parenchyma and also functional derangements. This article analyzes the pulmonary function derangements in 25 patients with isolated\/predominant mitral stenosis of varying severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>The aim of the study was to correlate the pulmonary function test (PFT) derangements (done by simple methods) with: a) patient demographics and clinical profile, b) severity of the mitral stenosis, and c) severity of pulmonary artery hypertension (PAH) and d) to evaluate its significance in preoperative assessment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>This cross-sectional study was conducted in 25 patients with mitral stenosis who were selected for mitral valve (MV) surgery. The patients were evaluated for clinical class, echocardiographic severity of mitral stenosis and pulmonary hypertension, and with simple methods of assessment of pulmonary function with spirometry and blood gas analysis. The diagnosis and classification were made on standardized criteria. The associations and correlations of parameters, and the difference in groups of severity were analyzed statistically with Statistical Package for Social Sciences (SPSS), using nonparametric measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The spirometric parameters showed significant correlation with increasing New York Heart Association (NYHA) functional class (FC): forced vital capacity (FVC,<jats:italic>r<\/jats:italic>= \u22120.4*,<jats:italic>p<\/jats:italic>= 0.04), forced expiratory volume in one second (FEV1,<jats:italic>r<\/jats:italic>= \u22120.5*,<jats:italic>p<\/jats:italic>= 0.01), FEV1\/FVC (<jats:italic>r<\/jats:italic>= \u22120.44*,<jats:italic>p<\/jats:italic>= 0.02), and with pulmonary venous congestion (PVC): FVC (<jats:italic>r<\/jats:italic>= \u22120.41*,<jats:italic>p<\/jats:italic>= 0.04) and FEV1 (<jats:italic>r<\/jats:italic>= \u22120.41*,<jats:italic>p<\/jats:italic>= 0.04). Cardiothoracic ratio (CTR) correlated only with FEV1 (<jats:italic>r<\/jats:italic>= \u22120.461*,<jats:italic>p<\/jats:italic>= 0.02) and peripheral saturation of oxygen (SPO2,<jats:italic>r<\/jats:italic>= \u22120.401*,<jats:italic>p<\/jats:italic>= 0.04). There was no linear correlation to duration of symptoms, mitral valve orifice area, or pulmonary hypertension, except for MV gradient with PCO2 (<jats:italic>r<\/jats:italic>= 0.594**,<jats:italic>p<\/jats:italic>= 0.002). The decreased oxygenation status correlated significantly with FC, CTR, PVC, and with deranged spirometry (<jats:italic>r<\/jats:italic>= 0.495*,<jats:italic>p<\/jats:italic>= 0.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PFT derangements are seen in all grades of severity of MS and correlate well with the functional class, though no significant linear correlation with grades of severity of stenosis or pulmonary hypertension. Even the early or mild derangements in pulmonary function such as small airway obstruction in the less severe cases of normal or mild PH can be detected by simple and inexpensive methods when the conventional parameters are normal. The supplementary data from baseline arterial blood gas analysis is informative and relevant. This reclassified pulmonary function status might be prognostically predictive.<\/jats:p><\/jats:sec>","DOI":"10.1556\/imas.6.2014.2.4","type":"journal-article","created":{"date-parts":[[2014,6,5]],"date-time":"2014-06-05T01:32:15Z","timestamp":1401931935000},"page":"75-84","update-policy":"http:\/\/dx.doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":0,"title":["Pulmonary function derangements in isolated or predominant mitral stenosis \u2014 Preoperative evaluation with clinicohemodynamic correlation"],"prefix":"10.1556","volume":"6","author":[{"given":"Usha T.","family":"Parvathy","sequence":"first","affiliation":[{"name":"1 MPS Hospital, Department of Cardiac Surgery, Peoples Friendship University of Russia, Moscow, Russian Federation"},{"name":"2 Department of Cardiac Surgery, Peoples Friendship University of Russia, Moscow, Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajesh","family":"Rajan","sequence":"additional","affiliation":[{"name":"1 MPS Hospital, Department of Cardiac Surgery, Peoples Friendship University of Russia, Moscow, Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faybushevich Alexander","family":"Georgevich","sequence":"additional","affiliation":[{"name":"1 MPS Hospital, Department of Cardiac Surgery, Peoples Friendship University of Russia, Moscow, Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"1","first-page":"744","article-title":"Disturbances of pulmonary function in mitral valve disease","volume":"89","author":"Palmer W.H.","year":"1963","journal-title":"Canad Med Ass J"},{"key":"2","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1136\/thx.37.10.751","article-title":"Relation between severity of mitral valve disease and results of routine lung function tests in non-smokers","volume":"37","author":"Rhodes K.M.","year":"1982","journal-title":"Thorax"},{"key":"3","first-page":"763","article-title":"The repercussions of pulmonary congestion on ventilatory volumes, capacities and flows","volume":"13","author":"Carmo M.M.","year":"1994","journal-title":"Rev Port Cardiol"},{"key":"4","first-page":"254","article-title":"The lung function in operated acquired mitral and aortic valve diseases without left ventricular failure \u2014 preliminary observations before operation","volume":"1","author":"Bitner M.","year":"2005","journal-title":"Arch Med Sci"},{"key":"5","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1097\/00000542-195605000-00008","article-title":"Convenient method of evaluating pulmonary ventilatory function with a single breath test","volume":"17","author":"Miller W.F.","year":"1956","journal-title":"Anesthesiology"},{"key":"6","volume-title":"Pulmonary function","author":"Conrad S.A.","year":"1983"},{"key":"7","first-page":"295","article-title":"Spirometric changes after open mitral surgery","volume":"37","author":"Vaidya R.","year":"1996","journal-title":"J Cardiovasc Surg (Torino)"},{"key":"8","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1159\/000026066","article-title":"ung function and severity of mitral stenosis","volume":"8","author":"Nour M.M.","year":"1999","journal-title":"Med Principles Pract"},{"key":"9","first-page":"63","article-title":"Pulmonary function in patients with rheumatic mitral valve disease. 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