{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:01:04Z","timestamp":1761058864358},"reference-count":25,"publisher":"Akademiai Kiado Zrt.","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MaSeb"],"published-print":{"date-parts":[[2007,4,1]]},"abstract":"<jats:title>Absztrakt<\/jats:title><jats:p>A k\u00f3ros hegk\u00e9pz\u0151d\u00e9sek etiol\u00f3gi\u00e1ja napjainkban is j\u00f3r\u00e9szt ismeretlen, k\u00fcl\u00f6n\u00f6s tekintettel a keloidok kialakul\u00e1s\u00e1ra. A szerz\u0151k a hazai \u00e9s a nemzetk\u00f6zi irodalom retrospekt\u00edv elemz\u00e9se, valamint saj\u00e1t eredm\u00e9nyeik alapj\u00e1n foglalj\u00e1k \u00f6ssze a k\u00f3ros hegek tapasztalaton alapul\u00f3 kezel\u00e9si \u00e9s megel\u0151z\u00e9si protokolljait. A kortikoszteroidokat az 1960-as \u00e9vekt\u0151l kezd\u0151d\u0151en alkalmazt\u00e1k intral\u00e9zion\u00e1lisan a hipertr\u00f3fi\u00e1s hegek \u00e9s a keloidok kezel\u00e9s\u00e9re. Ezt k\u00f6vette az 1970-es \u00e9vekt\u0151l a nyom\u00e1s kezel\u00e9s m\u00f3dszere, majd a k\u00f6vetkez\u0151 \u00e9vtizedben a poliszilox\u00e1n-tapaszos m\u00f3dszer. A keloidok magas recid\u00edva ar\u00e1nya miatt a k\u00fcl\u00f6nf\u00e9le elj\u00e1r\u00e1sokat \u00e9s a radioter\u00e1pi\u00e1t kombin\u00e1lt\u00e1k, \u00e9s aj\u00e1nlott\u00e1 v\u00e1lt a komplex kezel\u00e9s. Az \u00fajabb, modern elj\u00e1r\u00e1sokat is \u2013 a k\u00fcl\u00f6nb\u00f6z\u0151 t\u00edpus\u00fa l\u00e9zereket, \u00e9s a krioter\u00e1pi\u00e1t \u2013 bevetett\u00e9k a keloid ellen. B\u0151v\u00fclt a helyileg alkalmazhat\u00f3 k\u00e9sz\u00edtm\u00e9nyek k\u00f6re. A kutat\u00e1s az elm\u00falt \u00e9vtizedben \u00fajabb intral\u00e9zion\u00e1lisan adhat\u00f3 szerek keres\u00e9se \u00e9s a genetikai vizsg\u00e1latok fel\u00e9 fordult. Fokozatosan kialakul az adjuv\u00e1ns \u00e9s az alternat\u00edv elj\u00e1r\u00e1sok helye is a protokollokban. Mivel megsz\u00fcletett az objekt\u00edv \u00e9s az \u00e1ltal\u00e1nosan elfogadott heg\u00e9rt\u00e9kel\u0151 m\u00f3dszer, annak alkalmaz\u00e1sa (az \u00fan. Vancouver-klasszifik\u00e1ci\u00f3 \u00e9s pontrendszer) m\u00e1r lehet\u0151v\u00e9 tette a kontroll\u00e1lt, randomiz\u00e1lt tanulm\u00e1nyok v\u00e9gz\u00e9s\u00e9t. Lehets\u00e9ges a k\u00fcl\u00f6nf\u00e9le ter\u00e1pi\u00e1s protokollok hat\u00e1soss\u00e1g\u00e1nak prospekt\u00edv vizsg\u00e1lata, megfelel\u0151 ut\u00e1nk\u00f6vet\u00e9si id\u0151vel. A m\u00f3dszerek hat\u00e1soss\u00e1g\u00e1nak \u00f6sszehasonl\u00edt\u00e1sa azonban neh\u00e9z, mivel napjainkban m\u00e9g hi\u00e1nyzik egy-egy adott kezel\u00e9si m\u00f3d pontos ter\u00e1pi\u00e1s eredm\u00e9ny\u00e9nek meghat\u00e1roz\u00e1sa.<\/jats:p>","DOI":"10.1556\/maseb.60.2007.2.1","type":"journal-article","created":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T02:03:47Z","timestamp":1225505027000},"page":"63-70","source":"Crossref","is-referenced-by-count":5,"title":["A k\u00f3ros hegek kezel\u00e9s\u00e9nek \u00e9s megel\u0151z\u00e9s\u00e9nek lehet\u0151s\u00e9gei napjainkbanr"],"prefix":"10.1556","volume":"60","author":[{"given":"Ott\u00f3","family":"Kelemen","sequence":"first","affiliation":[{"name":"1 Seb\u00e9szeti Tansz\u00e9k, Baranya Megyei K\u00f3rh\u00e1z \u2013 P\u00e9csi Tudom\u00e1nyegyetem OEC \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, 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